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6/17/2016
1
Retinal considerations for
refractive surgery
Michael Dollin, MD, FRCSC
Assistant Professor
University of Ottawa Eye Institute
Ottawa, Ontario, Canada
June 2, 2016
Outline
• Vitreoretinal alterations during refractive surgery
• Disorders of the macula
• Disorders of the peripheral retina
6/17/2016
2
Outline
• Vitreoretinal alterations during refractive surgery
• Disorders of the macula
– Epiretinal membrane
– Vitreomacular traction
– Myopic foveoschisis
– Myopic macular hole
– Cystoid macular edema
• Disorders of the peripheral retina
– Lesions predisposing to retinal detachment
– Retinal detachment
– Retinoschisis
Homer Simpson
“Eye crusts” after laser eye surgery
6/17/2016
3
Serious retinal complications after
refractive surgery are rare
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4
Vitreoretinal alterations during
refractive surgery
• Corneal refractive surgery (CRS)
– Suction ring changes in eye shape power vectors
relayed to the macula and/or vitreous base
– Effect of the excimer laser shock wave appears negligible
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5
Vitreoretinal alterations during
refractive surgery
• Refractive lens exchange (RLE)
– VR alterations similar to those induced during
cataract surgery (PC trampolining, PC rupture)
Thorough pre-operative dilated fundus
examination is key
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6
Examination techniques
• Macula
– Slit lamp and 90D or 78D lens
– OCT?
• Peripheral retina
– Indirect ophthalmoscopy +/-
scleral depression
– Goldmann 3-mirror or wide
field contact lens
– Optos?
Disorders of the macula
• Epiretinal membrane
• Vitreomacular traction
• Myopic foveoschisis
• Myopic macular hole
• Cystoid macular edema
• Diabetic macular edema
MACULA
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MACULA
Epiretinal membrane (ERM)
• Glial cells and laminocytes that attach to a scaffold of vitreous
cortex on the inner retinal surface, typically after PVD
• ERM contracture causes macular traction distorting the
underlying foveal structure thickening +/- CME
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Epiretinal membrane (ERM)
• Incidence increases with age
– Seen in 7% of patients ≥50 years old
– 31% bilateral
• May occur during any stage of vitreous
separation (vitreoschisis)
– In younger patients, often present in absence of PVD
• Refer for Retina opinion
Case
• 36 year old male
• Referred for macular evaluation prior to CRS
• C/O mild blur OD, no distortion
• High myope (-9 OU)
• BCVA 20/25 OD, 20/20 OS
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OD OS
Subtle flattening of foveal
contour due to ERM Normal foveal contour
Important for pre-op counseling
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10
Vitreomacular adhesion (VMA)
• Perifoveal vitreous
separation with
remaining vitreomacular
attachment
• Unperturbed foveal
morphologic features
• May or may not lead to
pathologic conditions
Vitreomacular traction (VMT)
• Anomalous PVD accompanied by
anatomic distortion of the fovea
– Pseudocysts, macular schisis, cystoid
macular edema, and subretinal fluid
• Focal (≤ 1500μ) vs. broad (> 1500μ)
• Concurrent = associated with other
macular disease (e.g. ERM)
• Variably symptomatic
– Decreased vision, metamorphopsia,
central scotoma
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OCT essential in the diagnosis
Distinguish from vitreomacular adhesion
(VMA)
• Unperturbed foveal morphologic features
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VMT
• Management
– Observation
• 1/3 will release spontaneously
– Ocriplasmin (Jetrea)
– Vitrectomy
• 5% will require surgery due to
bothersome symptoms or
progression to full thickness
macular hole
• Refer for Retina opinion
Myopic foveoschisis
• Increasingly recognized entity with advent of OCT
– Prevalence 9-33% of myopic eyes with staphyloma
• Mechanism is mixture of tractional forces
– Abnormal vitreomacular interface pulling inward
– Abnormal scleral alterations pulling outward
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• Despite often impressive anatomic findings, most
