Anxiety Linked to Shortened Telomeres And Cell Division: Puzzling Findings Relating to Centromere Structure Reconciled
•
3 likes•399 views
This document summarizes recent findings relating to telomeres, centromeres, and their connection to anxiety and cell division. Specifically, it was found that: 1) anxiety is linked to shortened telomeres in middle-aged and older women, increasing risks of disease and early mortality, and 2) while centromeres were thought to contain a single Cse4 protein, live cell imaging revealed there are actually two Cse4 molecules interacting at the centromere during cell division. Understanding centromere structure is important for genomic integrity and detecting genetic diseases from cell division errors.
Report
Share
Report
Share
Recommended
Plegable aleja
Anxiety has been linked to shortened telomeres, markers of biological aging. A study found that phobic anxiety was associated with shorter telomeres in middle-aged and older women. Shortened telomeres increase the risk of diseases like cancer, heart disease, and dementia. Understanding the relationship between psychological stress and telomere length provides insight into how anxiety may lead to premature aging at the cellular level. Studying centromere structure helps explain errors in cell division that can cause genetic diseases.
Biologia molecular
Lem4 is a protein that coordinates the activity of kinases and phosphatases on target proteins essential for cell division. It plays an important role in ensuring the nuclear envelope disappears and reassembles correctly during cell division. Telomeres and the telomerase enzyme are involved in cell aging and linked to increased cancer risk if telomeres are shortened. Stress and anxiety can negatively impact telomere length through emotional responses.
Chromosomes, chromatin and cell cycle
The first document discusses the organization of DNA into chromosomes and the cell cycle. It explains that DNA must be packaged into chromosomes to fit in the nucleus, and that the cell cycle has four phases: G1, S, G2, and M. Mitosis results in two identical daughter cells.
The second document summarizes research finding that slow stem cell division can cause neurological disorders like microcephaly by producing too few neurons. Delayed stem cell division was shown to reduce neuron production in mice lacking a protein involved in gene expression.
The third document covers two related investigations. One showed that the tumor suppressor protein p53, which is mutated in over 50% of cancers, can suppress DNA damage at telomer
Telomere paper
Dr. Elizabeth Blackburn gives a lecture on telomeres and telomerase, and their implications for aging and age-related diseases. She explains that telomeres are repetitive DNA sequences that cap the ends of chromosomes and protect genetic material. Telomerase is an enzyme that adds telomere sequences to chromosomes to maintain their length during cell division. Studies show genetics play a role in longevity, and stress and caregiving can impact telomere length by reducing telomerase activity and increasing oxidative stress. Shorter telomeres are associated with increased mortality and disease susceptibility.
Hani hamed dessoki, telomeres and depression
A study of over 2,400 people found that those with a history of depression had significantly shorter telomeres, representing about 4 to 6 years of accelerated aging at the cellular level. Telomeres are structures at the end of chromosomes that protect DNA from damage. Shorter telomeres have been linked to aging and age-related diseases. While the study does not prove causation, depression is known to disrupt many physical systems in the body and this cellular evidence suggests psychological distress from depression may accelerate biological aging. Further research is still needed to understand the implications and potential for intervention.
Folding: chromosomes, chromatine and cell cycle
CK1 and CK2 proteins are overexpressed in some cancers and allow cancer cells to ignore checkpoints that normally stop the cell cycle. A new study found that this overexpression allows cancer cells to keep dividing unchecked. Research also linked short telomere length to increased risk of developing emphysema, as short telomeres combined with cigarette smoke may accelerate lung aging. These discoveries provide new targets for cancer treatment and ways to preserve organ function with age.
The implications of cellular dedifferentiation for regenerative medicine
This document summarizes the history and current state of stem cell research and its implications for regenerative medicine. It outlines key discoveries such as the first bone marrow stem cell transplantations in the 1960s, isolation of embryonic stem cells from mice in 1981 and humans in 1998, and generation of induced pluripotent stem cells from adult human cells in 2006 and 2007. While embryonic stem cells are pluripotent and easy to obtain and manipulate, they raise moral issues regarding embryo destruction and are banned in some countries. Adult stem cells have a lower chance of immune rejection but are harder to isolate and are tissue-specific. Induced dedifferentiation through somatic cell nuclear transfer or induced pluripotent stem cells has a high failure
Clinical Neurology and Neurosurgery
A novel myelin protein Zero V136G mutation desmyelinating causing polyneuropathy with brain white matter lesions
Recommended
Plegable aleja
Anxiety has been linked to shortened telomeres, markers of biological aging. A study found that phobic anxiety was associated with shorter telomeres in middle-aged and older women. Shortened telomeres increase the risk of diseases like cancer, heart disease, and dementia. Understanding the relationship between psychological stress and telomere length provides insight into how anxiety may lead to premature aging at the cellular level. Studying centromere structure helps explain errors in cell division that can cause genetic diseases.
Biologia molecular
Lem4 is a protein that coordinates the activity of kinases and phosphatases on target proteins essential for cell division. It plays an important role in ensuring the nuclear envelope disappears and reassembles correctly during cell division. Telomeres and the telomerase enzyme are involved in cell aging and linked to increased cancer risk if telomeres are shortened. Stress and anxiety can negatively impact telomere length through emotional responses.
Chromosomes, chromatin and cell cycle
The first document discusses the organization of DNA into chromosomes and the cell cycle. It explains that DNA must be packaged into chromosomes to fit in the nucleus, and that the cell cycle has four phases: G1, S, G2, and M. Mitosis results in two identical daughter cells.
The second document summarizes research finding that slow stem cell division can cause neurological disorders like microcephaly by producing too few neurons. Delayed stem cell division was shown to reduce neuron production in mice lacking a protein involved in gene expression.
The third document covers two related investigations. One showed that the tumor suppressor protein p53, which is mutated in over 50% of cancers, can suppress DNA damage at telomer
Telomere paper
Dr. Elizabeth Blackburn gives a lecture on telomeres and telomerase, and their implications for aging and age-related diseases. She explains that telomeres are repetitive DNA sequences that cap the ends of chromosomes and protect genetic material. Telomerase is an enzyme that adds telomere sequences to chromosomes to maintain their length during cell division. Studies show genetics play a role in longevity, and stress and caregiving can impact telomere length by reducing telomerase activity and increasing oxidative stress. Shorter telomeres are associated with increased mortality and disease susceptibility.
Hani hamed dessoki, telomeres and depression
A study of over 2,400 people found that those with a history of depression had significantly shorter telomeres, representing about 4 to 6 years of accelerated aging at the cellular level. Telomeres are structures at the end of chromosomes that protect DNA from damage. Shorter telomeres have been linked to aging and age-related diseases. While the study does not prove causation, depression is known to disrupt many physical systems in the body and this cellular evidence suggests psychological distress from depression may accelerate biological aging. Further research is still needed to understand the implications and potential for intervention.
Folding: chromosomes, chromatine and cell cycle
CK1 and CK2 proteins are overexpressed in some cancers and allow cancer cells to ignore checkpoints that normally stop the cell cycle. A new study found that this overexpression allows cancer cells to keep dividing unchecked. Research also linked short telomere length to increased risk of developing emphysema, as short telomeres combined with cigarette smoke may accelerate lung aging. These discoveries provide new targets for cancer treatment and ways to preserve organ function with age.
