The document summarizes a study evaluating treatment outcomes for Acinetobacter infections at a hospital. 112 patients with Acinetobacter infections were included in the retrospective study. Appropriate empiric and tailored antimicrobial therapy were associated with favorable outcomes. Common treatments included imipenem, colistin, tigecycline, and piperacillin/tazobactam. Colistin was effective against multi-drug resistant strains but caused increased creatinine and BUN levels in some patients. Selection of correct empiric therapy was found to be important for treatment success.

1. Evaluation of Acinetobacter Infection Sarah Nelson, Pharm.D. Pharmacy Practice Resident

4. Mechanisms of Resistance Munoz-Price, L. et al. Acinetobacter Infection. N Engl J Med. 2008;358(12):1271-81

15. Demographics 22 (20%) >1 source of Acinetobacter 2.6 2.5 2.5 Days to positive culture 32 27.5 28.5 LOS (days) 57.1 51.4 52.6 Age (years) 20 (59%) 38 (50%) 59 (53%) Male Unfavorable Outcome (n= 34) Favorable Outcome (n=76) Overall (n=112)

16. Source of Infection

17. Locality of Infection

18. Rates of Resistance 0% --- Colistin 31% --- Tigecycline 70% 48% Piperacillin/Tazobactam 64% 50% TMP/SMX 56% 31% Imipenem 68% 58% Gentamicin 76% 65% Ciprofloxacin 74% 60% Cefepime 72% --- Amikacin Study Group 2007 Antibiogram Antimicrobial