SlideShare a Scribd company logo
FUNCTIONS OF KIDNEY
PRATHYUSHA
Msc BIOTECHNOLOGY
SCHOOL OF BIOSCIENCE
MGU KOTTAYAM
OVERVIEW OF KIDNEY FUNCTIONS
 Excretion of wastes and other foreign
substances.
 Regulation of blood ionic composition.
 Regulation of blood pH.
 Production of hormones.
 Regulation of blood pressure.
 Regulation of blood volume.
 Maintenance of blood osmolarity.
 Regulation of blood glucose level.
EXCRETION OF WASTES AND OTHER FOREIGN
SUBSTANCES
 By forming urine, the kidneys help excrete wastes-
substances that have no useful function in the body.
 Some wastes excreted in urine result from metabolic
reactions in the body. These include:
 Ammonia and urea from deamination of amino acids.
 Bilirubin from the catabolism of haemoglobin.
 Creatinine from the breakdown of creatinine phosphate in muscle
fibres.
 Uric acid from the catabolism of nucleic acids.
 Other wastes include foreign substances from the diet,
such as drugs and environmental toxins.
REGULATION OF BLOOD IONIC
COMPOSITION AND PH
 The kidney can correct any imbalances by:
 Removing excess acid (hydrogen ion) or bases (bicarbonate)
in the urine and
 Restoring the bicarbonate concentration in the blood to
normal.
 The kidney cells produce a constant amount of
hydrogen ion and bicarbonate because of their own
cellular metabolism (production of carbon dioxide).
 Whether the kidney removes hydrogen ions or
bicarbonate ions in the urine depends upon the
amount of bicarbonate filtered in the glomerulus from
the blood relative to the amount of hydrogen ions
secreted by the kidney cells.
 If the amount of filtered bicarbonate is greater than the
amount of secreted hydrogen ions, then bicarbonate
will be lost in the urine.
 Likewise, If the amount of secreted hydrogen ion is
greater than the amount of filtered bicarbonate, then
hydrogen ions will be lost in the urine (i.e. acidic urine).
PRODUCTION OF HORMONES
 The human kidney secretes two
hormones:
 Erythropoietin (EPO)
 Clacitriol (1,25[OH]2 Vitamin D3
Erythropoietin
 Glycoprotein.
 It acts on the bone marrow to increase
the production of red blood cells.
 Stimuli such as bleeding or moving to
high altitudes (where oxygen is scarcer)
trigger the release of EPO.
 People with failing kidneys; dialysis.
Without a source of EPO, these patients
suffer from anaemia.
 Recombinant EPO.
 Athletes urine.
CALCITRIOL
 Calcitriol is 1,25[OH]2 Vitamin D3, the active form of vitamin D. It
is derived from
 calciferol (vitamin D3) which is synthesized in skin exposed to the
ultraviolet rays of the sun
 precursors ("vitamin D") ingested in the diet.
 Calciferol in the blood is converted into the active vitamin in two
steps:
 calciferol is converted in the liver into 25[OH] vitamin D3
 this is carried to the kidneys where it is converted into calcitriol. This
final step is promoted by the parathyroid hormone (PTH).
 Calcitriol acts on
 the cells of the intestine to promote the absorption of calcium and
phosphate from food
 bone to mobilize calcium from the bone to the blood
REGULATION OF BLOOD PRESSURE
RENIN
 One of the functions of the kidney is to monitor blood pressure and
take corrective action if it should drop. The kidney does this by
secreting the proteolytic enzyme renin.
 Renin acts on angiotensinogen, a plasma peptide, splitting off a
fragment containing 10 amino acids called angiotensin I.
 angiotensin I is cleaved by a peptidase secreted by blood vessels
called angiotensin converting enzyme (ACE) — producing
angiotensin II, which contains 8 amino acids.
 Angiotensin II
 constricts the walls of arterioles closing down capillary beds;
 stimulates the proximal tubules in the kidney to reabsorb sodium
ions;
 stimulates the adrenal cortex to release aldosterone. Aldosterone
causes the kidneys to reclaim still more sodium and thus water.
 increases the strength of the heartbeat;
 stimulates the pituitary to release the vasopressin .
 All of these actions lead to an increase in blood pressure.
REGUATION OF BLOOD VOLUME
MAINTENANCE OF BLOOD
OSMOLARITY
By separately regulating loss of water and
loss of solutes in the urine, the kidneys
maintain a relatively constant blood
osmolarity close to 300 milliosmoles per
litre.
REGULATION OF BLOOD GLUCOSE
LEVEL
Like the liver, the kidneys can use the
amino acid glutamine in gluconeogenesis,
the synthesis of new glucose molecules.
They can then release glucose into the
blood to help maintain a normal blood
glucose level.
Functions of kidney
Functions of kidney

