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Emphysema
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Emphysema
Emphysema Definition
โ€ข Definition: An
infection in the
pleural
space, causing
pus
accumulation.
โ€ข Type of chronic
obstructive
pulmonary
disease
(COPD): Airflo
w blockage
and breathing
problems.
Normal alveoli and emphysema
Emphysema Definition
โ€ข An
infection in the pleural
space, causing pus
accumulation.
โ€ข Type of
chronic obstructive
pulmonary disease
(COPD): Airflow
blockage and breathing
problems.
Emphysema Prevalence
More common in
men than women
Emphysema Prevalence
โ€ข 4th leading
cause of death in the
United States
โ€ข Estimated
16 million Americans
have COPD, including
emphysema
Anatomy and Function of Alveoli
โ€ข The
alveoli are the basic
units of gas exchange
in the lungs.
โ€ข They are
tiny, balloon-like
structures that are
surrounded by a
network of capillaries.
โ€ข The
alveoli are filled with
air, and the capillaries
are filled with blood.
โ€ข Gas
exchange occurs
through the walls of the
alveoli and the
capillaries.
โ€ข Oxygen
from the air diffuses
into the blood, and
carbon dioxide from
the blood diffuses into
the air.
Gas exchange process
โ€ข Gas exchange occurs
through the process of
diffusion.
โ€ข Oxygen from the air
diffuses into the blood,
and carbon dioxide from
the blood diffuses into
the air.
โ€ข The rate of diffusion is
determined by the
concentration gradient
of the gases.
โ€ข The concentration
gradient of oxygen is
higher in the air than in
the blood, so oxygen
diffuses from the air into
the blood.
โ€ข The concentration
gradient of carbon
dioxide is higher in the
blood than in the air, so
carbon dioxide diffuses
from the blood into the
air.
Normal and abnormal respiration
โ€ข In emphysema,
the alveoli are
damaged, which
makes it difficult
for them to
expand and
contract.
โ€ข This leads to air
trapping and
hyperinflation of
the lungs.
โ€ข As a result, gas
exchange is
impaired, and the
body does not
receive enough
oxygen.
Emphysema Causes
โ€ข
Smoki
ng: The leading
cause, of damaging
alveoli over time.
โ€ข
Polluti
on: Exposure to air
pollutants irritates
and inflames lung
tissues.
โ€ข Age:
Natural decline in
lung function
increases
susceptibility.
โ€ข Alpha-
1 Antitrypsin (AAT)
Deficiency: Genetic
condition leading to
enzyme deficiency
and emphysema
development.
Emphysema Risk factors
โ€ข Asthma: Pre-existing
condition can worsen
emphysema
symptoms.
โ€ข Smoking: Synergistic
effect with other risk
factors.
โ€ข Chemical
Exposure: Occupatio
nal exposure to
irritants can damage
lung tissues.
โ€ข Pollution: Increases
risk, especially in
high-pollution
environments.
โ€ข Age: Ageing lungs
are more susceptible
to damage and
emphysema
development.
โ€ข AAT
Deficiency: Genetic
predisposition
significantly increases
risk.
Emphysema Pathogenesis
โ€ข Emphysema is caused
by the destruction of
the alveolar walls.
โ€ข This destruction can be
caused by several
factors, including:
o Smoking:
o Alpha-1
antitrypsin
deficiency:
o Exposure to air
pollution:
Emphysema Pathogenesis
โ€ข Once the alveolar
walls are destroyed,
they cannot be
repaired.
โ€ข This leads to the
formation of larger
air spaces and a
loss of surface area
for gas exchange.
โ€ข As a result, the
lungs become less
efficient at taking in
oxygen and
releasing carbon
dioxide.
Emphysema Symptoms
โ€ข
Productiv
e cough (with phlegm)
โ€ข Wheezing
and shortness of breath
โ€ข Chest
pain or tightness
โ€ข Bluish
discoloration of fingers
and lips (cyanosis)
Emphysema Types
โ€ข Panacinar: Unifor
m destruction of
alveoli
throughout all
lung lobes.
โ€ข Centriacinar: Da
mage primarily
affects the
central regions of
the lung.
โ€ข Paraseptal: Alve
olar destruction
starts near the
walls of the
airways.
Emphysema Diagnosis
Lung function
tests: Spirometry
measures airflow
limitation.
Bronchodilators
โ€ข
Bronchod
ilators are medications
that relax the smooth
muscles in the airways.
โ€ข This
helps to open the
airways and make it
easier for air to flow in
and out of the lungs.
โ€ข
Bronchod
ilators are commonly
used to treat
emphysema and other
COPD symptoms.
Bronchodilators
โ€ข There are two main
types of
bronchodilators:
o Beta-
agonists:
These
medications
work by
mimicking the
effects of
adrenaline.
o Anticholinergi
cs: These
medications
work by
blocking the
effects of
acetylcholine,
a
neurotransmit
ter that
causes the
airways to
constrict.
Oxygen therapy
Supplementation for
patients with oxygen
deficiency.
Pulmonary rehabilitation
: Exercise training
and education
program to
improve quality of
life.
