Blood lipids refer to a group of fatty substances present in the blood, mainly including cholesterol and triglycerides. There are generally two forms of cholesterols circulating in the bloodstream: low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Abnormal lipid level in blood is always associated with a number of diseases, such as high blood pressure, coronary arteries, hypothyroidism, type 2 diabetes, obesity, pancreatitis, et al. https://diagnostic-enzymes.creative-enzymes.com/blood-lipids.html
INTRODUCTION
This presentation is a brief knowledge about cholesterol its importance and its role in our bodies along with respective diseases.
CHOLESTROL
A compound of the sterol type found in most body tissues, including the blood and the nerves. Cholesterol and its derivatives are important constituents of cell membranes and precursors of other steroid compounds
OCCURENCE
Endogenous: Cholesterol is naturally found in our bodies. 75% of your body’s requirements are fulfilled by the endogenous cholesterol produced in the liver.
Exogenous: The cholesterol we get from food. Exogenous cholesterol is obtained from animal products, and this source of cholesterol accounts for about 25% of the body’s cholesterol needs.
CLASSIFICATION OF CHOLESTROL
Two types of cholesterol:
HDL
“Good” Cholesterol
High levels of HDL have been found to lower risk of heart attack
Risk of heart disease increases when there are lower levels of HDL.
“Help remove cholesterol from artery walls and transport it to the liver for elimination from the body”
LDL
Bad cholesterol that can build up in the arteries.
High levels of LDL can increase risk of heart disease.
Composed mainly of cholesterol and a few proteins.
“Primarily responsible for depositing cholesterol within arteries”
BIOMEDICAL IMPORTANCE
Hypercholesterolemia
Atherosclerosis
Heart diseases
Cardiac attack/stroke
Death
HYPERCHOLESTEROLEMIA
Hypercholesterolemia
is a condition
characterized by
very high levels of
cholesterol in the
blood.
ATHEROSCLEROSIS
Atherosclerosis is a disease in which plaque builds up inside your arteries. Arteries are blood vessels that carry oxygen-rich blood to your heart and other parts of your body.
HEART DISEASES
the blood carries oxygen to our heart, atherosclerosis reduces the amount of blood flowing to our heart. If blood stops flowing to the heart because of a blockage in the arteries, a heart attack occurs.
CARDIAC ATTACK
When coronary artery of heart gets blocked by cholesterol deposition heart doesn’t get the blood supply it needs so cardiac attack occurs due to myocardial infarction.
STROKE
Plaque buildup can also keep your brain from getting enough blood and oxygen. If a clot completely blocks an artery feeding your brain, you have a stroke.
WHAT TO EAT???
Grains (Fiber)
Any source of oatmeal,
granola or nuts can be
considered a form of fiber.
Oils (Fats)
Unsaturated fats used in
moderation like: olive oil, canola oil or soybean oil
Cont…
Fruits
Any form of fruit or
vegetable Oranges
and raspberries
Meats
Skinless poultry
and lean meats
Lipid Profile Tests.A lipid profile is a blood test that measures the concentrations of fats and cholesterol in the blood and can be used to assess so-called 'good cholesterol' versus 'bad cholesterol levels.
INTRODUCTION
This presentation is a brief knowledge about cholesterol its importance and its role in our bodies along with respective diseases.
CHOLESTROL
A compound of the sterol type found in most body tissues, including the blood and the nerves. Cholesterol and its derivatives are important constituents of cell membranes and precursors of other steroid compounds
OCCURENCE
Endogenous: Cholesterol is naturally found in our bodies. 75% of your body’s requirements are fulfilled by the endogenous cholesterol produced in the liver.
Exogenous: The cholesterol we get from food. Exogenous cholesterol is obtained from animal products, and this source of cholesterol accounts for about 25% of the body’s cholesterol needs.
