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Unit-8 (EMBRYOLOGY)
Topic - General embryology
Course Instructors –
Dr. S.K.Gupta
Dr. S.K.Karmore
Dr. Alka Suman
Nanaji Deshmukh Veterinary Science, University, Jabalpur
College Of Veterinary Science And A.H. , Mhow
Department of Veterinary Anatomy and Histology
Embryology
 The study of developmental events that occur during the prenatal
stage.
 The branch of biology concerned with the study ofembryos
and their development.
Ontogeny: all the developmental events that occur during the
existence of a living organism
Phylogeny: it pertains to the evolutionary history or development
of a group of organisms, such as a tribe or a racial group.
Phylogeny vs. ontogeny
 Both phylogeny and ontogeny deals with the origin and the
development of organisms. They are both concerned with the
developmental histories. However, ontogeny is different from
phylogeny in a way that it looks through the historical
development of an organism within its own timeline (e.g. from its
simplest to the most complex form) and not on its evolutionary
history. Thus, ontogeny is to the development of an individual
organism as phylogeny is to the evolution of a species.
BRANCHES OF EMBRYOLOGY-
 1. DESCRIPTIVE EMBRYOLOGY: This field of embryology is associated
with the morphological description of different embryonic stages in the
ontogenetic development of individuals of different species. This involves
the initial work of embryologists till 18th century.
 2. COMPARATIVE EMBRYOLOGY: It embraces the comparative study of
embryology of different animal groups.
 3. EXPERIMENTAL EMBRYOLOGY: It involves all those studies that
attempt to understand the various fundamental mechanism in the
development of different animals, like fertilization, Cleavage, Gastrulation,
Embryonic induction, determination and differentiation.
 4. CHEMICAL EMBRYOLOGY: This branch of embryology includes all
those studies which employ various biochemical, biophysical and
physiological techniques for understanding embryological events at
molecular level.
 5. TERATOLOGY: It is the branch of embryology concerned with the study
of malformations or birth defects. The substances that cause birth defects
are called tetratogens. Eg.Phocomalia (poorly developed arms child),
Ectomalia (arm less child)
History of embryology
 Embryonic development has been a source of
wonder…
 Aristotle’s (384-322 B.C.) studies – a shift from
superstitions to observation.
 Galen (130-200A.D) – learned about advanced fetuses
but the minute dimensions resisted analysis
 De Graaf in 1672 – described ovarian follicle
 Hamm and Leeuwenhoek in 1677 – have seen the
sperm cells
Theory of Preformation
 Spermists - sperm contained new individual in
miniature and only nourished in the ovum
 Ovists- thought the same and that the seminal
fluid only stimulates it.
 Bonnet (1745) – discovered eggs of some insects
undergoing parthenogenesis
 Spallanzani (1729-1799) – demonstrated that
both male and female sex products are
necessary for the initiation of development

Wolff (1733–1794) – thesis on epigenesis
(embryological development occurs through progressive
growth and differentiation)
-Von Baer (1828) – discovered mammalian egg, first
emphasized that the more general basic features of any
animal group appear earlier in the development than
do special features of different members of the group–
Von Baer’s law (Demonstrated existence of germ layers)
-The formulation of cell theory by Matthias
-Schleiden and Theodore Schwann laid down the foundation of
modern embryology as a science.
-Ernst Haeckel (1834 -1919) – drafted the Biogenetic Law of
Muller and Haeckel – Haeckel’s Law of Recapitulation
Ontogeny recapitulates phylogeny Eg.Tail in vertebrates
Embryonic period vs. Foetal period in cattle
 Embryonic – first 2 months Development of the
three primary germ layers give rise to all
structures and Basic body plan takesshape
 Fetal period – remaining gestation period.
Structures and organs continue to grow and
develop.
Stages of Development
Embryogenesis
1. Fertilization
2. Cleavage
3.Gastrulation
4.Organogenesis
5.Maturation
Fertilization:
 The process of fusion or union of the spermatozoon with the
matureovum is known as conception /fertilizaiton/
impregnantation.
 Which produced the fertilized single mono-nucleated
cell called thezygote.
Embryogenesis: Theformation and development of anembryo.
1. Cleavage: is a series of rapidmitotic divisions (without
cellgrowth)
2.Gastrulation : is a phase early in the embryonic development
of most animals/human being, during which the single-
layered blastula is reorganized into a trilaminar ("three-
layered") structure known as thegastrula. These threegerm
layers are known as the ectoderm, mesoderm,and endoderm.
