Guillen barre syndrome
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Acute flaccid paralysis (AFP) is commonly caused by Guillain-Barré syndrome (GBS), an autoimmune condition where rapid onset of weakness results from peripheral nerve and root inflammation. Clinical features of GBS include symmetrical ascending weakness, diminished reflexes, sensory involvement, and potential respiratory impairment in 1/4 of cases. Subtypes include inflammatory demyelinating or axonal forms. Treatment focuses on immunotherapy like IVIG or plasma exchange to hasten recovery. Traumatic neuritis is defined as acute nerve inflammation after injury, causing asymmetric flaccid paralysis within hours to days without fever or cranial nerve involvement.
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This document discusses Gullain-Barre syndrome (GBS), including that it is the leading cause of acute flaccid paralysis in developed countries. GBS causes muscle weakness that starts in the legs and progresses upwards in an acute and symmetric manner. Ventilation is required in 25% of cases and 4-15% of patients die from GBS. The document outlines clinical features, variants of GBS, diagnostic tests including lumbar puncture and nerve conduction studies, treatment including immunoglobulin or plasmapheresis, and criteria for diagnosing GBS.
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Guillain Barre Syndrome
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Guillain-Barré syndrome is an autoimmune disorder that causes inflammation of the nerves. It is characterized by progressive weakness in the legs and arms, loss of reflexes, and ascending paralysis over 4 weeks or less. The disorder is usually preceded by a gastrointestinal or respiratory infection. Treatment involves supportive care and immunoglobulin therapy. Most patients recover, though some experience long-term weakness depending on the severity of symptoms.
Guillain-Barré syndrome.....My Understanding..
Guillain-Barré syndrome is an acute autoimmune disorder that causes inflammation of the peripheral nerves. It most commonly develops 1-3 weeks after a respiratory or gastrointestinal infection. Males have a slightly higher risk than females. Approximately 70% of cases are preceded by a viral or bacterial infection. The syndrome causes progressive weakness and paralysis due to damage to the myelin sheath surrounding peripheral nerves or to the axons themselves. Diagnosis involves clinical evaluation, cerebrospinal fluid analysis, and nerve conduction studies. Treatment focuses on supportive care and immunotherapy. Prognosis depends on severity but most patients recover fully if respiratory support is provided promptly as needed.
Gullian barre syndrome
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Acute Flaccid Paralysis (AFP) is defined as sudden onset of weakness or paralysis in a previously normal limb over 15 days in patients under 15 years old. Guillain-Barré Syndrome (GBS) is the most common cause of AFP and is an acute acquired inflammatory demyelinating polyneuropathy. It has an annual incidence of 0.6 to 2.4 cases per 100,000 people and usually occurs 2-4 weeks after a respiratory or GI infection. GBS is diagnosed through CSF analysis showing elevated proteins and electrophysiological studies showing demyelination. Treatment involves monitoring, IVIG or plasma exchange to shorten recovery time, and PICU care if respiratory involvement is present.
Gullian barre syndrome
Guillain-Barré syndrome is an acute polyneuropathic disorder that causes muscle weakness, loss of reflexes, and numbness in the limbs and face. It occurs when the immune system mistakenly attacks the peripheral nervous system. The symptoms can range from mild tingling to total paralysis. The disorder is usually triggered by a bacterial or viral infection. Treatment focuses on speeding recovery through measures like plasmapheresis, IVIG, respiratory therapy, and monitoring for complications like respiratory failure or paralysis. Nurses help manage symptoms, provide education, and address problems with mobility, swallowing, and sensation that arise due to the disease process.
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Guillain Barre Syndrome
Guillain-Barré syndrome is an acute inflammatory demyelinating polyneuropathy characterized by progressive muscle weakness and loss of reflexes. It is usually preceded by a gastrointestinal or respiratory infection and can cause paralysis. Treatment involves plasmapheresis or intravenous immunoglobulin to reduce antibodies, with most patients recovering fully or having minor deficits, but 5-10% having permanent disability and 3-8% dying despite intensive care.
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Gullian Barre Syndrome.pptx
Guillain-Barré syndrome (GBS) is an acute inflammatory disorder of the peripheral nervous system that causes progressive muscle weakness and paralysis. It is caused by an immune system attack on the peripheral nerves. The main symptoms are rapidly increasing muscle weakness, numbness, and tingling in the legs and arms. Diagnosis involves spinal fluid analysis and nerve conduction tests. Treatment focuses on supporting breathing, preventing complications, and hastening recovery through treatments like plasmapheresis or intravenous immunoglobulin. Most people recover fully or nearly fully from GBS, but some continue to have some degree of weakness.