More Related Content

What's hot

Glomerular filtration
Glomerular filtrationGlomerular filtration
Glomerular filtration
“Karishma R.Pandey”
 
STRUCTURE OF HUMAN KIDNEY
STRUCTURE OF HUMAN KIDNEYSTRUCTURE OF HUMAN KIDNEY
STRUCTURE OF HUMAN KIDNEY
MAHESWARI JAIKUMAR
 
Functions of kidney
Functions of kidneyFunctions of kidney
Functions of kidney
rohini sane
 
Glomerular filtration rate (GFR)
Glomerular filtration rate (GFR)Glomerular filtration rate (GFR)
Glomerular filtration rate (GFR)
Dr Sara Sadiq
 
Anatomy and physiology of the respiratory system
Anatomy and physiology of the respiratory systemAnatomy and physiology of the respiratory system
Anatomy and physiology of the respiratory system
Dipali Harkhani
 
Anatomy of kidneys
Anatomy of  kidneysAnatomy of  kidneys
Anatomy of kidneys
Swaroopa Beulah Perumalla
 
Function of the liver
Function of the liverFunction of the liver
Function of the liverAdil Rahimli
 
Physiology of the kidneys
Physiology of the kidneysPhysiology of the kidneys
Physiology of the kidneys
Chy Yong
 
General anatomy of urinary system ppt
General anatomy of urinary system pptGeneral anatomy of urinary system ppt
General anatomy of urinary system ppt
jagan _jaggi
 
Renal system
Renal systemRenal system
Renal system
Roger Watson
 
Anatomy of the Digestive system
Anatomy of the Digestive systemAnatomy of the Digestive system
Anatomy of the Digestive system
Victor Ekpo
 
Anatomy and physiology of the Urinary system by Dipali Harkhani
Anatomy and physiology of the Urinary system by Dipali HarkhaniAnatomy and physiology of the Urinary system by Dipali Harkhani
Anatomy and physiology of the Urinary system by Dipali Harkhani
Dipali Harkhani
 
pituitary gland
pituitary glandpituitary gland
pituitary gland
WahidahPuteriAbah
 
Pituitary gland (1)
Pituitary gland (1)Pituitary gland (1)
Pituitary gland (1)
maryamnoor21
 
Functions,Secretion and Regulation of Bile
Functions,Secretion and Regulation of  BileFunctions,Secretion and Regulation of  Bile
Functions,Secretion and Regulation of Bile
Kaif Qureshi
 
Structure and functions of liver
Structure and functions of liverStructure and functions of liver
Structure and functions of liver
K.M.College of Pharmacy, Madurai
 
Functions of human liver
Functions of human liverFunctions of human liver
Functions of human liverBubly Atif
 
Respiratory System - Physiology
Respiratory System - PhysiologyRespiratory System - Physiology
Respiratory System - Physiology
Dr. Binu Babu Nursing Lectures Incredibly Easy
 

What's hot (20)

Glomerular filtration
Glomerular filtrationGlomerular filtration
Glomerular filtration
 
Urine formation
Urine formationUrine formation
Urine formation
 
STRUCTURE OF HUMAN KIDNEY
STRUCTURE OF HUMAN KIDNEYSTRUCTURE OF HUMAN KIDNEY
STRUCTURE OF HUMAN KIDNEY
 
Functions of kidney
Functions of kidneyFunctions of kidney
Functions of kidney
 
Glomerular filtration rate (GFR)
Glomerular filtration rate (GFR)Glomerular filtration rate (GFR)
Glomerular filtration rate (GFR)
 
Anatomy and physiology of the respiratory system
Anatomy and physiology of the respiratory systemAnatomy and physiology of the respiratory system
Anatomy and physiology of the respiratory system
 
