Ectodomain
•Download as PPTX, PDF•
0 likes•170 views
The study examined whether ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is regulated through oligomerization. The researchers found that these processes are not regulated by oligomerization of Notch proteins in mammals.
Report
Share
Report
Share
Recommended
The Biological and environmental causes of Developmental Disabilities
This document summarizes key concepts in human reproduction including heredity, chromosomes, DNA, genes, and genetic principles like dominance and polygenic inheritance. It describes gametes, meiosis, fertilization, and the zygote. It outlines the three phases of prenatal development - the germinal phase, embryonic phase, and fetal phase. During each phase, critical developmental processes occur and abnormalities can arise from genetic or environmental factors and lead to developmental disabilities.
Spedreportipyang 151006062355-lva1-app6891
This document summarizes key concepts in human reproduction including heredity, chromosomes, DNA, genes, genetic principles of dominance-recessive and sex-linked genes. It describes meiosis, fertilization which results in a zygote, and the three phases of prenatal development: germinal phase involving cell division and implantation; embryonic phase of cell differentiation and organogenesis; and fetal phase of growth over seven months. Critical periods of vulnerability to teratogens are noted where genetic disorders, physical abnormalities or developmental disabilities can occur.
Genetic control of animal development
- Animal development is defined as the progressive changes in size, shape, and function that occur during an organism's life through which its genetic potential is translated into mature systems.
- Maternal genes play a major role in early development by providing nutritive and determinative materials to the egg during oogenesis, organizing the egg for subsequent development. Mutations in these maternal effect genes can impact offspring viability without affecting the mother.
- After fertilization, zygotic gene expression begins from the embryo genome, directing cell differentiation and organ formation under genetic control. Homeotic genes determine body segmentation by transforming one segment into another.
Determination of sex
This document discusses several methods for determining the sex of individuals, both living and deceased. It outlines that sex determination is important for identification, inheritance, marriage/divorce, and legal cases. Common methods include examining general appearance, secondary sex characteristics, gonads, nuclear structures like Barr bodies and Davidson bodies, and skeletal features after decomposition. Intersex conditions that involve mixed male and female characteristics are also discussed. Determining sex can be done by examining external genitalia, gonads, menstruation history, and skeletal features such as the pelvis.
Genetics in orthodontics
Molecular basis of inheritance, Patterns of genetic transmission, Gene mutation, structure of chromosome, chromosomes in Man, Genetic disorders, Numerical disorders, structural disorder, Genetics in an orthodontic perspective, Butler's field theory, methods of studying role of genes.
Child develpment, chapter 3, Caprice Paduano
This chapter discusses child development from a genetic and prenatal perspective. It covers topics like fertilization and the stages of prenatal development, the role of genes and chromosomes in heredity, genetic disorders, the interaction between nature and nurture, and threats to healthy prenatal development like maternal diet and environmental factors. The chapter aims to explain how genetics and the prenatal environment work together to influence human growth and characteristics.
Birth & reproductive developmental process
The document discusses reproduction and development across several species, including topics like fertilization, cell division, embryology, gametes, cleavage, gastrulation, induction, protostomes, deuterostomes, and the biogenetic law. It also covers reproduction systems in vertebrates like the role of hormones in development and the male and female reproductive systems. Finally, it discusses fetal development in humans, reproduction in bony fish and invertebrates like flatworms, and cites several references.
Epigenetics
Epigenetics refers to modifications that occur on top of genes in response to environmental factors like diet and stress. These modifications involve chemical tags that can turn genes on or off without altering the underlying genetic code. Studies show these epigenetic tags can be inherited from parents and influence stress response and tolerance in offspring. The environment can thus change our genes across generations through epigenetic mechanisms.
Recommended
The Biological and environmental causes of Developmental Disabilities
This document summarizes key concepts in human reproduction including heredity, chromosomes, DNA, genes, and genetic principles like dominance and polygenic inheritance. It describes gametes, meiosis, fertilization, and the zygote. It outlines the three phases of prenatal development - the germinal phase, embryonic phase, and fetal phase. During each phase, critical developmental processes occur and abnormalities can arise from genetic or environmental factors and lead to developmental disabilities.
Spedreportipyang 151006062355-lva1-app6891
This document summarizes key concepts in human reproduction including heredity, chromosomes, DNA, genes, genetic principles of dominance-recessive and sex-linked genes. It describes meiosis, fertilization which results in a zygote, and the three phases of prenatal development: germinal phase involving cell division and implantation; embryonic phase of cell differentiation and organogenesis; and fetal phase of growth over seven months. Critical periods of vulnerability to teratogens are noted where genetic disorders, physical abnormalities or developmental disabilities can occur.
Genetic control of animal development
- Animal development is defined as the progressive changes in size, shape, and function that occur during an organism's life through which its genetic potential is translated into mature systems.
- Maternal genes play a major role in early development by providing nutritive and determinative materials to the egg during oogenesis, organizing the egg for subsequent development. Mutations in these maternal effect genes can impact offspring viability without affecting the mother.
- After fertilization, zygotic gene expression begins from the embryo genome, directing cell differentiation and organ formation under genetic control. Homeotic genes determine body segmentation by transforming one segment into another.
Determination of sex
This document discusses several methods for determining the sex of individuals, both living and deceased. It outlines that sex determination is important for identification, inheritance, marriage/divorce, and legal cases. Common methods include examining general appearance, secondary sex characteristics, gonads, nuclear structures like Barr bodies and Davidson bodies, and skeletal features after decomposition. Intersex conditions that involve mixed male and female characteristics are also discussed. Determining sex can be done by examining external genitalia, gonads, menstruation history, and skeletal features such as the pelvis.
Genetics in orthodontics
Molecular basis of inheritance, Patterns of genetic transmission, Gene mutation, structure of chromosome, chromosomes in Man, Genetic disorders, Numerical disorders, structural disorder, Genetics in an orthodontic perspective, Butler's field theory, methods of studying role of genes.
