Las siguientes diapositivas fueron publicadas con el fin de informar sobre el receptor siglec-8 presente en eosinófilos y células mastocíticas, además de su función en enfermedades tan frecuentes como lo son las enfermedades de las vías aéreas superiores, también es de vital importancia saber por medio de que mecanismos actúan y los beneficios que pueden aportar en el tratamiento de algunas enfermedades.
Microglia-Derived ExosomalmicroRNA-151-3p enhances functional Healing After Spinal Cord Injury by attenuating Neuronal Apoptosis via Regulating the p53/p21/ CDK1 Signaling Pathway
Microglia-Derived ExosomalmicroRNA-151-3p enhances functional Healing After Spinal Cord Injury by attenuating Neuronal Apoptosis via Regulating the p53/p21/ CDK1 Signaling Pathway
CiteXplore - a more sophisticated search in the life science literatureNikolay12
A presentation that was given at the conference organised by the Post-doc society at the European Molecular Biology Laboratory - Heidelberg, October 2006.
Leaky Blood-Brain Barrier a Harbinger of Alzheimer s Disease - presentation made at Alzforum's live webinar of February 17, 2015. See details at: http://www.alzforum.org/webinars/leaky-blood-brain-barrier-harbinger-alzheimers
“A Chimeric Human-Mouse Model of Sjögren's Syndrome” Nicholas Young
My talk from The Federation of Clinical Immunology Societies (FOCIS) annual meeting June 24-28, 2014 in Chicago, IL: “A Chimeric Human-Mouse Model of Sjögren's Syndrome”. Recipient of a travel award given to selected abstracts to attend this conference.
Modelling gender-specific regulation of tau in Alzheimer’s diseaseEnrico Glaab
Public transcriptomic studies have shown that several genes display pronounced gender differences in their expression in the human brain, which may influence the manifestations and risk for neuronal disorders. Here, we apply a transcriptome-wide analysis to discover genes with gender-specific expression and significant alterations in public postmortem brain tissue from Alzheimer’s disease (AD) patients compared to controls. We identify the sex-linked ubiquitin-specific peptidase 9 (USP9) as an outstanding candidate gene with highly significant expression differences between the genders and male-specific underexpression in AD. Since previous studies have shown that USP9 can modulate the phosphorylation of the AD-associated protein MAPT, we investigate functional associations between USP9 and MAPT in further detail. After observing a high positive correlation between the expression of USP9 and MAPT in the public transcriptomics data, we show that USP9 knockdown results in significantly decreased MAPT expression in a DU145 cell culture model and a concentration-dependent decrease for the MAPT orthologs mapta and maptb in a zebrafish model. From the analysis of microarray and qRT-PCR experiments for the knockdown in DU145 cells and prior knowledge from the literature, we derive a data-congruent model for a USP9-dependent regulatory mechanism modulating MAPT expression via BACH1 and SMAD4. Overall, the analyses suggest USP9 may contribute to molecular gender differences observed in tauopathies and provide a new target for intervention strategies to modulate MAPT expression.
See associated publication: http://link.springer.com/article/10.1007%2Fs12035-016-0299-z
A community-based neurological practice in Charlotte, NC, The Neurological Institute is dedicated to improving patient care. In addition, The Neurological Institute prioritizes medical education and research in Charlotte, NC. The research in question focuses on conditions such as Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis (MS).
One of the most worrying applications of molecular
technology in sport is the gene doping, which is an outgrowth
of gene therapy. In gene therapy, the missing or out- functioned
gene or gene fragment is replaced with the functioning one, by
the help of transfectionable devices such as viruses. In gene
doping, the interested region is mostly the genetic material
for enhancing athletic capacity.
Presentation made by Jernej Ule on the 20th of April, 2017, at the live webinar hosted by Alzforum: http://www.alzforum.org/webinars/webinar-cortex-aging-too-fast-blame-tmem106b-and-progranulin
Biology, genetics, nanotechnology, neuroscience, materials science, biotech, ...Brian Russell
Over the past two years I've done a lot of interesting research which I've decided to aggregate. My research pertains to the following: Biology, Genetics, Nanotechnology, Neuroscience, Materials Science, Biotechnology, Chemical Engineering, All Things 3-D, Super Computing, Quantum Physics, Energy, Design, & Sustainability.
CiteXplore - a more sophisticated search in the life science literatureNikolay12
A presentation that was given at the conference organised by the Post-doc society at the European Molecular Biology Laboratory - Heidelberg, October 2006.
Leaky Blood-Brain Barrier a Harbinger of Alzheimer s Disease - presentation made at Alzforum's live webinar of February 17, 2015. See details at: http://www.alzforum.org/webinars/leaky-blood-brain-barrier-harbinger-alzheimers
“A Chimeric Human-Mouse Model of Sjögren's Syndrome” Nicholas Young
My talk from The Federation of Clinical Immunology Societies (FOCIS) annual meeting June 24-28, 2014 in Chicago, IL: “A Chimeric Human-Mouse Model of Sjögren's Syndrome”. Recipient of a travel award given to selected abstracts to attend this conference.