Anatomy of kidneys
Anatomy of  kidneysAnatomy of  kidneys
Anatomy of kidneys
 
Function of the liver
Function of the liverFunction of the liver
Function of the liver
 
Physiology of the kidneys
Physiology of the kidneysPhysiology of the kidneys
Physiology of the kidneys
 
General anatomy of urinary system ppt
General anatomy of urinary system pptGeneral anatomy of urinary system ppt
General anatomy of urinary system ppt
 
Renal system
Renal systemRenal system
Renal system
 
Anatomy of the Digestive system
Anatomy of the Digestive systemAnatomy of the Digestive system
Anatomy of the Digestive system
 
Anatomy and physiology of the Urinary system by Dipali Harkhani
Anatomy and physiology of the Urinary system by Dipali HarkhaniAnatomy and physiology of the Urinary system by Dipali Harkhani
Anatomy and physiology of the Urinary system by Dipali Harkhani
 
gastric juice
gastric juicegastric juice
gastric juice
 
pituitary gland
pituitary glandpituitary gland
pituitary gland
 
Pituitary gland (1)
Pituitary gland (1)Pituitary gland (1)
Pituitary gland (1)
 
Functions,Secretion and Regulation of Bile
Functions,Secretion and Regulation of  BileFunctions,Secretion and Regulation of  Bile
Functions,Secretion and Regulation of Bile
 
Structure and functions of liver
Structure and functions of liverStructure and functions of liver
Structure and functions of liver
 
Functions of human liver
Functions of human liverFunctions of human liver
Functions of human liver
 
Respiratory System - Physiology
Respiratory System - PhysiologyRespiratory System - Physiology
Respiratory System - Physiology
 

Similar to Functions of kidney

6. excretory system
6. excretory system6. excretory system
6. excretory system
Arosek Padhi
 
Renal system
Renal systemRenal system
Renal system
Pharmtechfau
 
The urinary system excretory system
The urinary system  excretory systemThe urinary system  excretory system
The urinary system excretory system
INTERNATIONAL COSMETOLOGIST, FREELANCER IN DELHI
 
Mineralocorticoids
MineralocorticoidsMineralocorticoids
Water electrolyte balance
Water electrolyte balanceWater electrolyte balance
Water electrolyte balanceAshley Santos
 
physiology : Excretion
physiology : Excretionphysiology : Excretion
physiology : Excretion
Osama Rifat
 
Kidney function
Kidney functionKidney function
Kidney function
MohammedAmeen94
 
Renal disease wps office
Renal disease wps officeRenal disease wps office
Renal disease wps office
home
 
Kidney as an endocrine gland and its non excretory fuctions
Kidney as an endocrine gland and its non excretory fuctionsKidney as an endocrine gland and its non excretory fuctions
Kidney as an endocrine gland and its non excretory fuctions
Usra Hasan
 
Role of diet and nutrition in prevention and treatment of renal failure
Role of diet and nutrition in prevention and treatment of renal failureRole of diet and nutrition in prevention and treatment of renal failure
Role of diet and nutrition in prevention and treatment of renal failure
karthikadurairaj
 
Lecture 15 kidney- pathology
Lecture 15 kidney- pathology Lecture 15 kidney- pathology
Lecture 15 kidney- pathology
Areej Abu Hanieh
 
Fluid metabolism
Fluid metabolismFluid metabolism
Fluid metabolism
Sinchana SK
 
Fluid metabolism
Fluid metabolismFluid metabolism
Fluid metabolism
Sinchana SK
 
Adrenal Glands.ppt
Adrenal Glands.pptAdrenal Glands.ppt
Adrenal Glands.ppt
Medical Knowledge
 
Human Body - Excretory System
Human Body - Excretory SystemHuman Body - Excretory System
Human Body - Excretory System
vzt00
 
Gu course chapter 1
Gu course chapter 1Gu course chapter 1
Gu course chapter 1
Judy D'Angelo RN MSN ARNP
 
Biochemical components
Biochemical componentsBiochemical components
Biochemical components
Dr.Priyanka Das
 

Similar to Functions of kidney (20)

6. excretory system
6. excretory system6. excretory system
6. excretory system
 
Renal system
Renal systemRenal system
Renal system
 
The urinary system excretory system
The urinary system  excretory systemThe urinary system  excretory system
The urinary system excretory system
 
