One high reading does not mean you have high blood pressure. It is necessary to measure your blood pressure at different times, while you are resting comfortably for at least five minutes. To make the diagnosis of hypertension, at least three readings that are elevated are usually required
Definition of heart failure - causes and types of heart failure - pathophysiology and risky factors for heart failure - Diagnosis clinical manifestations and investigations and classification of heart failure- treatment of chronic heart failure
Also Acute heart failure causes - clinical picture and treatment
Arterial Hypertension simply stated is high blood pressure.
It is defined as a persistent elevation of the systolic blood pressure (SBP) greater than 140 mm Hg or higher and the diastolic blood pressure (DBP) greater than 90 mm Hg or higher. types of hypertension
PRIMARY HYPERTENSION and SECONDARY HYPERTENSION .
Primary Hypertension or also known as essential or idiopathic Hypertension.
The cause of essential hypertension is unknown; however, there are several areas investigation.
It is more common type of hypertension it accounts for 90 to 95 % of all cause of HTN.
In this condition the BP is elevated from an unidentified cause.
Definition of heart failure - causes and types of heart failure - pathophysiology and risky factors for heart failure - Diagnosis clinical manifestations and investigations and classification of heart failure- treatment of chronic heart failure
Also Acute heart failure causes - clinical picture and treatment
Arterial Hypertension simply stated is high blood pressure.
It is defined as a persistent elevation of the systolic blood pressure (SBP) greater than 140 mm Hg or higher and the diastolic blood pressure (DBP) greater than 90 mm Hg or higher. types of hypertension
PRIMARY HYPERTENSION and SECONDARY HYPERTENSION .
Primary Hypertension or also known as essential or idiopathic Hypertension.
The cause of essential hypertension is unknown; however, there are several areas investigation.
It is more common type of hypertension it accounts for 90 to 95 % of all cause of HTN.
In this condition the BP is elevated from an unidentified cause.
Hypertension Emergencies and their managementpptxUzomaBende
This Presentation talks about Hyprtension, the mode of presentation of hypertensive crisis and the effective management of hypertensive crisis to prevent case fatalities.
This is a very simple presentation prepared for nurses. It will help nurses to understand the need of monitoring and the available methods. The presentation has been constructed on a clinical case base scenario and gradually different methods of monitoring has been introduced.
The complete vital signs by a Nurse for every patient at every contact ranging from first contact at the out-patient department to the assessment of residents on admission.
Changing your lifestyle can help control and manage high blood pressure. Your health care provider may recommend that you make lifestyle changes including:
Eating a heart-healthy diet with less salt
Getting regular physical activity
Maintaining a healthy weight or losing weight
Limiting alcohol
Not smoking
Getting 7 to 9 hours of sleep daily
Wellens syndrome. Wellens syndrome (also referred to as LAD coronary T-wave syndrome) refers to an ECG pattern specific for critical stenosis of the proximal left anterior descending artery. The anomalies described occur in patients with recent anginal chest pain, and do not have chest pain when the ECG is recorded.
Congenital defects can put a strain on the heart, causing it to work harder. To stop your heart from getting weaker with this extra work, your doctor may try to treat you with medications. They are aimed at easing the burden on the heart muscle. You need to control your blood pressure if you have any type of heart problem.
CRISPR technologies have progressed by leaps and bounds over the past decade, not only having a transformative effect on
biomedical research but also yielding new therapies that are poised to enter the clinic. In this review, I give an overview of (i)
the various CRISPR DNA-editing technologies, including standard nuclease gene editing, base editing, prime editing, and epigenome editing, (ii) their impact on cardiovascular basic science research, including animal models, human pluripotent stem
cell models, and functional screens, and (iii) emerging therapeutic applications for patients with cardiovascular diseases, focusing on the examples of Hypercholesterolemia, transthyretin amyloidosis, and Duchenne muscular dystrophy.