The implications of cellular dedifferentiation for regenerative medicine
This document summarizes the history and current state of stem cell research and its implications for regenerative medicine. It outlines key discoveries such as the first bone marrow stem cell transplantations in the 1960s, isolation of embryonic stem cells from mice in 1981 and humans in 1998, and generation of induced pluripotent stem cells from adult human cells in 2006 and 2007. While embryonic stem cells are pluripotent and easy to obtain and manipulate, they raise moral issues regarding embryo destruction and are banned in some countries. Adult stem cells have a lower chance of immune rejection but are harder to isolate and are tissue-specific. Induced dedifferentiation through somatic cell nuclear transfer or induced pluripotent stem cells has a high failure
Clinical Neurology and Neurosurgery
A novel myelin protein Zero V136G mutation desmyelinating causing polyneuropathy with brain white matter lesions
Thesis section: Restorative neurology
This document appears to be a thesis submitted for a master's degree in neuropsychiatry. It discusses the introduction and aims of studying stem cell therapies for various neurodegenerative disorders. The introduction defines stem cells and their potential uses in regenerative medicine and cell replacement therapies. The aim of the work is to summarize recent progress in stem cell therapies for neurodegenerative disorders.
Development and implementation of a novel interactome platform in studies on ...
Development and implementation of a novel interactome platform in studies on ...Ewelina Maliszewska-Cyna, PhD
This document summarizes a study on developing a novel protein interaction platform to study neurodegeneration. The study cultured neuronal stem cells to form neurospheres, which were used as a model system. Lentiviral transfection was optimized to introduce target genes stably into the neurospheres. The goal was to analyze protein interactions of Alzheimer's disease proteins by co-immunoprecipitation of neurosphere cultures expressing tagged target proteins. This model aims to further the understanding of molecular mechanisms in neurodegenerative disorders like Alzheimer's disease.Seminar Summaries
Dr Kad's talk summarized his lab's work using single molecule approaches to study nucleotide excision repair in prokaryotes. While prokaryotic nucleotide excision repair involves only 6 proteins compared to 30+ in eukaryotes, the interactions between the 6 proteins are complex. His lab uses DNA "tightropes" stretched between beads to observe individual repair protein interactions, finding that the UvrA protein does not slide along DNA as expected but instead binds and dissociates across the strand, while UvrAB complex slides to scan for damage.
Aging and the telomere connection dr. Jerry w. Shay - april 2012
1. Telomeres are repetitive DNA sequences at the ends of chromosomes that protect chromosomal DNA from deterioration. Each cell division, telomeres shorten until they reach a critical length that causes cells to stop dividing.
2. Short telomere length is associated with aging and age-related diseases by limiting tissue regeneration abilities. Telomere length measurements provide insight into overall health and longevity.
3. Environmental stressors like smoking can accelerate telomere shortening, while behaviors like exercise may help slow the rate of shortening. Quantitative telomere tests are being developed to monitor health and the effects of therapies on telomere biology.
Interesting medical news presentation
Here I show to you very interesting research news and medical utility. We can see the future of the epigenetics and molecular medicine.
Universidad Pontificia Bolivariana
Medicina School
Folding!!!
The document discusses new discoveries related to protein aggregation and chromosomal abnormalities. Researchers have quantified the effects of protein aggregation on cell aging and measured damage caused by misfolded proteins. Studies also found that many chromosomal pairs are lost or gained together across cancer types and the genome becomes more mutated as cancer advances. Understanding these chromosomal changes may help explain cancer's progression. As more is learned about chromosomal aberrations, it could allow for improved treatment of genetic conditions and cancer.
James_Fitch_Poster Presentation
This study analyzed microhemorrhages (MH) in brain tissue samples from individuals with Down syndrome (DS), Alzheimer's disease (AD), and DS with AD, compared to age-matched controls. Brain tissue was stained to identify iron-rich MH near blood vessels. MH counts were significantly higher in samples from individuals with DS/AD compared to all other groups, as well as higher in AD samples compared to controls. The results suggest cerebrovascular dysfunction may contribute to brain aging in DS, and that DS combined with AD further increases MH counts more than AD alone.
Cytoo story-epithelial-morphogenesis
Alejo Rodriguez-Fraticelli, from Dr Fernando Martin-Belmonte’s laboratory in the CBMSO in Spain, has recently published with co-workers a paper in the Journal of Cell Biology in which they describe their approach to epithelial cells morphogenesis and uncover the role of cell confinement on epithelial polarity via peripheral actin contractility. The team sheds light on a phenomenon that is crucial to understand the physiology of the organs, but also the mechanisms underlying the development and progression of agressive epithelial cancers.
Clinical use of telomere measurement in preventive and personalized medicine ...
Learn more about the value of telomere measurement, and how to use it in the field of preventive and personalized medicine.
“HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC ...
The document summarizes two scientific articles about RNA molecules and epigenomic coding during human development. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CG DNA methylation, rather than typical CG methylation, is predominant in mature human neurons and changes with age and brain development, influencing learning and memory through cell differentiation. Both discoveries have potential medical applications, like using Xist to treat Down syndrome or studying epigenetic changes related to psychiatric disorders.
HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC C...
The document summarizes two scientific articles about RNA molecules and epigenomic coding during human development. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CG DNA methylation, rather than typical CG methylation, is predominant in mature human neurons and changes with age and brain development, influencing learning and memory through cell differentiation. Both studies provide insights with potential medical applications like gene therapy for Down syndrome.
Cell junctions
Cell junctions are structures that allow for long-term association between neighboring cells. The three main types are tight junctions, adhesive junctions, and gap junctions. Adhesive junctions such as desmosomes and adherens junctions link cells together and to the extracellular matrix. These junctions contain intracellular attachment proteins and transmembrane linker proteins that anchor actin filaments or intermediate filaments. Gap junctions allow direct communication between cells by forming channels between their plasma membranes.
Muthusamy_et_al-2015-Aging_Cell
This study demonstrates that the protein MARCKS is important for maintaining the functions and barrier integrity of ependymal cells (ECs) in the brain as they age. ECs form a barrier between cerebrospinal fluid and brain tissue. The study found that MARCKS and related proteins are highly polarized in young ECs but lose their polarization as ECs age. Deleting MARCKS in ECs caused accumulation of mucins and lipids inside ECs, disrupting the barrier and inducing inflammation in surrounding brain tissue, mimicking aspects of normal aging. This suggests MARCKS is required for EC functions like mucin clearance and lipid metabolism that decline with aging and impact brain homeostasis.
Stem cell research in Parkinson's Disease
Stem cell research shows promise for treating Parkinson's disease. Studies have found that transplanting embryonic stem cells or neural stem cells into animal models of Parkinson's can reduce symptoms by generating new dopamine-producing cells. However, many of these transplanted cells have failed to maintain their function over time or have caused tumor formation. A clinical trial in Peru found that transplanting bone marrow-derived stem cells into the brains of Parkinson's patients improved their symptoms, but long-term data is still needed. Future research aims to develop safer and more effective stem cell therapies by improving protocols and understanding how to support long-term cell survival and specialization without tumor risks.
