This document provides an overview of disinfection and disinfectants. It begins by defining key terms like disinfection, sterilization, and antiseptics. It then discusses the types of disinfection like concurrent, terminal, and precurrent disinfection. Factors that impact disinfectant effectiveness and the ideal properties of a disinfectant are reviewed. Various chemical and physical disinfecting agents are described along with their mechanisms of action. The document concludes by emphasizing the importance of proper hand hygiene and other infection control procedures.
Antiseptic and disinfectant-Dr.Jibachha Sah,M.V.Sc,Lecturer,NPIDr. Jibachha Sah
Antiseptics• These are chemical substances which inhibit the growth or kill micro- organisms on living surfaces such as skin & mucous membrane .Disinfectants are used to kill or eliminate microorganisms and/or inactivate viruses on inanimate objects and surfaces (medical devices, instruments, equipment, walls, floors).
Antiseptic and disinfectant-Dr.Jibachha Sah,M.V.Sc,Lecturer,NPIDr. Jibachha Sah
Antiseptics• These are chemical substances which inhibit the growth or kill micro- organisms on living surfaces such as skin & mucous membrane .Disinfectants are used to kill or eliminate microorganisms and/or inactivate viruses on inanimate objects and surfaces (medical devices, instruments, equipment, walls, floors).
Chemical Disinfection is a topic under Public Health Dentistry which focuses on various methods and agents that can be used for disinfection of instruments, equipments and other substances used in Dental clinics and other fields of Dentistry.
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are antimicrobial agents that are applied to non-living objects to destroy microorganisms that are living on the objects.Disinfection does not necessarily kill all microorganisms, especially resistant bacterial spores; it is less effective than sterilization, which is an extreme physical and/or chemical process that kills all types of life.
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STERILIZATION AND DISINFECTION BY DR RAHUL ACHARYA.pptrahulacharya52
sterilization using chemical methods, sterilization using physical methods, sterilization using sun light, heat, autoclave, hot air oven . tindalisation, inspisation .
One of the most developed cities of India, the city of Chennai is the capital of Tamilnadu and many people from different parts of India come here to earn their bread and butter. Being a metropolitan, the city is filled with towering building and beaches but the sad part as with almost every Indian city
Antibiotic Stewardship by Anushri Srivastava.pptxAnushriSrivastav
Stewardship is the act of taking good care of something.
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
WHO launched the Global Antimicrobial Resistance and Use Surveillance System (GLASS) in 2015 to fill knowledge gaps and inform strategies at all levels.
ACCORDING TO apic.org,
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
ACCORDING TO pewtrusts.org,
Antibiotic stewardship refers to efforts in doctors’ offices, hospitals, long term care facilities, and other health care settings to ensure that antibiotics are used only when necessary and appropriate
According to WHO,
Antimicrobial stewardship is a systematic approach to educate and support health care professionals to follow evidence-based guidelines for prescribing and administering antimicrobials
In 1996, John McGowan and Dale Gerding first applied the term antimicrobial stewardship, where they suggested a causal association between antimicrobial agent use and resistance. They also focused on the urgency of large-scale controlled trials of antimicrobial-use regulation employing sophisticated epidemiologic methods, molecular typing, and precise resistance mechanism analysis.
Antimicrobial Stewardship(AMS) refers to the optimal selection, dosing, and duration of antimicrobial treatment resulting in the best clinical outcome with minimal side effects to the patients and minimal impact on subsequent resistance.
According to the 2019 report, in the US, more than 2.8 million antibiotic-resistant infections occur each year, and more than 35000 people die. In addition to this, it also mentioned that 223,900 cases of Clostridoides difficile occurred in 2017, of which 12800 people died. The report did not include viruses or parasites
VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratory
to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
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CHAPTER 1 SEMESTER V PREVENTIVE-PEDIATRICS.pdfSachin Sharma
This content provides an overview of preventive pediatrics. It defines preventive pediatrics as preventing disease and promoting children's physical, mental, and social well-being to achieve positive health. It discusses antenatal, postnatal, and social preventive pediatrics. It also covers various child health programs like immunization, breastfeeding, ICDS, and the roles of organizations like WHO, UNICEF, and nurses in preventive pediatrics.
