This document provides guidance on evaluating biomedical literature. It discusses reviewing literature efficiently by understanding article structure and study types. Key parts of articles that should be evaluated include the title, abstract, introduction, objectives, methods, study design, bias, statistics, results, discussion and conclusion. The summarizes emphasizes selecting relevant articles and properly evaluating these components to critically assess whether study results are scientifically valid.
ROLE OF COMMUNITY PHARMACIST IN MALARIAL CONTROL PROGRAMMALINIR14
Malaria is a serious or fatal disease caused by plasmodium parasite transmitted by the bite of infective female mosquitoes.
The term MALARIA is derived two italian words i.e mal means bad aria means air.
MALARIA is most important parasitic disease of the world.
Malaria in humans is caused by four Plasmodium species:
Plasmodium falciparum,
Plasmodium vivax,
Plasmodium malariae, and
Plasmodium ovale.
blood smear and Rapid Diagnostic Tests. India became independent, several measures have been taken under National Government to improve the health of people.Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, control of population and improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, control of population and improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, control of population and improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, control of population and improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, control of population and improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, control of population and improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, Cand improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, control of population and improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government.
ROLE OF COMMUNITY PHARMACIST IN MALARIAL CONTROL PROGRAMMALINIR14
Malaria is a serious or fatal disease caused by plasmodium parasite transmitted by the bite of infective female mosquitoes.
The term MALARIA is derived two italian words i.e mal means bad aria means air.
MALARIA is most important parasitic disease of the world.
Malaria in humans is caused by four Plasmodium species:
Plasmodium falciparum,
Plasmodium vivax,
Plasmodium malariae, and
Plasmodium ovale.
blood smear and Rapid Diagnostic Tests. India became independent, several measures have been taken under National Government to improve the health of people.Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, control of population and improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, control of population and improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, control of population and improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, control of population and improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, control of population and improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, control of population and improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, Cand improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government of control and eradication of communicable disease, improvement of environmental sanitation, raising the standard of nutrition, control of population and improving rural health.
Program among these measures are the NATIONAL HEALTH PROGRAMS, which has been launched by central government.
breif notes on what is pharmacoepidemiology, why do we need pharmacoepidemiology, whats is its aim and its main applications, advantages and disadvantages
In this presentation i have tried to thoroughly discuss about the concept of Drug induced kidney disease or injury, the mechanism behind it, its classification and how to access it.
Introduction To Pharmacoeconomics, Objectives, Need of Pharmacoecomics, Four methods of Pharmaeconomics Evaluation, Basic Terminology, Importance of
Pharmacoeconomics.
In this presentation I have tried to explain in brief about the dosage adjustment in renal disorders, how to carry out this process and the important formulae which are used in it.
Individualisation and optimization of drug dosing regimenJyoti Nautiyal
Drug dosing regimen, dosing frequency, individualisation, Steps Involved in Individualization of Dosage Regimen, optimization, variability, Clinical experience with individualization and optimization based on plasma drug levels.
Use of computers in hospital pharmacy, biostatistics and research methodology...shaistasumayya2
Computers in pharmacy are used for the information of drug data, records and files, drug management (creating, modifying, adding and deleting data in patient files to generate reports), business details.
Drug induced hematological disorders @rxvichu!!!RxVichuZ
This is my 35th powerpoint..published here in Google Slideshare...
And I wish to thank everyone who have supported me in my 2 year long journey......
This ppt is regarding DRUG INDUCED HEMATOLOGICAL DISORDERS, covering the definitions, causative drugs, pathophysiological mechanisms, manifestations,and management of 5 blood disorders.
Do go through this ppt, and send me ur reviews!!
Regards,
Vishnu.R.Nair.
conversion from INTRAVENOUS TO ORAL DOSING----- design of dosage regimenpavithra vinayak
conversion from INTRAVENOUS TO ORAL DOSING----- TYPES OF IV TO PO THERAPY CONVERSIONS: MEDICATIONS INCLUDED IN AN IV TO PO CONVERSION PROGRAM: SELECTION OF PATIENTS FOR IV TO PO THERAPY CONVERSION: design of dosage regimen--clinical pharmacokinetics and therapeutic drug monitoring-- fifth pharm D notes
Critical evaluation of biomedical literature - clinical pharmacyShaistaSumayya
Reviewing the ‘Biomedical Literature’ poses a great challenge to the clinical professionals.
Evaluating a scientific article is a complex task.
