This presentation tackles the growing problem of chronic toxicity and its effects on living systems, including the living system that is you. It describes toxin types, detoxification pathways, and a systems medicine model for supporting your body's detox capacity, and for thinking about what's really needed to reduce the pollution we're spewing into the world.
comprehensive presentation on Detoxification of xenobiotics in human body.This presentation is designed for undergraduate medical ,dental ,biotechnology & pharmacology students for self study.Presentation has Definition of detoxification , classification of toxic substances .Detoxification of endogenous & exogenous toxic substances along with molecular mechanism involved is presented here.Metabolism of xenobiotic (detoxification)
by oxidation. reduction , hydrolysis& conjugation is illustrated with suitable examples.Characteristics of cytochrome P450& its mode of action are described.Google images are used to support the text for better understanding.
comprehensive presentation on Detoxification of xenobiotics in human body.This presentation is designed for undergraduate medical ,dental ,biotechnology & pharmacology students for self study.Presentation has Definition of detoxification , classification of toxic substances .Detoxification of endogenous & exogenous toxic substances along with molecular mechanism involved is presented here.Metabolism of xenobiotic (detoxification)
by oxidation. reduction , hydrolysis& conjugation is illustrated with suitable examples.Characteristics of cytochrome P450& its mode of action are described.Google images are used to support the text for better understanding.
An antioxidant is a molecule capable of inhibiting the oxidation of other molecules.
Oxidation reactions can form free radicals and these start chain reactions that damage cells .
Antioxidants terminate these chain reactions by removing free radical intermediates and inhibit other oxidation reactions
Detoxification presentation 97 to 2003 formatTamar Clarke
This PowerPoint presentation highlights the key points associated with detoxification. Detoxification plays a major role in helping us to stay healthy as well as handle health issues.
An antioxidant is a molecule capable of inhibiting the oxidation of other molecules.
Oxidation reactions can form free radicals and these start chain reactions that damage cells .
Antioxidants terminate these chain reactions by removing free radical intermediates and inhibit other oxidation reactions
Detoxification presentation 97 to 2003 formatTamar Clarke
This PowerPoint presentation highlights the key points associated with detoxification. Detoxification plays a major role in helping us to stay healthy as well as handle health issues.
Mold Toxicity - A Chronic Inflammatory Response SyndromeKeith Berndtson
An overview of mold toxicity, an increasingly common but under-recognized cause of chronic multi-system illness. This slideshow details the remarkable science underlying the medical understanding of the pathophysiology, diagnosis, and treatment of this condition.
Detoxification
1. What kind of results will get from toxicity
2. Where is toxic come from
3. Detoxification from Liver
4. Detoxification from Intestine
5. Detoxification products introduce
This presentation delves into another commonly missed diagnosis in people with multiple symptoms that persist despite usual medical care. Mast Cell Disorders may help point you or your doctor to a correct diagnosis and a successful integrative care plan.
Event Details
This webinar will introduce the Advanced MethylDetox Profile, discuss the scientific underpinnings of methylation and detoxifications, and explain how this test can benefit your patients. Our speakers have a diverse range of backgrounds from research to clinical practice.
Key Learning Points
-Discover the critical genes in the methylation pathway
-Understand each gene’s role in patient methylation function
-See how the MethylDetox Profile can be used clinically
-Learn how to monitor treatment progress
Hydrogen Peroxide and Silver is effective in waste water sanitation. It is used in both oxidation ponds for a complete oxidation and detoxification of harmful sulphides and cyanides, and much more.
Cara Menurunkan Berat Badan Tanpa Diet Dan Olahraga - 10 kg 20 hariErning Oei
Cara Menurunkan Berat Badan Tanpa Diet dan Olahraga - 10 kg dalam 20 hari
1. Menjaga pola makan
2. Kurangi Gorengan, Santen dan Makanin berlemak
3. Air Putih min 3 liter per Hari
4. Lakukan program detoksifikasi secara alami
Info Program Detox yang modern yang menjadi Trend saat ini adalah Program Smart Detox
Apa itu Smart Detox ?
Smart Detox adalah program detoksifikasi modern yang dilakukan selama 20 hari dengan pola 232. di keluarkan oleh perusahaan Synergy Worldwide dari USA. Berkantor Pusat di Provo Utah Amerika. CEO dan owner dari Synergy worldwide adalah Mr. Dan Higginson.
