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IN DEPTH EFFICACY CHARACTERIZATION CRO
SYNCROSOME
In Depth Efficacy Characterization CRO
IN DEPTH EFFICACY CHARACTERIZATION CRO
Animal models Manipulation Read-outs
- Emesis & Nausea
- Safety evaluation
- Efficacy Studies
- Irritable Bowel Syndrome
- Inflammatory Bowel Disease
- Ulcer
- Gastric Emptying
- Intestinal Transit
- All type of treatments
- Small molecules
- Immunization
- Nutraceuticals
- All routes of administration
- po, ip, iv, sc, im, it, in,ir
- Sample collection
- Organs removal
- Blood
- Fecal pellet
- Tissue preparation
- Dissection of organs
- Emesis, vomiting
- Nausea
- Abdominal Contractions
- Inflammation
- Histology, Histopathology
- Biomarkers (MPO activity…°
- Cytokines dosages
- Intestinal motility
OVERVIEW OF SYNCROSOME’S GASTRO MODELS
IN DEPTH EFFICACY CHARACTERIZATION CRO
EMESIS AND NAUSEA
IN DEPTH EFFICACY CHARACTERIZATION CRO
EMESIS AND NAUSEA
SPECIES : Ferret & Piglet
TECHNIQUE : Behavioral assessment by trained observers
PARAMETERS : Number of episodes of retching and vomiting or
emesis
Nausea
REF. COMPOUNDS : Emetic and anti-emetic agents
IN DEPTH EFFICACY CHARACTERIZATION CRO
EMESIS: LIST OF EMETOGENS IN TWO SPECIES
Ferret Piglet
Ipecac syrup
AVP
Morphine PDE4 inhibitor
Copper sulfate PGE2
Apomorphine PGF2a
Cyclophosphamide Apomorphine
PDE4 inhibitor PAF
Galantamine
Staphylococcal
enterotoxin A
PGE2 Metformine
Isolflurane LVP
LPS
IN DEPTH EFFICACY CHARACTERIZATION CRO
IRRITABLE BOWEL SYNDROME
IN DEPTH EFFICACY CHARACTERIZATION CRO
SPECIES : Rodent, Guinea pig, Piglet
INDUCTION : Irritation, stress
TECHNIQUE : Manometric recording
PARAMETERS : Contractions
REF. COMPOUNDS: NK2 antagonist, 5-HT3 antagonist, 5-HT4 agonist
IRRITABLE BOWEL SYNDROME (IBS)
IN DEPTH EFFICACY CHARACTERIZATION CRO
INFLAMMATORY BOWEL DISEASE
IN DEPTH EFFICACY CHARACTERIZATION CRO
SPECIES : Mice
INDUCTION : DSS
PARAMETERS : Disease Activity Index
Inflammation
MPO activity
Cytokines dosages (TNFα, Il-1β, Il-2, IFNγ)
REF. COMPOUNDS : Sulfasalazine
INFLAMMATORY BOWEL DISEASE (IBD)
IN DEPTH EFFICACY CHARACTERIZATION CRO
GASTRIC EMPTYING AND INTESTINAL TRANSIT
IN DEPTH EFFICACY CHARACTERIZATION CRO
GASTRIC EMPTYING AND INTESTINAL TRANSIT
MODEL : Charcoal test and Red Phenol test
SPECIES : Rats
INDUCTION : Pharmacological
PARAMETERS : - Gut motility
- Gastric emptying
REF. COMPOUNDS : Atropine
IN DEPTH EFFICACY CHARACTERIZATION CRO

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Syncrosome Disease model Gastro intestinal - Preclinical CRO

  • 1. IN DEPTH EFFICACY CHARACTERIZATION CRO SYNCROSOME In Depth Efficacy Characterization CRO
  • 2. IN DEPTH EFFICACY CHARACTERIZATION CRO Animal models Manipulation Read-outs - Emesis & Nausea - Safety evaluation - Efficacy Studies - Irritable Bowel Syndrome - Inflammatory Bowel Disease - Ulcer - Gastric Emptying - Intestinal Transit - All type of treatments - Small molecules - Immunization - Nutraceuticals - All routes of administration - po, ip, iv, sc, im, it, in,ir - Sample collection - Organs removal - Blood - Fecal pellet - Tissue preparation - Dissection of organs - Emesis, vomiting - Nausea - Abdominal Contractions - Inflammation - Histology, Histopathology - Biomarkers (MPO activity…° - Cytokines dosages - Intestinal motility OVERVIEW OF SYNCROSOME’S GASTRO MODELS
  • 3. IN DEPTH EFFICACY CHARACTERIZATION CRO EMESIS AND NAUSEA
  • 4. IN DEPTH EFFICACY CHARACTERIZATION CRO EMESIS AND NAUSEA SPECIES : Ferret & Piglet TECHNIQUE : Behavioral assessment by trained observers PARAMETERS : Number of episodes of retching and vomiting or emesis Nausea REF. COMPOUNDS : Emetic and anti-emetic agents
  • 5. IN DEPTH EFFICACY CHARACTERIZATION CRO EMESIS: LIST OF EMETOGENS IN TWO SPECIES Ferret Piglet Ipecac syrup AVP Morphine PDE4 inhibitor Copper sulfate PGE2 Apomorphine PGF2a Cyclophosphamide Apomorphine PDE4 inhibitor PAF Galantamine Staphylococcal enterotoxin A PGE2 Metformine Isolflurane LVP LPS
  • 6. IN DEPTH EFFICACY CHARACTERIZATION CRO IRRITABLE BOWEL SYNDROME
  • 7. IN DEPTH EFFICACY CHARACTERIZATION CRO SPECIES : Rodent, Guinea pig, Piglet INDUCTION : Irritation, stress TECHNIQUE : Manometric recording PARAMETERS : Contractions REF. COMPOUNDS: NK2 antagonist, 5-HT3 antagonist, 5-HT4 agonist IRRITABLE BOWEL SYNDROME (IBS)
  • 8. IN DEPTH EFFICACY CHARACTERIZATION CRO INFLAMMATORY BOWEL DISEASE
  • 9. IN DEPTH EFFICACY CHARACTERIZATION CRO SPECIES : Mice INDUCTION : DSS PARAMETERS : Disease Activity Index Inflammation MPO activity Cytokines dosages (TNFα, Il-1β, Il-2, IFNγ) REF. COMPOUNDS : Sulfasalazine INFLAMMATORY BOWEL DISEASE (IBD)
  • 10. IN DEPTH EFFICACY CHARACTERIZATION CRO GASTRIC EMPTYING AND INTESTINAL TRANSIT
  • 11. IN DEPTH EFFICACY CHARACTERIZATION CRO GASTRIC EMPTYING AND INTESTINAL TRANSIT MODEL : Charcoal test and Red Phenol test SPECIES : Rats INDUCTION : Pharmacological PARAMETERS : - Gut motility - Gastric emptying REF. COMPOUNDS : Atropine
  • 12. IN DEPTH EFFICACY CHARACTERIZATION CRO