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Cholestero
l
Good? Or
Bad?
What is cholesterol ?
• a member of the
steroid family of
organic
compounds.
Structure:
• C27H45 OH.
• Hydrocarbon tail.
• A ring structure region
with 4 hydrocarbon rings.
• Hydroxyl group .
Structure
Characteristics:
• Soluble in water.
• All steroids are made from cholesterol.
• Cholesterol is called “sterol”.
• Cholesterol can dissolve in fatty and oily
substances.
• Cholesterol is an amphipathic molecule.
• Cholesterol travels in the blood through
lipoproteins such as LDL and HDL.
There are two types of
cholesterol :
 Dietary cholesterol.• Cholesterol (manufactured in
the body).
Cholesterol’s bad reputation
:
 What’s the reason of
cholesterol bad
reputation?
 Heart diseases.
 The difference between the
“Good” and the “Bad”
lipoproteins”.
Importance of
Cholesterol :
• Cell Membrane.
• Brain Tissue.
• Immune
system.
• Hormones.
• Nerves.
• Vitamin D.
• Bile salts.
Synthesis of
cholesterol :
3 molecules of Acetyl CoA (from
fatty acids oxidation )
Mevalonate
Isoprene intermediates
Squalene intermediates
Cholesterol
Heart
Diseases:
 Genetic predisposition :
 Hypercholesterolemia.
 lifestyle/ Diet.
A Test?..
Cholesterol test.
Cholesterol : Top 5 foods to lower your
numbers :

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Cholesterol