patients may be relatively asymptomatic
– Visual loss often eventually attributed to foveal
detachment and/or macular holes
• Choroidal thinning often an associated feature
– May reduce vision independent of schisis
• Refer for Retina opinion
Case
• 32 yo female
• Interested in CRS
• Myope (-6 OU)
• BCVA 20/20 OD, CF OS
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20/20 CF
Macular hole
• Foveal lesion with interruption of
all retinal layers from ILM to RPE
• Primary (due to VMT) or
secondary (e.g. traumatic)
• Small ≤ 250 μ
• Medium > 250 μ – 400 μ
• Large > 400 μ
• Status of vitreous:
– With VMT
– Without VMT
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Macular hole in high myopes
• Can be extremely subtle, if not impossible, to
detect clinically
– Particularly in the setting of posterior staphyloma
• Obtain an OCT
• Refer for Retina opinion
Case
• 48 year old female
• Referred for retina check prior to RLE
• High myope (-12 OU)
• BCVA 20/30-2 OD, 20/25 OS
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OS (20/25)
OD (20/30-2)
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Cystoid macular edema
• Various etiologies
– Vein occlusion, diabetes, radiation, uveitis, CNV, etc
• Presumed inflammatory etiology post RLE
Cystoid macular edema
• Presumed inflammatory etiology post RLE
– Stepwise approach to treatment beginning with
topical therapy:
– Prednisolone (e.g. Pred forte QID)
– NSAID (e.g. Acular QID, Nevanac TID)
– Taper slowly once CME has resolved
• Refer to Retina
– If not improving after 4-6 weeks of topical therapy
– May require sub-Tenon’s or intravitreal steroid
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A note about diabetic macular edema
• Refer to Retina if DME is
detected on pre-op
exam
• In patients receiving
anti-VEGF for DME and
wishing to undergo RLE,
ideal to time surgery 1
week after an injection
Disorders of the peripheral retina
• Lesions not predisposing to retinal detachment
• Lesions predisposing to retinal detachment
• Posterior vitreous detachment
• Retinal detachment
• Retinoschisis
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19
Lesions NOT predisposing to RD
• Pavingstone (cobblestone) degeneration
• RPE hyperplasia and hypertrophy
• Peripheral cystoid degeneration
• White without pressure
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Pavingstone (cobblestone) degeneration
• Small, discrete areas of
ischemic atrophy of outer
retina
• 22% of patients over 20
years of age, 38% bilateral
• May be single or multiple
and confluent
• Most commonly inferior
(5-7 o’clock) and anterior
to the equator
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21
Peripheral RPE abnormalities
• Hyperplasia/Hypertrophy
– Acquired secondary to mild vitreous traction,
previous inflammation or trauma
– Congenital (CHRPE)
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22
Peripheral cystoid degeneration
• Zones of microcysts with bubbly
appearance posterior to the ora
• Present in virtually all adults over 20
years old
• Holes may form but rarely lead to RD
• Coalescence and extension of
cavities can progress to retinoschisis
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23
White without pressure
• White appearance of the equator and/or peripheral
retina seen without scleral indentation
• Margins often sharply demarcated from normal retina
6/17/2016
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Lesions predisposing to RD
• Lattice degeneration
• Vitreoretinal tufts
• Meridional folds
• Retinoschisis
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Lattice degeneration
• Crisscrossing lattice work of white lines (hyalinized blood
vessels)
– Typically parallels the ora seratta
• 6-10% of general population
– Bilateral in 33%
• More common in myopes
• Familial predilection
• Atrophic holes within lattice present in 31%
Lattice degeneration
• Histopathology
– ILM discontinuity
– Inner retinal layer atrophy
– Liquefaction of overlying vitreous
– Condensation and adherence of vitreous at
margin
6/17/2016
26
6/17/2016
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Lattice degeneration and RD
