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Electrolytes
This document discusses electrolyte imbalances, including causes, signs and symptoms, and treatment approaches. It covers the major electrolytes: sodium, potassium, calcium, magnesium, and their roles in the body. Key points include how electrolytes are involved in neuromuscular function, acid-base balance, and fluid distribution. Electrolyte imbalances like hyponatremia, hyperkalemia, hypocalcemia and hypomagnesemia are described in terms of their definitions, causes, and clinical manifestations that clinicians should look for as well as treatment goals.
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Electrolytes
- 1.
- 2. Objectives • Electrolytes –Cations & Anions • Functions – Electrolytes • Electrolyte Imbalances – You See & You Do
- 3. Electrolytes • Charged particlesin solution • Cations (+) • Anions (-) • Integral part of metabolic and cellular processes
- 5. Composition of BodyFluidsComposition of Body Fluids
- 6. Major Cations • EXTRACELLULAR –SODIUM (Na+) • INTRACELLULAR – POTASSIUM (K+)
- 7. What do Electrolytes- Do? • Promotes neuromuscular impulses. • Maintain body fluid volume & Osmolarity. • Distribute body water between fluid compartments. • Regulate acid base balance.
- 8. Electrolyte Imbalances • Hyponatremia/ Hypernatremia •Hypokalemia/ Hyperkalemia • Hypomagnesemia/ Hypermagnesemia • Hypocalcemia/ Hypercalcemia • Hypophosphatemia/ Hyperphosphatemia • Hypochloremia/ Hyperchloremia
- 9. Hyponatremia • Serum Na+level < 135 mEq/L • Deficiency in Na+ related to amount of body fluid • Several types – Dilutional – Depletional – Hypovolemic – Hypervolemic – Isovolemic
- 10. Surgical Causes -Hyponatremia • Intestinal obstruction • Intestinal fistulas – biliary / duodenal / gastric / pancreatic • GOO – severe vomiting • Ryle’s tube aspiration • Severe diarrhoea – Colitis / colerectal polyps • After surgery & trauma – occurs
- 11. What Do YouSee ? • Sunken eyes, Dry coated tongue, poor skin turgor • Headache, N/V, muscle twitching, altered mental status • Irritability, neurological symptoms, convulsions , coma
- 12. What Do WeDo? • MILD / CHRONIC CASE – Na < 115 mEq/ L – Restrict fluid intake for hyper/isovolemic hyponatremia – IV fluids and/or increased Na+ intake for hypovolemic hyponatremia • SEVERE / ACUTE CASE – Na < 100 mEq/L – Infuse hypertonic NaCl solution (3% or 5% NaCl) – Frusemide to remove excess fluid – Monitor client in ICU
- 13. Hypernatremia • Excess Na+relative to body water • Occurs less often than hyponatremia • Na > 150 mEq / L • When hypernatremia occurs, fluid shifts outside the cells • May be caused by water deficit or over- ingestion of Na+ - Renal dysfuction • Also may result from diabetes insipidus, Cardiac failure, Drug – NSAID / Steroids
- 14. What Do YouSee ? • Think S-A-L-T Skin flushed Agitation Low grade fever Thirst • Neurological symptoms • Signs of hypovolemia Firm,
- 15. What Do WeDo? • Correct underlying disorder • Restrict saline & sodium • Gradual / Slow fluid replacement • Monitor for s/s of cerebral edema • Monitor serum Na+ level • Seizure precautions
- 16. Potassium • Major intracellularcation • Untreated changes in K+ levels can lead to serious neuromuscular and cardiac problems • Normal K+ levels = 3.5 - 5 mEq/L
- 17. Balancing Potassium • MostK+ ingested is excreted by the kidneys • Three other influential factors in K+ balance : – Na+/K+ pump – Renal regulation – pH level
- 18. Hypokalemia • Serum K+< 3.5 mEq/L • Caused by – • SUDDEN = Pts in Diabetic coma • GRADUAL – Diarrhoea – Villous+UC – PS + GOO – Duodenal fistula – Ileostomy / USD – Poisoning – Beta agonists
- 19. What Do YouSee? • Think S-U-C-T-I-O-N – Skeletal muscle weakness / Slurred speech – U wave (ECG changes) - Arrythmias – Constipation, ileus – Tone – Hypotonia = Sign – I rregular, weak pulse – O rthostatic hypotension – N umbness (paresthesias)
- 20.