Child develpment, chapter 3, Caprice Paduano
This chapter discusses child development from a genetic and prenatal perspective. It covers topics like fertilization and the stages of prenatal development, the role of genes and chromosomes in heredity, genetic disorders, the interaction between nature and nurture, and threats to healthy prenatal development like maternal diet and environmental factors. The chapter aims to explain how genetics and the prenatal environment work together to influence human growth and characteristics.
Birth & reproductive developmental process
The document discusses reproduction and development across several species, including topics like fertilization, cell division, embryology, gametes, cleavage, gastrulation, induction, protostomes, deuterostomes, and the biogenetic law. It also covers reproduction systems in vertebrates like the role of hormones in development and the male and female reproductive systems. Finally, it discusses fetal development in humans, reproduction in bony fish and invertebrates like flatworms, and cites several references.
Epigenetics
Epigenetics refers to modifications that occur on top of genes in response to environmental factors like diet and stress. These modifications involve chemical tags that can turn genes on or off without altering the underlying genetic code. Studies show these epigenetic tags can be inherited from parents and influence stress response and tolerance in offspring. The environment can thus change our genes across generations through epigenetic mechanisms.
Evolution (1)
There are four major factors that contribute to genetic variation in offspring of sexually reproducing species: mutations, crossing over, random assortment of homologous chromosomes, and random fertilization. An organism's appearance is influenced by both genetic and environmental factors. Adaptations are heritable traits that help organisms survive and pass their genes to offspring. Variation within a population leads to natural selection, where certain traits are selected for and allow organisms to better reproduce in their environment, leading to gradual evolutionary changes over time as new species potentially develop.
Salazar
This document discusses several concepts related to genetics and inheritance patterns:
1. Quantitative or polygenic inheritance involves two or more pairs of non-allelic genes that have a cumulative, additive effect on quantitative traits like height. Environmental factors also influence phenotypic expression.
2. Multiple alleles occupy the same locus and control the same character, with one allele dominant over the others. Examples include eye color in fruit flies and blood groups in humans.
3. Sex determination systems include chromosomal (XX-XY and XX-XO types), genic balance, hormonal influence, and environmental factors determining sex in some species. The chromosomal theory states genes are located on chromosomes that serve as vehicles for gene segregation
Child develpment, chapter 3, paduano
The document summarizes key concepts from a chapter on child development, genetics, and the prenatal environment. It discusses how genetics and the environment interact to influence human traits and characteristics. It covers topics like fertilization, fetal development, inherited disorders, genetic testing, and threats to healthy prenatal development like a mother's diet and age.
Chromosomal theory of heredity. Genetics of a sex
Chromosomal theory of heredity states that chromosomes, not just traits, are inherited. It was developed in 1902 and linked Mendel's work on genes to chromosome behavior. The key points are: chromosomes contain genes and are inherited in pairs from parents; during meiosis homologous chromosomes separate so gametes receive one of each; fertilization restores chromosome pairs. Later, researchers discovered that some genes are linked if on the same chromosome and can be mapped based on recombination rates. Sex chromosomes also carry traits, with mutations on the X chromosome being sex-linked in many species.
Module 9, lesson 3 reproduction3
Sexual reproduction involves two parents and meiosis, resulting in variation among offspring through processes like crossing over and nondisjunction, allowing for more natural selection. Asexual reproduction involves one parent and mitosis, producing identical offspring with less variation and natural selection, but allows reproduction in environments with few organisms. Bacteria can exchange DNA through conjugation, a form of horizontal gene transfer that is a type of sexual reproduction.
Genetics
Genes are sections of DNA that determine characteristics that are inherited from ancestors. Genetics is the study of genes and how they work to pass traits from one generation to the next. Genes provide the instructions for cells to make proteins, which carry out all the functions needed for cells and organisms to survive. Each gene codes for a specific protein, and cells produce more or less of certain proteins as needed to regulate processes or respond to changes.
Epigenetics
Epigenetics refers to factors above genetics that determine which genes are expressed. The epigenome controls which genes are expressed more than others through mechanisms like methyl groups binding to DNA and histone proteins winding DNA more or less tightly. Epigenetic changes can occur throughout life in response to environmental factors like diet, stress, and lifestyle, and some changes can be passed down from parents to children. While scientists originally thought epigenetic tags were removed before reproduction, it is now understood that some tags can be inherited intergenerationally.
Lesson 2 Inheritance And Selection
Brothers and sisters are different because they have different sets of genes. The male and female sex cells are called sperm and egg. Genetic information is stored in DNA located in the nuclei of cells. Fertilization is the meeting and fusion of sperm and egg during sexual reproduction. This allows for the genetic information from both the male and female parents to combine and be passed on to offspring.
Genetic and Evolutionary Roots of Behavior
This document provides an overview of a course on the genetic and evolutionary roots of behavior. It covers several key topics:
1. Genetics including DNA, genes, chromosomes, genetic transmission, and genetic influences on traits.
2. Evolution by natural selection, including concepts like adaptation, mutations, and the focus on proximate and ultimate causes in evolutionary psychology.
3. The genetics and evolution of behavior, exploring topics like behavior genetics, heritability estimates from twin studies, and how both genes and environment influence traits. Specific examples like intelligence and sexuality are discussed.
Environmental Control Sex Determination
Reference
Moeller, Karla T., "Temperature-Dependent Sex Determination in Reptiles". Embryo Project Encyclopedia (2013-02-01). ISSN: 1940-5030
Morjan, Carrie L. 2003. “How Rapidly Can Maternal Behavior Affecting Primary Sex Ratio Evolve in a Reptile with Environmental Sex Determination ?”
Shine, Richard. 1999. “Why Is Sex Determined by Nest Temperature in Many Reptiles?” 14(5): 186–89.
Wapstra, Erik et al. 2006. “Maternal Basking Behavior Determines Offspring Sex in a Viviparous Reptile.” : 230–32.