GBS.pptx
Elisha Mkakirwa, a 6-year old male, presented with a 4-month history of blood in stool and 3 days of lower limb pain and tingling. Examination found hypotonia and reduced power in the lower limbs. Tests showed elevated CSF protein. He was diagnosed with Guillain-Barré syndrome, a rare disorder where the immune system attacks nerves, causing muscle weakness and paralysis. Treatment included IV antibiotics, physiotherapy, and supportive care. Prognosis is generally good, with most patients recovering over months, though some experience long-term weakness.
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Gullain barre syndrome
This document discusses Gullain-Barre syndrome (GBS), including that it is the leading cause of acute flaccid paralysis in developed countries. GBS causes muscle weakness that starts in the legs and progresses upwards in an acute and symmetric manner. Ventilation is required in 25% of cases and 4-15% of patients die from GBS. The document outlines clinical features, variants of GBS, diagnostic tests including lumbar puncture and nerve conduction studies, treatment including immunoglobulin or plasmapheresis, and criteria for diagnosing GBS.
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Guillain-Barre syndrome presented with acute flaccid paralysis, that will result in long-term neurologic deficit. Cytomegalovirus ( CMV) is one of the most common etiology to induce Guallain-Barre syndrome (GBS). Some person think CMV-GBS has another pathogenesis which is different from Campylobacter jejuni. I will present a clinical case and discuss about this topics.
Guillain–Barré syndrome
Gullain-Barre syndrome is an acute polyneuropathy that affects the peripheral nervous system, causing ascending paralysis that begins in the feet and hands. It has an annual worldwide incidence of 0.6-1.9 per 100,000 people. Men are more likely to be affected than women. It is an autoimmune disorder where antibodies attack gangliosides in peripheral nerve tissues, and can be triggered by infections. Diagnosis involves progressive motor weakness in more than one limb and areflexia. Treatment focuses on respiratory support and immunoglobulins for severe cases. Recovery may take several months and 35% of untreated patients have residual effects.
Acute flaccid paralysis (polio&tm)
This document discusses acute flaccid paralysis (AFP), which is defined as sudden weakness or floppiness in a child under 15 or paralysis in anyone suspected of having polio. It lists several potential causes in the differential diagnosis including muscle, neuromuscular junction, and neurological disorders. The document outlines AFP surveillance procedures including reporting cases within 6 months and collecting stool samples within 14 days to test for poliovirus. It also compares the clinical features and presentations of poliomyelitis and transverse myelitis.
Guillain Barre Syndrome
Guillain-Barré syndrome is an acute inflammatory polyneuropathy typically presenting with progressive ascending motor weakness. Intravenous immunoglobulin and plasma exchange are first-line treatments aimed at hastening recovery. While some vaccinations have a temporal association with Guillain-Barré syndrome, the causal relationship remains unclear and risks must be weighed against benefits of preventing severe infectious diseases. Careful supportive care including respiratory monitoring is important given potential respiratory complications.
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Guillain-Barré syndrome is an autoimmune disorder that causes inflammation of the nerves. It is characterized by progressive weakness in the legs and arms, loss of reflexes, and ascending paralysis over 4 weeks or less. The disorder is usually preceded by a gastrointestinal or respiratory infection. Treatment involves supportive care and immunoglobulin therapy. Most patients recover, though some experience long-term weakness depending on the severity of symptoms.
Guillain-Barré syndrome.....My Understanding..
Guillain-Barré syndrome is an acute autoimmune disorder that causes inflammation of the peripheral nerves. It most commonly develops 1-3 weeks after a respiratory or gastrointestinal infection. Males have a slightly higher risk than females. Approximately 70% of cases are preceded by a viral or bacterial infection. The syndrome causes progressive weakness and paralysis due to damage to the myelin sheath surrounding peripheral nerves or to the axons themselves. Diagnosis involves clinical evaluation, cerebrospinal fluid analysis, and nerve conduction studies. Treatment focuses on supportive care and immunotherapy. Prognosis depends on severity but most patients recover fully if respiratory support is provided promptly as needed.
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Guillain-Barré syndrome is an autoimmune disorder where the immune system attacks the peripheral nervous system, causing muscle weakness and possible paralysis. It often follows a viral or bacterial infection. The body's immune system mistakenly attacks and destroys the myelin sheath surrounding nerves. This damages nerve impulses and causes muscle weakness. Symptoms include progressive muscle weakness, numbness, pain, and difficulty walking or breathing. It can range from mild to life-threatening. The cause is unknown but molecular mimicry between infectious agents and nerve tissues may play a role.
Acute flaccid paralysis afp
1. Acute flaccid paralysis (AFP) is defined as sudden onset of weakness or paralysis over 15 days in patients under 15 years old. It suggests involvement of the lower motor neuron complex.