India Clinical Trials Market: Industry Size and Growth Trends [2030] Analyzed...Kumar Satyam
According to TechSci Research report, "India Clinical Trials Market- By Region, Competition, Forecast & Opportunities, 2030F," the India Clinical Trials Market was valued at USD 2.05 billion in 2024 and is projected to grow at a compound annual growth rate (CAGR) of 8.64% through 2030. The market is driven by a variety of factors, making India an attractive destination for pharmaceutical companies and researchers. India's vast and diverse patient population, cost-effective operational environment, and a large pool of skilled medical professionals contribute significantly to the market's growth. Additionally, increasing government support in streamlining regulations and the growing prevalence of lifestyle diseases further propel the clinical trials market.
Growing Prevalence of Lifestyle Diseases
The rising incidence of lifestyle diseases such as diabetes, cardiovascular diseases, and cancer is a major trend driving the clinical trials market in India. These conditions necessitate the development and testing of new treatment methods, creating a robust demand for clinical trials. The increasing burden of these diseases highlights the need for innovative therapies and underscores the importance of India as a key player in global clinical research.
Telehealth Psychology Building Trust with Clients.pptxThe Harvest Clinic
Telehealth psychology is a digital approach that offers psychological services and mental health care to clients remotely, using technologies like video conferencing, phone calls, text messaging, and mobile apps for communication.
CHAPTER 1 SEMESTER V - ROLE OF PEADIATRIC NURSE.pdfSachin Sharma
Pediatric nurses play a vital role in the health and well-being of children. Their responsibilities are wide-ranging, and their objectives can be categorized into several key areas:
1. Direct Patient Care:
Objective: Provide comprehensive and compassionate care to infants, children, and adolescents in various healthcare settings (hospitals, clinics, etc.).
This includes tasks like:
Monitoring vital signs and physical condition.
Administering medications and treatments.
Performing procedures as directed by doctors.
Assisting with daily living activities (bathing, feeding).
Providing emotional support and pain management.
2. Health Promotion and Education:
Objective: Promote healthy behaviors and educate children, families, and communities about preventive healthcare.
This includes tasks like:
Administering vaccinations.
Providing education on nutrition, hygiene, and development.
Offering breastfeeding and childbirth support.
Counseling families on safety and injury prevention.
3. Collaboration and Advocacy:
Objective: Collaborate effectively with doctors, social workers, therapists, and other healthcare professionals to ensure coordinated care for children.
Objective: Advocate for the rights and best interests of their patients, especially when children cannot speak for themselves.
This includes tasks like:
Communicating effectively with healthcare teams.
Identifying and addressing potential risks to child welfare.
Educating families about their child's condition and treatment options.
4. Professional Development and Research:
Objective: Stay up-to-date on the latest advancements in pediatric healthcare through continuing education and research.
Objective: Contribute to improving the quality of care for children by participating in research initiatives.
This includes tasks like:
Attending workshops and conferences on pediatric nursing.
Participating in clinical trials related to child health.
Implementing evidence-based practices into their daily routines.
By fulfilling these objectives, pediatric nurses play a crucial role in ensuring the optimal health and well-being of children throughout all stages of their development.
Defecation
Normal defecation begins with movement in the left colon, moving stool toward the anus. When stool reaches the rectum, the distention causes relaxation of the internal sphincter and an awareness of the need to defecate. At the time of defecation, the external sphincter relaxes, and abdominal muscles contract, increasing intrarectal pressure and forcing the stool out
The Valsalva maneuver exerts pressure to expel faeces through a voluntary contraction of the abdominal muscles while maintaining forced expiration against a closed airway. Patients with cardiovascular disease, glaucoma, increased intracranial pressure, or a new surgical wound are at greater risk for cardiac dysrhythmias and elevated blood pressure with the Valsalva maneuver and need to avoid straining to pass the stool.
Normal defecation is painless, resulting in passage of soft, formed stool
CONSTIPATION
Constipation is a symptom, not a disease. Improper diet, reduced fluid intake, lack of exercise, and certain medications can cause constipation. For example, patients receiving opiates for pain after surgery often require a stool softener or laxative to prevent constipation. The signs of constipation include infrequent bowel movements (less than every 3 days), difficulty passing stools, excessive straining, inability to defecate at will, and hard feaces
IMPACTION
Fecal impaction results from unrelieved constipation. It is a collection of hardened feces wedged in the rectum that a person cannot expel. In cases of severe impaction the mass extends up into the sigmoid colon.