CLASSIFICATION OF CHOLESTROL
Two types of cholesterol:
HDL
“Good” Cholesterol
High levels of HDL have been found to lower risk of heart attack
Risk of heart disease increases when there are lower levels of HDL.
“Help remove cholesterol from artery walls and transport it to the liver for elimination from the body”
LDL
Bad cholesterol that can build up in the arteries.
High levels of LDL can increase risk of heart disease.
Composed mainly of cholesterol and a few proteins.
“Primarily responsible for depositing cholesterol within arteries”
BIOMEDICAL IMPORTANCE
Hypercholesterolemia
Atherosclerosis
Heart diseases
Cardiac attack/stroke
Death
HYPERCHOLESTEROLEMIA
Hypercholesterolemia
is a condition
characterized by
very high levels of
cholesterol in the
blood.
ATHEROSCLEROSIS
Atherosclerosis is a disease in which plaque builds up inside your arteries. Arteries are blood vessels that carry oxygen-rich blood to your heart and other parts of your body.
HEART DISEASES
the blood carries oxygen to our heart, atherosclerosis reduces the amount of blood flowing to our heart. If blood stops flowing to the heart because of a blockage in the arteries, a heart attack occurs.
CARDIAC ATTACK
When coronary artery of heart gets blocked by cholesterol deposition heart doesn’t get the blood supply it needs so cardiac attack occurs due to myocardial infarction.
STROKE
Plaque buildup can also keep your brain from getting enough blood and oxygen. If a clot completely blocks an artery feeding your brain, you have a stroke.
WHAT TO EAT???
Grains (Fiber)
Any source of oatmeal,
granola or nuts can be
considered a form of fiber.
Oils (Fats)
Unsaturated fats used in
moderation like: olive oil, canola oil or soybean oil
Cont…
Fruits
Any form of fruit or
vegetable Oranges
and raspberries
Meats
Skinless poultry
and lean meats
Lipid Profile Tests.A lipid profile is a blood test that measures the concentrations of fats and cholesterol in the blood and can be used to assess so-called 'good cholesterol' versus 'bad cholesterol levels.
https://www.crystalrunhealthcare.com/specialties/cardiology | Learn the difference between HDL and LDL cholesterol, along with what causes your cholesterol levels to go up or down. With risk factors including heart disease and stroke, it’s important to work with your doctor to design a health plan to maintain healthy cholesterol levels.
HYPERLIPIDAEMIA--LIPID PROFILE, TYPE OF HYPERLIPIDAEMIA ,LIPOPROTEINS, CLASSIFICATION OF DRUGS AND MECHANISM OF ACTION, ETIOPATHOLOGY,
METABOLISM OF LIPIDS, SIGN AND SYMPTOMS, PHARMACOKINETIC ,THERAPEUTIC USE, ADVERSE EFFECTS,CONTRAINDICATION .
https://www.crystalrunhealthcare.com/specialties/cardiology | Learn the difference between HDL and LDL cholesterol, along with what causes your cholesterol levels to go up or down. With risk factors including heart disease and stroke, it’s important to work with your doctor to design a health plan to maintain healthy cholesterol levels.
HYPERLIPIDAEMIA--LIPID PROFILE, TYPE OF HYPERLIPIDAEMIA ,LIPOPROTEINS, CLASSIFICATION OF DRUGS AND MECHANISM OF ACTION, ETIOPATHOLOGY,
METABOLISM OF LIPIDS, SIGN AND SYMPTOMS, PHARMACOKINETIC ,THERAPEUTIC USE, ADVERSE EFFECTS,CONTRAINDICATION .
An educational presentation for all ages discussing traditional and newly evolving methods for determining heart health risk based on cholesterol levels.