2. Common causes of AFP include poliomyelitis, Guillain-Barré syndrome, transverse myelitis, botulism, and non-polio enteroviruses. Clinical features and investigations can help differentiate between these causes.
3. Treatment depends on the underlying etiology but may include supportive care, IV immunoglobulin, plasmapheresis, and corticosteroids. Prognosis ranges from full recovery to residual deficits or death, depending on the cause and extent of
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Acute flaccid paralysis: make it easy
Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis among infants. It is an autoimmune disorder that causes acute, rapidly progressive, and potentially fatal paralysis. The classic presentation involves ascending symmetric motor weakness, areflexia, and ataxia. Treatment involves hospitalization, IV immunoglobulin, plasmapheresis, and supportive care including ventilation if needed. Most patients recover fully but some have residual deficits and rare cases are chronic or fatal.
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• This PPT – is about 3 rare but important diseases .As there is no satisfactory Treatments in Modem Medicine ,many patients come for Ayurvedic Treatment .So Ayurvedic students must understand these diseases .Also these diseases are included in CCIM syllabus of Kayachikitsa in 4th Year BAMS .This PPT will tell you causes ,Clinical features,Investigations ,Treatments for these 3 diseases .Even Ayurvedic Treatments are also given
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Gullian Barrè Syndrome (GBS) is an immune-mediated condition that can cause respiratory failure in 20% of cases. A 15-year old female patient presented with progressive weakness, inability to walk, and respiratory failure due to GBS. She required long-term ventilation and care over 9 months in the ICU for recovery. Her recovery was slow but she showed gradual improvements like returning speech, swallowing, and some spontaneous breathing over several months. Managing GBS patients in resource-poor settings presents challenges due to lack of medications, equipment, and support specialties, but dedicated care can improve outcomes.
Acute flaccid paralysis (AFP)
Acute Flaccid Paralysis (AFP) is defined as sudden onset of weakness or paralysis in a previously normal limb over 15 days in patients under 15 years old. Guillain-Barré Syndrome (GBS) is the most common cause of AFP and is an acute acquired inflammatory demyelinating polyneuropathy. It has an annual incidence of 0.6 to 2.4 cases per 100,000 people and usually occurs 2-4 weeks after a respiratory or GI infection. GBS is diagnosed through CSF analysis showing elevated proteins and electrophysiological studies showing demyelination. Treatment involves monitoring, IVIG or plasma exchange to shorten recovery time, and PICU care if respiratory involvement is present.
Gullian barre syndrome
Guillain-Barré syndrome is an acute polyneuropathic disorder that causes muscle weakness, loss of reflexes, and numbness in the limbs and face. It occurs when the immune system mistakenly attacks the peripheral nervous system. The symptoms can range from mild tingling to total paralysis. The disorder is usually triggered by a bacterial or viral infection. Treatment focuses on speeding recovery through measures like plasmapheresis, IVIG, respiratory therapy, and monitoring for complications like respiratory failure or paralysis. Nurses help manage symptoms, provide education, and address problems with mobility, swallowing, and sensation that arise due to the disease process.
Gullian barre syndrome
Guillain-Barré syndrome is an acute inflammatory demyelinating polyneuropathy characterized by progressive muscle weakness. It is an autoimmune disorder caused by the immune system attacking the peripheral nervous system. Campylobacter infection is the most common precipitant of Guillain-Barré syndrome. There are different types including acute inflammatory demyelinating polyneuropathy and Miller Fisher syndrome. Treatment involves plasmapheresis or intravenous immunoglobulin to remove antibodies and improve symptoms.
Guillain Barre Syndrome
Guillain-Barré syndrome is an acute inflammatory demyelinating polyneuropathy characterized by progressive muscle weakness and loss of reflexes. It is usually preceded by a gastrointestinal or respiratory infection and can cause paralysis. Treatment involves plasmapheresis or intravenous immunoglobulin to reduce antibodies, with most patients recovering fully or having minor deficits, but 5-10% having permanent disability and 3-8% dying despite intensive care.
Acute flaccid paralysis
This document provides information about acute flaccid paralysis (AFP), including its definition, causes, surveillance, and clinical management. AFP is defined as paralysis of acute onset (less than 4 weeks) where the limbs are flaccid and tone is decreased. The main causes of AFP include poliomyelitis, Guillain-Barré syndrome, transverse myelitis, and traumatic neuritis. Surveillance of AFP cases is important for monitoring polio eradication efforts. All AFP cases should be reported, investigated, and have stool samples collected and tested for poliovirus. Proper clinical evaluation and management is needed to diagnose the cause and provide specific treatment.
