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DIAGNOSIS OF HYPERTENSION
WHY
HYPERTENSI
ON IS SO
IMPORTANT
?
• CHRONIC DISEASE
• NONCOMMUNICABLE DISEASE
• HIGH BP REMAINS THE LEADING CAUSE OF DEATH
WORLDWIDE
• ONE OF THE WORLD'S GREAT PUBLIC HEALTH
PROBLEMS
• MOST OF THE PEOPLE HAVE IT [90% BY AGE OF 78]
• MOST OF THE PEOPLE FEAR IT
• TREATMENT IS LIFELONG
• BP IS NOT CONTOLLED -85%
• 40% OF STROKE DEATH AND 16% OF CVD DEATH
• WOMEN AFTER MENOPAUSE WORSE THAN MEN TO
OWN THIS
WHO WILL GOING TO HAVE IT ?
DEFINE
•SBP <120 mmHg
•DBP <80 mmHg
Normal blood
pressure
•SBP: 120 to 129 mmHg
•Diastolic <80 mmHg
Elevated blood
pressure
•Stage 1 :SBP 130 to 139 & DBP: 80 to 89
mmHg
•Stage 2 : SBP:≥140 mmHg & ≥ 90 mmHg
Hypertension:
OUT PATIENT CLINIC HTN
• HYPERTENSION IS DEFINED AS A USUAL OFFICE BP OF 140/90 MM HG OR HIGHER
• BUT SHOULD BE CONFIRMED BY HOME AND AMBULATORY BLOOD PRESSURE
MEASUREMENT IF THERE IS ANY SUSPICION OF WHITE COAT
DIFFERENT GUIDELINES HAVE DIFFERENT CUT
OFF
• EPIDEMIOLOGIC DATA SHOW CONTINUOUS POSITIVE RELATIONSHIPS BETWEEN
THE RISK OF CORONARY ARTERY DISEASE (CAD) AND STROKE DEATHS WITH
SYSTOLIC OR DIASTOLIC BP DOWN TO VALUES AS LOW AS 115 OR 75 MM HG
STAGING OF HTN
DIFFERENT METHOD –DIFFERENT CUT OFF
• MODIFIED FROM GABB GM, MANGONI A, ANDERSON CS, ET AL. GUIDELINE FOR
THE DIAGNOSIS AND MANAGEMENT OF HYPERTENSION IN ADULTS—2016. MED J
AUST 2016;205:85.
MEASUREMENT OF BP
• OFFICE [PRONE FOR WHITE COAT]
• HOME[MOST CORRECT ]
• AMBULATORY [24HOURS ]
INDICATION FOR AMBULATORY BP
MEASUREMENT
• OFFICE BP OF 140/90 MM HG OR
HIGHER ON AT LEAST THREE
SEPARATE OFFICE VISITS, WITH TWO
MEASUREMENTS MADE AT EACH VISIT
• AT LEAST TWO OUT-OF-OFFICE BP
READINGS LOWER THAN 140/90 MM
HG
• NO EVIDENCE OF TARGET-ORGAN
DAMAGE
TOOLS TO MEAUSRE
• SPIMGOMANOMETRE USING MERCURY COLUMN :OFFICE ,HOME,ICU
• ANEROID METER [OPD/HOUSE/AMBULATORY]
• OSCILLOMETER METHOD [ICU]
S
CUFF SIZE AND PLACEMENT
1. THE CUFF SIZE SHOULD HAVE A BLADDER WIDTH THAT IS
APPROXIMATELY 40 PERCENT OF THE CIRCUMFERENCE OF
THE UPPER ARM, MEASURED MIDWAY BETWEEN THE
OLECRANON AND THE ACROMION
2. THE LENGTH OF THE CUFF BLADDER SHOULD ENCIRCLE
80 TO 100 PERCENT OF THE CIRCUMFERENCE OF THE
UPPER ARM MIDWAY BETWEEN THE OLECRANON AND THE
ACROMION
3. THE BLADDER WIDTH-TO-LENGTH SHOULD BE AT LEAST
1:2
WHERE TO TIE BP CUFF
• AVOID STIMULANT DRINKING