Deaths that are caused due to coronary heart disease CHD is a major cause of deaths in most of the population. Even though the mortality rate has been reducing, dyslipidemia is the major known risk factor in pathogenesis of CHD. In this paper we review the role of dyslipidemia and lipid changes that occur in men and women at different stages. We discuss about dyslipidemia causes symptoms and treatments and all the other issues that arise due to dyslipidemia. We talk about different drugs that are used in treating dyslipidemia and their side effects. Yong Yuan | Wen Chen | Lei Luo | Chen Xu "Dyslipidemia: Causes, Symptoms and Treatment" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, URL: https://www.ijtsrd.com/papers/ijtsrd38594.pdf Paper Url: https://www.ijtsrd.com/pharmacy/pharmaceutics/38594/dyslipidemia-causes-symptoms-and-treatment/yong-yuan
Blood lipids refer to a group of fatty substances present in blood, mainly including cholesterol and triglycerides. There are generally two forms of cholesterols circulating in the bloodstream: low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Abnormal lipid level in blood is always associated with a number of diseases, such as high blood pressure, coronary arteries, hypothyroidism, type 2 diabetes, obesity, pancreatitis, et al. https://diagnostic-enzymes.creative-enzymes.com/blood-lipids.html
Native Bacillus licheniformis Protease at Creative EnzymesCreative Enzymes
A protease is an enzyme that helps proteolysis: protein catabolism by hydrolysis of peptide bonds. The native Bacillus licheniformis protease belongs to the serine endopeptidase subtilisin family, which breaks the peptide bond non-specifically under alkaline conditions. The enzyme is active in aqueous solutions and in some organic solvents such as dry octane. The protease is inactivated by serine active-site inhibitors, such as phenylmethylsulfonyl fluoride (PMSF) and diisopropyl fluorophosphate. https://www.creative-enzymes.com/product/native-bacillus-licheniformis-protease_936.html
Molecular biology grade lyophilized powder of Recombinant Proteinase KCreative Enzymes
Proteinase K is a broad-spectrum serine protease originally isolated from the fungus Engyodontiumalbum (Tritirachium album). The enzyme was named "proteinase K" for its ability to digest keratin. Structural and molecular biology studies suggest that the enzyme belongs to the subtilisin family characterized by a catalytic triad (Asp39-His9-Ser2) in the active site. Proteinase K has no pronounced cleavage specificity and the preferential cleavage site is the peptide bond adjacent to hydrophobic amino acids. https://www.creative-enzymes.com/product/proteinase-k-from-tritirachium-album-limber-recombinant_3427.html
β-Amylase hydrolyzes the a-(1,4)glucan linkages in polysaccharides of three or more a-(1,4)linked D-glucose units. Natural substrates such as starch and glycogen are broken down intoglucose and maltose. β-amylase, also known as starch β-1,4-galactosidase, is an exo-amylase that cleaves the separated a-1,4 bonds from non-reducing ends when acting on starch and produces maltose. Because amylase changes the configuration of C1 in the hydrolysate maltose molecule from alpha type to beta type during the hydrolysis process, it is named β-amylase. https://www.creative-enzymes.com/product/-amylase-food-grade-_3167.html
A protease is an enzyme that helps proteolysis: protein catabolism by hydrolysis of peptide bonds. The nave Bacillus licheniformis protease belongs to the serine endopeptidase subtilisin family, which breaks the peptide bond non-specifically under alkaline conditions. The enzyme is active in aqueous solutions and in some organic solvents such as dry octane. The protease is inactivated by serine active-site inhibitors, such as phenylmethylsulfonyl fluoride (PMSF) and diisopropylfluorophosphate. https://www.creative-enzymes.com/product/native-bacillus-licheniformis-protease_936.html
Proteinase K is a stable and highly reactive serine protease. Evidence from crystal and molecular structure studies indicates the enzyme belongs to the subtilisin family with an active-site catalytic triad (Asp39-His69-Ser224). It is stable in a broad range of environments:pH, buffer salts, detergents (SDS), and temperature. In the presence of 0.1-0.5% SDS, proteinase K retains activity and will digest a variety of proteins and nucleases in DNA preparations without compromising the integrity of the isolated DNA. https://www.creative-enzymes.com/product/proteinase-k-from-tritirachium-album-limber-recombinant_3427.html