• Cause of 20-30% of RRDs (present in 41%)
• Due to tractional tear at lateral or posterior
margin (55-70%)
– 90% under 50 yo and 43% myopic
– Progress rapidly and demarcation lines less likely
• Due to atrophic hole within lattice (30-45%)
– 70% under 40 yo and 70% myopic
– Progress slowly and see demarcation lines, due to tear
6/17/2016
28
Lattice degeneration and RD
• Lifetime risk (11-year study) of RD in all
patients with lattice is 1%
– Increases to 2% if atrophic holes present in lattice
• Presence of lattice, with or without atrophic
holes on routine exam, does not require
prophylactic treatment
Lattice with atrophic holes
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• 2% risk of RD
• Lesion should not be treated prophylactically
Atrophic hole not associated with lattice
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Lattice with tractional retinal tear
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Vitreoretinal tufts
• Small, peripheral retinal elevations caused by
focal areas of vitreous or zonular traction
– +/- surrounding RPE hyperplasia
• 3 types of tufts:
– Non-cystic (do not predispose to RD)
– Cystic and Zonular traction (predispose to RD)
6/17/2016
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6/17/2016
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• Risk of a retinal detachment from cystic retinal
tuft is quite low and estimated to be only 0.28%
– Prophylactic treatment not necessary if detected on
routine exam
– Treat if recent flashes and floaters and break is
suspected
Meridional folds
• Folds of redundant retina
• Usually superonasal
• Meridional folds can be associated with retinal
breaks at the tip
6/17/2016
34
• Prophylactic treatment of meridional folds not necessary if
detected on routine exam
• Treat if recent flashes and floaters and break is suspected
6/17/2016
35
Posterior vitreous detachment
• May develop in 2-24% of eyes
following CRS
– Increasing incidence with
increasing myopia
• Patients with new onset flashes
and floaters following CRS
should be evaluated with DFE
– Rule out retinal break
• 10-15% will have a retinal tear
– With hemorrhage 70%
– Without hemorrhage 2-4%
Weiss ring
6/17/2016
36
Case
• 26 year old female
• Sudden onset
floaters post-CRS
High risk for tears Refer to Retina
6/17/2016
37
Rhegmatogenous retinal detachment
• Risk of RRD after CRS is
very low
– Particuarly with adequate
pre-operative screening for
high risk peripheral retinal
lesions
• Characteristics of RRD are
similar in patients having
undergone CRS compared
to patients who have not
– Myopia likely contributes
more to the risk of RRD
than the refractive surgery
itself
6/17/2016
38
6/17/2016
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6/17/2016
40
Retinoschisis
• Intraretinal degenerative process with splitting of retina in
periphery, accumulation of intraretinal fluid, and loss of visual
function
– Split of sensory retina into outer and inner layer
• Found in 5% of population over 20 years
• 70% are hypermetropes
• Generally nonprogressive
– Posterior extension 3.2%
– Lateral extension 6.4%
– New areas 10%
6/17/2016
41
Retinoschisis-retinal detachment
• Responsible for 3.2% of full-thickness RD
• Expected incidence of progressive RD in patients with
retinoschisis 0.05%
• 2 types of RD:
– Hole in outer wall only: usually do not progress or do so
slowly (demarcation and RPE atrophy often present)
– Hole in outer and inner walls: may result in rapidly
progressive RD
6/17/2016
42
6/17/2016
43
Differentiating retinoschisis from
retinal detachment
CLINICAL FEATURE RD RS
High risk group
Symptoms
Location
Surface
Hgb or pigment (Shafer’s)
Scotoma
Reaction to photocoagulation
Shifting fluid
Myopia
F/F, VF loss
Superotemporal
Corrugated
Present
Relative
Absent
Variable
Hyperopia (70%)
Typically asymptomatic
Inferotemporal (70%)
Smooth, dome-shaped
Usually absent
Absolute
Present
Absent
6/17/2016
44
• Chronic RRD
– Retina may appear smooth, thin and transparent
– May also show underlying RPE atrophy, demarcation lines,
and macrocysts -- not present in retinoschisis
6/17/2016
45
Summary
• Retinal complications after LASIK are rare