- 21. What Do WeDo? • Increase dietary K+ • Oral KCl supplements • IV K+ replacement • Change to K+-sparing diuretic • Monitor ECG changes
- 22. IV K+ Replacement •Mix well when adding to an IV solution bag • Concentrations should not exceed 40-60 mEq/L • Rates usually 10- 20 mEq/hr NEVER GIVE IVNEVER GIVE IV PUSHPUSH POTASSIUMPOTASSIUM
- 23. Hyperkalemia • Serum K+> 6 mEq/L • Less common than hypokalemia • Caused by altered kidney function, increased intake (salt substitutes), blood transfusions, meds (K+-sparing diuretics), cell death (trauma)
- 24. What Do YouSee? • Irritability • Paresthesia • Muscle weakness (especially legs) • ECG changes (tented / peak T wave) • Irregular pulse • Hypotension • Nausea, abdominal cramps, diarrohea
- 26. What Do WeDo? • Mild – Loop diuretics (Lasix) – Dietary restriction • Moderate – Cation-exchange resin such as Kayexalate (act by exchanging the cations in the resin for the potassium in the intestine) potassium is then excreted in the stool • Emergency – 10% calcium gluconate for cardiac effects – Sodium bicarbonate for acidosis
- 27. Calcium • 99% inbones, 1% in serum and soft tissue (measured by serum Ca++) • Works with phosphorus to form bones and teeth • Role in cell membrane permeability • Affects cardiac muscle contraction • Participates in blood clotting • Normal value 8.5 – 10.5 mg/dl
- 28. Hypocalcemia • Serum calcium< 8.9 mg/dl • Caused by inadequate intake, malabsorption, pancreatitis, thyroid or parathyroid surgery, loop diuretics, low magnesium levels
- 29. What Do YouSee? • Neuromuscular – Anxiety, confusion, irritability, muscle twitching, paresthesias (mouth, fingers, toes), tetany, carpopedal spasms • Fractures • Diarrohea • Diminished response to digoxin • EKG changes
- 30. TESTS USED TOELICIT SIGNS OF CALCIUM DEFICIENCYTESTS USED TO ELICIT SIGNS OF CALCIUM DEFICIENCY
- 32. What Do WeDo? • Calcium gluconate for postop thyroid or parathyroid client • Cardiac monitoring • Oral or IV calcium replacement
- 33. Hypercalcemia • Serum calcium> 10.1 mg/dl • Two major causes – Cancer – Hyperparathyroidism
- 34. What Do YouSee? • Fatigue, confusion, lethargy, coma • Muscle weakness, hyporeflexia • Bradycardia ⇒ cardiac arrest • Anorexia, nausea/vomiting, decreased bowel sounds, constipation • Polyuria, renal calculi, renal failure
- 35. CLINICAL MANIFESTATIONS OFHYPERCALCEMIACLINICAL MANIFESTATIONS OF HYPERCALCEMIA Decreased GIDecreased GI MotilityMotility Cardiac DysrhythmiasCardiac Dysrhythmias ConstipationConstipation NauseaNausea Mental status changes:Mental status changes: lethargy, confusion,lethargy, confusion, memory lossmemory loss
- 36. CLINICAL MANIFESTATIONS OFHYPERCALCEMIACLINICAL MANIFESTATIONS OF HYPERCALCEMIA ImmobilizationImmobilization BoneBone DemineralizationDemineralization CalciumCalcium accumulates inaccumulates in the ECF andthe ECF and passes throughpasses through the kidneysthe kidneys Ca PrecipitationCa PrecipitationCalcium StonesCalcium Stones
- 37. What Do WeDo? • If asymptomatic, treat underlying cause • Hydrate the patient to encourage diuresis • Loop diuretics • Corticosteroids
- 38. Magnesium • Cofactor formany enzymes – ATP utilisation in muscle fiber • Role in protein synthesis & carbohydrate metabolism • Helps cardiovascular system function (vasodilation) • Regulates muscle contractions
- 39. Hypomagnesemia • Serum Mg++level < 1.5 mEq/L • Caused by poor dietary intake, poor GI absorption, excessive GI/urinary losses • High risk clients – Chronic alcoholism – Malabsorption – GI/urinary system disorders – Sepsis – Burns – Wounds needing debridement
- 40. What Do YouSee? • CNS –Altered LOC –Confusion –Hallucinations • Neuromuscular – Muscle weakness – Leg/foot cramps – Hyper DTRs – Tetany
- 41. CLINICAL MANIFESTATIONS OFHYPOMAGNESEMIACLINICAL MANIFESTATIONS OF HYPOMAGNESEMIA CONFUSIONCONFUSION DEPRESSIONDEPRESSION CRAMPSCRAMPS TETANYTETANY CONVULSIONSCONVULSIONS
- 42. What Do YouSee? • Cardiovascular –Tachycardia –Hypertension –ECG changes • Gastrointestinal –Dysphagia –Anorexia –Nausea/vomiting
- 43. What Do WeDo? • Mild – Dietary replacement • Severe – IV or IM magnesium sulfate • Monitor – Neuro status – Cardiac status – Safety
- 44. Mag Sulfate Infusion •Use infusion pump - no faster than 150 mg/min • Monitor vital signs for hypotension and respiratory distress • Monitor serum Mg++ level q6h • Cardiac monitoring • Calcium gluconate as an antidote for overdosage
- 45. Hypermagnesemia • Serum Mg++level > 2.5 mEq/L • Not common • Renal dysfunction is most common cause – Renal failure – Addison’s disease – Adrenocortical insufficiency – Untreated DKA
- 46. What Do YouSee? • Decreased neuromuscular activity • Hypoactive DTRs • Generalized weakness • Occasionally nausea/vomiting
- 47. What Do WeDo? • Increased fluids if renal function normal • Loop diuretic if no response to fluids • Calcium gluconate for toxicity • Mechanical ventilation for respiratory depression • Hemodialysis (Mg++-free dialysate)
Editor's Notes
- #6 Deficit: abnormal losses through skin, anorexia third spacing, nausea, Excessive sweating, inability to access fluids, polyuria, impaired swallowing, Fever, confusion, NG suction, depression, bleeding, prolonged rapid respiration, Vomiting, diarrhea symptomatology: decreased BP, pulse, urine output &lt;30 ml/ hour, decreased skin turgor, dry mucus membranes, sunken eyeballs, hemoconcentration, elevated temperature, concentrated urine weakness, confusion. Excess:, It can occur because of A. Excessive intake Na Cl B. rapid administration of sodium rich infusions, C. disease that impair regulatory mechanisms, like renal failure, congestive heart failure Symptomatology: weight gain &gt; 2lbs in 24 hours, elevated BP, full bounding pulses, moist, labored respirations, large volume of pale urine, pitting edema, crackles, Auscultate in lungs, dyspnea, distended jugular veins