The eye develops from the optic vesicles which invaginate to form the optic cups. The inner layer of the optic cup forms the neural retina while the outer layer forms the pigmented retina. The lens develops from surface ectoderm which invaginates to form the lens vesicle. Mesenchyme surrounding the eye differentiates into the choroid, sclera, iris and ciliary body. The optic nerve develops from the optic stalk as nerve fibers grow and the stalk walls fuse. Abnormalities can occur if structures like the choroid fissure fail to close properly or due to infections disrupting eye development.
anatomical consideration of development of eye from embryonic stage. gives insight into future anatomical and pharmacological basis of drug development in disorders of eye.
The retina is a thin layer of tissue that lines the back of the eye on the inside. It is located near the optic nerve. The purpose of the retina is to receive light that the lens has focused, convert the light into neural signals, and send these signals on to the brain for visual recognition. The two layers of the optic cup will further differentiate into the retina of the mature eye. ... The outer layer of the posterior 4/5 will become the pigment layer of the retina, and the inner one will become the neural retina.
The retina is the internal layer of the eyeball , which is a thin membrane having a purplish red color in living subject. This is a presentation by Dr. Shah-Noor Hassan regarding ANATOMY OF RETINA
anatomical consideration of development of eye from embryonic stage. gives insight into future anatomical and pharmacological basis of drug development in disorders of eye.
The retina is a thin layer of tissue that lines the back of the eye on the inside. It is located near the optic nerve. The purpose of the retina is to receive light that the lens has focused, convert the light into neural signals, and send these signals on to the brain for visual recognition. The two layers of the optic cup will further differentiate into the retina of the mature eye. ... The outer layer of the posterior 4/5 will become the pigment layer of the retina, and the inner one will become the neural retina.
The retina is the internal layer of the eyeball , which is a thin membrane having a purplish red color in living subject. This is a presentation by Dr. Shah-Noor Hassan regarding ANATOMY OF RETINA
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2. Development of the eye
⢠The developing eye appears in the 22-day embryo
as a pair of shallow grooves on the sides of the
forebrain.
⢠With closure of the neural tube, these grooves
form outpocketings of the forebrain, the optic
vesicles.
⢠These vesicles subsequently come in contact with
the surface ectoderm and induce changes in the
ectoderm necessary for lens formation.
3.
4. Optic Cup
⢠Shortly thereafter, the optic vesicle begins to
invaginate and forms the double-walled optic cup.
⢠The inner and outer layers of this cup are initially
separated by a lumen, the intraretinal space, but soon
this lumen disappears, and the two layers appose each
other.
⢠Invagination is not restricted to the central portion of
the cup but also involves a part of the inferior surface
that forms the choroid fissure.
⢠Formation of this fissure allows the hyaloid artery to
reach the inner chamber of the eye.
⢠During the seventh week, the lips of the choroid
fissure fuse, and the mouth of the optic cup becomes
a round opening, the future pupil.
5.
6.
7. The lens vesicle
⢠During these events, cells of the surface ectoderm, initially
in contact with the optic vesicle, begin to elongate and form
the lens placode. This placode subsequently invaginates
and develops into the lens vesicle.
⢠During the fifth week, the lens vesicle loses contact with
the surface ectoderm and lies in the mouth of the optic cup
⢠Shortly after formation of the lens vesicle, cells of the
posterior wall begin to elongate anteriorly and form long
fibers that gradually fill the lumen of the vesicle.
⢠By the end of the seventh week, these primary lens fibers
reach the anterior wall of the lens vesicle.
⢠Growth of the lens is not finished at this stage, however,
since new (secondary) lens fibers are continuously added to
the central core.
8.
9. RETINA, IRIS, AND CILIARY BODY
⢠The outer layer of the optic cup, which is characterized by small
pigment granules, is known as the pigmented layer of the retina.
⢠The inner (neural) layer of the optic cup is more complicated and
divided into: posterior four-fifths, the pars optica retinae, contains
cells bordering the intraretinal space that differentiate into light-
receptive elements, rods and cones. Adjacent to this
photoreceptive layer is the mantle layer, which gives rise to
neurons and supporting cells, including the outer nuclear layer,
inner nuclear layer, and ganglion cell layer. Nerve fibers of
ganglion cells converge toward the optic stalk, which develops
into the optic nerve.