• QUIET ROOM
• 2CM ABOVE ANTECUBETAL FOSSA
• 3-5 MINUTES REST
• RIGHT ARM SEATING POSITION
• PALPATE
• ARM IS AT THE LEVEL OF HEART
• MERCURY MANOMETER AT THE LEVEL OF
HEART
• USE THE BELL OF THE STETHOSCOPE
• ALLOWING THE ARM TO HANG BELOW THE HEART WILL ELEVATE BP LEVELS BY
THE ADDED HYDROSTATIC PRESSURE INDUCED BY GRAVITY (AS MUCH AS 10 TO
12 MMHG IN ADULTS)
WALK ONE STEP AT A TIME
• THE CUFF SHOULD BE INFLATED TO 20 TO 30 MMHG ABOVE THE ANTICIPATED
SYSTOLIC BP (SBP)
• DEFLATED SLOWLY AT A RATE OF 2 TO 3 MMHG PER HEARTBEAT
• THE SYSTOLIC BP IS EQUAL TO THE PRESSURE AT WHICH THE BRACHIAL PULSE
CAN FIRST BE HEARD BY AUSCULTATION (KOROTKOFF PHASE I)
• MUFFLING (KOROTKOFF PHASE IV) IS DIASTOLIC BP FOR ADULT
• PHASE V IS RECOMMENDED FOR DBP DETERMINATION IN CHILDREN
•
NUMBER OF MEASUREMENTS
• THE BP SHOULD BE TAKEN AT LEAST TWICE ON EACH VISIT
• THE MEASUREMENTS SEPARATED BY ONE TO TWO MINUTES TO ALLOW THE
RELEASE OF TRAPPED BLOOD
• IF THE SECOND VALUE IS MORE THAN 5 MMHG DIFFERENT FROM THE FIRST,
CONTINUED MEASUREMENTS SHOULD BE MADE UNTIL A STABLE VALUE IS
ATTAINED
• THE RECORDED VALUE ON THE PATIENT'S CHART SHOULD BE THE AVERAGE OF
THE LAST TWO MEASUREMENTS
OSCILLOMETER DEVICES
• AUTOMATED OSCILLOMETRIC DEVICES MEASURE MEAN ARTERIAL BP BASED
UPON PRESSURE OSCILLATIONS OF THE BRACHIAL ARTERY WALL AS THE CUFF IS
DEFLATED
• SBP AND DBP MEASUREMENTS ARE CALCULATED BASED ON THE MEAN BP
• EASY TO USE
• DECREASE IN OBSERVER BIAS
• HIGHER COMPARED WITH READINGS OBTAINED BY AUSCULTATION
• A HIGH BP SHOULD BE CONFIRMED BY SPHYGMOMANOMETER
MUST MENTION END ORGAN DAMGE
• MI
• STROKE
• RENAL FAILURE
• AORTIC DISSECTION
• HEART FAILURE
• LOSS OF VISION
ISOLATED SYSTOLIC HTN
• SYSTOLIC >140 AND DIASTOLIC <90 MMHG
• REPRESENT AN EXAGGERATION OF THIS AGE-DEPENDENT STIFFENING PROCESS
• ISH IS MORE COMMON IN WOMEN
• ASSOCIATED PROMINENTLY WITH HEART FAILURE WITH PRESERVED SYSTOLIC
FUNCTION
• THOSE WITH BP IN THE HIGH-NORMAL RANGE (PREHYPERTENSION) WILL MORE
LIKELY DEVELOP ISH AFTER 55 YEARS OF AGE
HYPERTENSIVE EMERGENCY
• SEVERE HYPERTENSION (USUALLY A DIASTOLIC BLOOD PRESSURE ABOVE 120
MMHG)
• EVIDENCE OF ACUTE END-ORGAN DAMAGE IS DEFINED
• HYPERTENSIVE EMERGENCIES CAN BE LIFE-THREATENING
• REQUIRE IMMEDIATE TREATMENT
• USUALLY WITH PARENTERAL MEDICATIONS IN A MONITORED SETTING
HYPERTENSIVE URGENCY