A post-splenectomy patient suffers from frequent infections due to capsulated bacteria like Streptococcus
pneumoniae, Hemophilus influenzae, and Neisseria meningitidis despite vaccination because of a lack of
memory B lymphocytes. Pacemaker implantation after splenectomy is less common. Our patient underwent
splenectomy for splenic rupture after a road traffic accident. He developed a complete heart block after
seven years, during which a dual-chamber pacemaker was implanted. However, he was operated on seven
times to treat the complication related to that pacemaker over a period of one year because of various
reasons, which have been shared in this case report. The clinical translation of this interesting observation
is that, though the pacemaker implantation procedure is a well-established procedure, the procedural
outcome is influenced by patient factors like the absence of a spleen, procedural factors like septic measures,
and device factors like the reuse of an already-used pacemaker or leads.
Transcatheter closure of patent ductus arteriosus (PDA) is feasible in low-birth-weight infants. A female baby was born prematurely with a birth weight of 924 g. She had a PDA measuring 3.7 mm. She was dependent on positive pressure ventilation for congestive heart failure in addition to the heart failure medications. She could not be discharged from the hospital even after 79 days of birth, and even though her weight reached 1.9 kg in the neonatal intensive care unit. We attempted to plug the PDA using an Amplatzer Piccolo Occluder, but the device failed to anchor. Then, the PDA was plugged using a 4-6 Amplatzer Duct Occluder using a 6-Fr sheath which was challenging.
Accidental misplacement of the limb lead electrodes is a common cause of ECG abnormality and may simulate pathology such as ectopic atrial rhythm, chamber enlargement or myocardial ischaemia and infarction
A Case of Device Closure of an Eccentric Atrial Septal Defect Using a Large D...Ramachandra Barik
Device closure of an eccentric atrial septal defect can be challenging and needs technical modifications to avoid unnecessary complications. Here, we present a case of a 45-year-old woman who underwent device closure of an eccentric defect with a large device. The patient developed pericardial effusion and left-sided pleural effusion due to injury to the junction of right atrium and superior vena cava because of the malalignment of the delivery sheath and left atrial disc before the device was pulled across the eccentric defect despite releasing the left atrial disc in the left atrium in place of the left pulmonary vein. These two serious complications were managed conservatively with close monitoring of the case during and after the procedure.
Trio of Rheumatic Mitral Stenosis, Right Posterior Septal Accessory Pathway a...Ramachandra Barik
A 57-year-old male presented with recurrent palpitations. He was diagnosed with rheumatic mitral stenosis, right posterior septal accessory pathway and atrial flutter. An electrophysiological study after percutaneous balloon mitral valvotomy showed that the palpitations were due to atrial flutter with right bundle branch aberrancy. The right posterior septal pathway was a bystander because it had a higher refractory period than the atrioventricular node.
Percutaneous balloon dilatation, first described by
Andreas Gruentzig in 1979, was initially performed
without the use of guidewires.1 The prototype
balloon catheter was developed as a double lumen
catheter (one lumen for pressure monitoring or
distal perfusion, the other lumen for balloon inflation/deflation) with a short fixed and atraumatic
guidewire at the tip. Indeed, initially the technique
involved advancing a rather rigid balloon catheter
freely without much torque control into a coronary
artery. Bends, tortuosities, angulations, bifurcations,
and eccentric lesions could hardly, if at all, be negotiated, resulting in a rather frustrating low procedural success rate whenever the initial limited
indications (proximal, short, concentric, noncalcified) were negated.2 Luck was almost as
important as expertise, not only for the operator,
but also for the patient. It is to the merit of
Simpson who, in 1982, introduced the novelty of
advancing the balloon catheter over a removable
guidewire, which had first been advanced in the
target vessel.3 This major technical improvement
resulted overnight in a notable increase in the procedural success rate. Guidewires have since evolved
into very sophisticated devices.