DIARRHEA
Diarrhea is an increase in the number of stools and the passage of liquid, unformed feces. It is associated with disorders affecting digestion, absorption, and secretion in the GI tract. Intestinal contents pass through the small and large intestine too quickly to allow for the usual absorption of fluid and nutrients. Irritation within the colon results in increased mucus secretion. As a result, feces become watery, and the patient is unable to control the urge to defecate. Normally an anal bag is safe and effective in long-term treatment of patients with fecal incontinence at home, in hospice, or in the hospital. Fecal incontinence is expensive and a potentially dangerous condition in terms of contamination and risk of skin ulceration
HEMORRHOIDS
Hemorrhoids are dilated, engorged veins in the lining of the rectum. They are either external or internal.
FLATULENCE
As gas accumulates in the lumen of the intestines, the bowel wall stretches and distends (flatulence). It is a common cause of abdominal fullness, pain, and cramping. Normally intestinal gas escapes through the mouth (belching) or the anus (passing of flatus)
FECAL INCONTINENCE
Fecal incontinence is the inability to control passage of feces and gas from the anus. Incontinence harms a patient’s body image
PREPARATION AND GIVING OF LAXATIVESACCORDING TO POTTER AND PERRY,
An enema is the instillation of a solution into the rectum and sig
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VERIFICATION AND VALIDATION TOOLKIT Determining Performance Characteristics o...
DISINFECTION & DISINFECTANTS.pptx
1. Dr. Khem R. Sharma
Assistant Professor
School of Public Health & Community
Medicine
DISINFECTION & DISINFECTANTS
2. Objectives
After this SIS every one of you will be expected to
be able to:
Define the term, “disinfection,” and explain how
disinfection differs from sterilization
Understand the types of disinfection
Review factors that impact the effectiveness of a
disinfectant
Distinguish between high-level, intermediate-level
& low-level disinfection.
Identify the properties of an ideal disinfectant
Gain knowledge on the Disinfection agents
(Disinfectants)
3. Introduction
Disinfection is the process of killing infectious
agents except spores outside the body by direct
exposure to chemical or physical agents.
It can refer to the action of antiseptics as well as
disinfectants.
Sterilisation - process by which an article, surface
or medium is made free of all living
microorganisms including spores.
4. A disinfectant is a substance which destroys
harmful microbes (except spores) with the object
of preventing transmission of infection.
Disinfectants are only suitable for application on
inanimate objects.
Antiseptics - Chemicals used on living tissue such
as skin, to kill or slow the growth of
microorganisms.
Introduction
5. A brief History
Early civilization practiced methods like salting, smoking,
pickling and exposure to sunlight to prolong shelf life of foods.
Semmelweis (1818-1865) – demonstrated the value of hand-
washing with antiseptic solutions to reduce the death rate from
puerperal fever.
Lister (1927-1972) was successful in reducing the number of
wound infections by prophylactic application of carbolic acid.
6. Types of Disinfection
1) Concurrent disinfection : It is the application of
disinfective measures as soon as possible after the
discharge of infectious material from the body of an
infected person.
7. 2) Terminal disinfection: Application of dis-infective
measures after the patient has been removed by death
or to a hospital or has ceased to be a source of
infection or after other hospital isolation practices
have been discontinued. Rarely practiced today.
3) Precurrent (prophylactic) disinfection: Disinfection of
water by chlorine, pasteurization of milk and
handwashing may be cited as examples of precurrent
disinfection.
Types of Disinfection
8. Chemical Disinfection
Cidal - chemical agents capable of killing
bacteria.
Agents that are bactericidal, virucidal,
fungicidal or sporicidal are capable of killing
these organisms.
Static - Chemical agents that inhibit the growth
of bacteria but do not necessarily kill them.
9. Properties of an Ideal Disinfectant
Broad spectrum
Fast acting
Not affected by environmental facters
Nontoxic
Surface compatibility
Residual effect on treated surfaces
Easy to use with clear lebel directions
Odourless
Ecological
Solubility
Cleaner , Environmentally friendly.
10. Factors Impacting the
Effectiveness of Disinfectants
Excessive Moisture
Excessive moisture can
cause disinfectant solutions
to become diluted.
Lowering the concentration
of the chemical disinfectant
can reduce its ability to kill
microorganisms
Type and number of
microorganisms present
11. Factors Impacting the
Effectiveness of Disinfectants:
Direct Contact with the Item
In order to be effective, disinfectants must
make direct contact with all surfaces
being disinfected
Time
Disinfectants must be allowed some time
to work
Check manufacturer’s instructions for the
correct exposure time required to achieve
the desired biocidal effect
12. Temperature of the Disinfectant
pH
Hardness of the Water
Material Compatibility
Positioning of the Device(s) being disinfected
Other Factors Impacting the
Effectiveness of Disinfectants
13. Selecting a
Disinfectant
Should be based on:
◦ The intended use of the device
◦ The degree of disinfection
required for the device
◦ Risk levels
14. Critical Items
Items introduced directly
into the bloodstream or
other normally sterile
areas of the body
Surgical Instruments,
Implants, etc.