• SEVERE HYPERTENSION (USUALLY A DIASTOLIC BLOOD PRESSURE ABOVE 120
MMHG) IN ASYMPTOMATIC
• NOT EXPERIENCING ACUTE END-ORGAN DAMAGE
• MOST CASES OF ASYMPTOMATIC
• BLOOD PRESSURE ELEVATIONS CAN BE ADDRESSED IN THE OFFICE SETTING
WITHOUT REFERRAL TO A HIGHER LEVEL OF CARE
RESISTANT HYPERTENSION
BLOOD PRESSURE THAT IS NOT CONTROLLED TO GOAL DESPITE ADHERENCE TO
AN APPROPRIATE REGIMEN OF THREE ANTIHYPERTENSIVE DRUGS OF DIFFERENT
CLASSES (INCLUDING A DIURETIC) IN WHICH ALL DRUGS ARE PRESCRIBED AT
SUITABLE ANTIHYPERTENSIVE DOSES
BLOOD PRESSURE THAT REQUIRES AT LEAST FOUR MEDICATIONS TO ACHIEVE
CONTROL IS CONSIDERED CONTROLLED RESISTANT HYPERTENSION.
REFRACTORY HYPERTENSION
• BP IS NOT CONTROLLED EVEN USING UP TO 5 DRUGS ,ONE OF WHICH IS
DIURETIC
ACCLERATED HTN
• ACCELERATED HYPERTENSION IS
DEFINED AS A RECENT SIGNIFICANT
INCREASE OVER BASELINE BP THAT
IS ASSOCIATED WITH TARGET
ORGAN DAMAGE. THIS IS USUALLY
SEEN AS VASCULAR DAMAGE ON
FUNDUSCOPIC EXAMINATION, SUCH
AS FLAME-SHAPED HEMORRHAGES
OR SOFT EXUDATES, BUT WITHOUT
PAPILLEDEMA
MALIGNANT HTN
• DEFINED AS A RECENT SIGNIFICANT
INCREASE OVER BASELINE BP THAT
IS ASSOCIATED WITH TARGET
ORGAN DAMAGE. THIS IS USUALLY
SEEN AS VASCULAR DAMAGE ON
FUNDUSCOPIC EXAMINATION, SUCH
AS FLAME-SHAPED HEMORRHAGES
OR SOFT EXUDATES, BUT WITH
PAPILLEDEMA
RENOVASCULAR HTN
• DUE TO RENAL ARTERY STENSOSIS
PREGNANCY INDUCED HTN
• BEYOND 20 WEEK OF PREGNANCY
INVESTIGATION
FEATURES SUGGESTIVE OF
PHEOCHROMOCYTOMA
Hypertension, Persistent or Paroxysmal
•Markedly variable blood pressures (± orthostatic hypotension)
•Sudden paroxysms (± subsequent hypertension) in relation to:
• Stress: anesthesia, angiography, parturition
• Pharmacologic provocation: histamine, nicotine, caffeine, beta blockers,
glucocorticoids, tricyclic antidepressants
• Manipulation of tumors: abdominal palpation, urination
•Rare patients persistently normotensive
•Unusual settings
•Childhood, pregnancy, familial
•Multiple endocrine adenomas: medullary carcinoma of the thyroid (MEN-2), mucosal
neuromas (MEN-2B)
•Von Hippel–Lindau syndrome
•Neurocutaneous lesions: neurofibromatosis
Associated Symptoms
•Sudden spells with headache, sweating, palpitations, nervousness, nausea, vomiting
•Pain in chest or abdomen
Associated Signs
Sweating, tachycardia, arrhythmia, pallor, weight loss
WHICH PATIENT MAY HAVE HTN
• WOMEN >65 YEARS