3. Organogenesis: The production and developmentof the
organs of an animal.
Events of Fertilization:
 1. Attraction
 2. Penitration
 3. Conjugation
How fertilization occurs..?
 Following ovulation, the ovum is picked up by the tubal fimbriae
and is moved along by theciliaand by peristaltic movementof the
tube.
 At the time the cervix under the influence of estrogen, secretes a
flow of alkaline mucus that deposited in the vagina, only
thousands capacitated spermatozoa enter the uterine tube while
300-500 reach theovum, and remainderaredestroyed by theacid
medium of thevagina.
 It takes about1 hour for sperm to reach thesite.
 The sperm release the enzyme, Hylluronidase which
allows penetration of the zona pellucidaand the cell
membrane surrounding theovum.
 Many sperm are needed for this to take place but only
onewill enter theovum.
 Afterthis the membrane is sealed to prevententry of
any further sperm and the nucluei of the two cell fuse.
 The sperm and ovum contribute half (n) the
complement of chromosomes to make a diploid
number (2n).
 The sperm (n) and ovum (n) is known as the male and
female gametes and the fertilizedovum as thezygote
(2n)
. Fertilization
 Normal site for Conception..?
 The most common site of conception is the ampullary part
(Ampulla ) of the fallopian tubewhich is thewidest part
located closed to theovary
 The sex of the new individual at the time of conception is
determined by sexchromosomes.
 Every cattle cell contains 60 chromosomes, which are made
up of 58 autosomechromosome and 2 sexchromosomes.
 Thesexchromosome areX and Y .
 Woman have noYchromosome and male has Y chromosome
(male 58+X+Y) (female58+X+X).
 There for e, in mammals sex of young one isalways
determined by Sire (While reverse is found in case of Birds)
Development of fertilized ovum/Zygote
Morula:
1. After fertilization, the Zygote divides into 2 cells
(blastomere) (mitosis division)in about 30 hours
after fertilization.
2. The blastomeres continue to divide by binary
division through 4, 8, and 16 cell stage until a
cluster of cells is formed– Morula,resemblibg
a mulberry
3. The morula after spending about 3 days(72
hours) in the uterine tube enters the uterine
cavity through the narrow uterine ostium
(1mm) on the 4th day
Morula
Morula
Blastocyst:
 Morula, once entering the uterine cavity, floats
freely(next 2 days) and is covered byendometrial
fluid and mucus.
 This fluid is absorbed through the canaliculi ofthe
zona pellucida and Morula begins toaccumulate
fluid and forms a cavity between its cells.
 Oncecavityappears, it is now called a blastocyst.
Blastocyst
 The zona pellucida
becomes stretched, thinned
and gradually disappear
soon prior toimplantation.
 The cell of the outer cell
mass forms the wall of the
blastocyst and is knownas
trophoblast.
 The inner cell massis
concerned with the
development of the
embryo.
Two Distinct Cell Types
1. Trophoblasts – will form theinvading
placenta
2. Innercell mass – will form theembryo
Trophoblasts
Blastocyst
Trophoblast Inner cellmass
Placenta Chorion Fetus Amnion umbilicalcord
DEVELOPMENT OF PLACENTA
From zygote to the placenta formation
DEVELOPMENT OF PLACENTA
➢The placenta is a foetomaternal composite structure
formed by the association of embryo and extra embryonic
membrane with uterine tissue for exchange of food
materials , oxygen and waste materials
➢Placenta develops from two sources:
Foetal part– From chorio-allantoic membrane
Maternal part– From Endometrium(decidua basils)
➢Placenta begins to develop upon implantation of the
blastocyst into the maternal endometrium (That means
development of placenta starts when blastocyst attached to
the endometrium)
➢Once blastocyst is embeded in the endometrial wall,
endometrium changed into Decidua and secretory activity
of endometrium started, glycogen and lipids are stored and
vacuole appear into the stroma
➢Placenta grows throughout the pregnancy
Decidua
➢ Decidua (cells loaded with lipid
and glycogen) is the term for the
uterine lining (endometrium)
during a pregnancy (endometrium
changes into functional part
which is more vascular and more
functional called decidua)
➢ Three layer:
1. Decidua basalis : where the
implantation takes place and the
basal plate is formed
2. Decidua capsularis : lies like a
capsule around chorion
3. Decidua Parietalis/vera : on the
opposite uterus wall
1.