• Complications of the myopic eye will persist
– Important to inform patients that refractive surgery only
corrects the refractive aspect of myopia
• Pre-op dilated fundus examination of the macula and
peripheral retina is very important to identify any high risk
lesions
– Also important post-op when vision is not as good as expected
• If high risk peripheral lesions or new macular lesions are
detected refer to Retina
6/17/2016
46
Acknowledgements
• Novartis
• John D. Pitcher, III
• Rahul Sharma
• Parnian Arjmand
Thank you
6/17/2016
47
Thank you

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Focus Co Management 2016 Dr Dolin

  • 1. 6/17/2016 1 Retinal considerations for refractive surgery Michael Dollin, MD, FRCSC Assistant Professor University of Ottawa Eye Institute Ottawa, Ontario, Canada June 2, 2016 Outline • Vitreoretinal alterations during refractive surgery • Disorders of the macula • Disorders of the peripheral retina
  • 2. 6/17/2016 2 Outline • Vitreoretinal alterations during refractive surgery • Disorders of the macula – Epiretinal membrane – Vitreomacular traction – Myopic foveoschisis – Myopic macular hole – Cystoid macular edema • Disorders of the peripheral retina – Lesions predisposing to retinal detachment – Retinal detachment – Retinoschisis Homer Simpson “Eye crusts” after laser eye surgery
  • 3. 6/17/2016 3 Serious retinal complications after refractive surgery are rare
  • 4. 6/17/2016 4 Vitreoretinal alterations during refractive surgery • Corneal refractive surgery (CRS) – Suction ring changes in eye shape power vectors relayed to the macula and/or vitreous base – Effect of the excimer laser shock wave appears negligible
  • 5. 6/17/2016 5 Vitreoretinal alterations during refractive surgery • Refractive lens exchange (RLE) – VR alterations similar to those induced during cataract surgery (PC trampolining, PC rupture) Thorough pre-operative dilated fundus examination is key
  • 6. 6/17/2016 6 Examination techniques • Macula – Slit lamp and 90D or 78D lens – OCT? • Peripheral retina – Indirect ophthalmoscopy +/- scleral depression – Goldmann 3-mirror or wide field contact lens – Optos? Disorders of the macula • Epiretinal membrane • Vitreomacular traction • Myopic foveoschisis • Myopic macular hole • Cystoid macular edema • Diabetic macular edema MACULA
  • 7. 6/17/2016 7 MACULA Epiretinal membrane (ERM) • Glial cells and laminocytes that attach to a scaffold of vitreous cortex on the inner retinal surface, typically after PVD • ERM contracture causes macular traction distorting the underlying foveal structure thickening +/- CME
  • 8. 6/17/2016 8 Epiretinal membrane (ERM) • Incidence increases with age – Seen in 7% of patients ≥50 years old – 31% bilateral • May occur during any stage of vitreous separation (vitreoschisis) – In younger patients, often present in absence of PVD • Refer for Retina opinion Case • 36 year old male • Referred for macular evaluation prior to CRS • C/O mild blur OD, no distortion • High myope (-9 OU) • BCVA 20/25 OD, 20/20 OS
  • 9. 6/17/2016 9 OD OS Subtle flattening of foveal contour due to ERM Normal foveal contour Important for pre-op counseling
  • 10. 6/17/2016 10 Vitreomacular adhesion (VMA) • Perifoveal vitreous separation with remaining vitreomacular attachment • Unperturbed foveal morphologic features • May or may not lead to pathologic conditions Vitreomacular traction (VMT) • Anomalous PVD accompanied by anatomic distortion of the fovea – Pseudocysts, macular schisis, cystoid macular edema, and subretinal fluid • Focal (≤ 1500μ) vs. broad (> 1500μ) • Concurrent = associated with other macular disease (e.g. ERM) • Variably symptomatic – Decreased vision, metamorphopsia, central scotoma
  • 11. 6/17/2016 11 OCT essential in the diagnosis Distinguish from vitreomacular adhesion (VMA) • Unperturbed foveal morphologic features
  • 12. 6/17/2016 12 VMT • Management – Observation • 1/3 will release spontaneously – Ocriplasmin (Jetrea) – Vitrectomy • 5% will require surgery due to bothersome symptoms or progression to full thickness macular hole • Refer for Retina opinion Myopic foveoschisis • Increasingly recognized entity with advent of OCT – Prevalence 9-33% of myopic eyes with staphyloma • Mechanism is mixture of tractional forces – Abnormal vitreomacular interface pulling inward – Abnormal scleral alterations pulling outward