Bio. Ch. 10
The document discusses sexual reproduction and genetics. It covers meiosis, which reduces chromosome number and involves two divisions. Meiosis produces four haploid cells with half the number of chromosomes. The document also discusses Mendel's experiments with pea plants and his principles of dominance, segregation and independent assortment. It introduces concepts like genes, alleles, genotypes and phenotypes. Punnett squares are used to predict offspring ratios from genetic crosses. The document notes that linked genes on the same chromosome may not assort independently, and polyploidy involves extra sets of chromosomes.
Chromosomal Inheritance
Chromosomes contain genes and determine inheritance patterns. During meiosis, each sex cell receives half the number of chromosomes as somatic cells. Sex chromosomes (X and Y) determine sex, with females usually being XX and males XY. Sex-linked traits are found on the X chromosome and are expressed differently in males versus females. Nondisjunction can result in extra or missing chromosomes, causing conditions like Down syndrome. Sexual determination is based on the number of sex chromosomes, with a single Y resulting in a male phenotype. Modes of inheritance include autosomal dominant, autosomal recessive, and sex-linked traits.
Stem cells
Stem cells can develop into specialized cells and act as a repair system in the body. They are found in embryos, umbilical cords, and fetuses. While stem cell research may help cure diseases, it is controversial because it involves embryos and fetal tissue. Supporters argue it could treat conditions like Parkinson's and heart disease, while opponents believe it amounts to killing embryos or playing God. The document discusses genetic disorders, the human genome project, and arguments for and against stem cell research.
Parthenogenesis, Natural parthenogenesis, Artificial parthenogenesis
Parthenogenesis, Natural parthenogenesis, Artificial parthenogenesis, Significations of parthenogenesis
Hox genes
This document discusses Hox genes, which are homeotic genes that encode transcription factors important for segment identity in animals. It describes two major homeotic gene complexes, ANT-C and BX-C, which determine segment identity in the head/thorax and posterior thorax/abdomen, respectively, in Drosophila. Mutations in these genes can lead to homeosis, where one body part develops with the identity of another part. The document also discusses how Hox genes regulate segment identity through binding DNA in a specific combination, the co-linear expression of Hox genes, and how changes in Hox gene expression have contributed to the evolution of arthropod body plans.
Epigenetics
Epigenetics is the study of changes in gene expression that do not involve changes to the underlying DNA sequence. It involves mechanisms like DNA methylation and histone modification that turn genes on and off. Epigenetic markers can be inherited from parents and influence traits and disease risk. While the genome contains the basic instructions, the epigenome controls which genes are expressed and when. Epigenetic changes may be influenced by environmental factors and can affect health by triggering conditions like cancer.
Psyche Determinants 4
This document discusses several key determinants of human behavior including heredity and environment. It provides details on fertilization, gametes, zygotes, chromosomes, genes, DNA structure, and several chromosome abnormalities such as Down Syndrome, Turner Syndrome, and Klinefelter Syndrome. It also discusses in vitro fertilization, Dolly the sheep who was the first cloned mammal, and some of the history and ethical implications of cloning.
Sex determination
Sex determination is controlled genetically and establishes the development of sexual characteristics in organisms. The presence of XX chromosomes in females and XY chromosomes in males is responsible for sex determination in humans and most mammals. During meiosis, females produce only X-bearing eggs while males produce equal numbers of X- and Y-bearing sperm, leading to a 1:1 sex ratio at fertilization. Fusion of an X-bearing sperm produces a XX zygote that develops as a female, while an Y-bearing sperm combines to create a XY zygote that becomes a male.
Intro. genetics
The document discusses genetics, including terms like alleles, dominant and recessive traits, genotype and phenotype. It describes Gregor Mendel's experiments with pea plants that established the laws of inheritance and segregation of traits. The document also covers sex determination and sex chromosomes, explaining how the presence of an X or Y chromosome determines whether offspring are male or female.
Chapter3
The document discusses several topics related to the influence of nature and nurture on human diversity and development, including:
- Behavioral genetics research on the heritability of traits using twin and adoption studies.
- Evolutionary psychology perspectives on how natural selection may have influenced certain human behaviors and preferences.
- The role of parents, peers, and culture in influencing development through early experiences and socialization across different groups.
- Similarities and differences in areas like gender, temperament, and brain development that have genetic and environmental influences.
W. L. F. Jamaica Sponsors Kit
A Movement To Unify The Global Community / Three (3) Days of Music; Powerful Workshops; Featured Speakers & More / 9th - 11th August
ganzyme PDF.pdf
Granzyme B (GrB) is a protease released by cytotoxic lymphocytes to induce apoptosis. This study found that GrB directly cleaves the Notch1 receptor at multiple sites, disabling its transcriptional activity. Specifically:
1) GrB cleaves Notch1 intracellularly at two distinct aspartic acid residues (Asp1860 and Asp1961), producing 55kDa and 45kDa fragments.
2) GrB cleavage of Notch1 can occur in all subcellular compartments and results in loss of Notch1 transcriptional activity, independent of receptor activation.
3) Cleavage by GrB disables Notch1 function, likely inducing anti-proliferation and cell death signals.
More Related Content
What's hot
Evolution (1)
There are four major factors that contribute to genetic variation in offspring of sexually reproducing species: mutations, crossing over, random assortment of homologous chromosomes, and random fertilization. An organism's appearance is influenced by both genetic and environmental factors. Adaptations are heritable traits that help organisms survive and pass their genes to offspring. Variation within a population leads to natural selection, where certain traits are selected for and allow organisms to better reproduce in their environment, leading to gradual evolutionary changes over time as new species potentially develop.
Salazar
This document discusses several concepts related to genetics and inheritance patterns:
1. Quantitative or polygenic inheritance involves two or more pairs of non-allelic genes that have a cumulative, additive effect on quantitative traits like height. Environmental factors also influence phenotypic expression.
