CK1 and CK2 proteins are overexpressed in some cancers and allow cancer cells to ignore checkpoints that normally stop the cell cycle. A new study found that this overexpression allows cancer cells to keep dividing unchecked. Research also linked short telomere length to increased risk of developing emphysema, as short telomeres combined with cigarette smoke may accelerate lung aging. These discoveries provide new targets for cancer treatment and ways to preserve organ function with age.

1. Chromosomes, chromatin and cellcycleCatalina Urango GiraldoMedicine Student3rd Semester

4. Cancer!!alterationsHas control pointsCELL CYCLECelldivisionDNA ispackaged in theform of2 daughtercellsguaranteeNormal cells and growthchromosomesEndingsequencestelomeresdetermineLifeexpectancyReproductivecapacity of cellsDependingonitslength

5. Scientistsfind “brake-override” proteinsthatenabledevelopment of somecancersBiology & NatureJuly 7/2011

6. CKs 1 and CKs 2 are twoproteinsknownforbeingoverexpressed in cancer.CancerCKsoverexpressioncancercellsuncontrolledgrowthbya checkpointnullifyingeffectRESEARCH DISCOVERYIn thepresentstudy, thesearchteamfoundthat a CKsoverexpressionallowscancercellstokeepdividing.When a mutation induces anuncontrolled and fastcellgrowth, thecellsends a break signal.The break signal, produced as a checkpoint response, stopscellcycle, and DNA’sreplicationwon’tgoeson.BUT…!!Whenit comes tocancer, itwasfoundthat:Thanksto a CKsoverexpression, thecancercellswill ignore the S-phasecheckpoint response, passoverit and keepdividing.

7. ObservationIn my opinion, every research that leads medicine to a better understanding of how cancer “operates” in the body, represents one more step to find a treatment.

8. Research links telomerelengthtoemphysemarisk.Health & MedicineJuly 15/2011

9. Thetelomeres are thebody’sowncelullarclocks. In thisstudy, itwasfound a closerelationshipbetweentelomerelength and a increasesusceptibilitytodevelopemphysema. Itslengthis determine :Genetically

10. byCelldivision (makesthemshorter)Gettingresults-> short telomere-> longtelomere↖↖DidNOTdeveloplungdiseaseDevelopedemphysema

11. the results obtained in this research indicates that short telomeres plus cigarette smoke might accelerates aging in the lung in some individuals.Short telomereCells can notlonger divideIncreasesrisktodevelopemphysemalungdamage

12. Observationin my opinion, it is important to keep searching about diseases that can be related to the telomere length, so it can be determine how the susceptibility to a disease can be affected and what can be done to improve health with age.

13. MedicalUtility

14. MedicalutilityThankstothisresearches, medicine can advance, and nowwiththediscover of CKs role in cancer, thereis a new target forcancertreatment.

15. MedicalutilityWiththediscovering of the link between short telomere and emphysema, new research can establishmethodsto preserve someorgansfunctionwithage.

16. MedicalutilityWithallthisresearch, medicine isgettingclosetoguaranteemore efficientmethodsforcuringcancer and preserve lifewiththeage.

17. Bibliography- Scientistsfind “brake-override” proteinsthatenabledevelopment of somecancers. URL: http://esciencenews.com/articles/2011/07/07/scientists.find.brake.override.proteins.enable.development.some.cancers (Biology & Nature)- Research links telomerelengthtoemphysemarisk. URL: http://esciencenews.com/articles/2011/07/15/research.links.telomere.length.emphysema.risk (Health & Medicine) - MARTINEZ S., Lina Maria. Biologia Molecular. 6.ed.Medellin:UPB.Fac.de Medicina,2011.52 p.