Multiple sclerosis
This document provides information on the structure and function of neurons and how they are affected in multiple sclerosis (MS). It discusses that neurons transmit electrical and chemical signals throughout the body. The neuron has a cell body that contains the nucleus, and dendrites and an axon that receive and transmit signals. The myelin sheath, formed by glial cells, insulates the axon and increases signal transmission speed. In MS, the immune system attacks the myelin sheath, slowing transmission and causing symptoms. MS can take several forms depending on whether symptoms are relapsing-remitting or progressively worsening over time. Genetic and environmental factors like viruses may contribute to MS, though the exact causes are unknown.
Cell junctions 2013
This document discusses cell junctions and their roles in various biological processes. It defines the main types of cell junctions, including tight junctions, gap junctions, focal adhesions, adherens junctions, and desmosomes. It provides examples of how cell junction gene expression changes during epithelial-to-mesenchymal transition, stem cell differentiation, cancer, atopic dermatitis, and the effects of probiotic bacteria on intestinal barriers. PCR array tools are presented as ways to study cell junctions and related pathways at the gene expression level to better understand their functions in normal and disease states.
Modulation_of_autophagy_as_a_therapeutic
This document summarizes recent research on the role of autophagy in Alzheimer's disease (AD) pathogenesis and its potential as a therapeutic target. Autophagy is a cellular degradation pathway important for neuronal homeostasis that declines with age, a major risk factor for AD. Evidence suggests autophagic dysfunction may contribute to AD pathology through impaired clearance of amyloid-β protein aggregates and tau. Modulating autophagy may therefore help treat AD. However, the pathway may be less "druggable" at late disease stages. The authors propose early-stage intervention trials to target autophagy as a potential AD therapy.
Hypothetical model of dynamic biomarkers of the alzheimer pathological cascade
The document presents a hypothetical model of biomarkers for Alzheimer's disease progression. It proposes that:
1) Abnormal amyloid beta processing occurs first, before symptoms, which is detected by reduced CSF Aβ42 and increased amyloid PET tracer retention.
2) After a lag period, neuronal dysfunction and neurodegeneration become dominant, detected by increased CSF tau and brain atrophy on structural MRI.
3) Neurodegeneration is accompanied by synaptic dysfunction detected by decreased fluorodeoxyglucose uptake on PET.
4) The model relates disease stage to biomarkers, with amyloid biomarkers becoming abnormal first before neurodegenerative biomarkers and symptoms, which then correlate with severity.
NEWS ABOUT TELOMERES
Telomeres play an important role in cellular aging and division. A study found that women with phobic anxiety had shorter telomeres, suggesting anxiety is a risk factor for accelerated aging. In cancer cells, telomerase remains active, allowing indefinite division by regenerating telomeres. Researchers discovered a protein complex that normally inhibits telomerase; in cancer it is delayed, allowing telomerase to extend telomeres and confer immortality. Understanding these processes may lead to new prevention and treatment strategies for diseases of aging and cancer.
Biologia molecular Laura Cuartas Q
Lem4 is a protein that coordinates the activity of kinases and phosphatases on target proteins essential for cell division. It plays an important role in ensuring the nuclear envelope disappears and reassembles correctly during cell division. Telomeres and the telomerase enzyme are involved in cell aging and linked to increased cancer risk if telomeres are shortened. Stress and anxiety can negatively impact telomere length through emotional responses.
Hani hamed dessoki, telomeres and depression
A new study found that people who had experienced depression had significantly shorter telomeres, representing about 4 to 6 years of accelerated aging at the cellular level. Telomeres are structures at the end of chromosomes that protect DNA from damage. Shorter telomeres have been linked to aging. The study of over 2,400 people showed that those with a history of depression had telomeres about 83 to 84 base pairs shorter than those without depression, even after accounting for other lifestyle factors. While the study did not prove cause and effect, depression is known to disrupt many physical systems, and these findings suggest psychological distress from depression may lead to accelerated biological aging.
More Related Content
What's hot
Thesis section: Restorative neurology
This document appears to be a thesis submitted for a master's degree in neuropsychiatry. It discusses the introduction and aims of studying stem cell therapies for various neurodegenerative disorders. The introduction defines stem cells and their potential uses in regenerative medicine and cell replacement therapies. The aim of the work is to summarize recent progress in stem cell therapies for neurodegenerative disorders.
Development and implementation of a novel interactome platform in studies on ...
Development and implementation of a novel interactome platform in studies on ...Ewelina Maliszewska-Cyna, PhD
This document summarizes a study on developing a novel protein interaction platform to study neurodegeneration. The study cultured neuronal stem cells to form neurospheres, which were used as a model system. Lentiviral transfection was optimized to introduce target genes stably into the neurospheres. The goal was to analyze protein interactions of Alzheimer's disease proteins by co-immunoprecipitation of neurosphere cultures expressing tagged target proteins. This model aims to further the understanding of molecular mechanisms in neurodegenerative disorders like Alzheimer's disease.Seminar Summaries
Dr Kad's talk summarized his lab's work using single molecule approaches to study nucleotide excision repair in prokaryotes. While prokaryotic nucleotide excision repair involves only 6 proteins compared to 30+ in eukaryotes, the interactions between the 6 proteins are complex. His lab uses DNA "tightropes" stretched between beads to observe individual repair protein interactions, finding that the UvrA protein does not slide along DNA as expected but instead binds and dissociates across the strand, while UvrAB complex slides to scan for damage.
Aging and the telomere connection dr. Jerry w. Shay - april 2012
1. Telomeres are repetitive DNA sequences at the ends of chromosomes that protect chromosomal DNA from deterioration. Each cell division, telomeres shorten until they reach a critical length that causes cells to stop dividing.
2. Short telomere length is associated with aging and age-related diseases by limiting tissue regeneration abilities. Telomere length measurements provide insight into overall health and longevity.
3. Environmental stressors like smoking can accelerate telomere shortening, while behaviors like exercise may help slow the rate of shortening. Quantitative telomere tests are being developed to monitor health and the effects of therapies on telomere biology.
Interesting medical news presentation
Here I show to you very interesting research news and medical utility. We can see the future of the epigenetics and molecular medicine.
Universidad Pontificia Bolivariana
Medicina School
Folding!!!
The document discusses new discoveries related to protein aggregation and chromosomal abnormalities. Researchers have quantified the effects of protein aggregation on cell aging and measured damage caused by misfolded proteins. Studies also found that many chromosomal pairs are lost or gained together across cancer types and the genome becomes more mutated as cancer advances. Understanding these chromosomal changes may help explain cancer's progression. As more is learned about chromosomal aberrations, it could allow for improved treatment of genetic conditions and cancer.
James_Fitch_Poster Presentation
This study analyzed microhemorrhages (MH) in brain tissue samples from individuals with Down syndrome (DS), Alzheimer's disease (AD), and DS with AD, compared to age-matched controls. Brain tissue was stained to identify iron-rich MH near blood vessels. MH counts were significantly higher in samples from individuals with DS/AD compared to all other groups, as well as higher in AD samples compared to controls. The results suggest cerebrovascular dysfunction may contribute to brain aging in DS, and that DS combined with AD further increases MH counts more than AD alone.