• SMOKING
• DYSLIPIDEMIA (LDL-C >115 MG/DL)
• IMPAIRED FASTING GLUCOSE (102-125 MG/DL) OR ABNORMAL GLUCOSE TOLERANCE
TEST RESULT
• FAMILY HISTORY OF PREMATURE CARDIOVASCULAR DISEASE
• ABDOMINAL OBESITY
• DIABETES MELLITUS
FROM SUBCLINICAL END ORGAN DAMAGE
• LEFT VENTRICULAR HYPERTROPHY
• CAROTID WALL THICKENING OR PLAQUE
• LOW ESTIMATED GLOMERULAR FILTRATION RATE ≤60 ML/MIN/1.73 M 2
• MICROALBUMINURIA
• ANKLE-BRACHIAL BP INDEX <0.9
ESTABLISHED TARGET ORGAN DAMAGE
• CEREBROVASCULAR DISEASE: ISCHEMIC STROKE, CEREBRAL HEMORRHAGE,
TRANSIENT ISCHEMIC ATTACK
• HEART DISEASE: MYOCARDIAL INFARCTION, ANGINA, CORONARY
REVASCULARIZATION, HEART FAILURE
• RENAL DISEASE: DIABETIC NEPHROPATHY, RENAL IMPAIRMENT
• PERIPHERAL ARTERIAL DISEASE
• ADVANCED RETINOPATHY: HEMORRHAGES OR EXUDATES, PAPILLEDEMA
THE GLOBAL MACHINE THAT PRODUCES
EVIDENCE TO SUPPORT CLINICAL PRACTICE
WORKS DAY AND NIGHT 24/7
• I HOPE YOU WOULD TRY TO BE
REMAIN UPDATED

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Diagnosis of hypertension

  • 2. WHY HYPERTENSI ON IS SO IMPORTANT ? • CHRONIC DISEASE • NONCOMMUNICABLE DISEASE • HIGH BP REMAINS THE LEADING CAUSE OF DEATH WORLDWIDE • ONE OF THE WORLD'S GREAT PUBLIC HEALTH PROBLEMS • MOST OF THE PEOPLE HAVE IT [90% BY AGE OF 78] • MOST OF THE PEOPLE FEAR IT • TREATMENT IS LIFELONG • BP IS NOT CONTOLLED -85% • 40% OF STROKE DEATH AND 16% OF CVD DEATH • WOMEN AFTER MENOPAUSE WORSE THAN MEN TO OWN THIS
  • 3. WHO WILL GOING TO HAVE IT ?
  • 4.
  • 5. DEFINE •SBP <120 mmHg •DBP <80 mmHg Normal blood pressure •SBP: 120 to 129 mmHg •Diastolic <80 mmHg Elevated blood pressure •Stage 1 :SBP 130 to 139 & DBP: 80 to 89 mmHg •Stage 2 : SBP:≥140 mmHg & ≥ 90 mmHg Hypertension:
  • 6. OUT PATIENT CLINIC HTN • HYPERTENSION IS DEFINED AS A USUAL OFFICE BP OF 140/90 MM HG OR HIGHER • BUT SHOULD BE CONFIRMED BY HOME AND AMBULATORY BLOOD PRESSURE MEASUREMENT IF THERE IS ANY SUSPICION OF WHITE COAT
  • 7. DIFFERENT GUIDELINES HAVE DIFFERENT CUT OFF • EPIDEMIOLOGIC DATA SHOW CONTINUOUS POSITIVE RELATIONSHIPS BETWEEN THE RISK OF CORONARY ARTERY DISEASE (CAD) AND STROKE DEATHS WITH SYSTOLIC OR DIASTOLIC BP DOWN TO VALUES AS LOW AS 115 OR 75 MM HG
  • 10. • MODIFIED FROM GABB GM, MANGONI A, ANDERSON CS, ET AL. GUIDELINE FOR THE DIAGNOSIS AND MANAGEMENT OF HYPERTENSION IN ADULTS—2016. MED J AUST 2016;205:85.