Program Smart Detox bukan hanya program Penurunan Berat badan, tapi juga untuk program kehamilan alami dan membantu penyembuhan berbagai macam keluhan kesehatan seperti diabetes, kolesterol, asam urat, persendian, jantung dll.
Smart Detox Synergy adalah solusi cerdas untuk mengeliminasi atau menetralkan racun (toksin) di dalam tubuh kita. Smart Detox merupakan suatu pencegahan dengan cara membuang timbunan kelebihan sampah sisa-sisa hasil metabolisme, yang merupakan racun bagi tubuh. Racun ini terakumulasi dalam tubuh kita selama bertahun-tahun. Racun yang terakumulasi dalam tubuh ini akan merusak sel-sel tubuh dan secara bertahap menurunkan kekebalan tubuh, yang dapat menjadi suatu penyakit.
Setelah tubuh mengalami DETOKSIFIKASI, maka tubuh kita akan merasa lebih KREATIF, BERSEMANGAT, PRODUKTIF, RILEKS dan NYAMAN.
Manfaat Smart Detox adalah :
* Badan Bebas Toksin
* Berat Badan IDEAL ALAMI
* Meningkatkan VITALITAS
* Menjaga IMMUNITIES
* Awet Muda
* Program Kehamilan
Hubungi Segera
Ibu Erning Oei
BRI Centre Park Lantai 9
Jl. jendral Sudirman Kav 44 - 46 Jakarta
0813-8855-2064 ( Telkomsel / WA/ Call )
0878-8657-3045 ( Call )
25a95d70 ( Pin BB )
www.smartdetoxcenter.com
Basic definition and types of toxicology (general, mechanistic, regulatory and descriptive), Regulatory guidelines for conducting toxicity studies OECD, ICH, EPA and Schedule Y OECD principles of Good laboratory practice (GLP)
This presentation is about the Biotransformation of toxicants in very effective way.
I hope you all will like it,,,
Don't forget to remember me in your precious Dua,,,
Inflammation_ Lecture material for beginners as PPT.pdfBerhanu Mekale
Organized and illustrated lecture material for better understanding of inflammation for undergraduate students. Enjoy reading and let me know if you have any questions or additional information and materials.
Microbial Biotransformation of Pesticides(xenobiotics).pptxAliya Fathima Ilyas
* Biotransformation is the chemical modification made by an organism on a chemical compound, often associated with change in pharmacologic and toxicologic activity.
Chemical conversion of a substance mediated by living organisms or enzymes
Can result in DETOXIFICATION and BIOACTIVATION
Vital to survive
Key in defense mechanism
Richard Altman, occurrence of mitochondria and called them bioblast.
Greek word mitos stands for thread and chondros means granule (Carl Benda )
Mitochondria can be created only by the division of the pre-existing mitochondria
Mitochondria are membrane-bound eukaryotic organelles that produce ATP (adenosine triphosphate) in the process of oxidative phosphorylation and tricarboxylic acid cycle.
Involved in regulation of programmed cell death and response to increased oxidative stress produced as a result of high salt, cold and drought conditions
Mitochondrion of land plants is not only almost 100 times larger than the animal mitochondrion
Circular (linear in some fungi and protozoa)
Double stranded
Supercoiled
No histones
Multiple copies located in nucleoids
Contain DNA which codes for mitochondrial proteins, ribosomes, etc.
Divide by a process similar to binary fission when cell divides
In plants the mitochondrial genes may become separated onto different circular molecules by a process of intramolecular recombination
This recombination is mediated by repetitive sequences located in the mtDNA.
An exchange between two of the repetitive sequences can partition the master DNA circle into two smaller circles
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
2. Definitions
• Toxin: a substance with harmful effects on living systems.
Includes heavy metals, biotoxins, and many industrial chemicals.
• Detoxification: to remove or neutralize the toxic quality of toxins.
• Xenobiotic: a chemical substance present within, but not made
within a living thing - a substance that is “a stranger to life.”
• Persistent Organic Pollutants (POPs): hazardous xenobiotics that
resist degradation within living systems.
• Toxic load: the sum total of toxins within a given living system.
3. How Toxicity Challenges
Our Natural Detoxification Systems
Truth
Ubiquitous
Too many to count
Complex interactions
Consequences
Altered brain function
Gut disturbances
Reproductive effects
Hormone disruption
Nutrient depletion
Inflammation
Cancer
Diabetes
Autoimmune disease
Degenerative disease
Cardiovascular disease
and more...