Optical coherence tomography-guided algorithm for percutaneous coronary intervention. Vessel diameter should be assessed using the external elastic lamina (EEL)-EEL diameter at the reference segments, and rounded down to select interventional devices (balloons, stents). If the EEL cannot be identified, luminal measures are used and rounded up to 0.5 mm larger for selection of the devices. Optical coherence tomography (OCT)-guided optimisation strategies post stent implantation per EEL-based diameter measurement and per lumen-based diameter measurement are shown. For instance, if the distal EEL-EEL diameter measures 3.2 mm×3.1 mm (i.e., the mean EEL-based diameter is 3.15 mm), this number is rounded down to the next available stent size and post-dilation balloon to be used at the distal segment. Thus, a 3.0 mm stent and non-compliant balloon diameter is selected. If the proximal EEL cannot be visualised, the mean lumen diameter should be used for device sizing. For instance, if the mean proximal lumen diameter measures 3.4 mm, this number is rounded up to the next available balloon diameter (within up to 0.5 mm larger) for post-dilation. MLA: minimal lumen area; MSA: minimal stent area;NC: non-compliant
Brugada syndrome (BrS) is an inherited cardiac disorder,
characterised by a typical ECG pattern and an increased
risk of arrhythmias and sudden cardiac death (SCD).
BrS is a challenging entity, in regard to diagnosis as
well as arrhythmia risk prediction and management.
Nowadays, asymptomatic patients represent the majority
of newly diagnosed patients with BrS, and its incidence
is expected to rise due to (genetic) family screening.
Progress in our understanding of the genetic and
molecular pathophysiology is limited by the absence
of a true gold standard, with consensus on its clinical
definition changing over time. Nevertheless, novel
insights continue to arise from detailed and in-depth
studies, including the complex genetic and molecular
basis. This includes the increasingly recognised
relevance of an underlying structural substrate. Risk
stratification in patients with BrS remains challenging,
particularly in those who are asymptomatic, but recent
studies have demonstrated the potential usefulness
of risk scores to identify patients at high risk of
arrhythmia and SCD. Development and validation of
a model that incorporates clinical and genetic factors,
comorbidities, age and gender, and environmental
aspects may facilitate improved prediction of disease
expressivity and arrhythmia/SCD risk, and potentially
guide patient management and therapy. This review
provides an update of the diagnosis, pathophysiology
and management of BrS, and discusses its future
perspectives.
The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understanding normal organogenesis, the effect of mutations, environmental factors and infectious agents on human development, congenital and childhood disorders, and the cellular basis of ageing, cancer and regenerative medicine. Here we outline the HDCA initiative and the challenges of mapping and modelling human development using state-of-the-art technologies to create a reference atlas across gestation. Similar to the Human Genome Project, the HDCA will integrate the output from a growing community of scientists who are mapping human development into a unified atlas. We describe the early milestones that have been achieved and the use of human stem-cell-derived cultures, organoids and animal models to inform the HDCA, especially for prenatal tissues that are hard to acquire. Finally, we provide a roadmap towards a complete atlas of human development.
The treatment of patients with advanced acute heart failure is still challenging.
Intra-aortic balloon pump (IABP) has widely been used in the management of
patients with cardiogenic shock. However, according to international guidelines, its
routinary use in patients with cardiogenic shock is not recommended. This recommendation is derived from the results of the IABP-SHOCK II trial, which demonstrated
that IABP does not reduce all-cause mortality in patients with acute myocardial infarction and cardiogenic shock. The present position paper, released by the Italian
Association of Hospital Cardiologists, reviews the available data derived from clinical
studies. It also provides practical recommendations for the optimal use of IABP in
the treatment of cardiogenic shock and advanced acute heart failure.
Left ventricular false tendons (LVFTs) are fibromuscular
structures, connecting the left ventricular
free wall or papillary muscle and the ventricular
septum.
There is some discussion about safety issues during
intense exercise in athletes with LVFTs, as these
bands have been associated with ventricular arrhythmias
and abnormal cardiac remodelling. However,
presence of LVFTs appears to be much more common
than previously noted as imaging techniques
have improved and the association between LVFTs
and abnormal remodelling could very well be explained
by better visibility in a dilated left ventricular
lumen.
Although LVFTsmay result in electrocardiographic abnormalities
and could form a substrate for ventricular
arrhythmias, it should be considered as a normal
anatomic variant. Persons with LVFTs do not appear
to have increased risk for ventricular arrhythmias or
sudden cardiac death.