  • 11.
  • 12. MEASUREMENT OF BP • OFFICE [PRONE FOR WHITE COAT] • HOME[MOST CORRECT ] • AMBULATORY [24HOURS ]
  • 13. INDICATION FOR AMBULATORY BP MEASUREMENT • OFFICE BP OF 140/90 MM HG OR HIGHER ON AT LEAST THREE SEPARATE OFFICE VISITS, WITH TWO MEASUREMENTS MADE AT EACH VISIT • AT LEAST TWO OUT-OF-OFFICE BP READINGS LOWER THAN 140/90 MM HG • NO EVIDENCE OF TARGET-ORGAN DAMAGE
  • 14. TOOLS TO MEAUSRE • SPIMGOMANOMETRE USING MERCURY COLUMN :OFFICE ,HOME,ICU • ANEROID METER [OPD/HOUSE/AMBULATORY] • OSCILLOMETER METHOD [ICU]
  • 15. S CUFF SIZE AND PLACEMENT 1. THE CUFF SIZE SHOULD HAVE A BLADDER WIDTH THAT IS APPROXIMATELY 40 PERCENT OF THE CIRCUMFERENCE OF THE UPPER ARM, MEASURED MIDWAY BETWEEN THE OLECRANON AND THE ACROMION 2. THE LENGTH OF THE CUFF BLADDER SHOULD ENCIRCLE 80 TO 100 PERCENT OF THE CIRCUMFERENCE OF THE UPPER ARM MIDWAY BETWEEN THE OLECRANON AND THE ACROMION 3. THE BLADDER WIDTH-TO-LENGTH SHOULD BE AT LEAST 1:2
  • 16. WHERE TO TIE BP CUFF • AVOID STIMULANT DRINKING • QUIET ROOM • 2CM ABOVE ANTECUBETAL FOSSA • 3-5 MINUTES REST • RIGHT ARM SEATING POSITION • PALPATE • ARM IS AT THE LEVEL OF HEART • MERCURY MANOMETER AT THE LEVEL OF HEART • USE THE BELL OF THE STETHOSCOPE
  • 17. • ALLOWING THE ARM TO HANG BELOW THE HEART WILL ELEVATE BP LEVELS BY THE ADDED HYDROSTATIC PRESSURE INDUCED BY GRAVITY (AS MUCH AS 10 TO 12 MMHG IN ADULTS)
  • 18. WALK ONE STEP AT A TIME • THE CUFF SHOULD BE INFLATED TO 20 TO 30 MMHG ABOVE THE ANTICIPATED SYSTOLIC BP (SBP) • DEFLATED SLOWLY AT A RATE OF 2 TO 3 MMHG PER HEARTBEAT • THE SYSTOLIC BP IS EQUAL TO THE PRESSURE AT WHICH THE BRACHIAL PULSE CAN FIRST BE HEARD BY AUSCULTATION (KOROTKOFF PHASE I) • MUFFLING (KOROTKOFF PHASE IV) IS DIASTOLIC BP FOR ADULT • PHASE V IS RECOMMENDED FOR DBP DETERMINATION IN CHILDREN •
  • 19. NUMBER OF MEASUREMENTS • THE BP SHOULD BE TAKEN AT LEAST TWICE ON EACH VISIT • THE MEASUREMENTS SEPARATED BY ONE TO TWO MINUTES TO ALLOW THE RELEASE OF TRAPPED BLOOD • IF THE SECOND VALUE IS MORE THAN 5 MMHG DIFFERENT FROM THE FIRST, CONTINUED MEASUREMENTS SHOULD BE MADE UNTIL A STABLE VALUE IS ATTAINED • THE RECORDED VALUE ON THE PATIENT'S CHART SHOULD BE THE AVERAGE OF THE LAST TWO MEASUREMENTS