Probiotics are living microorganisms that co-exist with humans. Different from pathogenic microorganisms, probiotics are beneficial, and sometimes essential to health. For example, intake of probiotics can increase the number of beneficial bacteria in the intense, maintain the dynamic balance of intestinal flora, and enhance
gastrointestinal health. https://www.creative-enzymes.com/cate/probiotics_99.html
Tn5 Transposase is a hyperactive form of Tn5 transposase. This enzyme can be used to randomly insert Tn5 transposon into target DNA. Robust Tn5 Transposase recognizes inside end sequences, outside end sequences and mosaic end sequences of Tn5 transposon. https://www.creative-enzymes.com/product/tn5-transposase_8479.html
Explore creative enzymes's enzyme products for triglyceride kitCreative Enzymes
A Triglyceride Kit is used to measure triglyceride concentration in mammalian samples. The triglyceride assay is easy and sensitive. Triglycerides are converted to free fay acids and glycerol. Glycerol is then oxidized to generate a product that reacts with a probe to generate colour and fluorescence. Creative Enzymes provides enzymes that are essential to produce triglyceride kits. https://diagnostic-enzymes.creative-enzymes.com/glycerol-3-phosphate-oxidase-from-pediococcus-sp-item-10.html
Creative Enzymes's Diagnostic Enzymes for POC Biosensor Creative Enzymes
Point-of-care testing (POCT) refers to a group of immediate test approaches that are implemented near or at the site of patient care. Various portable and handheld instruments and test kits, or biosensors, have supplemented the POC. Creative Enzymes serves diagnostic enzyme products to optimize your POC biosensors. https://diagnostic-enzymes.creative-enzymes.com/poct-bio-sensor.html
Explore Enzymes Involved in Blood Lipid Metabolism at Creative EnzymesCreative Enzymes
Blood lipids refer to a group of fay substances present in blood, mainly including cholesterol and triglycerides. There are generally two forms of cholesterols circulating in bloodstream: low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Abnormal lipid level in blood is always associated with a number of diseases, such as high blood pressure, coronary arteries, hypothyroidism, type 2 diabetes, obesity, pancreas, et al. https://diagnostic-enzymes.creative-enzymes.com/blood-lipids.html
Probiotics may exhibit antiallergic effects by degradation or structural modification of enteral antigens, stabilization of aberrant microbiota, improvement of the gut-barrier function, secretion regulation of pro-inflammatory mediators, and development of the immune system. https://probiotic.creative-enzymes.com/multi-strain-probiotics/antiallergic-formula.html
As an enzyme expert, Creative Enzymes is engaged in providing the best products and services for worldwide researchers, especially for enzymes modification. Immobilization is one of the most popular methods that were initially developed for biotechnology processes. Creative Enzymes offers enzyme immobilization services with reliable outcomes, improved performance, and surface analysis. https://www.creative-enzymes.com/service/Enzyme-Modification-By-Immobilization_366.html
Creative Enzymes is a worldwide leading company in diagnostic enzymes manufacturing and supply. We are committed to providing our customers with diverse enzyme products and custom enzyme-related services for medical and research diagnosis. Relying on our professional team and state-of-art technologies, we have gained solid reputation for having top of the line products and services.
Creative Enzymes is a professional and experienced supplier of probiotics. In the past decade, Creative Enzymes mainly provides enzyme-related products and services. With the continuous expansion of business areas and scale, we have set foot in other areas and established a sound probiotic production and supply chain. Based on our high-quality products and services, as well as the unique advantages of large-scale production, our probiotic products are widely favored by industrial customers and scientific research customers.