The optimal management of bifurcation lesions has received significant interest in recent years and remains a matter of debate among the
interventional cardiology community. Bifurcation lesions are encountered in approximately 21% of percutaneous coronary intervention procedures
and are associated with an increased risk of major adverse cardiac events. The Medina classification has been developed in an attempt to
standardise the terminology when describing bifurcation lesions. The focus of this article is on the management of the Medina 0,0,1 lesion
(‘Medina 001’), an uncommon lesion encountered in <5% of all bifurcations. Technical considerations, management options and interventional
techniques relating to the Medina 001 lesion are discussed. In addition, current published data supporting the various proposed interventional
treatment strategies are examined in an attempt to delineate an evidence-based approach to this uncommon lesion.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. WHY
HYPERTENSI
ON IS SO
IMPORTANT
?
• CHRONIC DISEASE
• NONCOMMUNICABLE DISEASE
• HIGH BP REMAINS THE LEADING CAUSE OF DEATH
WORLDWIDE
• ONE OF THE WORLD'S GREAT PUBLIC HEALTH
PROBLEMS
• MOST OF THE PEOPLE HAVE IT [90% BY AGE OF 78]
• MOST OF THE PEOPLE FEAR IT
• TREATMENT IS LIFELONG
• BP IS NOT CONTOLLED -85%
• 40% OF STROKE DEATH AND 16% OF CVD DEATH
• WOMEN AFTER MENOPAUSE WORSE THAN MEN TO
OWN THIS
6. OUT PATIENT CLINIC HTN
• HYPERTENSION IS DEFINED AS A USUAL OFFICE BP OF 140/90 MM HG OR HIGHER
• BUT SHOULD BE CONFIRMED BY HOME AND AMBULATORY BLOOD PRESSURE
MEASUREMENT IF THERE IS ANY SUSPICION OF WHITE COAT
7. DIFFERENT GUIDELINES HAVE DIFFERENT CUT
OFF
• EPIDEMIOLOGIC DATA SHOW CONTINUOUS POSITIVE RELATIONSHIPS BETWEEN
THE RISK OF CORONARY ARTERY DISEASE (CAD) AND STROKE DEATHS WITH
SYSTOLIC OR DIASTOLIC BP DOWN TO VALUES AS LOW AS 115 OR 75 MM HG
10. • MODIFIED FROM GABB GM, MANGONI A, ANDERSON CS, ET AL. GUIDELINE FOR
THE DIAGNOSIS AND MANAGEMENT OF HYPERTENSION IN ADULTS—2016. MED J
AUST 2016;205:85.
11.
12. MEASUREMENT OF BP
• OFFICE [PRONE FOR WHITE COAT]
• HOME[MOST CORRECT ]
• AMBULATORY [24HOURS ]
13. INDICATION FOR AMBULATORY BP
MEASUREMENT
• OFFICE BP OF 140/90 MM HG OR
HIGHER ON AT LEAST THREE
SEPARATE OFFICE VISITS, WITH TWO
MEASUREMENTS MADE AT EACH VISIT
• AT LEAST TWO OUT-OF-OFFICE BP
READINGS LOWER THAN 140/90 MM
HG
• NO EVIDENCE OF TARGET-ORGAN
DAMAGE
14. TOOLS TO MEAUSRE
• SPIMGOMANOMETRE USING MERCURY COLUMN :OFFICE ,HOME,ICU
• ANEROID METER [OPD/HOUSE/AMBULATORY]
• OSCILLOMETER METHOD [ICU]
15. S
CUFF SIZE AND PLACEMENT
1. THE CUFF SIZE SHOULD HAVE A BLADDER WIDTH THAT IS
APPROXIMATELY 40 PERCENT OF THE CIRCUMFERENCE OF
THE UPPER ARM, MEASURED MIDWAY BETWEEN THE
OLECRANON AND THE ACROMION
2. THE LENGTH OF THE CUFF BLADDER SHOULD ENCIRCLE
80 TO 100 PERCENT OF THE CIRCUMFERENCE OF THE
UPPER ARM MIDWAY BETWEEN THE OLECRANON AND THE
ACROMION
3. THE BLADDER WIDTH-TO-LENGTH SHOULD BE AT LEAST
1:2
16. WHERE TO TIE BP CUFF
• AVOID STIMULANT DRINKING
