The cell membrane is a barrier that protects cells and regulates what passes in and out. It is made of a phospholipid bilayer with embedded proteins. Phospholipids are amphipathic molecules with a hydrophobic tail and hydrophilic head. Embedded proteins also have hydrophilic and hydrophobic regions that allow selective permeability. The cell membrane uses passive and active transport. Passive transport relies on diffusion and does not require energy. Active transport, like the sodium-potassium pump, moves molecules against gradients and requires ATP.