Cytoo story-epithelial-morphogenesis
Alejo Rodriguez-Fraticelli, from Dr Fernando Martin-Belmonte’s laboratory in the CBMSO in Spain, has recently published with co-workers a paper in the Journal of Cell Biology in which they describe their approach to epithelial cells morphogenesis and uncover the role of cell confinement on epithelial polarity via peripheral actin contractility. The team sheds light on a phenomenon that is crucial to understand the physiology of the organs, but also the mechanisms underlying the development and progression of agressive epithelial cancers.
Clinical use of telomere measurement in preventive and personalized medicine ...
Learn more about the value of telomere measurement, and how to use it in the field of preventive and personalized medicine.
“HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC ...
The document summarizes two scientific articles about RNA molecules and epigenomic coding during human development. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CG DNA methylation, rather than typical CG methylation, is predominant in mature human neurons and changes with age and brain development, influencing learning and memory through cell differentiation. Both discoveries have potential medical applications, like using Xist to treat Down syndrome or studying epigenetic changes related to psychiatric disorders.
HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC C...
The document summarizes two scientific articles about RNA molecules and epigenomic coding during human development. The first article discusses how long non-coding RNA (lncRNA) molecules like Xist help regulate gene expression by organizing chromatin structure and packaging genetic information. The second article finds that non-CG DNA methylation, rather than typical CG methylation, is predominant in mature human neurons and changes with age and brain development, influencing learning and memory through cell differentiation. Both studies provide insights with potential medical applications like gene therapy for Down syndrome.
Cell junctions
Cell junctions are structures that allow for long-term association between neighboring cells. The three main types are tight junctions, adhesive junctions, and gap junctions. Adhesive junctions such as desmosomes and adherens junctions link cells together and to the extracellular matrix. These junctions contain intracellular attachment proteins and transmembrane linker proteins that anchor actin filaments or intermediate filaments. Gap junctions allow direct communication between cells by forming channels between their plasma membranes.
Muthusamy_et_al-2015-Aging_Cell
This study demonstrates that the protein MARCKS is important for maintaining the functions and barrier integrity of ependymal cells (ECs) in the brain as they age. ECs form a barrier between cerebrospinal fluid and brain tissue. The study found that MARCKS and related proteins are highly polarized in young ECs but lose their polarization as ECs age. Deleting MARCKS in ECs caused accumulation of mucins and lipids inside ECs, disrupting the barrier and inducing inflammation in surrounding brain tissue, mimicking aspects of normal aging. This suggests MARCKS is required for EC functions like mucin clearance and lipid metabolism that decline with aging and impact brain homeostasis.
Stem cell research in Parkinson's Disease
Stem cell research shows promise for treating Parkinson's disease. Studies have found that transplanting embryonic stem cells or neural stem cells into animal models of Parkinson's can reduce symptoms by generating new dopamine-producing cells. However, many of these transplanted cells have failed to maintain their function over time or have caused tumor formation. A clinical trial in Peru found that transplanting bone marrow-derived stem cells into the brains of Parkinson's patients improved their symptoms, but long-term data is still needed. Future research aims to develop safer and more effective stem cell therapies by improving protocols and understanding how to support long-term cell survival and specialization without tumor risks.
Multiple sclerosis
This document provides information on the structure and function of neurons and how they are affected in multiple sclerosis (MS). It discusses that neurons transmit electrical and chemical signals throughout the body. The neuron has a cell body that contains the nucleus, and dendrites and an axon that receive and transmit signals. The myelin sheath, formed by glial cells, insulates the axon and increases signal transmission speed. In MS, the immune system attacks the myelin sheath, slowing transmission and causing symptoms. MS can take several forms depending on whether symptoms are relapsing-remitting or progressively worsening over time. Genetic and environmental factors like viruses may contribute to MS, though the exact causes are unknown.
Cell junctions 2013
This document discusses cell junctions and their roles in various biological processes. It defines the main types of cell junctions, including tight junctions, gap junctions, focal adhesions, adherens junctions, and desmosomes. It provides examples of how cell junction gene expression changes during epithelial-to-mesenchymal transition, stem cell differentiation, cancer, atopic dermatitis, and the effects of probiotic bacteria on intestinal barriers. PCR array tools are presented as ways to study cell junctions and related pathways at the gene expression level to better understand their functions in normal and disease states.
Modulation_of_autophagy_as_a_therapeutic
This document summarizes recent research on the role of autophagy in Alzheimer's disease (AD) pathogenesis and its potential as a therapeutic target. Autophagy is a cellular degradation pathway important for neuronal homeostasis that declines with age, a major risk factor for AD. Evidence suggests autophagic dysfunction may contribute to AD pathology through impaired clearance of amyloid-β protein aggregates and tau. Modulating autophagy may therefore help treat AD. However, the pathway may be less "druggable" at late disease stages. The authors propose early-stage intervention trials to target autophagy as a potential AD therapy.
Hypothetical model of dynamic biomarkers of the alzheimer pathological cascade
The document presents a hypothetical model of biomarkers for Alzheimer's disease progression. It proposes that:
1) Abnormal amyloid beta processing occurs first, before symptoms, which is detected by reduced CSF Aβ42 and increased amyloid PET tracer retention.
2) After a lag period, neuronal dysfunction and neurodegeneration become dominant, detected by increased CSF tau and brain atrophy on structural MRI.
3) Neurodegeneration is accompanied by synaptic dysfunction detected by decreased fluorodeoxyglucose uptake on PET.
4) The model relates disease stage to biomarkers, with amyloid biomarkers becoming abnormal first before neurodegenerative biomarkers and symptoms, which then correlate with severity.
What's hot (19)
Development and implementation of a novel interactome platform in studies on ...
Development and implementation of a novel interactome platform in studies on ...
Aging and the telomere connection dr. Jerry w. Shay - april 2012
Aging and the telomere connection dr. Jerry w. Shay - april 2012
Clinical use of telomere measurement in preventive and personalized medicine ...
Clinical use of telomere measurement in preventive and personalized medicine ...
“HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC ...
“HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC ...
HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC C...
HOW SOME UNUSUAL RNA MOLECULES HOME IN ON TARGETS ” AND “UNIQUE EPIGENOMIC C...
Hypothetical model of dynamic biomarkers of the alzheimer pathological cascade
Hypothetical model of dynamic biomarkers of the alzheimer pathological cascade
Similar to Anxiety Linked to Shortened Telomeres And Cell Division: Puzzling Findings Relating to Centromere Structure Reconciled
NEWS ABOUT TELOMERES
Telomeres play an important role in cellular aging and division. A study found that women with phobic anxiety had shorter telomeres, suggesting anxiety is a risk factor for accelerated aging. In cancer cells, telomerase remains active, allowing indefinite division by regenerating telomeres. Researchers discovered a protein complex that normally inhibits telomerase; in cancer it is delayed, allowing telomerase to extend telomeres and confer immortality. Understanding these processes may lead to new prevention and treatment strategies for diseases of aging and cancer.
Biologia molecular Laura Cuartas Q
Lem4 is a protein that coordinates the activity of kinases and phosphatases on target proteins essential for cell division. It plays an important role in ensuring the nuclear envelope disappears and reassembles correctly during cell division. Telomeres and the telomerase enzyme are involved in cell aging and linked to increased cancer risk if telomeres are shortened. Stress and anxiety can negatively impact telomere length through emotional responses.
