This document discusses the economic benefits of a One Health approach to managing infectious diseases. It argues that a One Health approach can add value in three key areas: where resources are scarce; where resources are underutilized; and by taking a holistic view of food systems. A One Health approach that considers the entire food system context could improve understanding of health problems and allow for more proportional and timely responses. However, the benefits of One Health may not always outweigh the costs of institutional changes needed. Understanding the full impacts of issues like environmental effects, animal diseases, foodborne illness and nutrition within food systems could provide the tipping point for more widespread adoption of One Health.