2.
3.
Implantation
➢ The embryo along with extra-embryonic membranes are called
Conceptus and attachment of conceptus to the endometrium is
Implantation
➢ Implantation occur in three phases:
Apposition
Adhesion and
Attachment
➢ Embryo got nourishment in uterine tube by its own yolk and
secretion from oviducts
➢ In uterus embryo derive nutrition from uterine fluid , uterine fluid
consists of cellular debries, extravasated poly-morphonucleocutes
and secretion of endometrial gland called uterine milk (histotrophs)
➢ Implantation is slow and gradual process in domestic animals
➢ There is marked species difference in time of implantation, gestation
period and litter size
Species
Time of
implantation (in
days)
Gestation
period
(in days)
Litter size
(numbers)
Cow 28-35 282
(277-290)
01
Ewe 17-20 148
(144-152)
1-2
Sow 17-24 114
(110-116)
08-12
Mare 49-70 338
(330-345)
01
Bitch 14-21 61
(58-64)
06-10
Cat 14-21 64
(60-68)
04
Types of Implantation
➢ Three types of Implantation:
1. Superficial/Centric: The
chorionic vesicle remain
within uterine cavity and
expands to fill its lumen
Ex. Domestic Animals
2. Eccentric : The chorionic
vesicle become partially
embedded in pockets of the
uterine wall
Ex. Rat , Squirrel
3. Interstitial: The blastocyst
penetrate into the wall of
uterus and develops there
until parturition
Ex. Primates
1. 2. 3.
Implantation
➢ At the time of implantation Zona pellucida becomes disappear
➢ The trophoblastic layer differentiates into two parts:
Inner layer - Cytotrophoblast
Outer layer - Syncytotrophoblast
➢ Syncytotrophoblast proliferates into multilayered, multinucleated
protoplasmic mass
➢ Cytotrophoblast differentiates into layer of primary mesoderm
Primary
mesoderm
Cytotophoblast Syncytotrophoblast
CHORION
➢ Inside syncytotrophoblast a number of lacunar spaces appear
and syncytial cells form cords between the lacunar space, called
Trabeculae
➢ Cords of cytotrophoblast invade the trabeculae and convert into
Primary chorionic villi , lacunar space are now called
intervillous space
➢ Primary chorionic villi are transformed into Secondary chorionic
villi when primary mesodermic layer invade into the primary villi
➢ Secondary villi are transformed into Tertiary villi when the foetal
blood vessels appear within primary mesoderm and their
branches project into secondary villi
➢ Later on within primary mesoderm vacuoles are appeared
subsequently they coalase to form extra-embryonic coelome
between amniotic cavity and primary mesoderm
➢ In Birds and in some Farm animals like Cattle, Sheep, Goat
and Pig the allantoic vesicle expands into the extraembryonic
coelom and surrounds the whole amniotic cavity
➢ It occupies the space between the amnion and the chorion
(serosa), the outer wall of amnion fuses with chorion and
therefore forms Chorioallantioic Type of Placenta
➢ The amniotic cavity contains Amniotic fluids within which
embryo becomes float. Amniotic fluid contains salt, water,
protein and sugar . It gives protection to the foetus by
neutralizing shock and pressure. It also acts as lubricants at the
time of birth
➢ At the time of birth the placenta is discarded along with the
amnion and referred as Afterbirth
➢ In Bovines, attachment between maternal and foetal
membranes occur throughout the endometrium of the horn in
the sporadic manner as per distribution of cotyledones
➢ In Sow and Mare the union of chorion and uterine wall is
superficial and their separation at the time of birth without
injury to maternal tissue this type of placenta is called
Deciduate placenta
➢ In Carnivores The villi occupy on the girdle like band around
the middle of chorionic sac
➢ In Humans, The chorionic villi develop rapidly at the
embryonic pole of blastocyst called chorionic frondosum
➢ In Primates The union between foetal and maternal tissue is
so intimate and damage of uterine tissue at the time of birth,
that's why there is extensive bleeding at the time of birth in
primates
➢ Exchange of metabolites occurs directly through foetal and
maternal blood circulation
➢ There is no direct mixing of foetal and maternal blood in
placenta
➢ The chorio-allantoic placenta directly absorb nutrition from
maternal blood is called Haemotrope
➢ Therefore placenta formation (contact between foetal
membrane and endometrium) occurs in various zones which
differs characteristically depending upon the species
THANKS

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Embryology-Part-1 for public health students.pdf

  • 1. Unit-8 (EMBRYOLOGY) Topic - General embryology Course Instructors – Dr. S.K.Gupta Dr. S.K.Karmore Dr. Alka Suman Nanaji Deshmukh Veterinary Science, University, Jabalpur College Of Veterinary Science And A.H. , Mhow Department of Veterinary Anatomy and Histology
  • 2. Embryology  The study of developmental events that occur during the prenatal stage.  The branch of biology concerned with the study ofembryos and their development. Ontogeny: all the developmental events that occur during the existence of a living organism Phylogeny: it pertains to the evolutionary history or development of a group of organisms, such as a tribe or a racial group. Phylogeny vs. ontogeny  Both phylogeny and ontogeny deals with the origin and the development of organisms. They are both concerned with the developmental histories. However, ontogeny is different from phylogeny in a way that it looks through the historical development of an organism within its own timeline (e.g. from its simplest to the most complex form) and not on its evolutionary history. Thus, ontogeny is to the development of an individual organism as phylogeny is to the evolution of a species.