Mineralocorticoids
MineralocorticoidsMineralocorticoids
Mineralocorticoids
 
Kidney failure
Kidney failureKidney failure
Kidney failure
 
Water electrolyte balance
Water electrolyte balanceWater electrolyte balance
Water electrolyte balance
 
physiology : Excretion
physiology : Excretionphysiology : Excretion
physiology : Excretion
 
Kidney function
Kidney functionKidney function
Kidney function
 
Kidney127
Kidney127Kidney127
Kidney127
 
Renal disease wps office
Renal disease wps officeRenal disease wps office
Renal disease wps office
 
Kidney as an endocrine gland and its non excretory fuctions
Kidney as an endocrine gland and its non excretory fuctionsKidney as an endocrine gland and its non excretory fuctions
Kidney as an endocrine gland and its non excretory fuctions
 
Role of diet and nutrition in prevention and treatment of renal failure
Role of diet and nutrition in prevention and treatment of renal failureRole of diet and nutrition in prevention and treatment of renal failure
Role of diet and nutrition in prevention and treatment of renal failure
 
Lecture 15 kidney- pathology
Lecture 15 kidney- pathology Lecture 15 kidney- pathology
Lecture 15 kidney- pathology
 
Fluid metabolism
Fluid metabolismFluid metabolism
Fluid metabolism
 
Fluid metabolism
Fluid metabolismFluid metabolism
Fluid metabolism
 
Adrenal Glands.ppt
Adrenal Glands.pptAdrenal Glands.ppt
Adrenal Glands.ppt
 
Human Body - Excretory System
Human Body - Excretory SystemHuman Body - Excretory System
Human Body - Excretory System
 
Gu course chapter 1
Gu course chapter 1Gu course chapter 1
Gu course chapter 1
 
Excretion1
Excretion1Excretion1
Excretion1
 
Biochemical components
Biochemical componentsBiochemical components
Biochemical components
 

More from Raviz Prathyusha

Electrophoresis
ElectrophoresisElectrophoresis
Electrophoresis
Raviz Prathyusha
 
Scid mice
Scid miceScid mice
Scid mice
Raviz Prathyusha
 
Good laboratory practises
Good laboratory practisesGood laboratory practises
Good laboratory practises
Raviz Prathyusha
 
Forces stabilising structure of proteins
Forces stabilising structure of proteinsForces stabilising structure of proteins
Forces stabilising structure of proteins
Raviz Prathyusha
 
Transposons in bacteria
Transposons in bacteriaTransposons in bacteria
Transposons in bacteria
Raviz Prathyusha
 
Dna damage checkpoints
Dna damage checkpointsDna damage checkpoints
Dna damage checkpoints
Raviz Prathyusha
 

More from Raviz Prathyusha (6)

Electrophoresis
ElectrophoresisElectrophoresis
Electrophoresis
 
Scid mice
Scid miceScid mice
Scid mice
 
Good laboratory practises
Good laboratory practisesGood laboratory practises
Good laboratory practises
 
Forces stabilising structure of proteins
Forces stabilising structure of proteinsForces stabilising structure of proteins
Forces stabilising structure of proteins
 
Transposons in bacteria
Transposons in bacteriaTransposons in bacteria
Transposons in bacteria
 
Dna damage checkpoints
Dna damage checkpointsDna damage checkpoints
Dna damage checkpoints
 

Recently uploaded

How to Split Bills in the Odoo 17 POS Module
How to Split Bills in the Odoo 17 POS ModuleHow to Split Bills in the Odoo 17 POS Module
How to Split Bills in the Odoo 17 POS Module
Celine George
 
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptx
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxStudents, digital devices and success - Andreas Schleicher - 27 May 2024..pptx
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptx
EduSkills OECD
 
Language Across the Curriculm LAC B.Ed.
Language Across the  Curriculm LAC B.Ed.Language Across the  Curriculm LAC B.Ed.
Language Across the Curriculm LAC B.Ed.
Atul Kumar Singh
 
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
siemaillard
 
ESC Beyond Borders _From EU to You_ InfoPack general.pdf
ESC Beyond Borders _From EU to You_ InfoPack general.pdfESC Beyond Borders _From EU to You_ InfoPack general.pdf
ESC Beyond Borders _From EU to You_ InfoPack general.pdf
Fundacja Rozwoju Społeczeństwa Przedsiębiorczego
 
