1. Curriculum Vitae
PERSONAL INFORMATION
Name: Xiumei Cao
Nationality: Chinese with Green card
Date of Birth: Sept. 3, 1973
Address: 5537 Marlin ST, Rockville, MD 20853
Mobile: (240) 543-4373
EDUCATION
Ph.D. Biological Regulation, The Weizmann Institute of Science, Israel, 2005
M.S. Physiology, Chinese Academy of Sciences, China, 1999
B.S. Biology, Beijing Normal University, China, 1996
EXPERIENCE
2012--present Associate professor in the Department of Immunology and Microbiology,
Shanghai Jiaotong University
I am interested in the regulation of TLR and TNF signaling. These signaling
pathways are critical for innate immune response. I am looking for new molecules
and modification of these molecules that are involved in these signaling pathways,
so that new targets can be found for immune therapy.
2011– 2012. Associate professor in the Department of Development and Genetics,
Nanjing Medical University
My research interest is the regulation of Sonic Hedgehog signaling which plays a
key role in multiple cancers. My work focuses on the function of small GTPases
and microRNAs in Sonic Hedgehog signaling and the related cancers.
2006 – 2011. Postdoctoral training in National Cancer Institute, National Institute of
Health.
 Studied the function of TRADD in TRAIL-induced apoptosis and signaling using
cultured cells. Plenty molecular biology, cell biology and biochemistry

2. approaches, including molecular cloning and site-directed mutagenesis, co-
transfection and co-immunoprecipitation, cell and tissue staining, FACS sorting
and death assay, were applied.
 Investigated the molecular mechanism of ATIA (anti TNF-induced apoptosis)
release using in vitro cell culture and in vivo knockout mouse model. Many
techniques including mitochondria fraction, immunohistochemistry,
immunofluorecence and immunocytochemistry were used.
 Successfully cloned and purified ATIA C terminal peptide to prepare an antibody
for detecting endogenous ATIA.
 Negotiated with the company to get a pre-released product, and the replacement
for products that were not working.
 Received certificates for “Principle of clinical pharmacology” and “Translational
Research in Clinical Oncology”.
 Helped organizing the lab and ordering lab supplies.
 Gave suggestions for recruiting new lab members.
2005 – 2006. Postdoctoral training in Section of Molecular Biology, University of
California, San Diego.
 Examined the role of ubiquitination of pexins in peroxisomal biogenesis of Pichia
Pastoris.
 Applied various molecular and biochemical approaches including gene cloning
and mutagenesis, knockout, knockin, yeast two hybrid, and fluorescence
microscopy.
2000 – 2005. Ph.D. research in Department of Biological Regulation, The Weizmann
Institute of Science, Rehovot, Israel.
 Clarified the function of meiosis activating sterol (MAS), as well as the molecular
mechanisms involved.
 Utilized in vitro culture system and in vivo mouse model, as well as techniques
such a HPLC and western blot.
 Took lab courses of Bioinformatics, Pearl programming, Microarray,
Microinjection and Intracellular Traffic.
 Presented posters for three international conferences.
1996 – 1999. M.S. research in the State Key Laboratory of Reproductive Biology,
Institute of Zoology, Chinese Academy of Sciences, China
 Compared the expression of MMP-7 in rat uterus during estrous cycle and early
pregnancy, to identify the potential function and regulation of MMP-7.
 Conducted immunohistochemistry and in situ hybridization.
 Helped the other projects about the role of MMP-2 and -9 in implantation.
PUBLICATIONS