Hani hamed dessoki, telomeres and depression
A new study found that people who had experienced depression had significantly shorter telomeres, representing about 4 to 6 years of accelerated aging at the cellular level. Telomeres are structures at the end of chromosomes that protect DNA from damage. Shorter telomeres have been linked to aging. The study of over 2,400 people showed that those with a history of depression had telomeres about 83 to 84 base pairs shorter than those without depression, even after accounting for other lifestyle factors. While the study did not prove cause and effect, depression is known to disrupt many physical systems, and these findings suggest psychological distress from depression may lead to accelerated biological aging.
Wp seidman 07
This document summarizes research on age-related hearing loss (presbyacusis) and its association with reactive oxygen species and mitochondrial DNA damage. It discusses several theories of aging and applies them to presbyacusis. Several animal models of presbyacusis are described that have helped illuminate the molecular mechanisms, including mitochondrial dysfunction and hair cell loss. Presbyacusis is characterized by a progressive, high-frequency hearing loss that affects a significant portion of older populations. Understanding its molecular underpinnings may help address its socioeconomic impacts and identify methods for mitigating age-related hearing impairment.
Elusive z dna found on nucleosomes and flatworm flouts
Z-DNA, a rare left-handed helical form of DNA, has been found in nucleosomes and sites of active transcription. This suggests Z-DNA may play a role in regulating gene expression through remodeling of nucleosomes. Additionally, the planarian worm Schmidtea mediterranea was found to regenerate tissues despite lacking centrosomes, challenging the long-held belief that centrosomes are necessary for cell division during regeneration. Studying how these worms regenerate without centrosomes may provide new insights into the cell division process.
Cell ageing ty
This document discusses cellular aging and theories of aging. It covers several key points:
1) Cellular senescence and the Hayflick limit, where cells stop dividing after a certain number of divisions.
2) Theories of aging including the free radical theory, somatic mutation theory, and telomere loss theory.
3) Types of cell death including apoptosis, necrosis, necroptosis, and pyroptosis. Programmed cell death limits inflammation while necrosis causes damage and inflammation.
ROLE OF TELOMERE AND IN CELL AGEING
Telomeres play an important role in cellular aging. Telomeres are nucleoprotein structures located at the end of chromosomes that protect chromosomal DNA from deterioration. With each cell division, telomeres shorten due to the end-replication problem. When telomeres become too short, cells enter a permanent non-dividing state called senescence. Telomere shortening has thus been proposed as a molecular clock that counts the number of cell divisions and limits the replicative capacity of cells, contributing to aging at the cellular and organismal level. Telomerase is an enzyme that can add telomeric repeats to chromosome ends and counteract telomere shortening. Dysfunctional telomeres and telomerase
Telomeres
Telomeres are repetitive DNA sequences located at the ends of chromosomes that protect genetic material during cell division. As cells divide, telomeres slowly shorten due to the inability of DNA replication to fully copy chromosome ends. Eventually telomeres become so short that cells can no longer divide, leading to cellular aging. In most human cells, the enzyme telomerase is turned off, contributing to telomere shortening with each cell division. However, telomerase is active in approximately 90% of cancer cells, allowing them to divide indefinitely and overcome the natural limits of cellular replication. Telomere shortening may promote cancer by causing chromosome instability when telomeres become dysfunctional. Maintaining telomere length through telomerase
Telomere seminar dec2012_new
Unlocking the Secrets of the Telomere: The First Step to Reversing Aging 2012 Seminar by Dr. Al Sears, MD
G e N e t i c S , t e c H N o l o G Y , A N D S o c i e t .docx
G e N e t i c S , t e c H N o l o G Y , A N D S o c i e t Y 289
G e n e t i c s , t e c h n o l o G y , a n d s o c i e t y
telomeres: the Key to immortality?
Humans, like all multicellular organisms, grow old and die. As we age, our immune
systems become less efficient, wound
healing is impaired, and tissues lose re-
silience. It has always been a mystery why
we go through these age-related declines
and why each species has a characteris-
tic finite life span. Why do we grow old?
Can we reverse this march to mortality?
Some recent discoveries suggest that the
answers to these questions may lie at the
ends of our chromosomes.
The study of human aging begins with
a study of human cells growing in culture
dishes. Like the organisms from which the
cells are taken, cells in culture have a fi-
nite life span. This replicative senescence
was first noted by Leonard Hayflick in
the 1960s. He reported that normal hu-
man fibroblasts lose their ability to grow
and divide after about 50 cell divisions.
These senescent cells remain metaboli-
cally active but can no longer prolifer-
ate. Eventually, they die. Although we
don’t know whether cellular senescence
directly causes organismal aging, the evi-
dence is suggestive. For example, cells de-
rived from young people undergo more
divisions than those from older people;
cells from short-lived species stop grow-
ing after fewer divisions than those from
longer-lived species; and cells from pa-
tients with premature aging syndromes
undergo fewer divisions than those from
normal patients.
Another characteristic of aging cells
involves their telomeres. In most mam-
malian somatic cells, telomeres become
shorter with each DNA replication be-
cause DNA polymerase cannot synthe-
size new DNA at the ends of each parent
strand. However, as discussed in detail in
this chapter, cells that undergo extensive
proliferation, like embryonic cells, germ
cells, and adult stem cells, maintain their
telomere length by using telomerase—a re-
markable RNA-containing enzyme that
adds telomeric DNA sequences onto the
ends of linear chromosomes. However,
most somatic cells in adult organisms do
not proliferate and do not contain active
telomerase.
Could we gain perpetual youth and vi-
tality by increasing our telomere lengths?
Studies suggest that it may be possible to
reverse senescence by artificially increas-
ing the amount of telomerase in our cells.
When investigators introduced cloned
telomerase genes into normal human
cells in culture, telomeres lengthened,
and the cells continued to grow past their
typical senescence point. These studies
suggest that some of the atrophy of tis-
sues that accompanies old age could be
reversed by activating telomerase genes.
However, before we use telomerase to
achieve immortality, we need to consider
a potential serious side effect: cancer.
Although normal cells shorten their
telomeres and undergo senescence after
a specific num ...
PSP1 skills group presentation on ageing
A group collaborative effort of independent research pooled together to answer the question of why we age.
Najaf bio 4 4 (2)
Chromosomes contain DNA and are found in pairs in eukaryotic cells like humans who have 23 chromosome pairs. Genes are segments of DNA that control traits and can exist in different forms called alleles. Mutations are random changes in genetic material that can cause conditions like sickle cell anemia. Meiosis produces gametes with half the normal chromosome number through two cell divisions followed by crossing over and separation of homologous chromosomes. Genetic engineering techniques like polymerase chain reaction and DNA profiling allow manipulation and analysis of DNA.
Telomerase its role in aging and cancer
Telomeres are repetitive DNA sequences at the ends of chromosomes that protect chromosomal DNA from degradation. Telomerase is an enzyme that adds telomere repeats to the ends of chromosomes to overcome replication-induced shortening. In normal cells, telomerase is inactive and telomeres shorten with each cell division, eventually leading to senescence. Cancer cells maintain telomere length through telomerase reactivation, allowing unlimited proliferation. Studies found telomerase expressed in 90% of human tumors but not normal tissues, supporting its role in immortality.
Cell Mechanisms Presentation.pdf
This document provides an overview of a presentation on cell mechanisms that covers four main topics:
1) The mechanisms that confine cells and tissues to specific anatomical sites through intercellular adhesion and memory.