Fish and Chips - have they had their chips
Fish and Chips - have they had their chipsFish and Chips - have they had their chips
Fish and Chips - have they had their chips
GeoBlogs
 
Phrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXX
Phrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXXPhrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXX
Phrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXX
MIRIAMSALINAS13
 
The French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free downloadThe French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free download
Vivekanand Anglo Vedic Academy
 
Thesis Statement for students diagnonsed withADHD.ppt
Thesis Statement for students diagnonsed withADHD.pptThesis Statement for students diagnonsed withADHD.ppt
Thesis Statement for students diagnonsed withADHD.ppt
EverAndrsGuerraGuerr
 
CLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCE
CLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCECLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCE
CLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCE
BhavyaRajput3
 
Chapter 3 - Islamic Banking Products and Services.pptx
Chapter 3 - Islamic Banking Products and Services.pptxChapter 3 - Islamic Banking Products and Services.pptx
Chapter 3 - Islamic Banking Products and Services.pptx
Mohd Adib Abd Muin, Senior Lecturer at Universiti Utara Malaysia
 
Introduction to Quality Improvement Essentials
Introduction to Quality Improvement EssentialsIntroduction to Quality Improvement Essentials
Introduction to Quality Improvement Essentials
Excellence Foundation for South Sudan
 
PART A. Introduction to Costumer Service
PART A. Introduction to Costumer ServicePART A. Introduction to Costumer Service
PART A. Introduction to Costumer Service
PedroFerreira53928
 
Palestine last event orientationfvgnh .pptx
Palestine last event orientationfvgnh .pptxPalestine last event orientationfvgnh .pptx
Palestine last event orientationfvgnh .pptx
RaedMohamed3
 
Polish students' mobility in the Czech Republic
Polish students' mobility in the Czech RepublicPolish students' mobility in the Czech Republic
Polish students' mobility in the Czech Republic
Anna Sz.
 
GIÁO ÁN DẠY THÊM (KẾ HOẠCH BÀI BUỔI 2) - TIẾNG ANH 8 GLOBAL SUCCESS (2 CỘT) N...
GIÁO ÁN DẠY THÊM (KẾ HOẠCH BÀI BUỔI 2) - TIẾNG ANH 8 GLOBAL SUCCESS (2 CỘT) N...GIÁO ÁN DẠY THÊM (KẾ HOẠCH BÀI BUỔI 2) - TIẾNG ANH 8 GLOBAL SUCCESS (2 CỘT) N...
GIÁO ÁN DẠY THÊM (KẾ HOẠCH BÀI BUỔI 2) - TIẾNG ANH 8 GLOBAL SUCCESS (2 CỘT) N...
Nguyen Thanh Tu Collection
 
Ethnobotany and Ethnopharmacology ......
Ethnobotany and Ethnopharmacology ......Ethnobotany and Ethnopharmacology ......
Ethnobotany and Ethnopharmacology ......
Ashokrao Mane college of Pharmacy Peth-Vadgaon
 
The Roman Empire A Historical Colossus.pdf
The Roman Empire A Historical Colossus.pdfThe Roman Empire A Historical Colossus.pdf
The Roman Empire A Historical Colossus.pdf
kaushalkr1407
 
The Challenger.pdf DNHS Official Publication
The Challenger.pdf DNHS Official PublicationThe Challenger.pdf DNHS Official Publication
The Challenger.pdf DNHS Official Publication
Delapenabediema
 
Cambridge International AS A Level Biology Coursebook - EBook (MaryFosbery J...
Cambridge International AS  A Level Biology Coursebook - EBook (MaryFosbery J...Cambridge International AS  A Level Biology Coursebook - EBook (MaryFosbery J...
Cambridge International AS A Level Biology Coursebook - EBook (MaryFosbery J...
AzmatAli747758
 

Recently uploaded (20)

How to Split Bills in the Odoo 17 POS Module
How to Split Bills in the Odoo 17 POS ModuleHow to Split Bills in the Odoo 17 POS Module
How to Split Bills in the Odoo 17 POS Module
 
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptx
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxStudents, digital devices and success - Andreas Schleicher - 27 May 2024..pptx
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptx
 
Language Across the Curriculm LAC B.Ed.
Language Across the  Curriculm LAC B.Ed.Language Across the  Curriculm LAC B.Ed.
Language Across the Curriculm LAC B.Ed.
 