15. Semi-Critical Items
Items which come in
contact with intact
mucous membranes
Fiberoptic Endoscopes,
Cystoscopes, etc.
16. Non-Critical Items
Come in direct contact
with the patient’s
unbroken skin
Crutches, Blood Pressure
Cuffs, equipment, etc.
17. Classification of
Patient Care Items
Body Contact Activity Level Item Class
Intact skin Low level Non-critical
Mucous membranes Intermediate level Semi-critical
Sterile body cavity High level Critical
19. High level disinfection
This processes destroy vegetative bacteria,
mycobacteria, fungi and enveloped (lipid) and
non-enveloped (non lipid) viruses, but not
necessarily bacterial spores.
High level disinfectant chemicals (also called
chemical sterilants) must be capable of
sterilization when contact time is extended.
Items must be thoroughly cleaned prior to high
level disinfection.
21. Low level disinfection
Low level disinfectants kill most vegetative
bacteria and some fungi as well as
enveloped (lipid) viruses (e.g., hepatitis B,
C, hantavirus, and HIV).
Low level disinfectants do not kill
mycobacteria or bacterial spores.
Low level disinfectants are typically used to
clean environmental surfaces.
22. Wear PPE
Use an exhaust hood when necessary
Develop a spill plan
Provide an eyewash/shower and other first aid
supplies
Provide easy access to a phone and phone
numbers for emergencies
Provide yearly staff training
Monitor disinfectants (including air quality)
Chemical Disinfectant
Safety
23. Disinfectants
1) Natural Agents
Sunlight, Air
2) Physical Agents
Burning
Hot Air
Boiling
Autoclaving
Radiation
Many disinfectants are used alone or in
combinations in the health-care setting.
Chemical Agents
Alcohols
Chlorine and Chlorine compounds
Formaldehyde
Glutaraldehyde
Ortho-phthalaldehyde,
Hydrogen peroxide
Iodophors
Peracetic acid
Phenolics
Quaternary ammonium compounds.
24. Natural Agents
Sunlight: Direct and continuous exposure to
sunlight is destructive to many disease producing
organisms.
Air: Exposure to open air (airing) acts by drying or
evaporation of moisture which is lethal to most
microorganism.
25. Physical Agents
Burning/incineration is an excellent method of
disinfection.
Hot air sterilization is usually done in a hot air
oven & is very useful for sterilizing articles such
as glassware, syringes, swabs & dressings.
Boiling is an effective method of disinfection
which provides an atmosphere of boiling and
steam.
The drawbacks of boiling are that it is a slow
process, unsuitable for thick beddings and
woolen materials as they shrink.
26. Autoclaving: It generates steam under pressure
(saturated steam) which is the most effective
sterilizing agent.
Basically, the autoclave works on the same
principle as the domestic pressure cooker
Ionizing radiation has great penetrating powers
with little or no heating effect making it one of the
most viable, safe and economic methods used
today..
Physical Agents
27. Alcohol
denaturation of proteins
Alcohols are commonly used topical antiseptics. Rapid
bactericidal, tuberculocidal, fungicidal, and virucidal but
do not destroy bacterial spores.
optimum bactericidal concentration is 60%–90%
solutions in water.
Alcohols are not effective against bacterial spores and
have limited effectiveness against nonenveloped
viruses.
They are also used to disinfect the surface of medical
equipment. Alcohols require time to work and they may
not penetrate organic material.
28. • They have a broad spectrum of
antimicrobial activity, do not leave
toxic residues, are unaffected by
water hardness.
• Hypochlorite, the most widely used
of the chlorine disinfectants, are
available as liquid or solid.
• The most common chlorine
products in are aqueous solutions
of 4 to 6% sodium hypochlorite,
which are readily available as
“household bleach”.
Chlorine and Chlorine Compounds
(Hypochlorite)
29. Hypochlorite Most recommended in They are
included in most recommendation for
decontamination of hepatitis and AIDS viruses .
Hypochlorite are also the agent of choice in
disinfecting surfaces used for food preparation or
in bathrooms.
Organic material such as feces or blood
inactivate chlorine based disinfectants, therefore,
surfaces must be clean before their use.