2) Four types of cellular adaptations.
3) A comparison of necrosis and apoptosis, the two main types of cell death. Necrosis is unregulated cell death that causes inflammation, while apoptosis is a regulated process of cell suicide.
4) At least 20 slides are required to be created in PowerPoint or Impress covering these topics using at least four scholarly sources.
BIOMOL
Stem cell populations reside in niches within organs that control when stem cells replicate or produce daughter cells. A study in fruit flies found that the division of stem cells in testes is regulated at the final stage of replication before daughter cells separate. Previous studies showed different stem cell types in the fruit fly testis niche had to coordinate to properly make sperm. Advances in understanding stem cell replication and DNA damage repair could enable greater progress in tissue regeneration and gene therapy.
Cell Division -Mitosis -XI Biology- Tarini.pptx
XI Biology Topic - Cell Division - Mitosis. Sturdy material for NEET, CET Exams. It includes phases of mitosis explained with images.
Mitosis Essay
Essay Mitosis and Meiosis
Mitosis Key Process
Mitosis Research Paper
Cell Biology Meiosis and Mitosis
Mitosis Research Paper
Observing Mitosis
Mitosis And Meiosis Similarities
Essay on Meiosis Vs. Mitosis
Mitosis: Interphase I And Meiosis
Mitosis: A Meiosis In Diploid Cells
The Process of Mitosis Essay
Mitosis And The Phase Of Interphase Essay
Speech On Mitosis
Mitosis Case Study
Mitosis Research Paper
Lab Report On Mitosis
Mitosis And Phase Of Mitosis Essay
Compare and Contrast Mitosis and Meiosis Essay
Mitosis Lab Report
Mitosis Research Paper
About Tolemerase
Telomeres are repetitive DNA sequences at the ends of chromosomes that protect cellular DNA from degradation. Telomere shortening is linked to cellular aging and is thought to be a root cause of age-related diseases. Telomerase is an enzyme that adds telomere repeats to chromosome ends and counteracts telomere shortening during cell division. Studies have shown that activating telomerase can prolong cellular lifespan, rejuvenate cells, and delay age-related changes in animals. Preliminary studies in humans using TA-65, a molecule that activates telomerase, have shown benefits such as reduced levels of senescent immune cells and lengthened short telomeres without safety issues.
IVMS-OVERVIEW OF CELL BIOLOGY
The document provides an overview of cell biology, describing the key components and processes within cells. It defines cell biology as the study of cells, their structures, functions, and interactions. It then lists and briefly describes the main organelles found within animal cells, including the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, and cytoskeleton. It also summarizes several important cellular processes such as protein transport, membrane transport, cell signaling, reproduction, movement, and metabolism.
Topic 3_Nuclear Structure and Function_NMU.pdf
The document provides an overview of nuclear structure and function. It discusses the nucleus, nuclear envelope, nucleolus, chromatin, DNA replication and transcription processes. It describes chromosomal structure including centromeres, telomeres, and histones. It covers chromosomal abnormalities like deletions, duplications, inversions, insertions, and translocations. It discusses the Philadelphia chromosome translocation in CML cells. It also summarizes chromosomal karyotyping, the cell cycle phases of interphase and cell division, and mitosis and cytokinesis.
Similar to Anxiety Linked to Shortened Telomeres And Cell Division: Puzzling Findings Relating to Centromere Structure Reconciled (20)
Elusive z dna found on nucleosomes and flatworm flouts
Elusive z dna found on nucleosomes and flatworm flouts
G e N e t i c S , t e c H N o l o G Y , A N D S o c i e t .docx
G e N e t i c S , t e c H N o l o G Y , A N D S o c i e t .docx
Recently uploaded
Building Production Ready Search Pipelines with Spark and Milvus
Spark is the widely used ETL tool for processing, indexing and ingesting data to serving stack for search. Milvus is the production-ready open-source vector database. In this talk we will show how to use Spark to process unstructured data to extract vector representations, and push the vectors to Milvus vector database for search serving.
Skybuffer SAM4U tool for SAP license adoption
Manage and optimize your license adoption and consumption with SAM4U, an SAP free customer software asset management tool.
SAM4U, an SAP complimentary software asset management tool for customers, delivers a detailed and well-structured overview of license inventory and usage with a user-friendly interface. We offer a hosted, cost-effective, and performance-optimized SAM4U setup in the Skybuffer Cloud environment. You retain ownership of the system and data, while we manage the ABAP 7.58 infrastructure, ensuring fixed Total Cost of Ownership (TCO) and exceptional services through the SAP Fiori interface.
GraphRAG for Life Science to increase LLM accuracy
GraphRAG for life science domain, where you retriever information from biomedical knowledge graphs using LLMs to increase the accuracy and performance of generated answers
HCL Notes and Domino License Cost Reduction in the World of DLAU
Webinar Recording: https://www.panagenda.com/webinars/hcl-notes-and-domino-license-cost-reduction-in-the-world-of-dlau/
The introduction of DLAU and the CCB & CCX licensing model caused quite a stir in the HCL community. As a Notes and Domino customer, you may have faced challenges with unexpected user counts and license costs. You probably have questions on how this new licensing approach works and how to benefit from it. Most importantly, you likely have budget constraints and want to save money where possible. Don’t worry, we can help with all of this!
We’ll show you how to fix common misconfigurations that cause higher-than-expected user counts, and how to identify accounts which you can deactivate to save money. There are also frequent patterns that can cause unnecessary cost, like using a person document instead of a mail-in for shared mailboxes. We’ll provide examples and solutions for those as well. And naturally we’ll explain the new licensing model.
Join HCL Ambassador Marc Thomas in this webinar with a special guest appearance from Franz Walder. It will give you the tools and know-how to stay on top of what is going on with Domino licensing. You will be able lower your cost through an optimized configuration and keep it low going forward.
These topics will be covered
- Reducing license cost by finding and fixing misconfigurations and superfluous accounts
- How do CCB and CCX licenses really work?
- Understanding the DLAU tool and how to best utilize it
- Tips for common problem areas, like team mailboxes, functional/test users, etc
- Practical examples and best practices to implement right away
Digital Marketing Trends in 2024 | Guide for Staying Ahead
https://www.wask.co/ebooks/digital-marketing-trends-in-2024
Feeling lost in the digital marketing whirlwind of 2024? Technology is changing, consumer habits are evolving, and staying ahead of the curve feels like a never-ending pursuit. This e-book is your compass. Dive into actionable insights to handle the complexities of modern marketing. From hyper-personalization to the power of user-generated content, learn how to build long-term relationships with your audience and unlock the secrets to success in the ever-shifting digital landscape.
Programming Foundation Models with DSPy - Meetup Slides
Prompting language models is hard, while programming language models is easy. In this talk, I will discuss the state-of-the-art framework DSPy for programming foundation models with its powerful optimizers and runtime constraint system.