4. Lipophilic Toxins
Low molecular weight, non-polar, fat-soluble toxins easily move into
or through phospholipid membranes and into cells. They distribute
widely and can accumulate to hazardous levels. High molecular
weight lipophilic toxins are especially difficult to eliminate.
Common, Hazardous Lipophilic Toxins
volatile organics polyaromatic hydrocarbons mold toxins
polyvinyl chlorides industrial solvents ciguatera toxin
pesticides combustion products microcystin
phlalates perfluoro-octanoic acid dioxins
bisphenols tetrachloroethylene PCBs
flame retardants dinoflagellate toxins organohalides
5. Attention Please!
Doctors Needed to Engage this Problem
Growing awareness of the connection between toxicity and chronic disease.
6. Glutathione (GSH)
A molecule of primordial importance
Free radical and Phase 1 anions are
anion binding sites: stabilized and
COOH = carboxyl polarized, made
NH = amino ready for active
SH = sulfhydryl membrane transport
1. GSH maintains intracellular redox balance by mopping up
oxidative stress.
2. Glutathione-S-transferases conjugate GSH to phase 1 drugs,
toxins, and xenobiotics, preparing them for transport out.
3. GSH-dependent membrane transporters and efflux pumps
play key roles in toxin elimination.
7. The Biotransformation of Lipophilic Toxins
Phase 1 reactions add a functional group to a fat soluble toxin so the new
structure can be conjugated (joined to) a phase 2 substrate.
Phase 2 reactions continue the biotransformation process to create a water
soluble compound suitable for elimination into bile or blood for transport
and elimination by the bowel or kidneys.
Phase 1 Phase 2
Fat soluble Water soluble
Oxidation Sulfate conjugation
Reduction Glucuronide conjugation
Hydrolysis Glutathione conjugation
Acetylation Amino acid conjugation
8. Key Phase 1 and 2 Pathway Sites
The liver handles 70% of the
biotransformation work in the
body. Other active sites for these
pathways include:
1. kidneys
2. lungs
3. skin
4. intestinal cells
5. endothelial cells of the blood-
brain barrier
What these locations have in
common:
1. organs of detoxification
2. key tissue barriers
9.
10. Phase 3: Membrane Transporters
antigens from inflamed gut
and hepatic artery are
processed by Kupffer cells
membrane transporters pump
phase 2-processed toxins
from liver cells into the
biliary collection system
toxins from inflamed gut
enter liver from the
membrane transporters pump portal vein
phase 2-processed toxins
into sinusoids for lymph and
blood transport to kidneys
11. Membrane Transporters and Efflux Pumps
ATP binding cassette (ABC) transporters
modulate the absorption, distribution,
metabolism, secretion, and toxicity of
xenobiotics. Emerging evidence is
defining their role in tissue defense,
especially in the GI tract.
P-glycoprotein is an ATP-dependent
efflux pump whose role is to detoxify
cells. It actively pumps toxins out of
intestinal epithelial cells and helps resist
invasion by enteric pathogens.
MRP2 is an organic anion transporter
found in liver, intestinal, and kidney cells.
Mercado-Lubo R, McCormick BA.
Gut Microbes 2010;1(5):301.
It’s expression increases in the presence of
intestinal inflammation, decreases in the
presence of chronic toxicity.
12. Mercury Species as
Transporter Disrupters
Animal evidence shows that conjugates of methyl-mercury and inorganic mercury
are transportable substrates of MRP2.
Bridges CC, Joshee L, Zalups RK. MRP2 and the handling of mercuric ions in rats exposed
acutely to inorganic and organic species of mercury. Toxicol Appl Pharmacol 2011:251(1):50.
Mercury anions interact with MRP1 and MRP2 either alone or as a mercury-
glutathione complex.
Wortelboer HM, et al. Glutathione-dependent interaction of heavy metal compounds with
multidrug resistance proteins MRP1 and MRP2. Environ Toxicol Pharmacol 2008:26(1):102.
HYPOTHESIS 1: MRP2 concentrates in the duodenum and upper jejunum.
Inorganic mercury leaching from amalgams into swallowed saliva, and
methylmercury produced within the gut microbiome, can interfere with transporter
binding, slowing phase 3 and phase 2, creating a phase 1/2 mismatch.
HYPOTHESIS 2: Un-conjugated methylmercury and inorganic mercury anions
interact with transporters, causing malfunctions that would predict upper intestinal
inflammation and slowed detoxification pathways.