Chlorine and Chlorine Compounds
(Hypochlorite)
30. Formaldehyde is used as a disinfectant and
sterilants in both its liquid and gaseous states.
The aqueous solution is a bactericide,
tuberculocide, fungicide, virucidal and sporicidal.
Formaldehyde
formalin
31. Formaldehyde
Mode of Action. Formaldehyde inactivates
microorganisms by alkalizing the amino and
sulfhydral groups of proteins and ring nitrogen
atoms of purine bases.
Be careful in handling Formaldehyde, wear
mask (irritant and potential carcinogenic )
32. Glutaraldehyde
high-level disinfectant and chemical sterilant
Aldehydes have a wide germicidal spectrum.
Gluteraldehydes are bactericidal, virucidal,
fungicidal, sporicidal and parasiticidal.
33. Glutaraldehyde
They are used as a disinfectant or sterilant in
both liquid and gaseous forms.
Glutaraldehyde is used most commonly as a
high-level disinfectant for medical equipment
such as endoscopes.
Glutaraldehyde should not be used for cleaning
Noncritical surfaces because it is too toxic and
expensive.
34. Hydrogen Peroxide
3% hydrogen peroxide is a stable and effective
disinfectant when used on inanimate surfaces.
Peroxides such as hydrogen peroxide
are often used as antiseptics to clean
wounds.
The activity of peroxides is greatest
against anaerobic bacteria.
35. Hydrogen Peroxide
Hydrogen peroxide at high concentrations is in
some cases is damaging to tissues, resulting in a
prolonged healing time.
It is useful for cleaning surgical sites after closure,
but use sparingly to avoid penetrating suture
lines, which would inhibit healing.
36. Iodine
The best-known and most widely used iodophor is
povidone-iodine.
Mode of Action. Iodine can penetrate the cell wall of
microorganisms quickly, and the lethal effects are
believed to result from disruption of protein and nucleic
acid structure and synthesis.
37. Ortho-phthalaldehyde (OPA)
Ortho-phthalaldehyde is a high-level disinfectant
OPA solution is a clear, pale-blue liquid with a pH of 7.5.
advantages: excellent stability over a wide pH range (pH 3–9)
not a known irritant to the eyes and nasal passages, does not
require exposure monitoring, has a barely perceptible odor
38. Peracetic Acid
rapid action against all microorganisms.
Special advantages of peracetic acid are that it
lacks harmful decomposition products
It remains effective in the presence of organic
matter and is sporicidal even at low
temperatures Uses. An automated machine
using peracetic acid to chemically sterilize
medical (e.g., endoscopes, arthroscopes),
surgical, and dental instruments.
39. Peracetic Acid and Hydrogen
Peroxide
combination of peracetic acid and hydrogen
peroxide inactivated all microorganisms
except bacterial spores within 20 minutes.
The 0.08% peracetic acid plus 1.0% hydrogen
peroxide product effectively inactivated
glutaraldehyde-resistant mycobacteria.
Peracetic Acid
40. Phenolics
In high concentrations, phenol acts as a gross
protoplasmic poison, penetrating and disrupting the
cell wall and precipitating the cell proteins.
Pure phenol is not an elfective disinfectant & is
used as a standard to compare the germicidal
activity of disinfectants
Phenolics are bactericidal, fungicidal, virucidal, and
tuberculocidal (low level disinfectant).
41. Quaternary Ammonium Compounds
The quaternary ammonium compounds are widely used
as disinfectants and good cleaning agents.
Mode of Action. The bactericidal action of the
quaternaries has been attributed to the inactivation of
energy-producing enzymes, denaturation of essential cell
proteins, and disruption of the cell membrane.
Uses. The quaternaries commonly are used in ordinary
environmental sanitation of Noncritical surfaces, such as
floors, furniture, and walls.
42. Chlorhexidine
Chlorhexidine products are often used as
disinfectants for inanimate objects or
antiseptics for cleaning skin wounds.
Skin Antisepsis: 0.5% Chlorhexidine Skin
Preparation with Alcohol.
Low toxicity
Used in disinfection of the skin and hands
& mucous membranes
43. No disinfectant is substitute for
the following procedures
Hand washing (hand hygiene)
The use of personal protective equipment (e.g.
gloves) when handling blood, body substances
excretions and secretions.
Appropriate handling of patient care equipment
and soiled linen.
The prevention of needle stick/sharp injuries.
Environmental cleaning.
Appropriate handling of medical waste.
Taking care of yourself (e.g. immunization)