This document provides an overview of evaluating patients with benign prostatic hyperplasia (BPH). It discusses taking a history, performing a physical exam including a digital rectal exam and neurological exam, and relevant investigations like the International Prostate Symptom Score, urinalysis, ultrasound, uroflowmetry, and serum PSA. Treatment options for BPH include watchful waiting, medical therapy with alpha blockers or 5-alpha reductase inhibitors, and surgical options like transurethral resection of the prostate or open prostatectomy. The goal of treatment is to relieve symptoms and obstruction based on the patient's severity and risk factors.
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A benign (not cancer) condition in which an overgrowth of prostate tissue pushes against the urethra and the bladder, blocking the flow of urine. Also called benign prostatic hyperplasia and BPH.
here give the knowledge that you should possess to manage acute and chronic urine retention. the lecture is more concerned about practical patient care and ward setting management. you should minimally be aware about following facts regarding urine retention. the multiple causes of retention will be discussed later in detailed manner. Direction of the lecture seems more toward BPH and acute retention management. beware there are many aspects of a patient present with an AUR. do no harm and always try to keep patient satisfaction. Let me know about your comments an Ideas. try to improve the quality. good luck.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Evaluation of the patient with BPH
1. Evaluation of the patient with
BPH
Presented by :
Dr. Md. Ishtiaqul Haque Mortuza (Labib)
Resident
Department of Urology
Chittagong Medical College & Hospital
2. • BPH gives rise to LUTS ( lower urinary tract
symptoms) and Obstruction of varying
degree.
• “Symptom” is what the patients are worrying
about and “Obstruction” is what the urologist
should be concerned about
• Though the majority of patients with LUTS are
due to BPH, but some patients may have LUTS
due to other causes.
3. How to evaluate a patient with BPH ?
Evaluation of a patient with BPH includes the
following steps to establish a correct diagnosis
5. Pt. with BPH gives history of -
1. Obstructive symptoms:
• Hesitancy/Intermittency
• Decreased force and caliber of stream
• Sensation of incomplete bladder emptying
• Straining to urinate
• Post void dribbling
• Double voiding
2. Irritative symptoms:
• Urgency
• Frequency
• Nocturia
6. • Hesitancy- during micturation urine flow stops
and starts for several times
• Double voiding- second time voiding with in 2
hrs of last void
• Frequency- frequent micturation within a
short interval
• Urgency- difficult to postpone urination
• Nocturia- waking up from sleeping to urinate
at night
7. IPSS
(International Prostate Symptom Score)
IPSS
(International Prostate Symptom Score)
• IPSS is used to asses the severity of the
symptoms. This consist a score sheet of
obstructive & irritative symptoms mentioned
previously.
• There are some questions that will refer both
the obstructive & irritative symptoms
8.
9. • The severity is scored from ‘none at all (0)’ to
‘almost always (5)’ giving rise to a maximum
score of 35.
IPSS score 0-7 Mild symptom
score 8-19 Moderate symptom
score 20-35 Severe symptom
12. Physical examination includes:
1.DRE (Digital Rectal Examination)
2.Examination of genitourinary system
3.Focused neurological examination
4.Examination of hernial orifice
5.Related General examination including
cardiopulmonary status of the patient
14. Points to be noted in DREPoints to be noted in DRE
• Size of the prostate May be enlarged
• Surface Smooth
• Consistency Firm, elastic
• Rectal mucosa Free from prostate
• Median sulcus Obliterated
• Any rectal mass Absent
• Anal tone Normal
• Upper limit Can be reached
15. Examination of genitourinary systemExamination of genitourinary system
• External urethral meatus – normal
• Urethra – no palpable mass or cord like feeling
• Urinary bladder –
May or may not be palpable (> 200 ml)
Percussion of suprapubic region(dull on percussion)
• Kidney – usually not palpable
• Testis, Epididymis, Hydrocele, Varicocele
16. Focused Neurologic examinationFocused Neurologic examination
To exclude neurogenic bladder we have to take
history & perform examinations.