13. Mercury Dynamics
Species, Routes of Passage, and Analysis
Mercury Speciation Testing
Used to gauge methylmercury and inorganic
mercury dynamics by comparing hair and
urine levels to blood levels.
15. Mercury Toxicity
Effects on the Brain and Nervous System
Mechanisms
Carvalho CM, et al. Inhibition of
the human thioredoxin system: a
molecular mechanism of mercury
toxicity. J Biological Chemistry
2008;283(18):11913-23.
Type of Brain Pathology Witnessed Mercury Autism
Microtubule degeneration Yes Yes Overall, mercury inhibition
Neuroinflammation Yes Yes was selective toward the
thioredoxin system. In
Oxidative stress and lipid peroxidation Yes Yes particular, the remarkable
Microglial/astrocytic activation Yes Yes potency of the mercury
Reduced glutathione level Yes Yes compounds to bind the
selenol-thiol group in the
Mitochondrial dysfunction Yes Yes active site of the TrxR*
Vascular endothelial cell dysfunction Yes Yes should be a major molecular
Increased amyloid precursor protein Yes Yes mechanism of mercury
toxicity.
Impaired methylation Yes Yes
Higher pro-inflammatory cytokine levels Yes Yes *TrxR = thiodoxin reductase
17. Disrupting the Detoxification Chain
With compromise
of small intestinal
barrier integrity...
1. Small intestinal inflammation
overworks phase 3 transporters.
2. Phase 3 slowing down-regulates
phase 2 conjugation.
3. Phase 2 slowing results in a
backlog of un-conjugated toxins.
4. Free radical damage rises due to
the phase 1/phase 2 mismatch.
...comes systemic
damage caused by
chronic toxicity.
18. Leaky Gut
Precursor to Chronic Toxicity, Autoimmune Disease
“This new paradigm subverts traditional theories underlying the development of these
diseases and suggests that these processes can be arrested if the interplay between genes
and environmental triggers is prevented by re-establishing the zonulin-dependent
intestinal barrier function.”
Fasano A. Leaky gut and autoimmune disease. Clin Rev Allergy Immunol 2012;42(1):71-8.
19. Leaky Gut
Loss of Tight Junction Functional Integrity
Cascade Effects
•Maldigestion
Fasano A. Physiol Rev 2011;91:151 •Gluten sensitivity
•Delayed food sensitivities
•Dysbiosis
•Nutrient malabsorption
•Bacterial overgrowth
•Yeast overgrowth
•Bacterial translocation
•Metabolic endotoxemia
•Systemic inflammation
•Neuro-inflammation
•Autoimmune disorders
•Chronic toxicity
20. Leaky Gut
Celiac Permissive and Non-Celiac Gluten Sensitivity
Type 1: Celiac Permissive
•3 celiac permissive genes:
DQ 2.5, DQ 2.2, DQ8.
•Celiac panel predicts likelihood of
celiac disease, not gluten sensitivity.
•Both malabsorption and leaky gut can
appear with this form.
•Gluten-free trial warranted.
Type 2: Non-Celiac
•No HLA genotype predictors thus far.
•No testing helpful at present.
•Malabsorption only with this form?
•Gluten-free trial warranted.
21. Leaky Gut
Bacterial Lipopolysaccharide (LPS) Translocation
as a cause of Metabolic Syndrome
Recurrent LPS translocation causes metabolic endotoxemia.
LPS is an inflammatory component of the cell-wall of gram negative bacteria. Intestinal immune cells are
largely responsible for the maintenance of intestinal homeostasis and must elicit robust responses to
pathogens yet still tolerate the commensal microbiota. Leaky gut invites metabolic endotoxemia - an
LPS-driven immune cascade that leads to obesity, diabetes, cancer, and cardiovascular disease.
Burcelin R, Garidou L, Pomie C. Immuno-microbiota crosstalk: the new paradigm for metabolic diseases. Seminars in Immunology 2012;24:67-74.
22. Systemic Inflammation
Pathways Involved in Neuroinflammation
Gut- and peripherally-derived
neuroimmune processes produce
neuropsychiatric and
neurocognitive consequences.
Capuron L, Miller AH. Immune system to brain signaling: neuropsychopharmacological
implications. Pharmacology and Therapeutics 2011;130(2):226-238.
Collins SM, Bercik P. The relationship between intestinal microbiota and the central nervous
system in normal gastrointestinal function and disease. Gastroneterology 2009;136(6):2003-14.
23. The Sluggish
Bowel
Traffic jams
in the gut space
invite trouble.
