This document discusses several key global environmental changes and their impacts on human health, including climate change, ozone depletion, loss of biodiversity, fresh water supplies, and persistent organic pollutants. It defines each issue, provides facts about causes and effects, and examines consequences such as increased temperatures, extreme weather events, spread of diseases, food and water insecurity. Climate change is a particular focus, outlining the greenhouse effect, global warming trends, and direct and indirect health impacts through heatwaves, storms, droughts, floods and changes to disease transmission patterns.