  • 13. 6/17/2016 13 • Despite often impressive anatomic findings, most patients may be relatively asymptomatic – Visual loss often eventually attributed to foveal detachment and/or macular holes • Choroidal thinning often an associated feature – May reduce vision independent of schisis • Refer for Retina opinion Case • 32 yo female • Interested in CRS • Myope (-6 OU) • BCVA 20/20 OD, CF OS
  • 14. 6/17/2016 14 20/20 CF Macular hole • Foveal lesion with interruption of all retinal layers from ILM to RPE • Primary (due to VMT) or secondary (e.g. traumatic) • Small ≤ 250 μ • Medium > 250 μ – 400 μ • Large > 400 μ • Status of vitreous: – With VMT – Without VMT
  • 15. 6/17/2016 15 Macular hole in high myopes • Can be extremely subtle, if not impossible, to detect clinically – Particularly in the setting of posterior staphyloma • Obtain an OCT • Refer for Retina opinion Case • 48 year old female • Referred for retina check prior to RLE • High myope (-12 OU) • BCVA 20/30-2 OD, 20/25 OS
  • 17. 6/17/2016 17 Cystoid macular edema • Various etiologies – Vein occlusion, diabetes, radiation, uveitis, CNV, etc • Presumed inflammatory etiology post RLE Cystoid macular edema • Presumed inflammatory etiology post RLE – Stepwise approach to treatment beginning with topical therapy: – Prednisolone (e.g. Pred forte QID) – NSAID (e.g. Acular QID, Nevanac TID) – Taper slowly once CME has resolved • Refer to Retina – If not improving after 4-6 weeks of topical therapy – May require sub-Tenon’s or intravitreal steroid
  • 18. 6/17/2016 18 A note about diabetic macular edema • Refer to Retina if DME is detected on pre-op exam • In patients receiving anti-VEGF for DME and wishing to undergo RLE, ideal to time surgery 1 week after an injection Disorders of the peripheral retina • Lesions not predisposing to retinal detachment • Lesions predisposing to retinal detachment • Posterior vitreous detachment • Retinal detachment • Retinoschisis
  • 19. 6/17/2016 19 Lesions NOT predisposing to RD • Pavingstone (cobblestone) degeneration • RPE hyperplasia and hypertrophy • Peripheral cystoid degeneration • White without pressure
  • 20. 6/17/2016 20 Pavingstone (cobblestone) degeneration • Small, discrete areas of ischemic atrophy of outer retina • 22% of patients over 20 years of age, 38% bilateral • May be single or multiple and confluent • Most commonly inferior (5-7 o’clock) and anterior to the equator
  • 21. 6/17/2016 21 Peripheral RPE abnormalities • Hyperplasia/Hypertrophy – Acquired secondary to mild vitreous traction, previous inflammation or trauma – Congenital (CHRPE)
  • 22. 6/17/2016 22 Peripheral cystoid degeneration • Zones of microcysts with bubbly appearance posterior to the ora • Present in virtually all adults over 20 years old • Holes may form but rarely lead to RD • Coalescence and extension of cavities can progress to retinoschisis
  • 23. 6/17/2016 23 White without pressure • White appearance of the equator and/or peripheral retina seen without scleral indentation • Margins often sharply demarcated from normal retina
  • 24. 6/17/2016 24 Lesions predisposing to RD • Lattice degeneration • Vitreoretinal tufts • Meridional folds • Retinoschisis
  • 25. 6/17/2016 25 Lattice degeneration • Crisscrossing lattice work of white lines (hyalinized blood vessels) – Typically parallels the ora seratta • 6-10% of general population – Bilateral in 33% • More common in myopes • Familial predilection • Atrophic holes within lattice present in 31% Lattice degeneration • Histopathology – ILM discontinuity – Inner retinal layer atrophy – Liquefaction of overlying vitreous – Condensation and adherence of vitreous at margin
  • 27. 6/17/2016 27 Lattice degeneration and RD • Cause of 20-30% of RRDs (present in 41%) • Due to tractional tear at lateral or posterior margin (55-70%) – 90% under 50 yo and 43% myopic – Progress rapidly and demarcation lines less likely • Due to atrophic hole within lattice (30-45%) – 70% under 40 yo and 70% myopic – Progress slowly and see demarcation lines, due to tear