2. Multiple alleles occupy the same locus and control the same character, with one allele dominant over the others. Examples include eye color in fruit flies and blood groups in humans.
3. Sex determination systems include chromosomal (XX-XY and XX-XO types), genic balance, hormonal influence, and environmental factors determining sex in some species. The chromosomal theory states genes are located on chromosomes that serve as vehicles for gene segregation
Child develpment, chapter 3, paduano
The document summarizes key concepts from a chapter on child development, genetics, and the prenatal environment. It discusses how genetics and the environment interact to influence human traits and characteristics. It covers topics like fertilization, fetal development, inherited disorders, genetic testing, and threats to healthy prenatal development like a mother's diet and age.
Chromosomal theory of heredity. Genetics of a sex
Chromosomal theory of heredity states that chromosomes, not just traits, are inherited. It was developed in 1902 and linked Mendel's work on genes to chromosome behavior. The key points are: chromosomes contain genes and are inherited in pairs from parents; during meiosis homologous chromosomes separate so gametes receive one of each; fertilization restores chromosome pairs. Later, researchers discovered that some genes are linked if on the same chromosome and can be mapped based on recombination rates. Sex chromosomes also carry traits, with mutations on the X chromosome being sex-linked in many species.
Module 9, lesson 3 reproduction3
Sexual reproduction involves two parents and meiosis, resulting in variation among offspring through processes like crossing over and nondisjunction, allowing for more natural selection. Asexual reproduction involves one parent and mitosis, producing identical offspring with less variation and natural selection, but allows reproduction in environments with few organisms. Bacteria can exchange DNA through conjugation, a form of horizontal gene transfer that is a type of sexual reproduction.
Genetics
Genes are sections of DNA that determine characteristics that are inherited from ancestors. Genetics is the study of genes and how they work to pass traits from one generation to the next. Genes provide the instructions for cells to make proteins, which carry out all the functions needed for cells and organisms to survive. Each gene codes for a specific protein, and cells produce more or less of certain proteins as needed to regulate processes or respond to changes.
Epigenetics
Epigenetics refers to factors above genetics that determine which genes are expressed. The epigenome controls which genes are expressed more than others through mechanisms like methyl groups binding to DNA and histone proteins winding DNA more or less tightly. Epigenetic changes can occur throughout life in response to environmental factors like diet, stress, and lifestyle, and some changes can be passed down from parents to children. While scientists originally thought epigenetic tags were removed before reproduction, it is now understood that some tags can be inherited intergenerationally.
Lesson 2 Inheritance And Selection
Brothers and sisters are different because they have different sets of genes. The male and female sex cells are called sperm and egg. Genetic information is stored in DNA located in the nuclei of cells. Fertilization is the meeting and fusion of sperm and egg during sexual reproduction. This allows for the genetic information from both the male and female parents to combine and be passed on to offspring.
Genetic and Evolutionary Roots of Behavior
This document provides an overview of a course on the genetic and evolutionary roots of behavior. It covers several key topics:
1. Genetics including DNA, genes, chromosomes, genetic transmission, and genetic influences on traits.
2. Evolution by natural selection, including concepts like adaptation, mutations, and the focus on proximate and ultimate causes in evolutionary psychology.
3. The genetics and evolution of behavior, exploring topics like behavior genetics, heritability estimates from twin studies, and how both genes and environment influence traits. Specific examples like intelligence and sexuality are discussed.
Environmental Control Sex Determination
Reference
Moeller, Karla T., "Temperature-Dependent Sex Determination in Reptiles". Embryo Project Encyclopedia (2013-02-01). ISSN: 1940-5030
Morjan, Carrie L. 2003. “How Rapidly Can Maternal Behavior Affecting Primary Sex Ratio Evolve in a Reptile with Environmental Sex Determination ?”
Shine, Richard. 1999. “Why Is Sex Determined by Nest Temperature in Many Reptiles?” 14(5): 186–89.
Wapstra, Erik et al. 2006. “Maternal Basking Behavior Determines Offspring Sex in a Viviparous Reptile.” : 230–32.
Bio. Ch. 10
The document discusses sexual reproduction and genetics. It covers meiosis, which reduces chromosome number and involves two divisions. Meiosis produces four haploid cells with half the number of chromosomes. The document also discusses Mendel's experiments with pea plants and his principles of dominance, segregation and independent assortment. It introduces concepts like genes, alleles, genotypes and phenotypes. Punnett squares are used to predict offspring ratios from genetic crosses. The document notes that linked genes on the same chromosome may not assort independently, and polyploidy involves extra sets of chromosomes.
Chromosomal Inheritance
Chromosomes contain genes and determine inheritance patterns. During meiosis, each sex cell receives half the number of chromosomes as somatic cells. Sex chromosomes (X and Y) determine sex, with females usually being XX and males XY. Sex-linked traits are found on the X chromosome and are expressed differently in males versus females. Nondisjunction can result in extra or missing chromosomes, causing conditions like Down syndrome. Sexual determination is based on the number of sex chromosomes, with a single Y resulting in a male phenotype. Modes of inheritance include autosomal dominant, autosomal recessive, and sex-linked traits.
Stem cells
Stem cells can develop into specialized cells and act as a repair system in the body. They are found in embryos, umbilical cords, and fetuses. While stem cell research may help cure diseases, it is controversial because it involves embryos and fetal tissue. Supporters argue it could treat conditions like Parkinson's and heart disease, while opponents believe it amounts to killing embryos or playing God. The document discusses genetic disorders, the human genome project, and arguments for and against stem cell research.
Parthenogenesis, Natural parthenogenesis, Artificial parthenogenesis
Parthenogenesis, Natural parthenogenesis, Artificial parthenogenesis, Significations of parthenogenesis
Hox genes
This document discusses Hox genes, which are homeotic genes that encode transcription factors important for segment identity in animals. It describes two major homeotic gene complexes, ANT-C and BX-C, which determine segment identity in the head/thorax and posterior thorax/abdomen, respectively, in Drosophila. Mutations in these genes can lead to homeosis, where one body part develops with the identity of another part. The document also discusses how Hox genes regulate segment identity through binding DNA in a specific combination, the co-linear expression of Hox genes, and how changes in Hox gene expression have contributed to the evolution of arthropod body plans.