  • 3. BRANCHES OF EMBRYOLOGY-  1. DESCRIPTIVE EMBRYOLOGY: This field of embryology is associated with the morphological description of different embryonic stages in the ontogenetic development of individuals of different species. This involves the initial work of embryologists till 18th century.  2. COMPARATIVE EMBRYOLOGY: It embraces the comparative study of embryology of different animal groups.  3. EXPERIMENTAL EMBRYOLOGY: It involves all those studies that attempt to understand the various fundamental mechanism in the development of different animals, like fertilization, Cleavage, Gastrulation, Embryonic induction, determination and differentiation.  4. CHEMICAL EMBRYOLOGY: This branch of embryology includes all those studies which employ various biochemical, biophysical and physiological techniques for understanding embryological events at molecular level.  5. TERATOLOGY: It is the branch of embryology concerned with the study of malformations or birth defects. The substances that cause birth defects are called tetratogens. Eg.Phocomalia (poorly developed arms child), Ectomalia (arm less child)
  • 4. History of embryology  Embryonic development has been a source of wonder…  Aristotle’s (384-322 B.C.) studies – a shift from superstitions to observation.  Galen (130-200A.D) – learned about advanced fetuses but the minute dimensions resisted analysis  De Graaf in 1672 – described ovarian follicle  Hamm and Leeuwenhoek in 1677 – have seen the sperm cells
  • 5. Theory of Preformation  Spermists - sperm contained new individual in miniature and only nourished in the ovum  Ovists- thought the same and that the seminal fluid only stimulates it.  Bonnet (1745) – discovered eggs of some insects undergoing parthenogenesis  Spallanzani (1729-1799) – demonstrated that both male and female sex products are necessary for the initiation of development
  • 6.  Wolff (1733–1794) – thesis on epigenesis (embryological development occurs through progressive growth and differentiation) -Von Baer (1828) – discovered mammalian egg, first emphasized that the more general basic features of any animal group appear earlier in the development than do special features of different members of the group– Von Baer’s law (Demonstrated existence of germ layers) -The formulation of cell theory by Matthias -Schleiden and Theodore Schwann laid down the foundation of modern embryology as a science. -Ernst Haeckel (1834 -1919) – drafted the Biogenetic Law of Muller and Haeckel – Haeckel’s Law of Recapitulation Ontogeny recapitulates phylogeny Eg.Tail in vertebrates
  • 7. Embryonic period vs. Foetal period in cattle  Embryonic – first 2 months Development of the three primary germ layers give rise to all structures and Basic body plan takesshape  Fetal period – remaining gestation period. Structures and organs continue to grow and develop.
  • 8. Stages of Development Embryogenesis 1. Fertilization 2. Cleavage 3.Gastrulation 4.Organogenesis 5.Maturation
  • 9. Fertilization:  The process of fusion or union of the spermatozoon with the matureovum is known as conception /fertilizaiton/ impregnantation.  Which produced the fertilized single mono-nucleated cell called thezygote. Embryogenesis: Theformation and development of anembryo. 1. Cleavage: is a series of rapidmitotic divisions (without cellgrowth) 2.Gastrulation : is a phase early in the embryonic development of most animals/human being, during which the single- layered blastula is reorganized into a trilaminar ("three- layered") structure known as thegastrula. These threegerm layers are known as the ectoderm, mesoderm,and endoderm. 3. Organogenesis: The production and developmentof the organs of an animal.