Energy Efficient Video Encoding for Cloud and Edge Computing Instances
Energy Efficient Video Encoding for Cloud and Edge Computing Instances
SAP S/4 HANA sourcing and procurement to Public cloud
SAP S4 HANA to Public cloud data object differences
5th LF Energy Power Grid Model Meet-up Slides
5th Power Grid Model Meet-up
It is with great pleasure that we extend to you an invitation to the 5th Power Grid Model Meet-up, scheduled for 6th June 2024. This event will adopt a hybrid format, allowing participants to join us either through an online Mircosoft Teams session or in person at TU/e located at Den Dolech 2, Eindhoven, Netherlands. The meet-up will be hosted by Eindhoven University of Technology (TU/e), a research university specializing in engineering science & technology.
Power Grid Model
The global energy transition is placing new and unprecedented demands on Distribution System Operators (DSOs). Alongside upgrades to grid capacity, processes such as digitization, capacity optimization, and congestion management are becoming vital for delivering reliable services.
Power Grid Model is an open source project from Linux Foundation Energy and provides a calculation engine that is increasingly essential for DSOs. It offers a standards-based foundation enabling real-time power systems analysis, simulations of electrical power grids, and sophisticated what-if analysis. In addition, it enables in-depth studies and analysis of the electrical power grid’s behavior and performance. This comprehensive model incorporates essential factors such as power generation capacity, electrical losses, voltage levels, power flows, and system stability.
Power Grid Model is currently being applied in a wide variety of use cases, including grid planning, expansion, reliability, and congestion studies. It can also help in analyzing the impact of renewable energy integration, assessing the effects of disturbances or faults, and developing strategies for grid control and optimization.
What to expect
For the upcoming meetup we are organizing, we have an exciting lineup of activities planned:
-Insightful presentations covering two practical applications of the Power Grid Model.
-An update on the latest advancements in Power Grid -Model technology during the first and second quarters of 2024.
-An interactive brainstorming session to discuss and propose new feature requests.
-An opportunity to connect with fellow Power Grid Model enthusiasts and users.
Salesforce Integration for Bonterra Impact Management (fka Social Solutions A...
Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on integration of Salesforce with Bonterra Impact Management.
Interested in deploying an integration with Salesforce for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
Choosing The Best AWS Service For Your Website + API.pptx
Have you ever been confused by the myriad of choices offered by AWS for hosting a website or an API?
Lambda, Elastic Beanstalk, Lightsail, Amplify, S3 (and more!) can each host websites + APIs. But which one should we choose?
Which one is cheapest? Which one is fastest? Which one will scale to meet our needs?
Join me in this session as we dive into each AWS hosting service to determine which one is best for your scenario and explain why!
AWS Cloud Cost Optimization Presentation.pptx
This presentation provides valuable insights into effective cost-saving techniques on AWS. Learn how to optimize your AWS resources by rightsizing, increasing elasticity, picking the right storage class, and choosing the best pricing model. Additionally, discover essential governance mechanisms to ensure continuous cost efficiency. Whether you are new to AWS or an experienced user, this presentation provides clear and practical tips to help you reduce your cloud costs and get the most out of your budget.
Dandelion Hashtable: beyond billion requests per second on a commodity server
This slide deck presents DLHT, a concurrent in-memory hashtable. Despite efforts to optimize hashtables, that go as far as sacrificing core functionality, state-of-the-art designs still incur multiple memory accesses per request and block request processing in three cases. First, most hashtables block while waiting for data to be retrieved from memory. Second, open-addressing designs, which represent the current state-of-the-art, either cannot free index slots on deletes or must block all requests to do so. Third, index resizes block every request until all objects are copied to the new index. Defying folklore wisdom, DLHT forgoes open-addressing and adopts a fully-featured and memory-aware closed-addressing design based on bounded cache-line-chaining. This design offers lock-free index operations and deletes that free slots instantly, (2) completes most requests with a single memory access, (3) utilizes software prefetching to hide memory latencies, and (4) employs a novel non-blocking and parallel resizing. In a commodity server and a memory-resident workload, DLHT surpasses 1.6B requests per second and provides 3.5x (12x) the throughput of the state-of-the-art closed-addressing (open-addressing) resizable hashtable on Gets (Deletes).
Best 20 SEO Techniques To Improve Website Visibility In SERP
Boost your website's visibility with proven SEO techniques! Our latest blog dives into essential strategies to enhance your online presence, increase traffic, and rank higher on search engines. From keyword optimization to quality content creation, learn how to make your site stand out in the crowded digital landscape. Discover actionable tips and expert insights to elevate your SEO game.
HCL Notes und Domino Lizenzkostenreduzierung in der Welt von DLAU
Webinar Recording: https://www.panagenda.com/webinars/hcl-notes-und-domino-lizenzkostenreduzierung-in-der-welt-von-dlau/
DLAU und die Lizenzen nach dem CCB- und CCX-Modell sind für viele in der HCL-Community seit letztem Jahr ein heißes Thema. Als Notes- oder Domino-Kunde haben Sie vielleicht mit unerwartet hohen Benutzerzahlen und Lizenzgebühren zu kämpfen. Sie fragen sich vielleicht, wie diese neue Art der Lizenzierung funktioniert und welchen Nutzen sie Ihnen bringt. Vor allem wollen Sie sicherlich Ihr Budget einhalten und Kosten sparen, wo immer möglich. Das verstehen wir und wir möchten Ihnen dabei helfen!
Wir erklären Ihnen, wie Sie häufige Konfigurationsprobleme lösen können, die dazu führen können, dass mehr Benutzer gezählt werden als nötig, und wie Sie überflüssige oder ungenutzte Konten identifizieren und entfernen können, um Geld zu sparen. Es gibt auch einige Ansätze, die zu unnötigen Ausgaben führen können, z. B. wenn ein Personendokument anstelle eines Mail-Ins für geteilte Mailboxen verwendet wird. Wir zeigen Ihnen solche Fälle und deren Lösungen. Und natürlich erklären wir Ihnen das neue Lizenzmodell.
Nehmen Sie an diesem Webinar teil, bei dem HCL-Ambassador Marc Thomas und Gastredner Franz Walder Ihnen diese neue Welt näherbringen. Es vermittelt Ihnen die Tools und das Know-how, um den Überblick zu bewahren. Sie werden in der Lage sein, Ihre Kosten durch eine optimierte Domino-Konfiguration zu reduzieren und auch in Zukunft gering zu halten.
Diese Themen werden behandelt
- Reduzierung der Lizenzkosten durch Auffinden und Beheben von Fehlkonfigurationen und überflüssigen Konten
- Wie funktionieren CCB- und CCX-Lizenzen wirklich?
- Verstehen des DLAU-Tools und wie man es am besten nutzt
- Tipps für häufige Problembereiche, wie z. B. Team-Postfächer, Funktions-/Testbenutzer usw.
- Praxisbeispiele und Best Practices zum sofortigen Umsetzen
Generating privacy-protected synthetic data using Secludy and Milvus
During this demo, the founders of Secludy will demonstrate how their system utilizes Milvus to store and manipulate embeddings for generating privacy-protected synthetic data. Their approach not only maintains the confidentiality of the original data but also enhances the utility and scalability of LLMs under privacy constraints. Attendees, including machine learning engineers, data scientists, and data managers, will witness first-hand how Secludy's integration with Milvus empowers organizations to harness the power of LLMs securely and efficiently.
“Temporal Event Neural Networks: A More Efficient Alternative to the Transfor...