⢠The anterior fifth of the inner layer, the pars ceca retinae, remains
one cell layer thick. It later divides into the pars iridica retinae,
which forms the inner layer of the iris, and the pars ciliaris
retinae, which participates in formation of the ciliary body.
10. Development of the retina and the optic nerve
⢠Optic cup formed of 2 layers
⢠Outer layer outer pigmented layer of the retina
⢠Inner layer
Pars optica retinae
Posterior 4/5th
Pars ceca retinae
Anterior 1/5th
Rods and cones (light-receptive
elements)
Mantle layer
Outer nuclear layer
Inner nuclear layer
Ganglion cell layer
The pars iridica retinae, which
forms the inner layer of the iris
The pars ciliaris retinae,
which participates in
formation of the ciliary body.
11.
12. Iris
⢠In the adult, the iris is formed
by:
⢠the pigment-containing external
layer,
⢠the unpigmented internal layer
of the optic cup, and
⢠a layer of richly vascularized
connective tissue that contains
the pupillary muscles.
⢠The sphincter and dilator
pupillae muscles form in loose
mesenchyme in the region
between the optic cup and the
overlying surface epithelium
from the underlying ectoderm
of the optic cup.
13. Ciliary body
⢠The pars ciliaris retinae is
easily recognized by its
marked folding.
⢠Externally, it is covered by a
layer of mesenchyme that
forms the ciliary muscle; on
the inside, it is connected
to the lens by a network of
elastic fibers, the
suspensory ligament or
zonula.
⢠Contraction of the ciliary
muscle changes tension in
the ligament and controls
curvature of the lens.
14. CHOROID, SCLERA, AND CORNEA
⢠At the end of the fifth week, the eye primordium is completely
surrounded by loose mesenchyme.
⢠This tissue soon differentiates into an inner layer comparable with the pia
mater of the brain and an outer layer comparable with the dura mater.
⢠The inner layer later forms a highly vascularized pigmented layer known as
the choroid;
⢠the outer layer develops into the sclera and is continuous with the dura
mater around the optic nerve.
⢠Differentiation of mesenchymal layers overlying the anterior aspect of the
eye is different. The anterior chamber forms through vacuolization and
splits the mesenchyme into an inner layer in front of the lens and iris, the
iridopupillary membrane, and an outer layer continuous with the sclera,
the substantia propria of the cornea.
⢠The anterior chamber itself is lined by flattened mesenchymal cells.
Hence, the cornea is formed by (a) an epithelial layer derived from the
surface ectoderm, (b) the substantia propria or stroma, which is
continuous with the sclera, and (c) an epithelial layer, which borders the
anterior chamber.
⢠The iridopupillary membrane in front of the lens disappears completely.
15. Fate of mesenchyme surrounding the eye
primordium
Mesenchyme overlying the posterior aspect of the eye perimordium:
⢠Inner layer of mesenchyme surrounding the eye choroid
⢠Outer layer of mesenchyme sclera and continuous with the
dura around the optic nerve
Mesenchymal layers overlying the anterior aspect of the eye:
⢠The anterior chamber formed by the vacuolization and split of
mesenchyme into 2 layers
⢠The anterior chamber is lined by flattened mesenchymal cells.
⢠Inner layer (in front of the lens and iris) the iridopupillary
membrane disappears completely
⢠Outer layer the substantia propria of the cornea
16. Cornea
⢠The cornea is formed by:
⢠(a) an epithelial layer derived from the surface ectoderm,
⢠(b) the substantia propria or stroma, which is continuous with the sclera,
⢠(c) an epithelial layer, which borders the anterior chamber.
17. Posterior chamber of the eye
⢠The posterior chamber is the space between the iris
anteriorly and the lens and ciliary body posteriorly.
The anterior and posterior chambers communicate
with each other through the pupil and are filled with
fluid called the aqueous humor produced by the
ciliary process of the ciliary body. The clear aqueous
humor circulates from the posterior chamber into the
anterior chamber providing nutrients for the
avascular cornea and lens. From the anterior
chamber, the fluid passes through the scleral venous
sinus (canal of Schlemm) at the iridocorneal angle
where it is resorbed into the blood-stream.
