Gangrene results from necrosis or putrefaction of tissue due to infection. It can be caused by arterial obstruction from conditions like thrombosis, embolism, diabetes, or physical agents like burns, frostbite, or chemicals. There are three main types of gangrene: wet gangrene caused by severe bacterial infection on top of necrosis and found in internal organs or exposed parts; dry gangrene caused by gradual blood supply obstruction and found on exposed parts; and gas gangrene which has gas formation in addition to wet gangrene and is found on exposed parts. Treatment involves addressing predisposing factors and amputation of the gangrenous part to prevent spreading.

1. Gangrene
By
Amira Essam
Medical student
-source-
Short text book of pathology Dr Mohamed danish

2. Pathology
• The clinical condition results from necrosis or putrefaction of tissue
due to infection .
Necrosis putrefaction infection gangrene

3. causes
Arterial
obstruction
infection trauma Physical agents
Due to :
• Thrombosis
• Embolus
• Diabetes
• Burger’s disease
• Raynaud’s disease
In
• Boils
• carbuncles
In
• Crush injuries
• Pressure sores
With
• Burns
• Frostbite
• chemicals

4. Types
• Wet gangrene
• Dry gangrene
• Gas gangrene
• Appears moist , results from severe bacterial infection superimposed
on necrosis. Found on internal organs and exposed parts
• Appears dry ,wrinkled and discolored , results from gradual
obstruction of blood supply. Found on exposed parts.
• Wet gangrene + gas formation , Found on exposed parts.

5. Types
wet dry gas
Smell foul No smell foul
Edema + + +
Black color + + -
Line of discrimination no Yes between living and
dead cells
no
Gas bubbles no no Yes with crepitus

6. Treatment
• Treatment of predisposing factors.
• Amputation : surgical removal of gangrenous part to
prevent spreading.

7. Thanks