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
 
ESC Beyond Borders _From EU to You_ InfoPack general.pdf
ESC Beyond Borders _From EU to You_ InfoPack general.pdfESC Beyond Borders _From EU to You_ InfoPack general.pdf
ESC Beyond Borders _From EU to You_ InfoPack general.pdf
 
Fish and Chips - have they had their chips
Fish and Chips - have they had their chipsFish and Chips - have they had their chips
Fish and Chips - have they had their chips
 
Phrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXX
Phrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXXPhrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXX
Phrasal Verbs.XXXXXXXXXXXXXXXXXXXXXXXXXX
 
The French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free downloadThe French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free download
 
Thesis Statement for students diagnonsed withADHD.ppt
Thesis Statement for students diagnonsed withADHD.pptThesis Statement for students diagnonsed withADHD.ppt
Thesis Statement for students diagnonsed withADHD.ppt
 
CLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCE
CLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCECLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCE
CLASS 11 CBSE B.St Project AIDS TO TRADE - INSURANCE
 
Chapter 3 - Islamic Banking Products and Services.pptx
Chapter 3 - Islamic Banking Products and Services.pptxChapter 3 - Islamic Banking Products and Services.pptx
Chapter 3 - Islamic Banking Products and Services.pptx
 
Introduction to Quality Improvement Essentials
Introduction to Quality Improvement EssentialsIntroduction to Quality Improvement Essentials
Introduction to Quality Improvement Essentials
 
PART A. Introduction to Costumer Service
PART A. Introduction to Costumer ServicePART A. Introduction to Costumer Service
PART A. Introduction to Costumer Service
 
Palestine last event orientationfvgnh .pptx
Palestine last event orientationfvgnh .pptxPalestine last event orientationfvgnh .pptx
Palestine last event orientationfvgnh .pptx
 
Polish students' mobility in the Czech Republic
Polish students' mobility in the Czech RepublicPolish students' mobility in the Czech Republic
Polish students' mobility in the Czech Republic
 
GIÁO ÁN DẠY THÊM (KẾ HOẠCH BÀI BUỔI 2) - TIẾNG ANH 8 GLOBAL SUCCESS (2 CỘT) N...
GIÁO ÁN DẠY THÊM (KẾ HOẠCH BÀI BUỔI 2) - TIẾNG ANH 8 GLOBAL SUCCESS (2 CỘT) N...GIÁO ÁN DẠY THÊM (KẾ HOẠCH BÀI BUỔI 2) - TIẾNG ANH 8 GLOBAL SUCCESS (2 CỘT) N...
GIÁO ÁN DẠY THÊM (KẾ HOẠCH BÀI BUỔI 2) - TIẾNG ANH 8 GLOBAL SUCCESS (2 CỘT) N...
 
Ethnobotany and Ethnopharmacology ......
Ethnobotany and Ethnopharmacology ......Ethnobotany and Ethnopharmacology ......
Ethnobotany and Ethnopharmacology ......
 
The Roman Empire A Historical Colossus.pdf
The Roman Empire A Historical Colossus.pdfThe Roman Empire A Historical Colossus.pdf
The Roman Empire A Historical Colossus.pdf
 
The Challenger.pdf DNHS Official Publication
The Challenger.pdf DNHS Official PublicationThe Challenger.pdf DNHS Official Publication
The Challenger.pdf DNHS Official Publication
 
Cambridge International AS A Level Biology Coursebook - EBook (MaryFosbery J...
Cambridge International AS  A Level Biology Coursebook - EBook (MaryFosbery J...Cambridge International AS  A Level Biology Coursebook - EBook (MaryFosbery J...
Cambridge International AS A Level Biology Coursebook - EBook (MaryFosbery J...
 