  • 10. Events of Fertilization:  1. Attraction  2. Penitration  3. Conjugation How fertilization occurs..?  Following ovulation, the ovum is picked up by the tubal fimbriae and is moved along by theciliaand by peristaltic movementof the tube.  At the time the cervix under the influence of estrogen, secretes a flow of alkaline mucus that deposited in the vagina, only thousands capacitated spermatozoa enter the uterine tube while 300-500 reach theovum, and remainderaredestroyed by theacid medium of thevagina.  It takes about1 hour for sperm to reach thesite.
  • 11.  The sperm release the enzyme, Hylluronidase which allows penetration of the zona pellucidaand the cell membrane surrounding theovum.  Many sperm are needed for this to take place but only onewill enter theovum.  Afterthis the membrane is sealed to prevententry of any further sperm and the nucluei of the two cell fuse.  The sperm and ovum contribute half (n) the complement of chromosomes to make a diploid number (2n).  The sperm (n) and ovum (n) is known as the male and female gametes and the fertilizedovum as thezygote (2n)
  • 13.  Normal site for Conception..?  The most common site of conception is the ampullary part (Ampulla ) of the fallopian tubewhich is thewidest part located closed to theovary  The sex of the new individual at the time of conception is determined by sexchromosomes.  Every cattle cell contains 60 chromosomes, which are made up of 58 autosomechromosome and 2 sexchromosomes.  Thesexchromosome areX and Y .  Woman have noYchromosome and male has Y chromosome (male 58+X+Y) (female58+X+X).  There for e, in mammals sex of young one isalways determined by Sire (While reverse is found in case of Birds)
  • 14. Development of fertilized ovum/Zygote Morula: 1. After fertilization, the Zygote divides into 2 cells (blastomere) (mitosis division)in about 30 hours after fertilization. 2. The blastomeres continue to divide by binary division through 4, 8, and 16 cell stage until a cluster of cells is formed– Morula,resemblibg a mulberry 3. The morula after spending about 3 days(72 hours) in the uterine tube enters the uterine cavity through the narrow uterine ostium (1mm) on the 4th day
  • 16. Blastocyst:  Morula, once entering the uterine cavity, floats freely(next 2 days) and is covered byendometrial fluid and mucus.  This fluid is absorbed through the canaliculi ofthe zona pellucida and Morula begins toaccumulate fluid and forms a cavity between its cells.  Oncecavityappears, it is now called a blastocyst.
  • 17. Blastocyst  The zona pellucida becomes stretched, thinned and gradually disappear soon prior toimplantation.  The cell of the outer cell mass forms the wall of the blastocyst and is knownas trophoblast.  The inner cell massis concerned with the development of the embryo.
  • 18. Two Distinct Cell Types 1. Trophoblasts – will form theinvading placenta 2. Innercell mass – will form theembryo Trophoblasts
  • 19. Blastocyst Trophoblast Inner cellmass Placenta Chorion Fetus Amnion umbilicalcord
  • 20. DEVELOPMENT OF PLACENTA From zygote to the placenta formation
  • 21. DEVELOPMENT OF PLACENTA ➢The placenta is a foetomaternal composite structure formed by the association of embryo and extra embryonic membrane with uterine tissue for exchange of food materials , oxygen and waste materials ➢Placenta develops from two sources: Foetal part– From chorio-allantoic membrane Maternal part– From Endometrium(decidua basils) ➢Placenta begins to develop upon implantation of the blastocyst into the maternal endometrium (That means development of placenta starts when blastocyst attached to the endometrium) ➢Once blastocyst is embeded in the endometrial wall, endometrium changed into Decidua and secretory activity of endometrium started, glycogen and lipids are stored and vacuole appear into the stroma ➢Placenta grows throughout the pregnancy
  • 22. Decidua ➢ Decidua (cells loaded with lipid and glycogen) is the term for the uterine lining (endometrium) during a pregnancy (endometrium changes into functional part which is more vascular and more functional called decidua) ➢ Three layer: 1. Decidua basalis : where the implantation takes place and the basal plate is formed 2. Decidua capsularis : lies like a capsule around chorion 3. Decidua Parietalis/vera : on the opposite uterus wall 1. 2. 3.