Emphysema Prevention
โ€ข Smoking
cessation: The most
effective prevention
measure.
โ€ข Immunizations: Vac
cination against
respiratory
infections.
โ€ข Regular
monitoring: Early
detection and
management of
symptoms.
โ€ข Physical
activity: Improves
lung function and
overall health.
Emphysema Icons

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Emphysema

  • 3. Emphysema Definition โ€ข Definition: An infection in the pleural space, causing pus accumulation. โ€ข Type of chronic obstructive pulmonary disease (COPD): Airflo w blockage and breathing problems.
  • 4. Normal alveoli and emphysema
  • 5. Emphysema Definition โ€ข An infection in the pleural space, causing pus accumulation. โ€ข Type of chronic obstructive pulmonary disease (COPD): Airflow blockage and breathing problems.
  • 7. Emphysema Prevalence โ€ข 4th leading cause of death in the United States โ€ข Estimated 16 million Americans have COPD, including emphysema
  • 8. Anatomy and Function of Alveoli โ€ข The alveoli are the basic units of gas exchange in the lungs. โ€ข They are tiny, balloon-like structures that are surrounded by a network of capillaries. โ€ข The alveoli are filled with air, and the capillaries are filled with blood. โ€ข Gas exchange occurs through the walls of the alveoli and the capillaries. โ€ข Oxygen from the air diffuses into the blood, and carbon dioxide from the blood diffuses into the air.
  • 9. Gas exchange process โ€ข Gas exchange occurs through the process of diffusion. โ€ข Oxygen from the air diffuses into the blood, and carbon dioxide from the blood diffuses into the air. โ€ข The rate of diffusion is determined by the concentration gradient of the gases. โ€ข The concentration gradient of oxygen is higher in the air than in the blood, so oxygen diffuses from the air into the blood. โ€ข The concentration gradient of carbon dioxide is higher in the blood than in the air, so carbon dioxide diffuses from the blood into the air.
  • 10. Normal and abnormal respiration โ€ข In emphysema, the alveoli are damaged, which makes it difficult for them to expand and contract. โ€ข This leads to air trapping and hyperinflation of the lungs. โ€ข As a result, gas exchange is impaired, and the body does not receive enough oxygen.
  • 11. Emphysema Causes โ€ข Smoki ng: The leading cause, of damaging alveoli over time. โ€ข Polluti on: Exposure to air pollutants irritates and inflames lung tissues. โ€ข Age: Natural decline in lung function increases susceptibility. โ€ข Alpha- 1 Antitrypsin (AAT) Deficiency: Genetic condition leading to enzyme deficiency and emphysema development.
  • 12. Emphysema Risk factors โ€ข Asthma: Pre-existing condition can worsen emphysema symptoms. โ€ข Smoking: Synergistic effect with other risk factors. โ€ข Chemical Exposure: Occupatio nal exposure to irritants can damage lung tissues. โ€ข Pollution: Increases risk, especially in high-pollution environments. โ€ข Age: Ageing lungs are more susceptible to damage and emphysema development. โ€ข AAT Deficiency: Genetic predisposition significantly increases risk.
  • 13. Emphysema Pathogenesis โ€ข Emphysema is caused by the destruction of the alveolar walls. โ€ข This destruction can be caused by several factors, including: o Smoking: o Alpha-1 antitrypsin deficiency: o Exposure to air pollution:
  • 14. Emphysema Pathogenesis โ€ข Once the alveolar walls are destroyed, they cannot be repaired. โ€ข This leads to the formation of larger air spaces and a loss of surface area for gas exchange. โ€ข As a result, the lungs become less efficient at taking in oxygen and releasing carbon dioxide.
  • 15. Emphysema Symptoms โ€ข Productiv e cough (with phlegm) โ€ข Wheezing and shortness of breath โ€ข Chest pain or tightness โ€ข Bluish discoloration of fingers and lips (cyanosis)
  • 16. Emphysema Types โ€ข Panacinar: Unifor m destruction of alveoli throughout all lung lobes. โ€ข Centriacinar: Da mage primarily affects the central regions of the lung. โ€ข Paraseptal: Alve olar destruction starts near the walls of the airways.
  • 17. Emphysema Diagnosis Lung function tests: Spirometry measures airflow limitation.
  • 18. Bronchodilators โ€ข Bronchod ilators are medications that relax the smooth muscles in the airways. โ€ข This helps to open the airways and make it easier for air to flow in and out of the lungs. โ€ข Bronchod ilators are commonly used to treat emphysema and other COPD symptoms.
  • 19. Bronchodilators โ€ข There are two main types of bronchodilators: o Beta- agonists: These medications work by mimicking the effects of adrenaline. o Anticholinergi cs: These medications work by blocking the effects of acetylcholine, a neurotransmit ter that causes the airways to constrict.
  • 21. Pulmonary rehabilitation : Exercise training and education program to improve quality of life.
  • 22. Emphysema Prevention โ€ข Smoking cessation: The most effective prevention measure. โ€ข Immunizations: Vac cination against respiratory infections. โ€ข Regular monitoring: Early detection and management of symptoms. โ€ข Physical activity: Improves lung function and overall health.