Epigenetics
Epigenetics is the study of changes in gene expression that do not involve changes to the underlying DNA sequence. It involves mechanisms like DNA methylation and histone modification that turn genes on and off. Epigenetic markers can be inherited from parents and influence traits and disease risk. While the genome contains the basic instructions, the epigenome controls which genes are expressed and when. Epigenetic changes may be influenced by environmental factors and can affect health by triggering conditions like cancer.
Psyche Determinants 4
This document discusses several key determinants of human behavior including heredity and environment. It provides details on fertilization, gametes, zygotes, chromosomes, genes, DNA structure, and several chromosome abnormalities such as Down Syndrome, Turner Syndrome, and Klinefelter Syndrome. It also discusses in vitro fertilization, Dolly the sheep who was the first cloned mammal, and some of the history and ethical implications of cloning.
Sex determination
Sex determination is controlled genetically and establishes the development of sexual characteristics in organisms. The presence of XX chromosomes in females and XY chromosomes in males is responsible for sex determination in humans and most mammals. During meiosis, females produce only X-bearing eggs while males produce equal numbers of X- and Y-bearing sperm, leading to a 1:1 sex ratio at fertilization. Fusion of an X-bearing sperm produces a XX zygote that develops as a female, while an Y-bearing sperm combines to create a XY zygote that becomes a male.
Intro. genetics
The document discusses genetics, including terms like alleles, dominant and recessive traits, genotype and phenotype. It describes Gregor Mendel's experiments with pea plants that established the laws of inheritance and segregation of traits. The document also covers sex determination and sex chromosomes, explaining how the presence of an X or Y chromosome determines whether offspring are male or female.
Chapter3
The document discusses several topics related to the influence of nature and nurture on human diversity and development, including:
- Behavioral genetics research on the heritability of traits using twin and adoption studies.
- Evolutionary psychology perspectives on how natural selection may have influenced certain human behaviors and preferences.
- The role of parents, peers, and culture in influencing development through early experiences and socialization across different groups.
- Similarities and differences in areas like gender, temperament, and brain development that have genetic and environmental influences.
What's hot (20)
Parthenogenesis, Natural parthenogenesis, Artificial parthenogenesis
Parthenogenesis, Natural parthenogenesis, Artificial parthenogenesis
Viewers also liked
W. L. F. Jamaica Sponsors Kit
A Movement To Unify The Global Community / Three (3) Days of Music; Powerful Workshops; Featured Speakers & More / 9th - 11th August
ganzyme PDF.pdf
Granzyme B (GrB) is a protease released by cytotoxic lymphocytes to induce apoptosis. This study found that GrB directly cleaves the Notch1 receptor at multiple sites, disabling its transcriptional activity. Specifically:
1) GrB cleaves Notch1 intracellularly at two distinct aspartic acid residues (Asp1860 and Asp1961), producing 55kDa and 45kDa fragments.
2) GrB cleavage of Notch1 can occur in all subcellular compartments and results in loss of Notch1 transcriptional activity, independent of receptor activation.
3) Cleavage by GrB disables Notch1 function, likely inducing anti-proliferation and cell death signals.
Gastroenterology PDF.pdf
This document summarizes the role of Notch signaling in intestinal homeostasis and cancer. It discusses:
1) Notch signaling balances intestinal stem cell self-renewal and differentiation, maintaining homeostasis of the intestinal epithelium.
2) In the intestine, stem cells in the crypts fuel continuous production of differentiated cell types that move up the villi. Notch signaling controls this process.
3) Dysregulation of Notch is involved in intestinal cancer, as it controls lateral inhibition between stem cells and their differentiation.
ganzyme PDF.pdf
Granzyme B (GrB) is a protease released by cytotoxic lymphocytes to induce apoptosis in infected or tumor cells. This study found that Notch1, a receptor that regulates cell differentiation and proliferation, is directly cleaved by GrB. GrB cleaves Notch1 intracellularly at two distinct aspartic acid residues, Asp1860 and Asp1961, disabling its transcriptional activity independent of Notch1 activation. GrB cleavage of Notch1 can occur in all subcellular compartments and results in a loss of Notch1 signaling, likely inducing anti-proliferation and cell death signals.
Ectodomain
The study examined whether ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is regulated through oligomerization. The researchers found that these processes are not regulated by oligomerization of Notch proteins in mammals.
Functions
The document discusses Python functions. It explains that functions allow programmers to define reusable blocks of code to perform tasks or operations. It provides examples of defining functions using def, passing parameters to functions, and how each function call creates a new stack frame. It also discusses how functions can return values and the concept that every function in Python returns something, even if it is None.
Handouts lecture slides_lecture6_5
Dictionaries in Python allow keys of any immutable type to reference values. A dictionary is a collection of key-value pairs where values can be accessed by their keys. Keys must be immutable objects like strings, tuples, or integers. Dictionaries are unordered and entries are accessed by key rather than by index.
Control Flow
This document discusses Python control flow and various looping and conditional structures in Python like while loops, if/elif/else statements, and nested blocks. It provides examples of how while loops can execute zero times if the condition is never true, or forever if the condition is never made false. It also discusses why Python uses indentation rather than braces to define blocks and recommends using 4 spaces of indentation.
Alias
The document discusses aliasing in Python programming. It explains that an alias is a second name for a piece of data. It provides examples of how aliasing can cause bugs when working with mutable data like lists, but not with immutable data. It also discusses why Python allows aliasing despite the potential for bugs - for efficiency when working with large data structures and because sometimes in-place updates are desired.