Creative Enzymes is a world-wide provider of the best enzyme products. We now offer medical enzymes for pharmaceutical and diagnostic uses. In contrast to the industrial uses, enzymes of therapeutic uses are requested in relatively lower amounts but at a very high degree of purity and specificity. We have the capability to assure high-quality enzyme products based on our advanced equipment and professional techniques. In the past few years, the reliability of our products has been approved by thousands of customers and scientists. Specialized in the medical industry, the various kinds of enzyme products of Creative Enzymes will support your research in multiple areas.
As an enzyme expert, Creative Enzymes is engaged in providing the best products and services for worldwide researchers, especially for enzymes modification. Immobilization is one of the most popular methods that were initially developed for biotechnology processes. Creative Enzymes offers enzyme immobilization services with reliable outcomes, improved performance, and surface analysis.
Creative Enzymes is a worldwide leading company in diagnostic enzymes manufacturing and supply. We are committed to providing our customers with diverse enzyme products and custom enzyme-related services for medical and research diagnosis. Relying on our professional team and state-of-art technologies, we have gained solid reputation for having top of the line products and services. https://diagnostic-enzymes.creative-enzymes.com/
Creative Enzymes has long demonstrated expertise and reliability in development and establishment of biocatalysis systems. We provide products, services, and consultation covering every step in the whole process of a biocatalyst development, including the design, modification, expression, purification, production, and validation of specific enzymatic or microbial systems that catalyze the desired reactions. https://www.creative-enzymes.com/service/Biocatalysis-Services_67.html
Triplehelical domain of chicken sternum collagen type II. Gnd-HCl extracon, pepsin digeson, salt precipitaon, ion exchange chromatography, gel-filtraon. Nave type II collagen has posive effects on the treatment of early rheumatoid arthris. https://www.creative-enzymes.com/product/native-chicken-collagen-type-ii_3352.html
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
1. Email: info@crea ve-enzymes.com
Enzymes Involved in Blood Lipid Metabolism
Blood lipids refer to a group of fa y substances present in blood, mainly including
cholesterol and triglycerides. There are generally two forms of cholesterols circula ng in
bloodstream: low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Abnormal
lipid level in blood is always associated with a number of diseases, such as high blood
pressure, coronary arteries, hypothyroidism, type 2 diabetes, obesity, pancrea s, et al.
Learn More
Product List
Enzymes that are involved in the metabolism of lipids are being extensively studied. Crea ve
Enzymes has been endeavored to supply blood lipids related enzyme to industries, academic and
research ins tutes. Explore our catalog for cholesterol esterase, cholesterol oxidase, cholesterol
dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-3-phosphate oxidase, glycerokinase,
and hexokinase.
Glucose-6-phosphate Dehydrogenase
Cat No. Source
DIA-145 Microorganism
DIA-321 Leuconostoc
Glycerokinase
Cat No. Source
DIA-149 Microorganism
NATE-0287 Streptomyces sp.
Cholesterol Esterase
Cat No. Source
DIA-133 Schizophyllum commune
DIA-134 Pseudomonas sp.
DIA-135 Microorganism
NATE-1679 Candida Rugosa
Cholesterol Esterase
Cat No. Source
DIA-138 Microorganism
NATE-0128 Streptomyces sp.
Glycerol-3-phosphate oxidase
Cat No. Source
DIA-154 Pediococcus sp.
DIA-200 Microorganism
Cholesterol Dehydrogenase
Cat No. Source
NATE-0892 Nocardia sp.
Hexokinase
Cat No. Source
DIA-202 Microorganism
Crea ve Enzymes also provides other enzyme products for diagnos cs in addi on to the
ones listed above. Please contact us for any needs.
Note: Our products can only be used for the purpose of research and industrial produc on,
not for individual use.
Learn More
Contact Informa on Email: info@crea ve-enzymes.com
45-1 Ramsey Road, Shirley, NY 11967, USA Tel: 1-631-562-8517
diagnos c-enzymes.crea ve-enzymes.com Fax: 1-631-614-7828