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Gullian Barre Syndrome.pptx
Guillain-Barré syndrome (GBS) is an acute inflammatory disorder of the peripheral nervous system that causes progressive muscle weakness and paralysis. It is caused by an immune system attack on the peripheral nerves. The main symptoms are rapidly increasing muscle weakness, numbness, and tingling in the legs and arms. Diagnosis involves spinal fluid analysis and nerve conduction tests. Treatment focuses on supporting breathing, preventing complications, and hastening recovery through treatments like plasmapheresis or intravenous immunoglobulin. Most people recover fully or nearly fully from GBS, but some continue to have some degree of weakness.
GBS.pptx
Elisha Mkakirwa, a 6-year old male, presented with a 4-month history of blood in stool and 3 days of lower limb pain and tingling. Examination found hypotonia and reduced power in the lower limbs. Tests showed elevated CSF protein. He was diagnosed with Guillain-Barré syndrome, a rare disorder where the immune system attacks nerves, causing muscle weakness and paralysis. Treatment included IV antibiotics, physiotherapy, and supportive care. Prognosis is generally good, with most patients recovering over months, though some experience long-term weakness.
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Guillain Barre’ syndrome(GBS) and Anesthesia consideration
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CVS CASE PRESENTTION examination of cardiovascular systempptx
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Accute flaccid paralysis
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Guillain Barre’ syndrome(GBS) and Anesthesia consideration
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Guillen barre syndrome
- 2. • GULLAIN BARRE SYNDROME • TRAUMATIC NEURITIS
- 4. • Common cause of AFP in children • AUTO IMMUNE • Rapidly progressive • Symmetric polyradiculoneuropathy • Occur at any age • 2/3 rd patient have an infection within 6 week prior to symptom onset- URTI / gastroenteritis
- 6. CLINICAL FEATURES • A/c onset of symmetrical ascending weakness • More in distal muscles • Distal parasthesia & pain precede muscle weakness • Facial and bulbar weakness commonly develop • Involvement of respiratory muscles – ¼ th cases – ventilatory support
- 7. • Deep tendon reflexes are diminished • Hypotonia • Sensory involvement • Dysautonomia • Tachycardia, arrythmia , bladder dysfunction, labile blood pressure, impaired thermoregulation • Weakness reaches a max in 4 wks- gradual recovery over weeks to month
- 8. SUB TYPES • a/c inflammatory demyelinating polyradiculoneuropathy • a/c motor axonal neuropathy • a/c motor and sensory neuropathy • a/c sensory neuropathy • a/c pandysautonomia • Miller fisher syndrome
- 9. • Miller fisher syndrome • ophthalmological abnormalities • Ataxia • areflexia
- 10. INVESTIGATION • C/F • ELECTROPHYSIOLOGICAL STUDIES • CSF examination
- 11. • CSF protein is raised • CSF white cell count is normal(albumincytologic dissociation) or below 50 cells / mm₃ • Electrophysiological studies and CSF study nl – first week of illness
- 12. • Eletrophysiology • Absent F responses or H reflexes , Reduced compound muscle action potential or sensory nerve action potential - axonal forms • Prolonged distal latencies, reduced conduction velocities, abnormal temporal dispersion, &conduction blocks- demyelinating types
- 13. TREATMENT • IMMUNOTHERAPY – IVIG 2g/kg over 2-5 days • Plasma exchanges– within 2-4 wks of onset • Indicated Non ambulatory patient • Sev d/s , IVIG therapy(if initiated with in 2 wks from onset) hastens recovery as much as PE
- 14. • General supportive care • Cardio respiratory care • Physical therapy • Nutritional management • Management of neuropathic pain • Care of bladder and bowel • Prevention of DVT
- 17. TRAUMATIC NEURITIS • Defined as inflammation of nerve after injury • Progression to complete paralysis is hours to 4 days • No onset of fever • Flaccidity is acute and asymmetric • Hypotonia and deep tendon reflexes are diminished • Pain in gluteal region • No cranial nerve invovement
- 18. • CSF is normal • No bladder or bowel involvement • Nerve conduction velocity at 3 week is abnormal • Sequelae at 3 months – moderate atropy in affected limb
- 19. GBS TRAUMATIC NEURITIS fever May hav prodromal illness absent symmetry Symmetrical asymmetric sensations variable May be impaired in the distribution of affected nerve Respiratory insufficiency May be present absent Cranial nerves Usually affected absent Radicular signs present absent Bladder bowel complaints Transient ,d/t autonomic dysfunction absent Nerve conduction abnormal abnormal CSF Albumino cytologic dissociation normal M RI spine Usually normal normal
- 20. THANK U….