This document provides information on apophyseal injuries of the distal humerus, including fractures of the medial and lateral epicondyles and intercondylar fractures.
For medial epicondyle fractures, the fragment is often displaced distally and may become incarcerated in the joint. They are typically treated nonoperatively with immobilization, while operative treatment is required for irreducible fragments. Lateral epicondyle fractures involve avulsion of the extensor tendon origin and are also usually treated nonoperatively.
Intercondylar fractures involve displacement of articular fragments and rotation of the condyles. Treatment depends on the degree of displacement and comminution, ranging from nonoperative immobilization to open reduction
muscle pedicle grafting for delayed presentation of intra cpasular fracture neck of Femur.. a study of 65 cases in Osmania Medical College, Hyderabad, Telengana.
Osseous anatomy, Types of approaches(Position,landmarks,Incision,Superficial and Deep surgical dissection) , structures at risk, Extensile approaches with diagrams and eponymous .
muscle pedicle grafting for delayed presentation of intra cpasular fracture neck of Femur.. a study of 65 cases in Osmania Medical College, Hyderabad, Telengana.
Osseous anatomy, Types of approaches(Position,landmarks,Incision,Superficial and Deep surgical dissection) , structures at risk, Extensile approaches with diagrams and eponymous .
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. • These comprise 11%–20% of distal humerus fractures.
• Of these fractures, 60% are associated with elbow
dislocations.
• The male-to-female ratio is 4:1.
• The medial epicondyle is a traction apophysis for the
medial collateral ligament and wrist flexors.
MEDIAL EPICONDYLAR APOPHYSEAL INJURIES
3. • The fragment is usually displaced distally and may
be incarcerated in the joint (15% to 18%) .
• It is often associated with fractures of the proximal
radius, olecranon, and coronoid.
• More common than lateral epicondylar fractures
owing to the relative prominence of the epicondyle
on the medial side of the elbow
4. Mechanism of injury:
• Direct:
Trauma to the posterior or posteromedial aspect of the
medial epicondyle.
•Indirect:
Secondary to elbow dislocation: The ulnar
collateral ligament provides avulsion force.
5. Avulsion injury by flexor muscles results from valgus and
extension force during a fall onto an outstretched hand or
secondary to an isolated muscle avulsion from throwing a
ball or arm wrestling
6. Clinical evaluation:
• Pain, tenderness, and swelling medially.
• Symptoms may be exacerbated by resisted wrist
flexion.
• Decreased range of motion - mechanical block to range
of motion may result from incarceration of the
epicondylar fragment within the elbow joint.
• Valgus instability can be appreciated on stress testing
with the elbow flexed to 15 degrees to eliminate the
stabilizing effect of the olecranon
7. • AP, lateral, and oblique radiographs of the elbow should be
obtained.
• Better visualization may be obtained by a slight oblique
view, which demonstrates the posteromedial location of the
apophysis.
• A gravity stress test may be performed, demonstrating
medial opening on stress radiographs
Radiographic evaluation:
8. • Most medial epicondylar fractures may be managed
nonoperatively with immobilization.
• Nonoperative treatment is indicated for nondisplaced or
minimally displaced fractures and for significantly
displaced fractures in older or low-demand patients.
• The patient is initially placed in a posterior splint with
the elbow flexed to 90 degrees with the forearm in
neutral or pronation.
9. • The splint is discontinued 3 to 4 days after injury and
early active range of motion is instituted. A sling is
worn for comfort.
10. Operative
• An absolute indication for operative intervention is an
irreducible, incarcerated fragment within
the elbow joint.
• Closed manipulation may be used to attempt to extract
the incarcerated fragment from the joint - Roberts.
The forearm is supinated, and valgus stress is
applied to the elbow, followed by dorsiflexion of the wrist
and fingers to put the flexors on stretch.
11. • This maneuver is successful approximately 40% of the
time.
• Relative indications for surgery include ulnar nerve
dysfunction owing to scar or callus formation, valgus
instability in an athlete, or significantly displaced
fractures in younger or high-demand patients.
12. • After reduction and provisional fixation with Kirschner
wires, fixation may be achieved with a lag-screw
technique.
• Postoperatively, the patient is placed in a posterior splint
or long arm cast with the elbow flexed to 90 degrees and
the forearm pronated. This may be converted to a
removable posterior splint or sling at 7 to 10 days
postoperatively, at which time active range-of-motion
exercises are instituted.
