This document summarizes two scientific articles. The first article discusses how the condensin protein folds chromosome arms during cell division in yeast, helping prevent errors. The second article discusses how scientists identified molecular mechanisms behind DNA breakage, a hallmark of cancer cells, finding some DNA regions are more susceptible to damage and cancer results when repair mechanisms fail. The document discusses potential medical applications, like developing new treatments that target these molecules to help prevent genetic disorders and cancers.

1. Cell Division: How Condensin Keeps Chromosome Arms Folded.ANDScientists Identify Molecular Basis for DNA Breakage, a Hallmark of Cancer Cells. Estefani La Rotta Gallego Medicine Student Medellín, Colombia UPB 2011

4. INTRODUTION Scientific methodology used to study DNA to find sites that break is fragile situations as cancer. Found in yeast, condensin protein that keeps your arms bent and makes the transport of chromosomes is much easier.

5. Cell Division: How Condensin Keeps Chromosome Arms Folded.

6. Cell Division: How Condensin Keeps Chromosome Arms Folded. Cell division is and will always important in all organisms, with the discovery of condensin protein is intended that no errors occur during the division.

7. Cell Division: How Condensin Keeps Chromosome Arms Folded. The condensin has a ring that can surround different chromosome regions, functioning as a rope-stopper.

8. Cell Division: How Condensin Keeps Chromosome Arms Folded. The condensin, manages to fold the arms of the chromosomes, it is known that the centromere is the one who moves and leaves the chromosome arms without any protection which causes damage that may occur at the time of division, in yeast has but you want to see this, this can be achieved in human bodies to prevent disease mutations or by a bad cell division.

9. OBSERVATION Other agencies have served as experimentation, to develop drugs, vaccines or treatments that help solve diseases in other cases serve as a method of comparison with humans, in this case the yeast which has been found the condensin is a protein that would help prevent errors at the time of cell division .

10. Scientists Identify Molecular Basis for DNA Breakage, a Hallmark of Cancer Cells.

11. Scientists Identify Molecular Basis for DNA Breakage, a Hallmark of Cancer Cells. DNA is important because it is one that contains our genetic information, when it breaks may lead to changes in cellular function, leading to defects in the control of proliferation and generate cancer.

12. Scientists Identify Molecular Basis for DNA Breakage, a Hallmark of Cancer Cells. The DNA has certain regions more susceptible to the damage, in a normal state, the cell tries to control the amount of damage. In cancer cells, this mechanism of control cannot avoid the lesion of the DNA strand.

13. Scientists Identify Molecular Basis for DNA Breakage, a Hallmark of Cancer Cells. Cancer not always results from the first lesion in the DNA strands, in some cases, there are several damages before the cancer starts. Before the development of cancer, the cell starts to divide trying to repair the damages, when this mechanism fails, the cancer cell appears.

14. OBSERVATION Are important scientific advances that have been made throughout history, the development of study could achieve significant reductions in the development of cancer and everything about this, thus ensuring that the cancer will become a thing of the past .

15. MEDICAL UTILITY The discovery of new molecules involved in the process of cell division helps us to understand better this mechanism in which are involved many regulatory steps and tries to avoid the posterior lesions.

16. MEDICAL UTILITY With the discovery of unknown molecules appear new molecular targets for posterior treatments in pathologies in which this protein has responsibility. A fail in the activity of this protein may have an important roll in some genetic disorders.

17. MEDICAL UTILITY The second news is very important because it With the passage of time has generated more diseases, climatic changes and the revolution that has taken the world, humans are increasingly more prone to disease so that achieving DNA repair, would help in the case cancer, possible to help people who are predisposed.

18. MEDICAL UTILITY CANCER People every day are more likely develop and the development of different types of cancer, every day are more aggressive and kill people quickly, with this break through could make people with cancer and find a solution to their illness and avoid other treatments that cause damage so severe in their bodies, while opening up to other fields such as this would achieve a better result and a possible total eradication.

19. REFERENCE: EfratOzeri-Galai, Ronald Lebofsky, AyeletRahat, Assaf C. Bester, AaronBensimon, BatshevaKerem. Failure of OriginActivation in Response toForkStalling Leads toChromosomalInstability at FragileSites. Molecular Cell, 2011.www.scienciedaily.com Sara Cuylen, Jutta Metz, Christian H Haering. Condensinstructureschromosomal DNA throughtopologicallinks.NatureStructural & Molecular Biology, 2011. www.scienciedaily.com

20. THANK YOU!! Nada es demasiado insignificante. Somos tan pequeños que miramos todo desde una óptica de pequeñez. Pero el Señor, siendo todopoderoso, ve hasta lo más pequeño como grande. Madre teresa de Calcuta.