• QUIET ROOM
• 2CM ABOVE ANTECUBETAL FOSSA
• 3-5 MINUTES REST
• RIGHT ARM SEATING POSITION
• PALPATE
• ARM IS AT THE LEVEL OF HEART
• MERCURY MANOMETER AT THE LEVEL OF
HEART
• USE THE BELL OF THE STETHOSCOPE
17. • ALLOWING THE ARM TO HANG BELOW THE HEART WILL ELEVATE BP LEVELS BY
THE ADDED HYDROSTATIC PRESSURE INDUCED BY GRAVITY (AS MUCH AS 10 TO
12 MMHG IN ADULTS)
18. WALK ONE STEP AT A TIME
• THE CUFF SHOULD BE INFLATED TO 20 TO 30 MMHG ABOVE THE ANTICIPATED
SYSTOLIC BP (SBP)
• DEFLATED SLOWLY AT A RATE OF 2 TO 3 MMHG PER HEARTBEAT
• THE SYSTOLIC BP IS EQUAL TO THE PRESSURE AT WHICH THE BRACHIAL PULSE
CAN FIRST BE HEARD BY AUSCULTATION (KOROTKOFF PHASE I)
• MUFFLING (KOROTKOFF PHASE IV) IS DIASTOLIC BP FOR ADULT
• PHASE V IS RECOMMENDED FOR DBP DETERMINATION IN CHILDREN
•
19. NUMBER OF MEASUREMENTS
• THE BP SHOULD BE TAKEN AT LEAST TWICE ON EACH VISIT
• THE MEASUREMENTS SEPARATED BY ONE TO TWO MINUTES TO ALLOW THE
RELEASE OF TRAPPED BLOOD
• IF THE SECOND VALUE IS MORE THAN 5 MMHG DIFFERENT FROM THE FIRST,
CONTINUED MEASUREMENTS SHOULD BE MADE UNTIL A STABLE VALUE IS
ATTAINED
• THE RECORDED VALUE ON THE PATIENT'S CHART SHOULD BE THE AVERAGE OF
THE LAST TWO MEASUREMENTS
20. OSCILLOMETER DEVICES
• AUTOMATED OSCILLOMETRIC DEVICES MEASURE MEAN ARTERIAL BP BASED
UPON PRESSURE OSCILLATIONS OF THE BRACHIAL ARTERY WALL AS THE CUFF IS
DEFLATED
• SBP AND DBP MEASUREMENTS ARE CALCULATED BASED ON THE MEAN BP
• EASY TO USE
• DECREASE IN OBSERVER BIAS
• HIGHER COMPARED WITH READINGS OBTAINED BY AUSCULTATION
• A HIGH BP SHOULD BE CONFIRMED BY SPHYGMOMANOMETER
21. MUST MENTION END ORGAN DAMGE
• MI
• STROKE
• RENAL FAILURE
• AORTIC DISSECTION
• HEART FAILURE
• LOSS OF VISION
22. ISOLATED SYSTOLIC HTN
• SYSTOLIC >140 AND DIASTOLIC <90 MMHG
• REPRESENT AN EXAGGERATION OF THIS AGE-DEPENDENT STIFFENING PROCESS
• ISH IS MORE COMMON IN WOMEN
• ASSOCIATED PROMINENTLY WITH HEART FAILURE WITH PRESERVED SYSTOLIC
FUNCTION
• THOSE WITH BP IN THE HIGH-NORMAL RANGE (PREHYPERTENSION) WILL MORE
LIKELY DEVELOP ISH AFTER 55 YEARS OF AGE
23. HYPERTENSIVE EMERGENCY
• SEVERE HYPERTENSION (USUALLY A DIASTOLIC BLOOD PRESSURE ABOVE 120
MMHG)
• EVIDENCE OF ACUTE END-ORGAN DAMAGE IS DEFINED
• HYPERTENSIVE EMERGENCIES CAN BE LIFE-THREATENING
• REQUIRE IMMEDIATE TREATMENT
• USUALLY WITH PARENTERAL MEDICATIONS IN A MONITORED SETTING
24. HYPERTENSIVE URGENCY
• SEVERE HYPERTENSION (USUALLY A DIASTOLIC BLOOD PRESSURE ABOVE 120
MMHG) IN ASYMPTOMATIC
• NOT EXPERIENCING ACUTE END-ORGAN DAMAGE
• MOST CASES OF ASYMPTOMATIC
• BLOOD PRESSURE ELEVATIONS CAN BE ADDRESSED IN THE OFFICE SETTING
WITHOUT REFERRAL TO A HIGHER LEVEL OF CARE
25. RESISTANT HYPERTENSION
BLOOD PRESSURE THAT IS NOT CONTROLLED TO GOAL DESPITE ADHERENCE TO
AN APPROPRIATE REGIMEN OF THREE ANTIHYPERTENSIVE DRUGS OF DIFFERENT
CLASSES (INCLUDING A DIURETIC) IN WHICH ALL DRUGS ARE PRESCRIBED AT
SUITABLE ANTIHYPERTENSIVE DOSES
BLOOD PRESSURE THAT REQUIRES AT LEAST FOUR MEDICATIONS TO ACHIEVE
CONTROL IS CONSIDERED CONTROLLED RESISTANT HYPERTENSION.