“Temporal Event Neural Networks: A More Efficient Alternative to the Transfor...Edge AI and Vision Alliance
For the full video of this presentation, please visit: https://www.edge-ai-vision.com/2024/06/temporal-event-neural-networks-a-more-efficient-alternative-to-the-transformer-a-presentation-from-brainchip/
Chris Jones, Director of Product Management at BrainChip , presents the “Temporal Event Neural Networks: A More Efficient Alternative to the Transformer” tutorial at the May 2024 Embedded Vision Summit.
The expansion of AI services necessitates enhanced computational capabilities on edge devices. Temporal Event Neural Networks (TENNs), developed by BrainChip, represent a novel and highly efficient state-space network. TENNs demonstrate exceptional proficiency in handling multi-dimensional streaming data, facilitating advancements in object detection, action recognition, speech enhancement and language model/sequence generation. Through the utilization of polynomial-based continuous convolutions, TENNs streamline models, expedite training processes and significantly diminish memory requirements, achieving notable reductions of up to 50x in parameters and 5,000x in energy consumption compared to prevailing methodologies like transformers.
Integration with BrainChip’s Akida neuromorphic hardware IP further enhances TENNs’ capabilities, enabling the realization of highly capable, portable and passively cooled edge devices. This presentation delves into the technical innovations underlying TENNs, presents real-world benchmarks, and elucidates how this cutting-edge approach is positioned to revolutionize edge AI across diverse applications.Your One-Stop Shop for Python Success: Top 10 US Python Development Providers
Simplify your search for a reliable Python development partner! This list presents the top 10 trusted US providers offering comprehensive Python development services, ensuring your project's success from conception to completion.
Recently uploaded (20)
Building Production Ready Search Pipelines with Spark and Milvus
Building Production Ready Search Pipelines with Spark and Milvus
GraphRAG for Life Science to increase LLM accuracy
GraphRAG for Life Science to increase LLM accuracy
HCL Notes and Domino License Cost Reduction in the World of DLAU
HCL Notes and Domino License Cost Reduction in the World of DLAU
Digital Marketing Trends in 2024 | Guide for Staying Ahead
Digital Marketing Trends in 2024 | Guide for Staying Ahead
Programming Foundation Models with DSPy - Meetup Slides
Programming Foundation Models with DSPy - Meetup Slides
Energy Efficient Video Encoding for Cloud and Edge Computing Instances
Energy Efficient Video Encoding for Cloud and Edge Computing Instances
Deep Dive: AI-Powered Marketing to Get More Leads and Customers with HyperGro...
Deep Dive: AI-Powered Marketing to Get More Leads and Customers with HyperGro...
SAP S/4 HANA sourcing and procurement to Public cloud
SAP S/4 HANA sourcing and procurement to Public cloud
Salesforce Integration for Bonterra Impact Management (fka Social Solutions A...
Salesforce Integration for Bonterra Impact Management (fka Social Solutions A...
Choosing The Best AWS Service For Your Website + API.pptx
Choosing The Best AWS Service For Your Website + API.pptx
Dandelion Hashtable: beyond billion requests per second on a commodity server
Dandelion Hashtable: beyond billion requests per second on a commodity server
Best 20 SEO Techniques To Improve Website Visibility In SERP
Best 20 SEO Techniques To Improve Website Visibility In SERP
HCL Notes und Domino Lizenzkostenreduzierung in der Welt von DLAU
HCL Notes und Domino Lizenzkostenreduzierung in der Welt von DLAU
Generating privacy-protected synthetic data using Secludy and Milvus
Generating privacy-protected synthetic data using Secludy and Milvus
“Temporal Event Neural Networks: A More Efficient Alternative to the Transfor...
“Temporal Event Neural Networks: A More Efficient Alternative to the Transfor...
Your One-Stop Shop for Python Success: Top 10 US Python Development Providers
Your One-Stop Shop for Python Success: Top 10 US Python Development Providers
Anxiety Linked to Shortened Telomeres And Cell Division: Puzzling Findings Relating to Centromere Structure Reconciled
- 1. Anxiety Linked to Shortened Telomeres And Cell Division: Puzzling Findings Relating to Centromere Structure Reconciled Alejandra Henao Buitrago Medical student
- 2. FOLDING
- 3. FOLDING
- 4. INTRODUCTION Understanding Telomeres are centromeres is critical considered markers of because of the role biological or cellular they play in maintaining aging. genomic integrity.
- 5. Cell Division: Puzzling Findings Relating To Centromere Structure Reconciled Science Daily (July 19, 2012)
- 6. Cell Division: Puzzling Findings Relating To Centromere Structure Reconciled A nucleosome, a short coil of DNA twisted around a core of proteins forms at each centromere. Within the core is a protein, called Cse4 in yeast. But the overall architecture of that nucleosome was unknown. has used live cell imaging to reveal constituents of the centromeric protein core.
- 7. Cell Division: Puzzling Findings Relating To Centromere Structure Reconciled • Two methods were combined to probe yeast cells engineered to express Cse4 hooked to a green fluorescent protein (GFP) tag. • The approach allowed them to track and then count in a living cell the number of Cse4 molecules in a centromeric nucleosome. • Yeast cells have 16 chromosomes, each with one centromere. If each centromere contained just one copy of Cse4, then the dot glowing in each cell should be 16 times brighter than a single GFP molecule.
- 8. Cell Division: Puzzling Findings Relating To Centromere Structure Reconciled Was found that two evidence molecules of Cse4 were interacting at the centromere in anaphase, but these interactions were not present during the rest of the cell cycle. Is concluded that the timing of structural changes differs in yeast and human cells, But that human and yeast centromeres undergo similar dynamic changes with the cell cycle.
- 9. Comment know the functioning of the centromere is important for understanding the segregation of chromosomes and of the consequences of errors in cell division.
- 10. Anxiety Linked to Shortened Telomeres, Accelerated Aging ScienceDaily (July 11, 2012)
- 11. Anxiety Linked to Shortened Telomeres, Accelerated Aging
- 12. Anxiety Linked to Shortened Telomeres, Accelerated Aging A new study shows that a phobic anxiety was associated with shorter telomeres in middle aged and older women.
- 13. Anxiety Linked to Shortened Telomeres, Accelerated Aging Shortened telomeres have been linked to increased risk of cancers, heart disease, dementia and mortality. This study is notable for showing a connection between a common form of psychological stress, phobic anxiety, and a plausible mechanism for premature aging.
- 14. Comment See the relationship between a psychological stress with premature aging, is important to give appropriate diagnostic, provide timely treatment using the molecular analysis.
- 15. MEDICAL UTILITY
- 16. MEDICAL UTILITY Most cells in the adult exhibit only limited telomerase activity, meaning that as cells divide and replicate their DNA, the chromosomes’ telomeres become shorter. This limits the number of times a cell can divide and contributes to aging.
- 17. MEDICAL UTILITY Longer telomeres are hypothesized to correlate with improved longevity and reduced disease burden.
- 18. MEDICAL UTILITY The study of centromere helps detect genetic diseases when there are errors in cell division
- 19. BIBLIOGRAPHY MARTINEZ S, Lina María, Biología molecular, 7 ed. Medellín: UPB. Fac de Medicina , 2012. 69-70 p. WATSON, James, Biología molecular del Gen, 5 ed. Buenos Aires, Madrid, ed panamericana, 2006. 151-153 p.