  • 20. OSCILLOMETER DEVICES • AUTOMATED OSCILLOMETRIC DEVICES MEASURE MEAN ARTERIAL BP BASED UPON PRESSURE OSCILLATIONS OF THE BRACHIAL ARTERY WALL AS THE CUFF IS DEFLATED • SBP AND DBP MEASUREMENTS ARE CALCULATED BASED ON THE MEAN BP • EASY TO USE • DECREASE IN OBSERVER BIAS • HIGHER COMPARED WITH READINGS OBTAINED BY AUSCULTATION • A HIGH BP SHOULD BE CONFIRMED BY SPHYGMOMANOMETER
  • 21. MUST MENTION END ORGAN DAMGE • MI • STROKE • RENAL FAILURE • AORTIC DISSECTION • HEART FAILURE • LOSS OF VISION
  • 22. ISOLATED SYSTOLIC HTN • SYSTOLIC >140 AND DIASTOLIC <90 MMHG • REPRESENT AN EXAGGERATION OF THIS AGE-DEPENDENT STIFFENING PROCESS • ISH IS MORE COMMON IN WOMEN • ASSOCIATED PROMINENTLY WITH HEART FAILURE WITH PRESERVED SYSTOLIC FUNCTION • THOSE WITH BP IN THE HIGH-NORMAL RANGE (PREHYPERTENSION) WILL MORE LIKELY DEVELOP ISH AFTER 55 YEARS OF AGE
  • 23. HYPERTENSIVE EMERGENCY • SEVERE HYPERTENSION (USUALLY A DIASTOLIC BLOOD PRESSURE ABOVE 120 MMHG) • EVIDENCE OF ACUTE END-ORGAN DAMAGE IS DEFINED • HYPERTENSIVE EMERGENCIES CAN BE LIFE-THREATENING • REQUIRE IMMEDIATE TREATMENT • USUALLY WITH PARENTERAL MEDICATIONS IN A MONITORED SETTING
  • 24. HYPERTENSIVE URGENCY • SEVERE HYPERTENSION (USUALLY A DIASTOLIC BLOOD PRESSURE ABOVE 120 MMHG) IN ASYMPTOMATIC • NOT EXPERIENCING ACUTE END-ORGAN DAMAGE • MOST CASES OF ASYMPTOMATIC • BLOOD PRESSURE ELEVATIONS CAN BE ADDRESSED IN THE OFFICE SETTING WITHOUT REFERRAL TO A HIGHER LEVEL OF CARE
  • 25. RESISTANT HYPERTENSION BLOOD PRESSURE THAT IS NOT CONTROLLED TO GOAL DESPITE ADHERENCE TO AN APPROPRIATE REGIMEN OF THREE ANTIHYPERTENSIVE DRUGS OF DIFFERENT CLASSES (INCLUDING A DIURETIC) IN WHICH ALL DRUGS ARE PRESCRIBED AT SUITABLE ANTIHYPERTENSIVE DOSES BLOOD PRESSURE THAT REQUIRES AT LEAST FOUR MEDICATIONS TO ACHIEVE CONTROL IS CONSIDERED CONTROLLED RESISTANT HYPERTENSION.