18. VITREOUS BODY
⢠Mesenchyme not only surrounds the eye primordium
from the outside but also invades the inside of the
optic cup by way of the choroid fissure. Here it forms
the hyaloid vessels, which during intrauterine life
supply the lens and form the vascular layer on the
inner surface of the retina. In addition, it forms a
delicate network of fibers between the lens and
retina. The interstitial spaces of this network later fill
with a transparent gelatinous substance, forming the
vitreous body.
⢠The hyaloid vessels in this region are obliterated and
disappear during fetal life, leaving behind the hyaloid
canal.
19. OPTIC NERVE
⢠The optic cup is connected to the brain by the optic stalk, which
has a groove, the choroid fissure, on its ventral surface. In this
groove are the hyaloid vessels.
⢠The nerve fibers of the retina returning to the brain lie among
cells of the inner wall of the stalk.
⢠During the seventh week, the choroid fissure closes, and a
narrow tunnel forms inside the optic stalk. As a result of the
continuously increasing number of nerve fibers, the inner wall of
the stalk grows, and the inside and outside walls of the stalk
fuse. Cells of the inner layer provide a network of neuroglia that
support the optic nerve fibers.
⢠The optic stalk is thus transformed into the optic nerve. Its
center contains a portion of the hyaloid artery, later called the
central artery of the retina. On the outside, a continuation of the
choroid and sclera, the pia arachnoid and dura layer of the
nerve, respectively, surround the optic nerve
20. Optic nerve
⢠The nerve fibers of the retina returning to the brain lie among cells of the inner
wall of the stalk.
⢠During the seventh week, the choroid fissure closes, and a narrow tunnel forms
inside the optic stalk. As a result of the continuously increasing number of nerve
fibers, the inner wall of the stalk grows, and the inside and outside walls of the
stalk fuse. Cells of the inner layer provide a network of neuroglia that support the
optic nerve fibers.
⢠The optic stalk is thus transformed into the optic nerve. Its center contains a
portion of the hyaloid artery, later called the central artery of the retina.
21.
22.
23. Clinical Correlates; Eye Abnormalities
⢠Coloboma may occur if the choroid
fissure fails to close.
⢠Normally, this fissure closes during
the seventh week of development.
When it does not, a cleft persists.
Although such a cleft is usually in the
iris onlyâcoloboma iridisâit may
extend into the ciliary body, the
retina, the choroid, and the optic
nerve.
⢠The iridopupillary membrane may
persist instead of being resorbed
during formation of the anterior
chamber.
24. ⢠In congenital cataracts, the lens becomes opaque during intrauterine life. Although this
anomaly is usually genetically determined, many children of mothers who have had
German measles (rubella) between the fourth and seventh weeks of pregnancy have
cataracts. If the mother is infected after the seventh week of pregnancy, the lens escapes
damage, but the child may be deaf as a result of cochlear abnormalities.
⢠The hyaloid artery may persist to form a cord or cyst. Normally, the distal portion of this
vessel degenerates, leaving the proximal part to form the central artery of the retina.
⢠In microphthalmia, the eye is too small; the eyeball may be only two thirds of its normal
volume. Usually associated with other ocular abnormalities, microphthalmia frequently
results from intrauterine infections such as cytomegalovirus and toxoplasmosis.
⢠Anophthalmia is absence of the eye. In some cases, histological analysis reveals some
ocular tissue. The defect is usually accompanied by severe cranial abnormalities.
⢠Congenital aphakia (absence of the lens) and aniridia (absence of the iris) are rare
anomalies that result from disturbances in induction and development of tissues
responsible for formation of these structures. Mutations in PAX6 result in aniridia and may
also contribute to anophthalmia and microphthalmia.
⢠Cyclopia (single eye) and synophthalmia (fusion of the eyes) comprise a spectrum of
defects in which the eyes are partially or completely fused. The defects are caused by a
loss of midline tissue that may occur as early as days 19 to 21 of gestation or at later stages
when facial development is initiated. This loss results in underdevelopment of the
forebrain and frontonasal prominence. These defects are invariably associated with cranial
defects, such as holoprosencephaly, in which the cerebral hemispheres are partially or
completely merged into a single telencephalic vesicle. Factors affecting the midline include
alcohol, mutations in SHH, and abnormalities in cholesterol metabolism that may disrupt
SHH signaling