Basics
The document provides an introduction to Python basics, including that Python is an interpreted language with no separate compilation step. It discusses using Python in an interactive shell or by putting commands in a file. Variables are created by use and do not require declaration. Variables can be reassigned different types of values. Functions can be used to convert between types. Numbers in Python include integers, floats, and complex numbers. Arithmetic operations in Python include addition, subtraction, multiplication, and division.
Slicing
The document discusses slicing in Python. It explains that lists, strings, and tuples can be sliced using a range of indices. It provides examples of slicing elements and strings, demonstrating how slicing returns a substring or subsequence. It notes that slicing always creates a new collection, rather than being an alias, so changes to a slice do not affect the original object.
Lists
The document provides an overview of Python lists, including how to create and access list elements using indexes, loop through lists, modify lists by adding, removing, or changing elements, and several common list methods. Key points include: lists allow storing multiple values in a single variable; values can be accessed by index with list[index]; common operations include append() to add elements, sort() and reverse() modify the list in-place, and in tests for membership in a list.
Tuples
The document discusses tuples in Python. It explains that tuples are immutable sequences, like lists but that cannot be changed after creation. It provides examples of creating tuples using parentheses or without parentheses if context is clear. Tuples allow functions to return multiple values, provide a way to swap variable values, and are often used in loops like with the enumerate function.
Strings
This document summarizes key concepts about strings in Python. It explains that strings are sequences of characters that can be indexed and iterated over like lists. Strings are immutable and concatenated using +. Formatting uses % operator. Escape characters represent special characters. Triple quotes allow multi-line strings. Strings have useful methods like upper(), lower(), find(), replace(), etc. that can be chained together.
Libraries
The document discusses Python libraries and modules. It explains that libraries allow for organizing related functions hierarchically and avoiding duplication. Modules create namespaces and allow code reuse through importing. The key Python standard libraries are described, including math for mathematical functions and sys for system functions like getting command line arguments and the Python path. Import statements and conventions are covered for accessing library functionality.
Input and Output
The document discusses various methods for reading data from files in Python, including reading the entire file content into a string, reading the file in chunks, reading one line at a time, and reading all lines at once into a list. It demonstrates counting the total number of characters or getting the average line length for a sample haiku file using different reading methods.
Viewers also liked (16)
Similar to Ectodomain
Genetic control of animal development
presented by HAFIZ M WASEEM
university of education LAHORE Pakistan
i am from mailsi vehari and studied in lahore
bsc in science college multan
msc from lahore
GMO - Genetically Modified Organisms
The document discusses the need for genetically modified organisms (GMOs) to address challenges in food production. Climate change is expected to make feeding the world population increasingly difficult through impacts like more extreme weather, droughts and storms. This will reduce crop yields further. GMOs could help by developing crops that are resistant to these conditions and produce higher yields. The global population is projected to reach over 9 billion by 2050, requiring more food production. GMOs may offer varieties adapted to different climates and resilient to climate impacts, helping ensure adequate global food supply.
Seminario 2
SEMINARIO DE BIOLOGIA MOLECULAR
DAVID JIMENEZ Y SARA GUZMAN
ESTUDIANTES DE MEDICINA
UPB-2012
MEDELLIN - COLOMBIA
Early Development of Mammals (Mouse and Human).pdf
All vertebrate embryos pass through a similar set of developmental stages.
Soy Poster Final Version1
Male infertility is increasing and diet is being researched as a contributing factor. Soy consumption is also rising and studies have looked at soy's isoflavones - daidzein and genistein - and their potential effects on sperm quality. While isoflavones are endocrine disruptors that can impact sperm concentration, the evidence does not show soy consumption directly causes male infertility. More research is still needed to determine if men seeking fertility should avoid soy.
Soy Poster Final Version (2)
Male infertility is increasing and diet is being researched as a contributing factor. Soy consumption is also rising and studies have looked at soy's phytoestrogens, called isoflavones, and their potential impact on male reproductive health. Research has found that the isoflavones daidzein and genistein, which are abundant in soy, can act as endocrine disruptors and negatively impact sperm quality parameters like concentration. However, soy consumption has not been directly linked to male infertility and avoiding all soy products is not necessary based on current evidence. While isoflavones may decrease sperm quality markers, there is no evidence they decrease overall fertility in men.
Lecture
This document outlines objectives and content for a lesson on the key differences between prokaryotic and eukaryotic cells. The objectives include comparing cellular components, genome organization, generation of new genes, and explaining the endosymbiotic theory of organelle evolution. Key differences discussed are that eukaryotes have membrane-bound organelles and complex genome organization with introns, while prokaryotes have simpler genome structure without introns. The endosymbiotic theory proposes that eukaryotic organelles like mitochondria and chloroplasts evolved from ancient endosymbiotic prokaryotes.
Cv i chiao lee 2016
I-Chiao Lee is a molecular microbiologist from Taiwan with over 10 years of experience studying probiotics. She received her PhD from Wageningen University in the Netherlands, where she focused on surface molecules of probiotics, including proteins, polysaccharides, and teichoic acids. Her work has resulted in several publications examining ways to improve the survival and expression of beneficial molecules in probiotic bacteria like Lactobacillus plantarum. She is skilled in a variety of techniques and enjoys working independently and creatively in a friendly environment.
Biotechnology for the livestock improvements and phb degradation
Meat and milk from farmed animals including livestock (cattle, goat and buffalo) and poultry are sources of high quality protein and essential amino acids, minerals, fats and fatty acids, readily available vitamins, small quantities of carbohydrates and other bioactive components.1 The Food and Agriculture Organization (FAO) 2008 estimate shows that meat consumption has grown with increase in population. The average global per capita meat consumption is 42.1 kg/year with 82.9 kg/year in developed and 31.1 kg/year in developing countries in a recommended daily animal-sourced protein per capita of 50 kg per year2. Milk on the other hand is consumed in various forms: liquid, cheese, powder, and cream at a global per capita consumption of 108 kg per person per year which is way below the FAO recommended daily consumption of 200 kg.
