The document discusses the Diels-Alder reaction, which is a [4+2] cycloaddition reaction between a conjugated diene and a dienophile to form a six-membered ring. The reaction is initiated by heat and proceeds through a concerted mechanism. The reaction is stereospecific and favors the endo product. It has many applications including the synthesis of steroids, aromatic compounds, flame retardants, and pesticides.
The video lecture for this presentation is available at the following link on YouTube
https://youtu.be/3sxal579RNM
The presenation will be useful for Ug/PG (Chemistry) students
An organic species which has a carbon atom bearing only six electrons in its outermost shell and has a positive charge is called carbocation.
The positively charged carbon of carbocation is sp2 hybridized.
The unhybridized p-orbital remains vacant.
They are highly reactive and act as reaction intermediate.
They are also called carbonium ion.
Favorskii rearrangement is one the important reactions in organic chemistry. Let us have some prior understanding of its mechanism and its applications.
The video lecture for this presentation is available at the following link on YouTube
https://youtu.be/3sxal579RNM
The presenation will be useful for Ug/PG (Chemistry) students
An organic species which has a carbon atom bearing only six electrons in its outermost shell and has a positive charge is called carbocation.
The positively charged carbon of carbocation is sp2 hybridized.
The unhybridized p-orbital remains vacant.
They are highly reactive and act as reaction intermediate.
They are also called carbonium ion.
Favorskii rearrangement is one the important reactions in organic chemistry. Let us have some prior understanding of its mechanism and its applications.
This is the biggy, the one everyone wants to achieve. Here we will be looking at metal-based chiral catalysis. We will concentrate on bisoxazoline-based Lewis acid catalysis and then look at reductions before finishing with the ubiquitous Sharpless epoxidation and dihydroxylation.
My notes for A2 Chemistry Unit 5, typed by me and compiled from various sources.
I cannot trace back where everything came from but again shall any intellectual property rights be violated, please comment /contact me and I will try my best to rectify them as soon as possible.
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The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
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The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
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The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
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Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
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3. HISTORY
The Diels-Alder reaction is a method of
producing cyclical organic compounds
(cycloaddition reaction), and is named for Otto
Diels and Kurt Alder who in 1950 received the
Nobel Prize for their experiments.
4.
5.
6. Diels alder reaction is a [4+2] cycloaddition reaction
The Diels-Alder reaction is an addition reaction
between a 1,3-diene and an alkene or alkyne
(called a dienophile), to form a new ring.
dienophile: Diene-loving
7. Diene : diene are electron rich compound. In the
presence of electron releasing groups such as
alkyl,phenyl,or alkoxy groups may further enhance the
reactivity of diene
Dienophile: the most common dienophiles are the
electron poor alkenes and alkyne. A good dienophile
generally has one or more electron-withdrawing
groups(CHO,COOH,CN) pulling electron density away
from the Π bond
8.
9. All Diels-Alder reactions have the following features in
common:
1. They are initiated by heat; that is, the Diels-Alder
reaction is a thermal reaction.
2. They form new six-membered rings.
3. Three bonds break, and two new C—C bonds
and one new C—C bond forms.
4. All old bonds are broken and all new bonds are
formed in a single step
12. Diels alder reaction
initiated by thermally, in
the case of thermal
reaction we consider the
interaction between
HOMO of diene and
LUMO of dienophile or
LUMO-HOMO
interaction
13. system thermal photochemical
4n+2 S-S S-A
4n S-A S-S
Depending upon nature and interaction of
system we can predict weather the reaction
thermal or photochemical
Diels alder reaction 4n+2 systems supra-supra
interaction so that the reaction is thermally
allowed reaction
15. Several rules govern the Diels-Alder reaction.
1. The diene can react only when it adopts the s-cis
conformation.
This rotation is prevented in cyclic alkenes. When the two
double bonds are constrained to an s-cis conformation, the
diene is unusually reactive. When the two double bonds are
constrained in the s-trans conformation, the diene is
unreactive.
16. 2.When endo and exo products are possible, the endo
product is preferred.(alder rule)
•Consider the reaction of 1,3-cyclopentadiene with ethylene. A
new six-membered ring forms and above the ring there is a one
atom “bridge.”
In transition state the electron withdrawing group(z) is more closer to
diene, the product become more stable. In the case of bridge carbon ring
system endo product more stable then exo
17. •When cyclopentadiene reacts with a substituted alkene as the dienophile
(CH2=CHZ), the substituent Z can be oriented in one of two ways in the product.
22. •When heated, dicyclopentadiene undergoes a retro Diels-
Alder reaction, and two molecules of cyclopentadiene are re-
formed.
•If the newly produced cyclopentadiene is immediately treated
with a different dienophile, it reacts to form a new Diels-Alder
adduct with this dienophile.
•This is how cyclopentadiene used in Diels-Alder reactions is
produced.
Diels alder reaction 4n+2 systems supra-supra interaction so that the reaction is thermally allowed reaction
Ground state orbitals of reactants correlate with the ground state orbitals of product. Therefore the Diels alder reaction is thermally allowed
In transition state the electron withdrawing group is more closer to diene, the product become more stable. In the case of bridge carbon ring system endo product more stable then exo
The diels alder reaction is stereospecific. Substituents that are cis in dienophile remain cis in product. It is same in the case of trans.
Use for the syntheses of steroids
Use for the synthetic equivalent of unreactive species