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Bipolar disorder
• Bipolar disorders:
• Are characterized by episodes of mania and depression, which may
alternate, although many patients have a predominance of one or
the other.
• Bipolar disorders usually begin in the teens, 20s, or 30s.
• Lifetime prevalence is about 4%.
• Rates of bipolar I disorder are about equal for men and women.
• Bipolar disorders are classified as:
I. Bipolar I disorder: Defined by the presence of at least one full-fledged
(ie, disrupting normal social and occupational function) manic episode
and usually depressive episodes
II. Bipolar II disorder: Defined by the presence of major depressive
episodes with at least one hypomanic episode but no full-fledged manic
episodes
III. Unspecified bipolar disorder: Disorders with clear bipolar features that
do not meet the specific criteria for other bipolar disorders
• In cyclothymic disorder, patients have prolonged (> 2-yr) periods that
include both hypomanic and depressive episodes; however, these episodes
do not meet the specific criteria for a bipolar disorder.
• Exact cause is unknown. However, heredity plays a significant role.
• There is also evidence of dysregulaton of serotonin and norepinephrine.
• Psychosocial factors may be involved. Stressful life events are often
associated with initial development of symptoms and later exacerbations,
although cause and effect have not been established.
• Certain drugs can trigger exacerbations in some patients with bipolar
disorder; these drugs include:
I. Sympathomimetics (eg, cocaine, amphetamines).
II. Alcohol.
III. Certain antidepressants (eg, tricyclics, MAOIs).
• Bipolar disorder begins with an acute phase of symptoms, followed by
a repeating course of remission and relapse.
• Episodes last anywhere from a few weeks to 3 to 6 month.
Mania Hypomania Depression Mixed feature
A manic episode is defined
as ≥ 1 wk of a persistently
elevated mood, plus ≥ 3
additional symptoms:
• Inflated self-esteem.
• Decreased need for sleep.
• Greater talkativeness .
• Flight of ideas.
• Distractibility.
• Increased goal-directed
activity.
• A hypomanic episode is a
less extreme of mania.
• Includes ≥ 3 of symptoms
listed under mania.
• During the hypomanic
period, mood brightens,
the need for sleep
decreases, and
psychomotor activity
accelerates.
• A depressive episode
has features typical
of major depression.
• Psychotic features are
more common in
bipolar depression
than in unipolar
depression.
An episode of
mania or
hypomania is
designated as
having mixed
features of
depressive
symptoms are
present for most
days of the
episode.
I. Clinical criteria (DSM, Fifth Edition) see pic below.
II. Thyroxine (T4) and TSH levels to exclude hyperthyroidism
III. Exclusion of stimulant drug abuse clinically or by urine testing
 Mood stabilizers (eg, lithium, certain anticonvulsants), a 2nd-
generation antipsychotic, or both.
 Support and psychotherapy.
• Treatment of bipolar disorder usually has 3 phases:
I. Acute: To stabilize and control the initial, sometimes severe
manifestations
II. Continuation: To attain full remission
III. Maintenance or prevention: To keep patients in remission
• Although most patients with hypomania can be treated as
outpatients, severe mania or depression often requires inpatient
management.
• Has significant morbidity and mortality rates.
Factors suggesting a worse prognosis
include the following:
 Poor job history.
 Substance abuse.
 Psychotic features.
 Depressive features between periods of
mania and depression.
 Evidence of depression.
 Male sex.
 Pattern of depression-mania-euthymia.
Factors suggesting a better prognosis
include the following:
 Length of manic phases (short duration).
 Late age of onset.
 Few thoughts of suicide.
 Few psychotic symptoms.
 Few medical problems.
• Merk manual (Nineteenth edition, page 1548-1552).
• Medscape:
• http://emedicine.medscape.com/article/286342-overview#a6
• Goegle image.
Everything About Bipolar disorder!

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Everything About Bipolar disorder!

  • 1. Covered by: Arwa H. Al-Onayzan.
  • 3. • Bipolar disorders: • Are characterized by episodes of mania and depression, which may alternate, although many patients have a predominance of one or the other. • Bipolar disorders usually begin in the teens, 20s, or 30s. • Lifetime prevalence is about 4%. • Rates of bipolar I disorder are about equal for men and women.
  • 4. • Bipolar disorders are classified as: I. Bipolar I disorder: Defined by the presence of at least one full-fledged (ie, disrupting normal social and occupational function) manic episode and usually depressive episodes II. Bipolar II disorder: Defined by the presence of major depressive episodes with at least one hypomanic episode but no full-fledged manic episodes III. Unspecified bipolar disorder: Disorders with clear bipolar features that do not meet the specific criteria for other bipolar disorders • In cyclothymic disorder, patients have prolonged (> 2-yr) periods that include both hypomanic and depressive episodes; however, these episodes do not meet the specific criteria for a bipolar disorder.
  • 5. • Exact cause is unknown. However, heredity plays a significant role. • There is also evidence of dysregulaton of serotonin and norepinephrine. • Psychosocial factors may be involved. Stressful life events are often associated with initial development of symptoms and later exacerbations, although cause and effect have not been established. • Certain drugs can trigger exacerbations in some patients with bipolar disorder; these drugs include: I. Sympathomimetics (eg, cocaine, amphetamines). II. Alcohol. III. Certain antidepressants (eg, tricyclics, MAOIs).
  • 6. • Bipolar disorder begins with an acute phase of symptoms, followed by a repeating course of remission and relapse. • Episodes last anywhere from a few weeks to 3 to 6 month. Mania Hypomania Depression Mixed feature A manic episode is defined as ≥ 1 wk of a persistently elevated mood, plus ≥ 3 additional symptoms: • Inflated self-esteem. • Decreased need for sleep. • Greater talkativeness . • Flight of ideas. • Distractibility. • Increased goal-directed activity. • A hypomanic episode is a less extreme of mania. • Includes ≥ 3 of symptoms listed under mania. • During the hypomanic period, mood brightens, the need for sleep decreases, and psychomotor activity accelerates. • A depressive episode has features typical of major depression. • Psychotic features are more common in bipolar depression than in unipolar depression. An episode of mania or hypomania is designated as having mixed features of depressive symptoms are present for most days of the episode.
  • 7. I. Clinical criteria (DSM, Fifth Edition) see pic below. II. Thyroxine (T4) and TSH levels to exclude hyperthyroidism III. Exclusion of stimulant drug abuse clinically or by urine testing
  • 8.  Mood stabilizers (eg, lithium, certain anticonvulsants), a 2nd- generation antipsychotic, or both.  Support and psychotherapy. • Treatment of bipolar disorder usually has 3 phases: I. Acute: To stabilize and control the initial, sometimes severe manifestations II. Continuation: To attain full remission III. Maintenance or prevention: To keep patients in remission • Although most patients with hypomania can be treated as outpatients, severe mania or depression often requires inpatient management.
  • 9. • Has significant morbidity and mortality rates. Factors suggesting a worse prognosis include the following:  Poor job history.  Substance abuse.  Psychotic features.  Depressive features between periods of mania and depression.  Evidence of depression.  Male sex.  Pattern of depression-mania-euthymia. Factors suggesting a better prognosis include the following:  Length of manic phases (short duration).  Late age of onset.  Few thoughts of suicide.  Few psychotic symptoms.  Few medical problems.
  • 10.
  • 11. • Merk manual (Nineteenth edition, page 1548-1552). • Medscape: • http://emedicine.medscape.com/article/286342-overview#a6 • Goegle image.