Biotechnology for the livestock improvements and phb degradation
Meat and milk from farmed animals including livestock (cattle, goat and buffalo) and poultry are sources of high quality protein and essential amino acids, minerals, fats and fatty acids, readily available vitamins, small quantities of carbohydrates and other bioactive components.1 The Food and Agriculture Organization (FAO) 2008 estimate shows that meat consumption has grown with increase in population. The average global per capita meat consumption is 42.1 kg/year with 82.9 kg/year in developed and 31.1 kg/year in developing countries in a recommended daily animal-sourced protein per capita of 50 kg per year2. Milk on the other hand is consumed in various forms: liquid, cheese, powder, and cream at a global per capita consumption of 108 kg per person per year which is way below the FAO recommended daily consumption of 200 kg.
RELATION OF GENE , NEUROLOGY AND BEHAVIOUR CASE STUDY ANIMAL BEHAVIOUR
This document discusses several case studies on the relationship between genes, neurology, and behavior. It describes knockout gene experiments in mice that showed how single genes can be critical for behavioral development. It also discusses experiments with fosB and Oxt genes in rats that showed their protein products play a role in neural pathways and behaviors like pup retrieval and mate recognition. Finally, it discusses how social cues regulate hormone synthesis and the switching of honeybee behaviors from nursing to foraging.
Bruno pot
This document summarizes a talk on probiotics and mucosal immunity interactions in early life. It discusses how the microbiota changes throughout life, from pregnancy and birth through adulthood. Signals from the environment, including probiotics, shape immune development during critical windows. While some probiotic studies show benefits, effects depend on many factors and probiotics alone may not be sufficient. The microbiota plays an important role in immune maturation, and disturbances could impact health through epigenetic changes. Careful consideration of the microbiota is needed when evaluating human development and health.
Biofilms
Bacterial biofilms are communities of surface-associated microorganisms encased in a self-produced extracellular matrix. Biofilm formation is a nearly universal bacterial trait found on natural and artificial surfaces. The document discusses the complex structure of biofilms and the different environmental niches within biofilms that allow cells to experience different conditions. It also examines the stages of biofilm formation and dispersion, and how biofilms can lead to drug resistance and infectious diseases in humans.
Embryological and physiological evidences of evolution
The document discusses various embryological and physiological evidences that support the theory of evolution. It describes how early embryonic development is fundamentally similar across animals, with similarities in germ layer formation and fate. It also discusses similarities in organ development like the heart and aortic arches in vertebrates. Physiological evidence includes universal biochemical constituents, identical enzymes and hormones, similar metabolic pathways, and biochemical comparisons like cytochrome c and hemoglobin that indicate common ancestry. Analysis of excretory products and blood groups also provide evidence of evolutionary relationships.
QUESTION 1Random changes in gene frequency that occur in small.docx
QUESTION 1
Random changes in gene frequency that occur in small populations describes the concept of
A.
sympatric speciation.
B.
parapatric speciation.
C.
convergent evolution.
D.
genetic drift.
E.
adaptive radiation.
5 points
QUESTION 2
Animals that possess both male and female sexual organs
A.
are dioecious and typically self-fertilize.
B.
are hermaphroditic and typically cross-fertilize.
C.
are dioecious and typically cross-fertilize.
D.
are parthenogenetic and typically self-fertilize.
E.
are hermaphroditic and typically self-fertilize.
5 points
QUESTION 3
Immature eggs are called
A.
blastocysts.
B.
basal cells.
C.
follicles.
D.
oocytes.
E.
ovaries.
5 points
QUESTION 4
On a molecular level, all organisms
A.
use different means of storing genetic information.
B.
have the same bases in DNA and RNA, the same amino acids in proteins, but use different genetic codes.
C.
have the same bases in DNA and RNA, the same amino acids in proteins, and use the same genetic code.
D.
have the same bases in DNA and RNA, but different amino acids in proteins.
E.
show no similarities.
5 points
QUESTION 5
The primary male hormone is
A.
only involved in sperm production.
B.
produced in the brain.
C.
testosterone.
D.
estrogen.
E.
produced throughout a male’s entire lifetime.
5 points
QUESTION 6
Up until the late eighteenth and early nineteenth centuries, many naturalists believed that all species of living organism(s) had been created separately and had remained unchanged since the creation. Around that time, scientific research provided findings that were contradictory to that idea. All of the following are findings that contradict the idea of a single creation. Choose the exception.
A.
Even though the limbs of various mammals carry out different functions (swimming, gliding, running, holding, etc.), the bone patterns are very similar.
B.
The limbs of some mammals serve the same purpose but their bone patterns are very different.
C.
Some fossils of extinct organisms are quite different from living organisms.
D.
The platypus is only found in Australia and the dodo was only found on Madagascar.
E.
As scientists explored more of the earth, they found that different groups of organisms were found in the different regions.
5 points
QUESTION 7
A population in Hardy-Weinberg equilibrium
A.
requires a small population size.
B.
is under no selective pressures.
C.
consists of genotype frequencies that are constantly changing.
D.
consists of allele frequencies that are constantly changing.
E.
is very common in nature.
5 points
QUESTION 8
Human chorionic gonadotropin (hCG)
A.
is produced by the amnion.
B.
is needed to form the placenta.
C.
acts as a hormone signaling menstruation.
D.
can be used to reveal pregnancy.
E.
is stored in the ovaries.
5 points
QUESTION 9
Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are
A.
produced in both male ...
195163005Prokaryotic-chromosomes-organization.pdf
Prokaryotic chromosomes are circular in shape and located in the nucleoid region of the cell. They contain a single set of genes and lack histone proteins. The Escherichia coli chromosome is composed of a single closed circular DNA molecule that is divided into 50-100 loop domains. The chromosome is highly condensed and negatively supercoiled through the action of nucleoid-associated proteins like HU, H-NS, and DNA gyrase. This supercoiling and the binding of proteins allows for the compact organization and maintenance of the prokaryotic genome.