Knowledge of the standard anatomy of an article and idiosyncrasy of various types of studies will assist the reader to review the ‘Biomedical Literature’ efficiently
Biomedical Literature includes critical appraisal of the following contents:
Title
Abstract
Introduction
Objective
Materials and Methods
Study Designs
Bias
Statistics
Results and Analysis
Discussion and Conclusion
References
breif notes on what is pharmacoepidemiology, why do we need pharmacoepidemiology, whats is its aim and its main applications, advantages and disadvantages
In this presentation i have tried to thoroughly discuss about the concept of Drug induced kidney disease or injury, the mechanism behind it, its classification and how to access it.
Introduction To Pharmacoeconomics, Objectives, Need of Pharmacoecomics, Four methods of Pharmaeconomics Evaluation, Basic Terminology, Importance of
Pharmacoeconomics.
In this presentation I have tried to explain in brief about the dosage adjustment in renal disorders, how to carry out this process and the important formulae which are used in it.
Individualisation and optimization of drug dosing regimenJyoti Nautiyal
Drug dosing regimen, dosing frequency, individualisation, Steps Involved in Individualization of Dosage Regimen, optimization, variability, Clinical experience with individualization and optimization based on plasma drug levels.
Use of computers in hospital pharmacy, biostatistics and research methodology...shaistasumayya2
Computers in pharmacy are used for the information of drug data, records and files, drug management (creating, modifying, adding and deleting data in patient files to generate reports), business details.
Drug induced hematological disorders @rxvichu!!!RxVichuZ
This is my 35th powerpoint..published here in Google Slideshare...
And I wish to thank everyone who have supported me in my 2 year long journey......
This ppt is regarding DRUG INDUCED HEMATOLOGICAL DISORDERS, covering the definitions, causative drugs, pathophysiological mechanisms, manifestations,and management of 5 blood disorders.
Do go through this ppt, and send me ur reviews!!
Regards,
Vishnu.R.Nair.
conversion from INTRAVENOUS TO ORAL DOSING----- design of dosage regimenpavithra vinayak
conversion from INTRAVENOUS TO ORAL DOSING----- TYPES OF IV TO PO THERAPY CONVERSIONS: MEDICATIONS INCLUDED IN AN IV TO PO CONVERSION PROGRAM: SELECTION OF PATIENTS FOR IV TO PO THERAPY CONVERSION: design of dosage regimen--clinical pharmacokinetics and therapeutic drug monitoring-- fifth pharm D notes
Critical evaluation of biomedical literature - clinical pharmacyShaistaSumayya
Reviewing the ‘Biomedical Literature’ poses a great challenge to the clinical professionals.
Evaluating a scientific article is a complex task.
Knowledge of the standard anatomy of an article and idiosyncrasy of various types of studies will assist the reader to review the ‘Biomedical Literature’ efficiently
Biomedical Literature includes critical appraisal of the following contents:
Title
Abstract
Introduction
Objective
Materials and Methods
Study Designs
Bias
Statistics
Results and Analysis
Discussion and Conclusion
References
Article Briefing. Ms. Sweta Krishna Gaude, Post graduate student, SDM Institute of Nursing Sciences, Shri Dharmasthala Manjunatheshwar University, Dharwad, Karnataka.
This article briefing slideshare will help how to write article paper and how to present research paper.
Critiquing research studies and articles is one of the method to improve the quality of research projects and it is also a method to learn research methodology for beginners.
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CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
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Agriculture: Engineering crops resistant to pests and harsh environments.
Research: Studying gene function to unlock new knowledge.
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Off-target Effects: Unintended DNA edits can have unforeseen consequences.
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Equity: High costs could limit access to this potentially life-saving technology.
The Path Forward: Responsible development is crucial:
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Public Education: Open discussions ensure informed decisions about CRISPR.
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Stewardship is the act of taking good care of something.
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ACCORDING TO apic.org,
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ACCORDING TO pewtrusts.org,
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According to WHO,
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In 1996, John McGowan and Dale Gerding first applied the term antimicrobial stewardship, where they suggested a causal association between antimicrobial agent use and resistance. They also focused on the urgency of large-scale controlled trials of antimicrobial-use regulation employing sophisticated epidemiologic methods, molecular typing, and precise resistance mechanism analysis.
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According to the 2019 report, in the US, more than 2.8 million antibiotic-resistant infections occur each year, and more than 35000 people die. In addition to this, it also mentioned that 223,900 cases of Clostridoides difficile occurred in 2017, of which 12800 people died. The report did not include viruses or parasites
VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratory
to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
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1. Critical Evaluation of Biomedical literature
Khadga Raj Aran
M. Pharm, Ph.D. Research scholar
(Pharmacology)
2. INTRODUCTION
● Reviewing the ‘Biomedical Literature’ poses a
great challenge to the clinical professionals.