History
1. H/O stroke
2. H/O Any spinal injury
3. H/O DM
4. H/O Alteration of bowel habit (e.g. constipation)
Examinations
1. Perianal sensation
2. Bulbocavernosus reflex
3. Anal tone
4. Lower extremity function (motor & sensory)
18. Investigation required for the evaluation of a
patient with BPH includes:
1. Urnie analysis
2. USG of KUB ,Prostate with PVR
3. Uroflowmetry
4. Serum PSA
5. Plain X-ray KUB (A/P view)
6. Pressure flow study
7. Filling cystometry
8. Urethocystoscopy
Not recommended
routinely
19. Urine analysisUrine analysis
• Urine analysis assist in distinguishing
UTI & bladder cancer from BPH
• Components are:
1. Urine R/M/E
2. Urine for C/S
3. Urine cytology
20. Findings of urine analysisFindings of urine analysis
Urine R/M/E
1. Sugar for DM
2. Pus cell for UTI
3. RBC for UTI & other causes
Urine for C/S
• To identify any significant infection & selection of
proper antibiotic
Urine cytology
1. Should be considered in men with H/O smoking
with severe irritative symptoms
2. To exclude specially CIS
22. USG of KUB, Prostate with PVRUSG of KUB, Prostate with PVR
1. Size
2. Intravesical potrusion
3. Echogenicity
4. Capsule
1. Bladder wall (thickened or not)
2. Presence of any diverticulum
3. Presence of any stone
4. Any growth obstructing the
bladder neck
5. Determination of PVR
ProstateProstate BladderBladder
Following points are to be observed in USG
KidneyKidney
To see any bilateral pelvicalyceal
dilatation, which reveals any
back pressure effect of the
23. • Size of the prostate can be classified into:
1. Small prostate – < 20 gm
2. Medium prostate – 20-40 gm
3. Large prostate - > 40 gm
• Intravesical potrusion of prostate can be
graded into:
1. Grade I – 0-5 mm
2. Grade II – 6-10 mm
3. Grade III - >10 mm
24. • Echogenicity (sonographic pattern of BPH)
Mixed, heterogenous, mostly hypo echoic
parenchyma, often arranged in the form of one or
more hyperplastic nodules and sometimes
recognizable internal architecture
• Capsule
Bright echogenic structure surrounding the
prostate (in BHP it is intact)
Capsular bulging & irregularity associated with an
adjacent focal hypo echoic lesion often indicate
‘capsular invasion’ (a sign of malignancy)
26. Some important informationSome important information
• Size of the prostate correlate less well with the degree
of obstruction
• A small prostate may obstruct and a large prostate
may not obstruct. This is because of the distortion of
the “funneling effect of the bladder neck” which is
more important cause of obstruction than the
compression of the urethra.
• A small nodule sitting at the strategic position at the
outlet (such as median lobe) can cause a “ball-valve”
effect leading to significant obstruction
27. • Usually large prostate are more likely to
obstruct than the small prostate due to
compression of the urethra
• In a study it was found that :
Patients with grade I protrusion:
84% has a good flow rate > 10 ml/sec
Patients with grade III protrusion:
72% has a flow rate < 10 ml/sec
28. PVR (Post Voidal Residue)PVR (Post Voidal Residue)
• When voiding function of bladder is impaired
it will be manifested as residual urine
• Normal person with no significant obstruction
should have residual urine 0 ml
• Any patient with a persistent PVR > 100 ml
with no obvious neurogenic cause and
association with poor flow rate of 10ml/sec or
less, would be suspected to have significant
obstruction
29. UroflowmetryUroflowmetry
• Uroflowmetry is the electronic recording of
the urinary flow rate throughout the course of
micturition.
• Results of uroflowmetry are non-specific for
the causes of symptoms
• For proper uroflow test, voided volume
should be at least 150 ml.
30. Points to be noted in uroflowmetryPoints to be noted in uroflowmetry
Maximum flow rate
Average flow rate
Voiding time
Voiding volume
Pattern of voiding
curve
31. • With properly performed uroflow test:
Normal flow rate in male about 20-25 ml/sec
Normal flow rate in female about 25-30
ml/sec
• Obstruction should be suspected when
maximum flow rate is < 15 ml/sec
• definitive evidence of obstruction when
maximum flow rate < 10ml/sec
32. Plain X-ray KUBPlain X-ray KUB
• To see any stone in the
urinary bladder, vesical neck
or in the urethra, which
might be cause of LUTS
• Any metastatic lesion in the
bone
• Any calcification in Kidney,
ureter, bladder, prostate
33. Serum PSASerum PSA
• PSA is a tumor marker used for screening of Ca
prostate
• Serum PSA is considered optional, but most
physician will include it in the initial evaluation.
34. What we should know about PSA?What we should know about PSA?
PSA is a glycoprotein enzyme(serine protease)
It is secreted by the epithelial tissue of prostate
It circulates in serum in free & bound form
Its normal value is <4 ng/ml
Its level raises with increasing age & size of prostate gland
Real outcome of PSA test can be obtained by evaluating the
level from time to time and observing the rate of changes
Medical opinion is divided about the usefulness of single
PSA test
One test out of range could be caused by other problems
Moreover PSA is not specific for Ca prostate
35. Confounding factors for PSAConfounding factors for PSA
• PSA level increases in
1. Ca prostate
2. BPH
3. Prostatitis
4. Instrumentation
5. DRE
6. Aging
7. Ejaculation
• PSA level decreases in
1. LHRH agonist
2. 5 alpha reductase inhibitors
36. Other PSA parametersOther PSA parameters
PSA velocity
• It means rate of change of PSA over time
• Man with Ca prostate has more rapidly rising serum
PSA than in man with BPH
• Serum PSA increases by .75ng/ml/yr appear to be at
increased risk of harboring cancer.
