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Heart failure
Diagnosis &
Differential Diagnosis
Manoz marwin--
22/3/20141
Diagnosis
• Routine laboratory testing
• Electrocardiogram
• Chest X-ray
• Assessment of LV function
• Biomarkers
• Exercise testing
22/3/20142
Routine laboratory testing
• Complete blood count
• Panel of electrolytes
• Blood urea nitrogen
• Serum creatinine
• Hepatic enzymes
• Urinalysis
• Fasting serum glucose
• Oral glucose tolerance
• Fasting lipid panel
• Thyroid-stimulating hormone level
Diabetic patients
Dyslipidemia
Thyroid
abnormalities22/3/20143
Electrocardiogram (ECG)
 To asses cardiac rhythm
 To determine the presence of LV hypertrophy
 Old or recent MI
 To ascertain whether the patient may benefit from
resynchronization therapy
Presence or absence of Q waves
QRS width
22/3/20144
Chest X-ray
22/3/20145
 Cardiac size & shape
 State of pulmonary vasculature
 Identify noncardiac causes of the patient’s symptoms
Assessment of LV function
22/3/20146
• 2D echocardiogram/Doppler
• Magnetic resonance imaging (MRI)
2D echocardiogram/Doppler
22/3/20147
 Provide a semiquantitative assessment of LV size &
function
 Presence/absence of valvular and/or regional wall
motion abnormalities
 Assess RV size & pulmonary pressures – evaluating
and management of cor pulmonale
 The presence of left atrial dilatation and LV
hypertrophy + abnormalities of LV diastolic filling
provided by pulse-wave and tissue Doppler – useful for
the assessment of HF with a preserved EF.
Magnetic resonance imaging (MRI)
22/3/20148
 Analysis of cardiac anatomy and function
 Gold standard for assessing LV mass and volumes
 Determining the cause of HF
22/3/20149
 EF - most useful index of LV function
 EF - easy to measure by noninvasive testing
 EF - normal (>50%) – adequate systole function
 EF - depressed (<30-40%) – contractility depressed
 EF - influenced by alterations in afterload/preload
Ejection Fraction
Biomarkers
22/3/201410
 Adjunctive tools in diagnosis
 Released from failing heart
 Natriuretic peptides
 Other biomarkers
 B-type natriuretic peptide
 N- terminal pro-BNP
 Elevate with increase in age & renal impairment
 More in women
 Falsely low in obese patients
 troponin T & I
 c-reactive protein
 TNF receptors
 uric acid
Exercise testing
22/3/201411
 Treadmill/ bicycle exercise
 Assessing the need for cardiac transplantation
 Peak oxygen uptake (Vo2) <14 ml/kg/min – poor
prognosis
Differential diagnosis
22/3/201412
Non cardiac causes of
• circulatory congestion secondary to abnormal
sodium and water retention ( renal failure)
• pulmonary edema ( acute respiratory distress
syndrome)
• ankle edema (varicose veins, obesity, renal
disease or gravitational effect)
• dyspnoea (chronic lung disease, obesity)
…Thank you
22/3/201413

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Heart Failure - Diagnosis and Differential Diagnosis

  • 1. Heart failure Diagnosis & Differential Diagnosis Manoz marwin-- 22/3/20141
  • 2. Diagnosis • Routine laboratory testing • Electrocardiogram • Chest X-ray • Assessment of LV function • Biomarkers • Exercise testing 22/3/20142
  • 3. Routine laboratory testing • Complete blood count • Panel of electrolytes • Blood urea nitrogen • Serum creatinine • Hepatic enzymes • Urinalysis • Fasting serum glucose • Oral glucose tolerance • Fasting lipid panel • Thyroid-stimulating hormone level Diabetic patients Dyslipidemia Thyroid abnormalities22/3/20143
  • 4. Electrocardiogram (ECG)  To asses cardiac rhythm  To determine the presence of LV hypertrophy  Old or recent MI  To ascertain whether the patient may benefit from resynchronization therapy Presence or absence of Q waves QRS width 22/3/20144
  • 5. Chest X-ray 22/3/20145  Cardiac size & shape  State of pulmonary vasculature  Identify noncardiac causes of the patient’s symptoms
  • 6. Assessment of LV function 22/3/20146 • 2D echocardiogram/Doppler • Magnetic resonance imaging (MRI)
  • 7. 2D echocardiogram/Doppler 22/3/20147  Provide a semiquantitative assessment of LV size & function  Presence/absence of valvular and/or regional wall motion abnormalities  Assess RV size & pulmonary pressures – evaluating and management of cor pulmonale  The presence of left atrial dilatation and LV hypertrophy + abnormalities of LV diastolic filling provided by pulse-wave and tissue Doppler – useful for the assessment of HF with a preserved EF.
  • 8. Magnetic resonance imaging (MRI) 22/3/20148  Analysis of cardiac anatomy and function  Gold standard for assessing LV mass and volumes  Determining the cause of HF
  • 9. 22/3/20149  EF - most useful index of LV function  EF - easy to measure by noninvasive testing  EF - normal (>50%) – adequate systole function  EF - depressed (<30-40%) – contractility depressed  EF - influenced by alterations in afterload/preload Ejection Fraction
  • 10. Biomarkers 22/3/201410  Adjunctive tools in diagnosis  Released from failing heart  Natriuretic peptides  Other biomarkers  B-type natriuretic peptide  N- terminal pro-BNP  Elevate with increase in age & renal impairment  More in women  Falsely low in obese patients  troponin T & I  c-reactive protein  TNF receptors  uric acid
  • 11. Exercise testing 22/3/201411  Treadmill/ bicycle exercise  Assessing the need for cardiac transplantation  Peak oxygen uptake (Vo2) <14 ml/kg/min – poor prognosis
  • 12. Differential diagnosis 22/3/201412 Non cardiac causes of • circulatory congestion secondary to abnormal sodium and water retention ( renal failure) • pulmonary edema ( acute respiratory distress syndrome) • ankle edema (varicose veins, obesity, renal disease or gravitational effect) • dyspnoea (chronic lung disease, obesity)