3.  Cao X, Yan J, Shu S, Brzostowski J, Jin T. 2014 Arrestins function in cAR1
GPCR-mediated signaling and cAR1 internalization in the development of D.
discoideum. Mol. Biol. Cell 2014 25:20 3210-3221; First Published on August 20,
2014; doi:10.1091/mbc.E14-03-0834
 Jin Yucui, Xiong Anwen, Zhang Ziyu, Li Sanen, Huang Huijie, Yu Tingting, Cao
Xiumei, Cheng Steven Y. 2014 MicroRNA-31 suppresses medulloblastoma cell
growth by inhibiting DNA replication through minichromosome maintenance 2.
Oncotarget. 5:4821-33.
 Cao X., Yelena L.Pobezinskaya, Michael Morgan, Zhenggang Liu. 2011 The
Role of TRADD in TRAIL-induced Apoptosis and Signaling. FASEB J. 25：
1353-8.
 Swati Choksi*, Yong Lin*, Yelena Pobezinskaya*, Li Chen*, Chung Park,
Michael Morgan, Tao Li, Siriporn Jitkaew, Xiumei Cao, You-Sun Kim, Hong-
Sug Kim, Peter Levitt, Grace Shih, Michael Birre, Chu-Xia Deng, and Zheng-
gang Liu. 2011 A Novel HIF-1 Target, ATIA, Protects Cells from Apoptosis by
Modulating the Mitochondrial Thioredoxin, TRX2. Mol Cell. 42:597-609.
 Yelena Pobezinskaya, Swati Choksi, Michael J. Morgan, Xiumei Cao, and
Zhenggang Liu. 2011 The adaptor protein TRADD is essential for TL1A/DR3
signaling. J Immunol. 186:5212-6.
 Motola S*, Cao X*, Popliker M, Tsafriri A. 2008 Involvement of mitogen-
activated protein kinase (MAPK) Pathway in LH- and meiosis-activating sterol
(MAS) - Induced Maturation in Rat and Mouse oocytes. Molecular Reproduction
and Development 75:1533-41 (*Co-first authors).
 Motola S., Cao X., Ashkenazi H., Popliker M. and Tsafriri A. 2006 GnRH actions
on rat preovulatory follicles are mediated by paracrine EGF-like factors.
Molecular Reproduction and Development 73:1271-6
 Ashkenazi H., Cao X., Motola S., Popliker M. and Tsafriri A. 2005 EGF-like
growth factors as endogenous mediators of the ovulatory response in the rat.
Endocrinology 146: 77 – 84.
 Tsafriri A., Cao X., Ashkenazi, H., Motola, S., Popliker, M., Pomerantz, S.H.
2005 Resumption of oocyte meiosis in mammals: On models, meiosis activating
sterols, steroids and EGF-like factors. Molecular and Cellular Endocrinology 234:
37 - 45.
 Cao X., Pomerantz S.H., Popliker M. and Tsafriri A. 2004 MAS synthesis in rat
preovulatory follicle: is it involved in resumption of meiosis? Biology of
Reproduction 71: 1807 – 12.
 Tsafriri A., Cao X., Vaknin K.M., and Popliker M. 2002. Is meiosis activating
sterol (MAS) an obligatory mediator of meiotic resumption in mammals.
Molecular and Cellular Endocrinology 187: 197 - 204.
 Zhao Y., Xiao Ai., Cao X., and Zhu Ch. 2002. Expression of Matrix
Metalloproteinase-2, -9, and Tissue Inhibitors of Metalloproteinase-1, -2, -3
mRNAs in Rat Uterus During Early Pregnancy. Molecular Reproduction and
Development 62: 149 - 158.
 Zhao Y., Cao X., Xiao Ai, and Zhu Ch. 1999. Expressions of MMP-2, -9, TIMP-1,
-2, -3 mRNA in Rat Uterus during Estrous Cycle. Developmental &Reproductive
Biology 8: 1 - 10.

4. REFEREES：
Jianshe Yan, PhD, professor
Department of Immunology and Microbiology, Shanghai Jiaotong University
280 South Chongqing Road, Huangpu, Shanghai, P.R. China 200025
Email: yanjianshe@sjtu.edu.cn
Changyan Ma, PhD, professor
Department of Development and Genetics, Nanjing Medical University
140 Hanzhong Road, Nanjing, Jiangshu Province, P.R. China 210029
Email: cyma@njmu.edu.cn
Li Chen, PhD, professor
University of Southern Denmark
Winsløwparken 25, 1. Sal, Odense C 5000, Denmark
Email: lchen@health.sdu.dk