PSA density
• It is ratio of PSA to the gland volume
• PSA levels are elavated approximately .12ng/ml/gm of
BPH tissue
Thus patients with enlarged prostate due to BPH
may have elavated PSA level
37. Differential diagnosis of BPHDifferential diagnosis of BPH
• BNH
• Urethal stricture
• Ca Prostate
• Ca Bladder
• Infection (Cystitis, Prostatitis)
• Stones
• Neurogenic Bladder
39. Stage 1
No bothersome symptom(QOL 2 or less)
No significant obstruction( Qmax >10ml/sec,PVR <100 ml)
Stage 2
With bothersome symptom(QOL 3 or more)
No significant obstruction
Stage 3
With significant obstruction irrespective of
symptoms (Qmax<10ml/sec, PVR >100ml)
Stage 4
BOO with complication
41. Treatment of BPH is planned after
• Proper evaluation
• Properly informed about the disease &
various therapeutic options of BPH
So treatment can be given on the basis of
• Relative efficacy of the Rx
• Side effects
42. Rx modalities depends on
• Age of the patient
• IPSS of the patient
• DRE findings
• USCD(Ultrasound cystodynamogram)
• Uroflowmetry findings
• Serum PSA level
• Complication of BEP
45. The severity & distress due to symptoms may be
improved through simple measures such as:
• Decreased fluid intake specially prior to bed time
• Reduced intake of alcohol & caffeine contaning
product
• Follow timed voiding schedules
Patient should be observed for bothering
symptoms & development of significant
obstrution
47. Aim of medical therapy
To decrease BOO, thereby-
• Relieving symptoms
• Improving bladder emptying
• Ameliorating detrusor instability
• Preventing future episodes of UTI & urinary
retention
48. Ideal candidate for medical Rx
• Bothersome symptoms that impact negatively on quality of
life
• No significant obstruction(Qmax>10ml/sec, PVR<100 ml)
Medical Rx should not be offered to individual
presenting with-
1. Refractory urinary retention
2. Recurrent UTI
3. Renal insufficiency
4. Bladder calculi/diverticula
5. Recurrent gross hematuria
49. Medical therapy include
1) Alpha blokers
• Non selective-phenoxybenzamine,
• Alpha 1 (short acting)- prazosin,
• Alpha 1 (long acting)- terazosin, doxazosin
• Alpha 1a selective(uroselective)-tamsulosin,
alfuzosin,silodosin
2) Androgen suppression (5 alpha reductase
inhibitor)
Finesteride, dutasteride
3) Plant extract (Phytotherapy)- popular in europe
& USA
50. Surgical therapy
A) Endoscopic method
• TURP
• TUIP
• TULIP- 1) HoLEP, 2)Free beam laser, 3)Contact laser,
4) Interstitial laser
• TUVP
• TUNA
• HIFU
• TUBD
• TUMT
• Intraurethral prostatic stent- Cobalt-Chromium stent,
Titenium nickel stent
Out of all minimally invasive technique, TURP is the gold
standered
51. B) Open method
• Retropubic prostatectomy(Millins
prostaectomy)
• Perineal prostatectomy(Youngs
prostatectomy)
• Transvesical prostatectomy
C) Laparoscopic prostatectomy
D) Robot assisted simple prostatectomy
52. Indications of TURP
Absolute indications
1. Refractory urinary retention
2. Chronic retention with renal insufficiency----
increased serum creatinine
increased blood urea level,
residual urine volume 200 ml or more,
hydroureteronephrosis in IVU
uremic manifestation.
3. BOO with complication
• Recurrent UTI
• Recurrent gross heamaturia
• Large bladder diverticula
• Stone formation
54. Pre operative counselling
• Retrograde ejaculation
• Erectile dysfunction
• Success rate
• Risk of re-operation
• Post operative morbidity
UTI & dysuria
Incontinence
Hematuria
Dribbling
Frequency, urgency etc.
55. Complications of TURP
A) Local complication
1.Penile erection
2.TUR syndrome
3.Excessive bleeding
4.Perforation of capsule & extravasation of
urine
5.Bladder perforation, trigonal injury
6.Injury to external sphincter & urethra
Per operative complicationPer operative complication
56. B) General complication
• Myocardial infarction
• CVA
• Cardiac arrest
A)Local
• Bleeding
• Clot retention
• UTI
• Sepsis
• Failure to void
• Epidedymoorchitis
Immidiate Post operative complicationImmidiate Post operative complication
57. B) General complication
• MI
• DVT
• Pulmonary embolism
• Spinal headache
• Stricture urethra
• Bladder neck contracture
• Urinary incontinence
• Retrograde ejaculation
• impotence
Local complicationLocal complication
58. Indications of open Prostetectomy
• Large prostate > 100 gm
• Concomitant bladder condition that requires
Rx (such as symptomatic bladder
diverticulumn, large hard calculus that cant be
manage transurethally)
• Marked ankylosis of the hips that prevents
proper placement of dorsal lithotomy position
• Co-existing unilateral/bilateral inguinal hernia