This document discusses different types of genetic mutations including their causes and effects. It describes several kinds of mutations such as substitutions, deletions, insertions, inversions, and translocations. It also discusses transition, transversion, frameshift, silent, missense, and nonsense mutations. The document notes that genetic mutations can occur during DNA replication in germline or somatic cells and can be caused by errors in replication or exposure to mutagens. Mutations in germline cells may be inherited by offspring while somatic mutations usually only affect the individual cell.
A mutation is a change that occurs in our DNA sequence, either due to mistakes when DNA is copied or as the result of environmental factors such as UV light. The DNA sequence of a gene can be altered in a number of ways. Gene mutations have varying effects on health, depending on where they occur and whether they alter the function of essential proteins. Mutations are two types that are Gene mutation and Chromosome mutation. Gene mutation are further divided into Point and frameshift mutation. Point mutation are three types ie. Silent mutation, Missense mutation and Nonsense mutation. Frameshift mutation are of two types that are addition and deletion. Chromosome mutations are further classified into Deletion, duplication, inversion and translocation.
A mutation is a change that occurs in our DNA sequence, either due to mistakes when DNA is copied or as the result of environmental factors such as UV light. The DNA sequence of a gene can be altered in a number of ways. Gene mutations have varying effects on health, depending on where they occur and whether they alter the function of essential proteins. Mutations are two types that are Gene mutation and Chromosome mutation. Gene mutation are further divided into Point and frameshift mutation. Point mutation are three types ie. Silent mutation, Missense mutation and Nonsense mutation. Frameshift mutation are of two types that are addition and deletion. Chromosome mutations are further classified into Deletion, duplication, inversion and translocation.
Cell Biology and genetics paper - Mutation a basic touch to b.sc students with examples. DNA, genome, gene level mutation and chromosome level with examples. Touched some of the mutation types.
Alterations in the DNA code, such as changing a letter, deleting a letter, inserting a letter or moving sections aroun proteins with abnormal functions.
If these abnormal functions cause the cell to grow, divide, ignore regulatory signals or assume new functions, cancers can develop
Fortunately, normal cells are good at repairing mistakes should they occur and have multiple systems for ensuring that the DNA co transmitted to its two daughter cells when it divides. Normal cells even have suicide programs if the mistakes are beyond repair, a p death, known as apoptosis. [Source: https://www.loxooncology.com/genomically-defined-cancers/genomic-alterations]
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In this Presentation Chapter 7 & 8 from the book Advanced Molecular Biology are discussed. Focus has been given to the mutation, its types, mutation repair, Different Repairing mechanisms and DNA Replication is explained with details.
DNA molecule is composed of 2 strands of complementary nucleotides bound together by a double Helix.
Bacterial nucleus contains circular chromosome of a double strand DNA molecule of 1000um (1mm) long when straightened.
Each strand have a backbone of deoxyribose sugar and phosphate groups
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One of these four nitrogenous bases is attached to each deoxyribose (sugar)
The two stands are held together by hydrogen bonds between the nitrogenous bases on the opposite strands
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Alterations in the DNA code, such as changing a letter, deleting a letter, inserting a letter or moving sections aroun proteins with abnormal functions.
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Genetic Mutations dieses A genetic mutation is a change that occurs in our DNA code
1. Supervisor: Dr/Asmaa
Team leader: Fady Fayez
Presenter: Abdalla Gamal
Designer: Mohamed Ragab
Data collector: Mohamed Nady
Summarizer: Hassan
2. A genetic mutation is a
change that occurs in our
DNA code (sequence of
nucleotides).
3. Internal causes: external
causes:
1- Result from errors in
DNA replication during
cell division.
1- Exposure to mutagens
or a viral invasion.
2- Exposed to certain
chemicals or radiations.
12. It is a mutation where
one nucleotide is deleted
so there is a shift in
codon transcription.
13. It is a mutation where one
nucleotide is inserted so
there is a shift in codon
transcription.
14. • When protein-coding DNA is divided into codons three bases long, insertions
and deletions can alter a gene so that its message is no longer correctly parsed.
• This usually generates truncated proteins that are useless.
15. Silent
• mutated codon codes for the same amino
acid.
• CAA (glutamine) → CAG (glutamine).
• Not dangerous.
Missense
• mutated codon codes for a different amino
acid.
• CAA (glutamine) → CCA (proline).
• May cause diseases.
Nonsense
• mutated codon is a premature stop
codon.
• CAA (glutamine) - UAA (stop).
• Usually serious.
16.
17. • Occurs in gametes. These
mutations are especially
significant because they can
be transmitted to offspring
and every cell in the offspring
will have the mutation.
• Occurs in other cells of the body.
These mutations may have little
effect on the organism because they
are confined to just one cell and its
daughter cells. Somatic mutations
cannot be passed on to offspring.