Examination of Swelling in a patient is always a task for MBBS students. This PPT provides the students, how to elicit a history & also the easy way to examine a swelling.
Examination of Swelling in a patient is always a task for MBBS students. This PPT provides the students, how to elicit a history & also the easy way to examine a swelling.
Anatomy of facial nerve/certified fixed orthodontic courses by Indian dental ...Indian dental academy
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The term facial palsy generally refers to weakness of the facial muscles, mainly resulting from temporary or permanent damage to the facial nerve
Facial palsy not only cause a paresis of the target muscles, but as the nerve is responsible for a range of facial expressions, it causes serious disturbances in social life, facial expression being so important in transferring emotion.
Facial nerve (VII):
Involved in facial expressions, taste sensation, and control of the lacrimal and salivary glands. The facial nerve emerges from the pons.
It has two roots
Medial Motor root
Sensory (Nervous intermedius) root
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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1. Dr. Shahnawaz Alam
Guided by: Dr. Vikas Chandra Jha
HOD, Dept. of Neurosurgery
Moderated by: Dr. Saraj kumar Singh
Faculty, Dept. of Neurosurgery
Facial Nerve Examination
5. 1. Supranuclear: Fibers in cerebral
cortex to brain stem
2. Brain stem/intramedullary: from
BS nuclei to its exit point
3. Intra-cranial/cisternal(12 mm): exit
point to entry into IAC
4. Meatal (10 mm): Within Internal
Auditory Canal
5. Labyrinthine (4 mm): Fundus of
I.A.C. to Geniculate ganglion
6. Tympanic (11 mm): Geniculate
ganglion to pyramid
7. Mastoid (13 mm): Pyramid to
stylomastoid foramen
*
**
6. Anatomy of the cisternal and meatal segments
CN VII and VIII exit the brainstem at the CPA (cisternal segment) and enter
the IAC together.CN VII is anterior and superior to CN VIII in the IAC
11. Examination of the Motor Functions
Inspection: Facial symmetry at resting position/Atrophy and fasciculations/
Spontaneous blinking/synkinesia/nasolabial fold with forehead wrinkles/width of
palpebral fissure/Observe movements during spontaneous/voluntary facial expression
Facial synkinesias myasthenic smile or snarl parkinsonism
Progressive SNP
12. • Testing the temporal branch: patient is asked to frown and wrinkle his or her forehead
• Testing the Zygomatic branch: patient is asked to close their eyes tightly
• Testing the buccal branch: Puff up cheeks (buccinator)/ Smile and show teeth (orbicularis oris)/ Tap
with finger over each cheek to detect ease of air expulsion on the affected side
13. Examination of Sensory Functions
• Hypesthesia of posterior wall of EAM:
proximal CN VII lesions
• Taste on anterior two-thirds of the
tongue: sweet/salty/bitter/sour
14. Examination of Secretory Functions
• History and observation: tearing/salivation
• Lacrimal and nasolacrimal reflex
15. • Little practical value
• Corneal Reflex: Afferent- CN V1,efferent- CN VII
• Stapedius reflex: by Impedance audiometry, Absence or a
reflex less than half the amplitude is due to a lesion
proximal to stapedius nerve
• Orbicularis oculi reflex: focal/non-focal
• Auditory-palpebral/visuo-palpebral/trigemino-facial reflex
• Chovostek’s sign
Examinations of the reflexes
19. Peripheral Facial Palsy
• Flaccid weakness (c/o-numbness & wooden feeling)/ Ipsilateral side/ both upper and lower
face/paralysis is usually complete
• Flaccid side of face: smooth/no wrinkles/eye wide open/inferior lid sag (epiphora)/ flattened
nasolabial fold/drooping of angle of mouth
• Can't raise eyebrow/blow out cheek/ clinch or bare teeth
• Talk or smile with one side of mouth, drawn to sound side
• Flaccid cheek- food accumulates/cheek bite/ saliva or liquid spill
• Involved eye Both direct & consensual corneal reflex absent
Bell’s phenomenon
A. Patient is attempting to retract
both angles of the mouth
B. Patient is attempting to elevate
both eyebrows
20. Sir Charles Bell
Bell’s palsy
• Idiopathic PFP/frequently follow viral infection
• Facial weakness on waking (ischemia/narrow labyrinthine part;
enhancement on Gd MRI-SPECIFIC)
• F>>M, during pregnancy
• Criteria: diffuse PFP/sudden onset (1-2 days)/ paralysis reaches max.
within 3 weeks/ full or partial recovery within 6 Months
• Symptoms begin with pain behind ear f/b facial weakness within 1-2
days
• MC symptoms: increased tearing associated with pain in or around
ear/ taste abnormalities (dysgeusia 60%)
• Paralysis complete in both upper & lower face (70%)
• 80% Full recovery within 6 Months
• Aberrant nerve regeneration: synkinesia/crocodile tear
(1829):THE DISCOVERY OF
THE NERVE OF FACIAL
EXPRESSION
• Scottish surgeon,
anatomist & artist
• Book “Anatomy of facial
expression for artists”
22. Facial Weakness of Central Origin
• Weakness of C/L lower face with relative sparing of upper face/ paralysis rarely
complete
• Subtle weakness of orbicularis oculi But involvement of frontalis & corrugator is
unusual
• Always able to close eye/ Bell phenomenon absent/ corneal reflex present
• In most cases, facial asymmetry present in both voluntary & spontaneous facial
movement; But when it is more marked with one than other (Dissociation)
Two variations:
1. Volitional/voluntary: Facial asymmetry more marked during voluntary
contraction/ Lesion of lower third of the precentral gyrus or the
corticobulbar tract
2. Emotional/mimetic: Thalamic or striatocapsular lesions
24. Voluntary Central Facial Weakness > Mimetic (Involuntary) Central Facial Weakness
Mimetic (Involuntary) Central Facial Weakness > Voluntary Central Facial Weakness
25. Abnormal Facial Movements
Hemifacial spasm
• Mostly d/t intermittent compression by an ectatic arterial loop in posterior circulation
( redundant loop of AICA- pulsation cause nerve demyelination)
• May be Sequele Facial synkinesia
• It begins with twitching in orbicularis oculi, progress to other terminal branches
• Fully developed HFS- repetitive, paroxysmal, involuntary, spasmodic, tonic-clonic contraction
of involved side of face
• Mouth twisted to involved side, nasolabial fold deepens, eye closes, there is contraction
frontalis muscle
• Spasm persist in sleep, increased on chewing/speaking
Tic Convulsif: HFS with trigeminal neuralgia
Facial Myokymia: continuous involuntary rippling & worm like facial contraction; brainstem lesions
Brissaud-Sicard syndrome: HFS with C/L hemiplegia; pontine lesion