Functions of kidney

  • 1. FUNCTIONS OF KIDNEY PRATHYUSHA Msc BIOTECHNOLOGY SCHOOL OF BIOSCIENCE MGU KOTTAYAM
  • 2.
  • 3. OVERVIEW OF KIDNEY FUNCTIONS  Excretion of wastes and other foreign substances.  Regulation of blood ionic composition.  Regulation of blood pH.  Production of hormones.  Regulation of blood pressure.  Regulation of blood volume.  Maintenance of blood osmolarity.  Regulation of blood glucose level.
  • 4.
  • 5. EXCRETION OF WASTES AND OTHER FOREIGN SUBSTANCES  By forming urine, the kidneys help excrete wastes- substances that have no useful function in the body.  Some wastes excreted in urine result from metabolic reactions in the body. These include:  Ammonia and urea from deamination of amino acids.  Bilirubin from the catabolism of haemoglobin.  Creatinine from the breakdown of creatinine phosphate in muscle fibres.  Uric acid from the catabolism of nucleic acids.  Other wastes include foreign substances from the diet, such as drugs and environmental toxins.
  • 6.
  • 7. REGULATION OF BLOOD IONIC COMPOSITION AND PH  The kidney can correct any imbalances by:  Removing excess acid (hydrogen ion) or bases (bicarbonate) in the urine and  Restoring the bicarbonate concentration in the blood to normal.  The kidney cells produce a constant amount of hydrogen ion and bicarbonate because of their own cellular metabolism (production of carbon dioxide).
  • 8.  Whether the kidney removes hydrogen ions or bicarbonate ions in the urine depends upon the amount of bicarbonate filtered in the glomerulus from the blood relative to the amount of hydrogen ions secreted by the kidney cells.  If the amount of filtered bicarbonate is greater than the amount of secreted hydrogen ions, then bicarbonate will be lost in the urine.  Likewise, If the amount of secreted hydrogen ion is greater than the amount of filtered bicarbonate, then hydrogen ions will be lost in the urine (i.e. acidic urine).
  • 9.
  • 10. PRODUCTION OF HORMONES  The human kidney secretes two hormones:  Erythropoietin (EPO)  Clacitriol (1,25[OH]2 Vitamin D3 Erythropoietin  Glycoprotein.  It acts on the bone marrow to increase the production of red blood cells.  Stimuli such as bleeding or moving to high altitudes (where oxygen is scarcer) trigger the release of EPO.  People with failing kidneys; dialysis. Without a source of EPO, these patients suffer from anaemia.  Recombinant EPO.  Athletes urine.
  • 11. CALCITRIOL  Calcitriol is 1,25[OH]2 Vitamin D3, the active form of vitamin D. It is derived from  calciferol (vitamin D3) which is synthesized in skin exposed to the ultraviolet rays of the sun  precursors ("vitamin D") ingested in the diet.  Calciferol in the blood is converted into the active vitamin in two steps:  calciferol is converted in the liver into 25[OH] vitamin D3  this is carried to the kidneys where it is converted into calcitriol. This final step is promoted by the parathyroid hormone (PTH).  Calcitriol acts on  the cells of the intestine to promote the absorption of calcium and phosphate from food  bone to mobilize calcium from the bone to the blood
  • 13. RENIN  One of the functions of the kidney is to monitor blood pressure and take corrective action if it should drop. The kidney does this by secreting the proteolytic enzyme renin.  Renin acts on angiotensinogen, a plasma peptide, splitting off a fragment containing 10 amino acids called angiotensin I.  angiotensin I is cleaved by a peptidase secreted by blood vessels called angiotensin converting enzyme (ACE) — producing angiotensin II, which contains 8 amino acids.  Angiotensin II  constricts the walls of arterioles closing down capillary beds;  stimulates the proximal tubules in the kidney to reabsorb sodium ions;  stimulates the adrenal cortex to release aldosterone. Aldosterone causes the kidneys to reclaim still more sodium and thus water.  increases the strength of the heartbeat;  stimulates the pituitary to release the vasopressin .  All of these actions lead to an increase in blood pressure.
  • 15. MAINTENANCE OF BLOOD OSMOLARITY By separately regulating loss of water and loss of solutes in the urine, the kidneys maintain a relatively constant blood osmolarity close to 300 milliosmoles per litre.
  • 16. REGULATION OF BLOOD GLUCOSE LEVEL Like the liver, the kidneys can use the amino acid glutamine in gluconeogenesis, the synthesis of new glucose molecules. They can then release glucose into the blood to help maintain a normal blood glucose level.