  • 26. REFRACTORY HYPERTENSION • BP IS NOT CONTROLLED EVEN USING UP TO 5 DRUGS ,ONE OF WHICH IS DIURETIC
  • 27. ACCLERATED HTN • ACCELERATED HYPERTENSION IS DEFINED AS A RECENT SIGNIFICANT INCREASE OVER BASELINE BP THAT IS ASSOCIATED WITH TARGET ORGAN DAMAGE. THIS IS USUALLY SEEN AS VASCULAR DAMAGE ON FUNDUSCOPIC EXAMINATION, SUCH AS FLAME-SHAPED HEMORRHAGES OR SOFT EXUDATES, BUT WITHOUT PAPILLEDEMA
  • 28. MALIGNANT HTN • DEFINED AS A RECENT SIGNIFICANT INCREASE OVER BASELINE BP THAT IS ASSOCIATED WITH TARGET ORGAN DAMAGE. THIS IS USUALLY SEEN AS VASCULAR DAMAGE ON FUNDUSCOPIC EXAMINATION, SUCH AS FLAME-SHAPED HEMORRHAGES OR SOFT EXUDATES, BUT WITH PAPILLEDEMA
  • 29. RENOVASCULAR HTN • DUE TO RENAL ARTERY STENSOSIS
  • 30. PREGNANCY INDUCED HTN • BEYOND 20 WEEK OF PREGNANCY
  • 31.
  • 32.
  • 33.
  • 35.
  • 36.
  • 37.
  • 38.
  • 39. FEATURES SUGGESTIVE OF PHEOCHROMOCYTOMA Hypertension, Persistent or Paroxysmal •Markedly variable blood pressures (± orthostatic hypotension) •Sudden paroxysms (± subsequent hypertension) in relation to: • Stress: anesthesia, angiography, parturition • Pharmacologic provocation: histamine, nicotine, caffeine, beta blockers, glucocorticoids, tricyclic antidepressants • Manipulation of tumors: abdominal palpation, urination •Rare patients persistently normotensive •Unusual settings •Childhood, pregnancy, familial •Multiple endocrine adenomas: medullary carcinoma of the thyroid (MEN-2), mucosal neuromas (MEN-2B) •Von Hippel–Lindau syndrome
  • 40. •Neurocutaneous lesions: neurofibromatosis Associated Symptoms •Sudden spells with headache, sweating, palpitations, nervousness, nausea, vomiting •Pain in chest or abdomen Associated Signs Sweating, tachycardia, arrhythmia, pallor, weight loss
  • 41. WHICH PATIENT MAY HAVE HTN • WOMEN >65 YEARS • SMOKING • DYSLIPIDEMIA (LDL-C >115 MG/DL) • IMPAIRED FASTING GLUCOSE (102-125 MG/DL) OR ABNORMAL GLUCOSE TOLERANCE TEST RESULT • FAMILY HISTORY OF PREMATURE CARDIOVASCULAR DISEASE • ABDOMINAL OBESITY • DIABETES MELLITUS
  • 42. FROM SUBCLINICAL END ORGAN DAMAGE • LEFT VENTRICULAR HYPERTROPHY • CAROTID WALL THICKENING OR PLAQUE • LOW ESTIMATED GLOMERULAR FILTRATION RATE ≤60 ML/MIN/1.73 M 2 • MICROALBUMINURIA • ANKLE-BRACHIAL BP INDEX <0.9
  • 43. ESTABLISHED TARGET ORGAN DAMAGE • CEREBROVASCULAR DISEASE: ISCHEMIC STROKE, CEREBRAL HEMORRHAGE, TRANSIENT ISCHEMIC ATTACK • HEART DISEASE: MYOCARDIAL INFARCTION, ANGINA, CORONARY REVASCULARIZATION, HEART FAILURE • RENAL DISEASE: DIABETIC NEPHROPATHY, RENAL IMPAIRMENT • PERIPHERAL ARTERIAL DISEASE • ADVANCED RETINOPATHY: HEMORRHAGES OR EXUDATES, PAPILLEDEMA
  • 44. THE GLOBAL MACHINE THAT PRODUCES EVIDENCE TO SUPPORT CLINICAL PRACTICE WORKS DAY AND NIGHT 24/7 • I HOPE YOU WOULD TRY TO BE REMAIN UPDATED