Syncrosome: Respiratory disease models for efficacy characterization
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You will find our preclinical in vivo models for your compounds in pneumology. Syncrosome is a preclinical CRo running in vivo experiments in its own labs with its own animal facilities, working in GLP like conditions
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Syncrosome: Respiratory disease models for efficacy characterization
- 1. IN DEPTH EFFICACY CHARACTERIZATION CRO SYNCROSOME In Depth Efficacy Characterization CRO
- 2. IN DEPTH EFFICACY CHARACTERIZATION CRO Animal models Manipulation Read-outs - ASTHMA - COPD - PULMONARY FIBROSIS - COUGH - Pulmonary Arterial Hypertension (PAH) - All type of treatments - Small molecules - Immunization - Nutraceuticals - All routes of administration - Ip, iv, sc, im - Intranasal - Intra-Tracheal (Penn Century Device) - Oral (gavage, food, water) - Sample collection - Lung – blood – organs - Tissue preparation - Lung - Preparation for histology in paraffin or liquid nitrogen - Biochemistry - Cell counting on Bronchoalveolar Lavage (BAL) - Cytokine monitoring (IL1, IL8, IL6, TNF-α…) - Immunohistochemistry - Cardiac parameters and functiun - Biomarkers - Plethysmography - Tidal Volume - Respiratory Rate OVERVIEW OF SYNCROSOME’S RESPIRATORY MODELS
- 3. IN DEPTH EFFICACY CHARACTERIZATION CRO ASTHMA DISEASE MODEL
- 4. IN DEPTH EFFICACY CHARACTERIZATION CRO ASTHMA MODEL: ANTIGEN-INDUCED LUNG EOSINOPHILIA MODELS : Immunization SPECIES : mouse, rat TECHNIQUE : Cell counting Plethysmography PARAMETERS : Inflammation Respiratory parameters Cytokines REF. CPDS : Roflumilast, Budesonide, Dexamethasone
- 5. IN DEPTH EFFICACY CHARACTERIZATION CRO COPD DISEASE MODEL
- 6. IN DEPTH EFFICACY CHARACTERIZATION CRO COPD MODEL: LPS-INDUCED LUNG NEUTROPHILIA MODELS : LPS SPECIES : Mouse, rat TECHNIQUE : Cell counting Plethysmography PARAMETERS : Inflammation Respiratory parameters Cytokines REF. CPDS : Roflumilast, Budesonide, Dexamethasone
- 7. IN DEPTH EFFICACY CHARACTERIZATION CRO PULMONARY FIBROSIS MODEL
- 8. IN DEPTH EFFICACY CHARACTERIZATION CRO PULMONARY FIBROSIS MODEL MODELS : Bleomycin SPECIES : Rats PARAMETERS : IHC Fibrosis Histological evaluation Biochemical markers REF. CPDS : Cortisone
- 9. IN DEPTH EFFICACY CHARACTERIZATION CRO PULMONARY ARTERIAL HYPERTENSION
- 10. IN DEPTH EFFICACY CHARACTERIZATION CRO PAH : 3 DIFFERENT INDUCTION MODELS : Pharmacological, Hypoxia, and others… SPECIES : mouse, rat TECHNIQUE : Cell counting, plexiform lesions Plethysmography Cardiac parameters, Doppler PARAMETERS : Inflammation, vascular remodeling Respiratory parameters Cytokines…. REF. CPDS : PDE5 inhibitor, Bosentan, Tadalafil, Vardenafil
- 11. IN DEPTH EFFICACY CHARACTERIZATION CRO