27. ACCLERATED HTN
• ACCELERATED HYPERTENSION IS
DEFINED AS A RECENT SIGNIFICANT
INCREASE OVER BASELINE BP THAT
IS ASSOCIATED WITH TARGET
ORGAN DAMAGE. THIS IS USUALLY
SEEN AS VASCULAR DAMAGE ON
FUNDUSCOPIC EXAMINATION, SUCH
AS FLAME-SHAPED HEMORRHAGES
OR SOFT EXUDATES, BUT WITHOUT
PAPILLEDEMA
28. MALIGNANT HTN
• DEFINED AS A RECENT SIGNIFICANT
INCREASE OVER BASELINE BP THAT
IS ASSOCIATED WITH TARGET
ORGAN DAMAGE. THIS IS USUALLY
SEEN AS VASCULAR DAMAGE ON
FUNDUSCOPIC EXAMINATION, SUCH
AS FLAME-SHAPED HEMORRHAGES
OR SOFT EXUDATES, BUT WITH
PAPILLEDEMA
39. FEATURES SUGGESTIVE OF
PHEOCHROMOCYTOMA
Hypertension, Persistent or Paroxysmal
•Markedly variable blood pressures (± orthostatic hypotension)
•Sudden paroxysms (± subsequent hypertension) in relation to:
• Stress: anesthesia, angiography, parturition
• Pharmacologic provocation: histamine, nicotine, caffeine, beta blockers,
glucocorticoids, tricyclic antidepressants
• Manipulation of tumors: abdominal palpation, urination
•Rare patients persistently normotensive
•Unusual settings
•Childhood, pregnancy, familial
•Multiple endocrine adenomas: medullary carcinoma of the thyroid (MEN-2), mucosal
neuromas (MEN-2B)
•Von Hippel–Lindau syndrome
40. •Neurocutaneous lesions: neurofibromatosis
Associated Symptoms
•Sudden spells with headache, sweating, palpitations, nervousness, nausea, vomiting
•Pain in chest or abdomen
Associated Signs
Sweating, tachycardia, arrhythmia, pallor, weight loss
41. WHICH PATIENT MAY HAVE HTN
• WOMEN >65 YEARS
• SMOKING
• DYSLIPIDEMIA (LDL-C >115 MG/DL)
• IMPAIRED FASTING GLUCOSE (102-125 MG/DL) OR ABNORMAL GLUCOSE TOLERANCE
TEST RESULT
• FAMILY HISTORY OF PREMATURE CARDIOVASCULAR DISEASE
• ABDOMINAL OBESITY
• DIABETES MELLITUS
42. FROM SUBCLINICAL END ORGAN DAMAGE
• LEFT VENTRICULAR HYPERTROPHY
• CAROTID WALL THICKENING OR PLAQUE
• LOW ESTIMATED GLOMERULAR FILTRATION RATE ≤60 ML/MIN/1.73 M 2
• MICROALBUMINURIA
• ANKLE-BRACHIAL BP INDEX <0.9