  • 23. Implantation ➢ The embryo along with extra-embryonic membranes are called Conceptus and attachment of conceptus to the endometrium is Implantation ➢ Implantation occur in three phases: Apposition Adhesion and Attachment ➢ Embryo got nourishment in uterine tube by its own yolk and secretion from oviducts ➢ In uterus embryo derive nutrition from uterine fluid , uterine fluid consists of cellular debries, extravasated poly-morphonucleocutes and secretion of endometrial gland called uterine milk (histotrophs) ➢ Implantation is slow and gradual process in domestic animals ➢ There is marked species difference in time of implantation, gestation period and litter size
  • 24. Species Time of implantation (in days) Gestation period (in days) Litter size (numbers) Cow 28-35 282 (277-290) 01 Ewe 17-20 148 (144-152) 1-2 Sow 17-24 114 (110-116) 08-12 Mare 49-70 338 (330-345) 01 Bitch 14-21 61 (58-64) 06-10 Cat 14-21 64 (60-68) 04
  • 25. Types of Implantation ➢ Three types of Implantation: 1. Superficial/Centric: The chorionic vesicle remain within uterine cavity and expands to fill its lumen Ex. Domestic Animals 2. Eccentric : The chorionic vesicle become partially embedded in pockets of the uterine wall Ex. Rat , Squirrel 3. Interstitial: The blastocyst penetrate into the wall of uterus and develops there until parturition Ex. Primates 1. 2. 3.
  • 27. ➢ At the time of implantation Zona pellucida becomes disappear ➢ The trophoblastic layer differentiates into two parts: Inner layer - Cytotrophoblast Outer layer - Syncytotrophoblast ➢ Syncytotrophoblast proliferates into multilayered, multinucleated protoplasmic mass ➢ Cytotrophoblast differentiates into layer of primary mesoderm Primary mesoderm Cytotophoblast Syncytotrophoblast CHORION
  • 28. ➢ Inside syncytotrophoblast a number of lacunar spaces appear and syncytial cells form cords between the lacunar space, called Trabeculae ➢ Cords of cytotrophoblast invade the trabeculae and convert into Primary chorionic villi , lacunar space are now called intervillous space ➢ Primary chorionic villi are transformed into Secondary chorionic villi when primary mesodermic layer invade into the primary villi ➢ Secondary villi are transformed into Tertiary villi when the foetal blood vessels appear within primary mesoderm and their branches project into secondary villi ➢ Later on within primary mesoderm vacuoles are appeared subsequently they coalase to form extra-embryonic coelome between amniotic cavity and primary mesoderm
  • 29.
  • 30.
  • 31.
  • 32. ➢ In Birds and in some Farm animals like Cattle, Sheep, Goat and Pig the allantoic vesicle expands into the extraembryonic coelom and surrounds the whole amniotic cavity ➢ It occupies the space between the amnion and the chorion (serosa), the outer wall of amnion fuses with chorion and therefore forms Chorioallantioic Type of Placenta ➢ The amniotic cavity contains Amniotic fluids within which embryo becomes float. Amniotic fluid contains salt, water, protein and sugar . It gives protection to the foetus by neutralizing shock and pressure. It also acts as lubricants at the time of birth ➢ At the time of birth the placenta is discarded along with the amnion and referred as Afterbirth
  • 33. ➢ In Bovines, attachment between maternal and foetal membranes occur throughout the endometrium of the horn in the sporadic manner as per distribution of cotyledones ➢ In Sow and Mare the union of chorion and uterine wall is superficial and their separation at the time of birth without injury to maternal tissue this type of placenta is called Deciduate placenta ➢ In Carnivores The villi occupy on the girdle like band around the middle of chorionic sac ➢ In Humans, The chorionic villi develop rapidly at the embryonic pole of blastocyst called chorionic frondosum ➢ In Primates The union between foetal and maternal tissue is so intimate and damage of uterine tissue at the time of birth, that's why there is extensive bleeding at the time of birth in primates
  • 34. ➢ Exchange of metabolites occurs directly through foetal and maternal blood circulation ➢ There is no direct mixing of foetal and maternal blood in placenta ➢ The chorio-allantoic placenta directly absorb nutrition from maternal blood is called Haemotrope ➢ Therefore placenta formation (contact between foetal membrane and endometrium) occurs in various zones which differs characteristically depending upon the species THANKS