Xiumei Cao's CV2015
Xiumei Cao is a Chinese scientist currently working as an associate professor in Shanghai Jiaotong University. She has a Ph.D. in Biological Regulation from the Weizmann Institute of Science in Israel and extensive experience in immunology and cancer research. Her work has focused on the regulation of signaling pathways like TLR, TNF, and Sonic Hedgehog that are important in innate immunity and cancer. She has published numerous papers investigating the roles of various molecules in these pathways.
Diagnostic-Structures-Of-Enterobius-Vermicularis.pptx
Enterobius vermicularis, commonly known as the pinworm, is a parasitic nematode that infects the large intestine of humans. The document describes the diagnostic structures of E. vermicularis by presenting an image of one of its fertilized eggs found in a fecal sample. The egg is oval shaped, measuring 50-60 μm by 20-40 μm, with a thin colorless shell. Diagnosis is usually made by detecting the eggs on cellophane tape pressed against the anal skin, as the female pinworms lay their eggs perianally. This causes itching and rash around the anus. The image was captured using light microscopy at 1000x magnification after preparing the fecal
Similar to Ectodomain (18)
Early Development of Mammals (Mouse and Human).pdf
Early Development of Mammals (Mouse and Human).pdf
Biotechnology for the livestock improvements and phb degradation
Biotechnology for the livestock improvements and phb degradation
Biotechnology for the livestock improvements and phb degradation
Biotechnology for the livestock improvements and phb degradation
RELATION OF GENE , NEUROLOGY AND BEHAVIOUR CASE STUDY ANIMAL BEHAVIOUR
RELATION OF GENE , NEUROLOGY AND BEHAVIOUR CASE STUDY ANIMAL BEHAVIOUR
Embryological and physiological evidences of evolution
Embryological and physiological evidences of evolution
QUESTION 1Random changes in gene frequency that occur in small.docx
QUESTION 1Random changes in gene frequency that occur in small.docx
Diagnostic-Structures-Of-Enterobius-Vermicularis.pptx
Diagnostic-Structures-Of-Enterobius-Vermicularis.pptx
More from Marc Vooijs
Ectodomain PDF.pdf
This study investigated whether oligomerization regulates ectodomain shedding and intramembrane cleavage of mammalian Notch proteins by γ-secretase. The researchers found that while Notch epidermal growth factor repeats can promote dimer formation, most surface Notch molecules in mammalian cells and constitutively active or inactive Notch1 proteins are monomeric. Using a bacterial assay, they also found that the isolated transmembrane domain of Notch and amyloid precursor protein self-associate, and mutations affecting Notch cleavage by γ-secretase do not alter transmembrane domain dimerization. Therefore, the study concludes that ligand-induced reversal of controlled transmembrane domain dimerization by the Notch extracellular domain is unlikely to underlie the
Granzyme
The document discusses a study which found that granzyme B disables the transcriptional activity of Notch1 by cleaving Notch1. The study was conducted by van Tetering et al. and published in Biochemical Journal in 2011.
Vooijs gastroenterology 2011
This article discusses the role of Notch signaling in the development and maintenance of the intestine. It describes how Notch acts as an architect by regulating cell differentiation during intestinal development, a landscaper by controlling the balance between secretory and absorptive cells in the adult intestine, and a guardian by promoting intestinal stem cell renewal and preventing inflammation.
proteolyc.pptx
This paper discusses the proteolytic cleavage of the Notch receptor protein. Notch signaling requires two cleavage events - one mediated by ADAM metalloproteases (HIT) and the other by gamma-secretase (RUN). These cleavages are necessary to release the Notch intracellular domain, which then translocates to the nucleus to regulate transcription of target genes.
Gort cmm 2008
This paper discusses how low oxygen (hypoxic) conditions can regulate cancer metastasis through hypoxia-inducible factors (HIFs), which are transcription factors that help cells adapt to low oxygen. The paper examines the role of HIFs in cancer metastasis and how they may help cancer cells invade nearby tissues and spread to other parts of the body when oxygen levels are low.
More from Marc Vooijs (7)
Recently uploaded
The Best Ayurvedic Antacid Tablets in India
Treat the symptoms of indigestion, heartburn and stomach reflux with the 10 Best Ayurvedic Antacid Tablets in India.
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Learn about body grief and ways to cope with it. We will also explore methods to heal from this challenging experience.
share - Lions, tigers, AI and health misinformation, oh my!.pptx
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...rightmanforbloodline
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Versio
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest VersionOsteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
The Electrocardiogram - Physiologic Principles
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...rightmanforbloodline
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.Role of Mukta Pishti in the Management of Hyperthyroidism
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Top-Vitamin-Supplement-Brands-in-India List
Swisschem Dermacare provides the Top 10 Vitamin Supplement Brands in India. To know more about us give us call at our official number
Top 10 Best Ayurvedic Kidney Stone Syrups in India
we have mentioned the best 10 ayurvedic Kidney Stone Syrups. You can check all these products and choose the best one for yourself.
Recently uploaded (20)
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
share - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptx
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdf
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Tests for analysis of different pharmaceutical.pptx
Tests for analysis of different pharmaceutical.pptx
Role of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of Hyperthyroidism
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Ectodomain
- 2. Vooijs, M., Schroeter, E. H., Pan, Y., Blandford, M. & Kopan, R. Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol
- 3. Vooijs, M., Schroeter, E. H., Pan, Y., Blandford, M. & Kopan, R. Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol
- 4. Vooijs, M., Schroeter, E. H., Pan, Y., Blandford, M. & Kopan, R. Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol
- 5. Vooijs, M., Schroeter, E. H., Pan, Y., Blandford, M. & Kopan, R. Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol
- 6. Vooijs, M., Schroeter, E. H., Pan, Y., Blandford, M. & Kopan, R. Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol
- 7. Vooijs, M., Schroeter, E. H., Pan, Y., Blandford, M. & Kopan, R. Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol