Glutaraldehyde is a hazardous chemical that can cause skin, eye and respiratory irritation. It may be carcinogenic and toxic to several organs over long term exposure. Glutaraldehyde is commonly used as a sterilizing agent in healthcare and other industries due to its strong disinfecting properties. While it is less caustic than formaldehyde, glutaraldehyde remains the gold standard for chemical sterilization. It can be produced through various chemical reactions and may polymerize under alkaline conditions.
Fumigation is a process of gaseous sterilisation which is used for killing of micro-organisms and prevention of microbial growth in air, surface of wall or floor.
This topic has been introduced in the new edition of Bailey & Love - 26th. This topic covers the types, uses & special uses as well as complications of Diathermy.
Iv fluid therapy (types, indications, doses calculation)kholeif
All what you need to know intravenous fluids, types, indications, contraindications, how to calculate fluid rate and drug dosages.
Embed code (http://www.slideshare.net/slideshow/embed_code/16138690)
Diathermy
• Diathermy uses an electric current to cause localized heating,
permitting cutting of tissue and coagulation of blood.
• It may be unipolar or bipolar, the former having several settings
depending on which function is required.
Unipolar diathermy
Bipolar diathermy
• Advantages
• Allows surgery to proceed with better hemostatic control than using sharp
instruments.
• Different modes can be used to achieve different effects on different
tissues.
• Disadvantages
• High currents used in diathermy equipment cause induction in cables
used for other purposes. This results in interference in the ECG and other
monitors when diathermy is in use.
Safety
The above PPT includes different methods of sterilization- Dry heat, Moist heat, Radiation and Chemical methods. It also includes principle and working of hot air oven and autoclave.
The sterilization of surgical instruments is a process that removes all microorganisms from medical instruments before a surgery can take place. Proper sterilization ensures that all equipment has been thoroughly cleaned, sanitized and sterilized, and minimizes the risk of preventable surgical site infections. This process should be completed by a certified central sterilization technician.
Fumigation is a process of gaseous sterilisation which is used for killing of micro-organisms and prevention of microbial growth in air, surface of wall or floor.
This topic has been introduced in the new edition of Bailey & Love - 26th. This topic covers the types, uses & special uses as well as complications of Diathermy.
Iv fluid therapy (types, indications, doses calculation)kholeif
All what you need to know intravenous fluids, types, indications, contraindications, how to calculate fluid rate and drug dosages.
Embed code (http://www.slideshare.net/slideshow/embed_code/16138690)
Diathermy
• Diathermy uses an electric current to cause localized heating,
permitting cutting of tissue and coagulation of blood.
• It may be unipolar or bipolar, the former having several settings
depending on which function is required.
Unipolar diathermy
Bipolar diathermy
• Advantages
• Allows surgery to proceed with better hemostatic control than using sharp
instruments.
• Different modes can be used to achieve different effects on different
tissues.
• Disadvantages
• High currents used in diathermy equipment cause induction in cables
used for other purposes. This results in interference in the ECG and other
monitors when diathermy is in use.
Safety
The above PPT includes different methods of sterilization- Dry heat, Moist heat, Radiation and Chemical methods. It also includes principle and working of hot air oven and autoclave.
The sterilization of surgical instruments is a process that removes all microorganisms from medical instruments before a surgery can take place. Proper sterilization ensures that all equipment has been thoroughly cleaned, sanitized and sterilized, and minimizes the risk of preventable surgical site infections. This process should be completed by a certified central sterilization technician.
Silver Hydrogen Peroxide, an eco-friendly disinfectant, with a variety of uses. It breaks down into water and oxygen after work. Oxidizing in nature, and silver provides extra benefit of long lasting disinfection.
Used for disinfection of soil, dairy, water, etc.
Compatible with most materials and can be used in any media.
Compact Hydrogen Peroxide Sensor for Sterilization Cycle MonitoringClinton Smith
We demonstrate a compact hydrogen peroxide (H2O2) sensor capable of measuring as little as 32 parts-per-billion (ppb) concentration H2O2. This sensor was also shown to measure as little as 9 ppb concentration methane. The technology works by measuring the mid-Infrared absorption of the trace-gas analyte, which results in a virtually interference free signal.
Methylene glycol is an ingredient
used in some hair-straightening
products. It is formed by the reaction
of formaldehyde with water.
Formaldehyde is a toxic substance,
and since the reaction with water
is reversible, products containing
methylene glycol can, under some
circumstances, release formaldehyde.
The question is thus: is the
use of methylene glycol in hair
straightening products safe?
Chemical Method Sterilization Disinfection Powerpoint Presentation PPT.pdfVohnArchieEdjan
This ppt contributes to literature by investigating effective methods of sterilization and disinfection using chemical agents, focusing on alcohols, aldehydes, and halogens. Through detailed explanations of the mechanisms of action, advantages, and disadvantages of each chemical, it provides valuable insights for healthcare professionals and researchers in the field of infection prevention and control. Additionally, by referencing authoritative sources, the paper ensures credibility and relevance in the discussion of chemical disinfectants.
Chemical sterilization methods
Disinfection techniques
Sterilization solutions
Chemical disinfectants
Sterilization processes
Chemical agents for sterilization
Disinfection technology
Sterilization best practices
Chemical decontamination
Sterilization efficacy
Disinfection standards
Chemical sanitation methods
Sterilization PowerPoint presentation
Disinfection training materials
Chemical sterilization guidelines
Disinfection protocols PPT
Sterilization procedures
seminar
Four common formaldehyde releasers to avoid in your cosmetics and skin careMohammad Baghaei
Quaternium-15 is a quaternary ammonium salt. It is most commonly used as part of what is usually a large "cocktail" of preservatives in personal and skin care products that require a long shelf life. It is a known formaldehyde donor. . It can cause contact dermatitis, a symptom of an allergic reaction, especially in those with sensitive skin, on an infant's skin, or on sensitive areas such as the genitals.
Above ppt includes different types of disinfectants used in microbiology ,classification of disinfectants, and also it includes some important techniques like Plasma sterilization ,ETO sterilization and bleaching of water.
Directory of Toxic Ingredient in Cosmetics & Body Care Products v2zq
Directory of Toxic Ingredient in Cosmetics & Body Care Products - Resources for Healthy Children www.scribd.com/doc/254613619 - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
Classification and mode of action of disinfectants PHARMACEUTICAL MICROBIOLOG...Ms. Pooja Bhandare
PHARMACEUTICAL MICROBIOLOGY (BP303T)Unit-III Classification and mode of action of disinfectants. DISINFECTANT
Definition: Ideal properties of disinfectants: CLASSIFICATION OF DISINFECTANTS: Based on consistency 1. Liquid (E.g., Alcohols, Phenols) 2.Gaseous (Formaldehyde vapor, Ethylene oxide). Based on spectrum of activity 1. High level disinfectant
2. Intermediate level disinfectant
3. Low level disinfectant .Based on mechanism of action: 1.Action on membrane2.Denaturation of cellular proteins 3.Damage to nucleic acids 4.Oxidation of essential sulfhydryl groups of enzymes 5.Alkylation of amino-, carboxyl- and hydroxyl group. MODE OF ACTION AND APPICATION OF DISINFECTANT
Acid and alkalies
Halogens
Heavy metals
Phenols and its derivatives
Alcohol
Aldehydes
Dyes:
Quaternary ammonium compounds
Detergents and soaps.
Zagro aims to help farmers improve farm hygienic practices to control and prevent disease-causing microbes. Through its Zagro Farm Hygiene Program, they introduce a range of disinfectant products that are independently proven to be effective and can be applied for multiple purposes. View our range of products to see more information about these disinfectants.
For more information https://www.zagro.com/
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
2. Health Risks
• Potential Acute Health Effects:
• Hazardous in case of skin contact (irritant), of eye
contact (irritant), of ingestion, of inhalation (lung
irritant, lung sensitizer).
• Slightly hazardous in case of skin contact
(sensitizer, permeator). Liquid or spray mist may
produce tissue damage particularly
• on mucous membranes of eyes, mouth and
respiratory tract. Skin contact may produce burns.
Inhalation of the spray mist may
• produce severe irritation of respiratory tract,
characterized by coughing, choking, or shortness of
breath. Severe over-exposure
• can result in death.
• Potential Chronic Health Effects:
• CARCINOGENIC EFFECTS: Classified A4 (Not classifiable for
human or animal.) by ACGIH [Glutaraldehyde]. MUTAGENIC
• EFFECTS: Mutagenic for mammalian somatic cells.
[Glutaraldehyde]. Mutagenic for bacteria and/or yeast.
[Glutaraldehyde].
• TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL
TOXICITY: Classified Reproductive system/toxin/female,
• Reproductive system/toxin/male [SUSPECTED] [Glutaraldehyde].
The substance may be toxic to blood, the reproductive
• system, liver, mucous membranes, spleen, central nervous system
(CNS), Urinary System. Repeated or prolonged exposure
• to the substance can produce target organs damage. Repeated or
prolonged contact with spray mist may produce chronic
• eye irritation and severe skin irritation. Repeated or prolonged
exposure to spray mist may produce respiratory tract irritation
• leading to frequent attacks of bronchial infection. Repeated exposure
to a highly toxic material may produce general
• deterioration of health by an accumulation in one or many human
organs.
3.
4. Background
In the late 1950's a successful method of industrialization was
patented that utilized a Diels-Alder type reaction of acrolein and
vinylethyl ether forming 2-ethoxy-3, 4-dihydro-2H-pyran which
readily hydrolyzes to glutaraldehyde with a by product of ethano.
Interest peaked in the 1960's after several investigations
discovered glutaraldehyde's outstanding disinfection and
sterilization capabilities; capabilities that exceeded even
formaldehyde (industry standard at the time). During this boom in
interest, glutaraldehyde performed duties as active ingredient in
products such as: high-level disinfectants, cold-chemical sterilants,
and potent sporicides.
Even today glutaraldehyde is essentially considered the gold-
standard for chemical forms of sterilization.
"All disinfectants and new alternative disinfectant chemicals efficacy are
based upon comparison to glutaraldehyde efficacy." - James H. Bedino
5. Production and Structure
Glutaraldehyde is produced industrially by the oxidation of cyclopentene
and by the Diels-Alder reaction of acrolein and methyl vinyl ether
followed by hydrolysis.
Like other dialdehydes (e.g., glyoxal), it does not exist as the dialdehyde
but as the hydrate. These hydrates adopt several structures.
Monomeric glutaraldehyde can polymerize by aldol condensation
reaction yielding alpha, beta-unsaturated poly-glutaraldehyde. This
reaction usually occurs at alkaline pH values.
6. Also used for...
Sterilant in the health care
industry
Tanning agent (most interesting,
previously unknown fact about
glutaraldehyde for me)
A biocide for metalworking fluids
A biocide for oil and gas pipelines
An antimicrobial in water-treatment
systems
A preservative in cosmetics
A disinfectant in animal housing
A slimicide (paper manufacturing)
In the development of X-rays
(hardening agent)
A tissue fixative in pathology and
histology labs
In the preparation of grafts and
bioprostheses
In various clinical applications
7. Glutaraldehyde vs. Formaldehyde
There is constant debate as to the advantages/disadvantages of embalming
uses of formaldehyde and glutaraldehyde.
Formaldehyde excels in such embalming scenarios as edema and produces
rapid results that embalmers as a whole generally considers valuable.
Glutaraldehyde excells at sanitation, has a mildness in reaction, and provides a
favorable cosmetic effect; all with prolonged, delayed action making it an excellent
cavity fluid (where contact times are long and resistant fixation is essential).
Options for using both chemicals to their full advantage (recommended):
(during a routine embalming) use a pre-injection of glutaraldehyde followed by a
primary injection of formaldehyde (to induce the desired results of firmness, rigidity,
skin tightness). Given the low volume of formaldehyde necessary to produce desired
results (typically 4-6 ounces in the last part of the injection of a moderate
concentration [index 20] fluid), it is also favorably effective to use injections consisting
of both glutaraldehyde and a low quantity of formaldehyde (especially useful when
avoiding pre-injection).
Summarily, both formaldehyde and glutaraldehyde have their uses in the
embalming room. Using both in a manner that facilitates their advantages to be taken
advantage of would be optimal.
"The overall goal of chemical selection mix in the modern embalming room should be
a juxtaposition of lowered total overall exposure risk balanced against sufficient and
effective embalming results." - James H. Bedino
8. Works Cited
Pg 2 "MSDS Glutaraldehyde Water 50%/50%." Science Lab.com
21 May 2013. Web document. Data accessed 02 July 2013.
http://www.sciencelab.com/msds.php?msdsId=9924161
Pg 3 "Glutaraldehyde." Chemical Labels
2013. Web image. Data accessed 02 July 2013.
http://www.chemicallabels.com/img/lg/L/Glutaraldehyde-NFPA-Chemical-Label-LB-
1592-063.gif
Pg 4/7 Bedino, James H. "Embalming Chemistry: Glutaraldehyde versus Formaldehyde." Champion
Expanding Encyclopedia of Mortuary Practices No. 649, 2003.
2003. Web document. Data accessed 02 July 2013.
https://docs.google.com/viewer?url=http%3A%2F%2Fwww.champion-newera.com
%2FCHAMP.PDFS%2Fencyclo649.pdf
Pg 5 "Glutaraldehyde." Wikipedia
8 April 2013. Web. Web image. Data accessed 02 July 2013.
http://en.wikipedia.org/wiki/Glutaraldehyde
Pg 6 "Glutaraldehyde." Workplace Safety & Health Topics. CDC
24 Feb 2012. Web. Data accessed 02 July 2013.
http://www.cdc.gov/niosh/topics/glutaraldehyde/
Pg 8 "Quantofix® Glutaraldehyde" Macherey-Nagel
2013. Web image. Data accessed 02 July 2013.
http://www.mn-net.com/tabid/11208/default.aspx