This document discusses how to empower honors students to thrive in the 21st century. It argues that honors programs need to integrate 21st century literacies and pedagogies into their curricula by reconsidering what and how they teach based on who is being taught (21st century digital native students) and the current economic setting. Specifically, it advocates for using student-driven, technology-enabled, collaborative, and inquiry-based learning approaches over traditional classroom-based education. This includes incorporating skills like critical thinking, communication, creativity, problem-solving across disciplines, and learning how to learn, unlearn and relearn.