  • 28. 6/17/2016 28 Lattice degeneration and RD • Lifetime risk (11-year study) of RD in all patients with lattice is 1% – Increases to 2% if atrophic holes present in lattice • Presence of lattice, with or without atrophic holes on routine exam, does not require prophylactic treatment Lattice with atrophic holes
  • 29. 6/17/2016 29 • 2% risk of RD • Lesion should not be treated prophylactically Atrophic hole not associated with lattice
  • 31. 6/17/2016 31 Vitreoretinal tufts • Small, peripheral retinal elevations caused by focal areas of vitreous or zonular traction – +/- surrounding RPE hyperplasia • 3 types of tufts: – Non-cystic (do not predispose to RD) – Cystic and Zonular traction (predispose to RD)
  • 33. 6/17/2016 33 • Risk of a retinal detachment from cystic retinal tuft is quite low and estimated to be only 0.28% – Prophylactic treatment not necessary if detected on routine exam – Treat if recent flashes and floaters and break is suspected Meridional folds • Folds of redundant retina • Usually superonasal • Meridional folds can be associated with retinal breaks at the tip
  • 34. 6/17/2016 34 • Prophylactic treatment of meridional folds not necessary if detected on routine exam • Treat if recent flashes and floaters and break is suspected
  • 35. 6/17/2016 35 Posterior vitreous detachment • May develop in 2-24% of eyes following CRS – Increasing incidence with increasing myopia • Patients with new onset flashes and floaters following CRS should be evaluated with DFE – Rule out retinal break • 10-15% will have a retinal tear – With hemorrhage 70% – Without hemorrhage 2-4% Weiss ring
  • 36. 6/17/2016 36 Case • 26 year old female • Sudden onset floaters post-CRS High risk for tears Refer to Retina
  • 37. 6/17/2016 37 Rhegmatogenous retinal detachment • Risk of RRD after CRS is very low – Particuarly with adequate pre-operative screening for high risk peripheral retinal lesions • Characteristics of RRD are similar in patients having undergone CRS compared to patients who have not – Myopia likely contributes more to the risk of RRD than the refractive surgery itself
  • 40. 6/17/2016 40 Retinoschisis • Intraretinal degenerative process with splitting of retina in periphery, accumulation of intraretinal fluid, and loss of visual function – Split of sensory retina into outer and inner layer • Found in 5% of population over 20 years • 70% are hypermetropes • Generally nonprogressive – Posterior extension 3.2% – Lateral extension 6.4% – New areas 10%
  • 41. 6/17/2016 41 Retinoschisis-retinal detachment • Responsible for 3.2% of full-thickness RD • Expected incidence of progressive RD in patients with retinoschisis 0.05% • 2 types of RD: – Hole in outer wall only: usually do not progress or do so slowly (demarcation and RPE atrophy often present) – Hole in outer and inner walls: may result in rapidly progressive RD
  • 43. 6/17/2016 43 Differentiating retinoschisis from retinal detachment CLINICAL FEATURE RD RS High risk group Symptoms Location Surface Hgb or pigment (Shafer’s) Scotoma Reaction to photocoagulation Shifting fluid Myopia F/F, VF loss Superotemporal Corrugated Present Relative Absent Variable Hyperopia (70%) Typically asymptomatic Inferotemporal (70%) Smooth, dome-shaped Usually absent Absolute Present Absent
  • 44. 6/17/2016 44 • Chronic RRD – Retina may appear smooth, thin and transparent – May also show underlying RPE atrophy, demarcation lines, and macrocysts -- not present in retinoschisis
  • 45. 6/17/2016 45 Summary • Retinal complications after LASIK are rare • Complications of the myopic eye will persist – Important to inform patients that refractive surgery only corrects the refractive aspect of myopia • Pre-op dilated fundus examination of the macula and peripheral retina is very important to identify any high risk lesions – Also important post-op when vision is not as good as expected • If high risk peripheral lesions or new macular lesions are detected refer to Retina
  • 46. 6/17/2016 46 Acknowledgements • Novartis • John D. Pitcher, III • Rahul Sharma • Parnian Arjmand Thank you