Modelling gender-specific regulation of tau in Alzheimer’s diseaseEnrico Glaab
Public transcriptomic studies have shown that several genes display pronounced gender differences in their expression in the human brain, which may influence the manifestations and risk for neuronal disorders. Here, we apply a transcriptome-wide analysis to discover genes with gender-specific expression and significant alterations in public postmortem brain tissue from Alzheimer’s disease (AD) patients compared to controls. We identify the sex-linked ubiquitin-specific peptidase 9 (USP9) as an outstanding candidate gene with highly significant expression differences between the genders and male-specific underexpression in AD. Since previous studies have shown that USP9 can modulate the phosphorylation of the AD-associated protein MAPT, we investigate functional associations between USP9 and MAPT in further detail. After observing a high positive correlation between the expression of USP9 and MAPT in the public transcriptomics data, we show that USP9 knockdown results in significantly decreased MAPT expression in a DU145 cell culture model and a concentration-dependent decrease for the MAPT orthologs mapta and maptb in a zebrafish model. From the analysis of microarray and qRT-PCR experiments for the knockdown in DU145 cells and prior knowledge from the literature, we derive a data-congruent model for a USP9-dependent regulatory mechanism modulating MAPT expression via BACH1 and SMAD4. Overall, the analyses suggest USP9 may contribute to molecular gender differences observed in tauopathies and provide a new target for intervention strategies to modulate MAPT expression.
See associated publication: http://link.springer.com/article/10.1007%2Fs12035-016-0299-z
A community-based neurological practice in Charlotte, NC, The Neurological Institute is dedicated to improving patient care. In addition, The Neurological Institute prioritizes medical education and research in Charlotte, NC. The research in question focuses on conditions such as Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis (MS).
One of the most worrying applications of molecular
technology in sport is the gene doping, which is an outgrowth
of gene therapy. In gene therapy, the missing or out- functioned
gene or gene fragment is replaced with the functioning one, by
the help of transfectionable devices such as viruses. In gene
doping, the interested region is mostly the genetic material
for enhancing athletic capacity.
Presentation made by Jernej Ule on the 20th of April, 2017, at the live webinar hosted by Alzforum: http://www.alzforum.org/webinars/webinar-cortex-aging-too-fast-blame-tmem106b-and-progranulin
Biology, genetics, nanotechnology, neuroscience, materials science, biotech, ...Brian Russell
Over the past two years I've done a lot of interesting research which I've decided to aggregate. My research pertains to the following: Biology, Genetics, Nanotechnology, Neuroscience, Materials Science, Biotechnology, Chemical Engineering, All Things 3-D, Super Computing, Quantum Physics, Energy, Design, & Sustainability.
International Journal of Pharmaceutical Science Invention (IJPSI)inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online
Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies
Published Online: 15 October 2014
Including Comment By, Anthony Atala
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
4. 4
Objective: Our aim was
to identify the major
Siglec-8 sialoglycan ligand
on the mucus layer of
human airways
https://www.slideshare.net/RashmiPriyemSaravana/histology-of-trachea
5. MÉTODOS-Inmunohistoquímica
5
Se basa en la reacción
antígeno anticuerpo para
detectar Proteínas
“Hacer visible un antígeno”
https://www.cancerquest.org/es/para-los-pacientes/det
eccion-y-diagnosis/inmunohistoquimica
7. MÉTODOS-Blot
7
“Medir el tamaño de las proteínas”
Se debe realizar una electroforesis y
se incuban anticuerpos junto a las
proteínas de interés
● Se identifica la proteína a la cual está dirigida el
anticuerpo
Linkwestern blotting - Búsqueda de Google
8. MÉTODOS- Ensayo de inhibición
8
“Evaluación de la actividad
enzimática”
Link: enzimas - Búsqueda de Google
Se evaluó la reducción o
eliminación del siglec-8 gracias a
la actividad enzimática
Sialidase, keratanase I, keratanase II
13. Discussion
13
AUTOR WHAT HE SAID AGREE OR DISAGREE
Kerr SC, et al. Siglec-8 is expressed selectively on eosinophils
and mast cells on human inflamed airways,
where cross-linking induces eosinophil
apoptosis and inhibits mast cells
Duan S,
Paulson JC.
The Siglec family of immune cell surface
receptors and the extracellular sialoglycans to
which they bind provide receptor- ligand
interactions that modulate immune responses.
Propster JM, et
al.
Siglec-8 is highly specific in its structural
specificity for sialoglycan binding, requiring the
precise juxtaposition of a sialic acid and a
sulfate carried on the same subterminal
galactose.
14. Conclusions
14
“Molecular biology is a branch of great importance for medicine, thanks to this it is
possible to carry out in-depth studies on molecules, genes and, as in this case, some
receptors that may be involved in very frequent diseases such as respiratory
diseases, all by technological advances that, although they have been of vital
importance, they are not yet at their peak. Despite all the knowledge that we have
every day, new discoveries are made that constitute great advances for human
beings and foster their development”.