13. Complications:
• Unrecognized intra-articular incarceration: An
incarcerated fragment tends to adhere and form a
fibrous union to the coronoid process, resulting in
significant loss of elbow range of motion.
excision of the fragment.
• Ulnar nerve dysfunction: 10% to 16%
• Nonunion: May occur in up to 60% of cases with
significant displacement treated nonoperatively
14. • Loss of extension: A 5% to 10% loss of extension is
seen in up to 20% of cases
• Myositis ossificans
15. • very rare
• The lateral epicondyle represents the origin of many of
the wrist and forearm extensors; therefore,avulsion
injuries account for a proportion of these fractures.
.
Lateral Epicondylar Apophyseal Fractures
16. Mechanism of Injury:
• Direct trauma to the lateral epicondyle
• Indirect trauma may occur with forced volar flexion of
an extended wrist, causing avulsion of the extensor
origin
17. Clinical Evaluation:
• Lateral swelling and painful range of motion of the
elbow and wrist, with tenderness to palpation of the
lateral epicondyle.
• Loss of extensor strength
18. Treatment:
Nonoperative
With the exception of an incarcerated fragment within the
joint, almost all lateral epicondylar apophyseal fractures
may be treated with immobilization with the elbow in the
flexed, supinated position until comfortable, usually by 2
to 3 weeks.
19. Operative:
• Incarcerated fragments within the elbow joint may be
simply excised.
• Large fragments with associated tendinous origins may
be reattached with screws or Kirschner wire fixation
and postoperative immobilization for 2 to 3 weeks until
comfortable.
20. Complications
• Nonunion: Commonly occurs with established fibrous
union of the lateral epicondylar fragment
• Incarcerated fragments: May result in limited range of
motion, most commonly in the radiocapitellar
articulation, although free fragments may migrate to the
olecranon fossa and limit terminal extension.
21. • It is the second most common distal humeral fracture
(next to extra-articular).
• Fracture fragments are often displaced by unopposed
muscle pull at the medial (flexor mass) and lateral
(extensor mass) epicondyles, which rotate the articular
surfaces.
Intercondylar Fractures
22. Mechanism of Injury:
Force is directed against the posterior aspect of an elbow
flexed >90 degrees, thus driving the ulna into the trochlea.
23. Riseborough and Radin
classification
Type I: Nondisplaced
Type II: Slight
displacement with no
rotation between the
condylar fragments
Type III: Displacement
with rotation
Type IV: Severe
comminution of the
articular surface
24. Treatment:
Treatment must be individualized according to patient
age, bone quality, and degree of comminution.
Nonoperative: indications
1. nondisplaced fractures
2. elderly patients with displaced fractures and
severe osteopenia and comminution,
3. patients with significant comorbid conditions
precluding operative management.
25. Nonoperative options for displaced fractures include:
• Cast immobilization
• “Bag of bones”: The arm is placed in a collar and cuff
with as much flexion as possible after initial reduction
is attempted; gravity traction helps effect reduction.
The idea is to obtain a painless “pseudarthrosis,” which
allows for motion.
26. Operative
• Open reduction and internal fixation
• This is indicated for displaced reconstructible
fractures.
• Goals of fixation are to restore articular congruity and
to secure the supracondylar component.
27. Methods of fixation include:
• Interfragmentary screws
• Dual plate fixation: one plate medially and another plate
placed posterolaterally, 90 degrees from the medial plate
or two plates on either column, 180 degrees from one
another
• Total elbow arthroplasty (cemented, semiconstrained):
This may be considered in markedly comminuted
fractures and with fractures in osteoporotic bone
28. Postoperative care: Early range of motion of the elbow is
essential unless fixation is tenuous.
Complications:
• Posttraumatic arthritis
• Failure of fixation: Postoperative collapse of fixation is
related to the degree of comminution, the stability of
fixation, and protection of the construct during the
postoperative course.
29. • Loss of motion (extension): This is increased with
prolonged periods of immobilization. Rangeof- motion
exercises should be instituted as soon as the patient is
able to tolerate therapy, unless fixation is tenuous.
• Heterotopic bone formation
• Neurologic injury (up to 15%): The ulnar nerve is
most commonly injured during surgical exposure.