● evaluating a scientific article is a complex task.
● Knowledge of the standard anatomy of an article
and idiosyncrasy of various types of studies will
assist the reader to review the ‘Biomedical
Literature’efficiently.
3. Biomedical research
● It is the basic research, applied research or translational
researches conducted to aid and support the body of
knowledge in the field of Clinical Practice.
Literature evaluation
● It is the process of reading and evaluating article, journal,
literature, and scientific study in a systematic way to reach
at a conclusion that one can interpret itself whether the
study results are scientifically proved and applicable to
Clinical Practice.
Scientific Study
● It is a written and published report that describes original
research results. Scientific studies are written in a style that
is exceedingly clear and concise. A well-written scientific
literature explains the author's interest.Author should
summarize and give an idea on previous research, and
Reader should be able to distinguish between previous
research and the actual current study
4. SELECTING THEARTICLE
● Primary step in evaluation of a literature is to select an
article which has a greater impact in clinical practice.
Initially, read the title, authors and abstract.The title
should be comprehensive that the reader can efficiently
analyze the article’s potential and its importance in
current clinical practice. If not, reader can reject it and
move on to the next article.
5. READING THE LITERATURE
● Reviewing begins with reading and understanding the
abstract or short summary that gives a brief background
about the research. Initial reading gives the concept of
objectives, methodology,results and proposed significance
of the study. A proper understanding of research study’s
nature is must for a reader.
6. Biomedical Literature includes critical appraisal
of the following contents:
Title
● ‘Title’ describes the breadth and depth of the current
study and indicates the methodology used. It is the
limited possible words that adequately describe
contents of the study.The title of an article should be
brief, definite and concise and should catch the
attention of the readers interested in the study
7. EVALUATION OFTITLE
1)Based on the title itself reader cannot review or
discard the study.
2)Title should not contain abbreviations,
proprietary names, chemical formulae.
The title should inform the real subject of the article.
3)Title should not reflect its content. First impression is
the best impression; the title should be specific and
studiedwell.
4)Title should not indicate author’s preference for
any specific subject
8. ABSTRACT
● an abbreviated accurate representing the contents of a
document, mainly prepared by its author(s) for publication in
it.
● abstract can be defined as a summary of the
information in a document.
● A synopsis (not more than 250 words) should be mentioned
before introduction in the article.
Evaluation of Abstract
● ‘Abstract’ should outline a brief
● summary of each section; Introduction,objectives,
scope of investigation, materials and brief
● methodology, results, and conclusion which indicates study
findings.
● complete information about the study and should not be used
alone to evaluate the study
9. INTRODUCTION
● It serves two purposes in the study, creating
readers interest in subject and providing them
with enough information to understand the
study.
Evaluation of Introduction
● Introduction should be presented, with all
possible clarity, the nature and scope of the
problem investigated.
● It should provide pertinent literature to orient
the reader.
● It should explain the reason why the current
research is needed?
10. OBJECTIVE
● ‘Objective’ of a study is what the author is
trying to achieve. It is a specific, clear and
succinct statement of intended outcomes
from research. Objective should be stated in
a clear and concise manner.
Evaluation of Objective
1. Establishing new health programs
2. Implementing new
policies
3. Trying to settle a
controversy
4. Showing the validity of a new technique
5. Opening up a new field of inquiry.
11. MATERIALS AND METHODS
● Methodology is one of the most important sections of a study.
Its purpose is to describe the methods used in the
experiment and materials by which the experiment was
carried out.The description of this section should be detailed
enough to allow other researchers to replicate the work.
Evaluation of Study Methods
● Methods used, and their description should be elucidated.
● What are the dose regimens, route and frequency of
administration, the overall length of the study to be
mentioned.
● What was the length of wash-out period
12. STUDY DESIGNS
● The first part of this section is generally an
overview of the type of study design that is
utilized in doing research. A sound study design
supports study conclusion and result. Study
design should be clear and provide enough
details so that potential reader can repeat the
research
13. VARIOUS TYPES OF STUDY DESIGN
● Observational studies
Data collected from one or more group of subjects,
Observational studies may be prospective or retrospective.
● Single blind
Either subjects or investigators are unaware of treatment
allocation.
● Double blind
Neither subjects nor investigators are aware of
treatment allocation.
