The document discusses new discoveries related to protein aggregation and chromosomal abnormalities. Researchers have quantified the effects of protein aggregation on cell aging and measured damage caused by misfolded proteins. Studies also found that many chromosomal pairs are lost or gained together across cancer types and the genome becomes more mutated as cancer advances. Understanding these chromosomal changes may help explain cancer's progression. As more is learned about chromosomal aberrations, it could allow for improved treatment of genetic conditions and cancer.

1. NEW DISCOVERIES AND PATTERNS OF CHROMOSOME ABNORMALITY Alejandra Restrepo Ochoa Universidad Pontificia Bolivariana Medicine Student , 3rd semester Teacher: Lina María Martínez Sánchez Molecular Biology

2. FOLDING

3. FOLDING

4. INTRODUCTION Bad folding, synthesizing and aggregation of proteins contributes to decrease the cell’s ability to live and reproduce. In cancer is possible to see many chromosomal aberrations, but unlike normal cells, cancer cells can strongly grow and reproduce.

5. NEW DISCOVERIES IN CELL AGING

6. NEW DISCOVERIES IN CELL AGING The researchers have quantified the effect of protein aggregation on cell aging. Protein aggregations are important in different neurodegenerative deseases.

7. NEW DISCOVERIES IN CELL AGING For the first time, they mesured the damage caused by bad folding and aggregation of proteins.

8. NEW DISCOVERIES IN CELL AGING The expression of Alzheimer’s AB42 peptide in bacteria, induces protein aggregation.

9. COMMENT I think that is important to know more about proteins and their behavior because they are involved in a lot of natural processes and diseases.

10. PATTERNS OF CHROMOSME ABNORMALITY: THE KEY TO CANCER?

11. PATTERNS OF CHROMOSME ABNORMALITY: THE KEY TO CANCER? Many chromosomal pairs are lost or gained together across different cancer types. As cancer advances the genome becomes more mutated.

12. PATTERNS OF CHROMOSME ABNORMALITY: THE KEY TO CANCER? The researchers could confirm the chromosomal aberrations that are seen in specific cancer types.

13. PATTERNS OF CHROMOSME ABNORMALITY: THE KEY TO CANCER? The possibility to answer the question about cancer’s changes, can help us to understand the characteristics of its progress.

14. COMMENT These discoveries are very important to understand better cancer in order to find how to make it less lethal.

15. MEDICAL UTILITY

16. MEDICAL UTILITY Each little thing about the human being is so complex and so well done, that is very difficult to clear up all the mysteries that it keeps.

17. MEDICAL UTILITY With all the knowledge about this, it will be easier to prevent and even to cure a lot of acute, chronic or lethal diseases.

18. MEDICAL UTILITY As we learn more about these chromosomal aberrations, we get to be able to give a better life to people that have genetic chromosomal aberrations or cancer.

19. BIBLIOGRAPHY “ New discoveries in cell aging”, Science Daily Journal, internet edition, january 2012, http://www.sciencedaily.com/releases/2012/01/120123101831.htm “ Patterns of chromosome abnormality: the key to cancer?, Science Daily Journal, internet edition, january 2012, http://www.sciencedaily.com/releases/2012/01/120123115527.htm

20. THANKS