● Triple blind
Subjects and investigators are unaware of treatment allocation;
another group involved with interpretation of data is also unaware
of treatment allocation.
● Parallel study
All subjects receive only one treatment.
14. ● Prospective
Data is collected forward in time from the start of the study.
● Retrospective
Historical data (i.e., data referring to past events) is collected.
● Cohort studies
Cohort studies consist of prospective observation of one or
more groups with certain characteristics.
● Randomized control trial
Subjects are randomly allocated to either an intervention
group or control group. Randomized controlled trials are described
as the“gold standard” in clinical research.
15. EVALUATION OF STUDY DESIGNS
● The study design selected by an
investigator should be sound and likely
to answer the research questions.
● Author(s) must describe study population
well enough so that the reader is able to
visualize the sample population precisely
under investigation.
16. BIAS
● It is a systemic variation in which treatment
groups under study are treated or measured
differently on a consistent basis. Bias can
mislead one to get into an erroneous
outcome.The reader should be able to find out
the source of bias and its influence on the final
outcome of study
17. TYPES OF BIAS
● Missing clinical data bias
Certain clinical data may be missing
because they were normal, negative or never
measured.
● Withdrawal bias
Patients who withdraw from a study may
differ from those who remain.
● Sample size bias
Too small Samples are insignificant; samples
which are too large are proved to be helpful.
● Instrument bias
Defects in the calibration or maintenance of
instruments may lead to systematic deviations in
18. STATISTICS
● Knowledge of ‘Statistics’ can help an individual to evaluate
whether the statistical tests used in a study are appropriate
or not. Different types of data (or variables) are
encountered in statistics. Errors in statistical analysisof
data lead to invalid result/conclusion
19. TYPES OF DATA TWO
COMPARISIO
N GROUPS
MORE THAN TWO
COMPARISION
GROUPS
UNPAIRED DATA PAIRED DATA UNPAIRED DATA
Nominal Chi square McNemar Chi square
Ordinal Mann-Witney
U test
Wilcoxon Kruskal-Wallis
Parametric Student t-test Paired
student test
Analysis-
of
variance
(ANOVA)
20. EVALUATION OF STATISTICS
● Readers should determine whether
appropriate statistical methods were used
for data analysis.
● Use of inappropriate methods will
results in misleading conclusion.
● Method section of any scientific literature
should include a summary description of
the statistical tests that were used to
evaluate data. Qualitative and quantitative
data are examined differently.
21. STUDY RESULTS ANDANALYSIS
● ‘Results’ should be described and presented in
figures, tables, and charts, as they are the heart
of the scientific literature.
● Figures, tables, and charts will assist the reader in
deciding whether it is worth to read the rest of the
article or to discard it.
● A properly conducted study should present data on
subjects involved in the study.All the data collected
in the method section should also be presented
22. EVALUATION OF STUDY RESULTS AND
ANALYSIS
● Reader should have a proper understanding of study and
should evaluate clinical and statistical reliability of the
study
● Sometimes authors try to present results in a confusing
way, which most likely reflects hap hazardous data
collection and lack of clearly defined study objectives.
● Are the negative results been quoted? In case of any
negative results those should be quoted and the
limitations have to be specified.
23. DISCUSSION AND CONCLUSION
● ‘Discussion Section’ of a study provides an
opportunity for the author to interpret results and
explain their clinical importance by relating or
comparing with previous work or practice.
● ‘Conclusion’ is the author’s generated inferences,
opinions and hypotheses about results.This
section should contain views that the author
draws from data obtained by the study
24. EVALUATION OF DISCUSSION AND
CONCLUSION
● Is the conclusion over-generalized? The ‘Conclusion’ must
be clear and understandable to the reader. Conclusion must
be consistent with study objectives and justified by results.
● Conclusion should not be a matter of dispute.
● How does the research fit into the context of its
conclusion? It should give the answer of the study
objective for which claim was made prior to study.
● Readers must understand the relationship between the data
and the conclusions.
25. REFERENCES
● While writing article, authors always refer to some information
from other sources.
● All these sources are listed in ‘Reference Section’, sometimes
referred to as ‘Bibliography’.
Evaluation of References
1)Are the references given? Whether appropriate and
adequate references are used in the study?
2)Are the references quoted appropriately in the research article?
3)Are the references given recent and important?
4)What is the size of ‘Reference Section’?
5) How the references are used for support, rebuttal etc.?
6) Do the references match citations in the text?
7)Authors should avoid citing their own research efforts and
publication.