24. Biotoxin Illness
Chronic Inflammatory Response Syndrome
High cytokine levels in the capillaries attract white
The Biotoxin Pathway Capillaries
blood cells, leading to restricted blood flow, and lower
oxygen levels. HIF stimulates VEGF and TGF B-1.
In genetically susceptible people, biotoxins bind to pattern receptors, HIF Reduced VEGF leads to fatigue, muscle cramps, and
causing continuing, unregulated production of cytokines. shortness of breath (may be over-ridden by
replacement with erythropoietin). TGF B-1 changes
Surface cell type and interacts with Treg cells.
Receptors Dendritic
Biotoxin (Toll; Cells Immune System Symptoms
tible) C-type Increased Cytokines
(HLA suscep lectin;
Patients with certain HLA genotypes
HLA-DR (immune response genes) may develop
mannose inappropriate immunity. Most common
& others) are antibodies to:
Fat cells then -Gliadin (affects digestion)
produce more -Cardiolipins (affects blood clotting)
leptin, leading to Treg cells: Pathogenic T cells
obesity (which
doesn’t respond to Split Products of
exercise and diet). Complement Activation
Excessive cytokine Leptin C4a: capillary hypoperfusion
levels can damage receptor
Bioto
C3a: bacterial membranes
leptin receptors in Damaged leptin
the hypothalamus. Inflammation-related
receptors lead to
xin
Nerve cell/ Hypothalamus symptoms
reduced production
axon by the hypothalamus High levels of cytokines produce flu-like
VIP AVP of MSH, a hormone
MSH symptoms: Headaches, muscle aches, fatigue,
with many functions. unstable temperature, difficulty concentrating
Biotoxins have direct and more. High levels of cytokines also result in
!"#$%&'(( effects, including increased levels of several other immune-
)*$#(+,"( impairment of nerve response related substances, including TGF
-$./( cell function.
Reduced B-1, MMP-9, IL-1B, and PAI-1. MMP-9 delivers
MSH inflammatory elements from blood to brain,
In most people, Sleep Disturbance nerve, muscle, lungs, and joints. It combines
biotoxins are
Production of melatonin with PAI-1 in increasing clot formation and
either removed
is reduced, leading to arterial blockage.
from the blood
by the liver or chronic, non-restorative Resistant Coag-negative
attached by the sleep.
Staph Bacteria
immune system, Chronic Pain
broken down, Colonies of MARCoNS with resistance to multiple
and excreted Endorphin production is antibiotics may develop in biofilm or mucus membranes.
harmlessly. In suppressed. This can lead The bacteria produce substances that aggravate both
people who to chronic, sometimes the high cytokine levels and low MSH levels.
don’t have the unusual, pain.
Reduced ADH
right immune Gastrointestinal
response genes, Changes in Cortisol Reduced MSH can cause the pituitary to
Problems Prolonged Illness
however, and ACTH levels produce lower levels of anti-diuretic
biotoxins can Lack of MSH can cause White blood cells lose The pituitary may produce
hormone (ADH), leading to thirst, frequent
remain in the regulation of cytokine urination, and susceptibility to shocks from
malabsorption in the gut, elevated levels of cortisol and
body indefinitely. response, so that recovery ACTH in early stages of illness, static electricity.
resulting in diarrhea. This is
sometimes called “leaky from other illnesses, then drop to excessively low
including infections levels later. (Patients should Reduced Androgens
gut” and resembles (but is
diseases, may be slowed. avoid steroids such as Reduced MSH can cause the pituitary to lower its
not) celiac disease. IBS is prednisone, which can lower
c R. Shoemaker, 2011 often present. production of sex hormones.
levels of ACTH)
Find this chart @ www.survivingmold.com
25. Stealth Infections
Tick-borne and various other bacteria, viruses,
and parasites can stress detoxification systems
Anaplasmosis Babesiosis Bartonella Ehrlichiosis
Borreliosis Mycoplasma Chlamydia Epstein-Barr
HHV-6 Cytomegalovirus Entamoeba Blastocystis
26. The main problem is not
exposure level, but toxicity retention caused
by slowed detoxification pathways.
• Sluggish and/or leaky bowel =
slowed elimination, overworked
transporters. Chronic toxicity is
• Slowed phase 3 activity = retained a detox traffic jam
toxicity as elimination doors close.
• Slowed phase 2 activity = phase 1/2
mismatch, more oxidative stress.
• Poor nutrition = added systemic
pathway malfunctions.
• Weak genes = susceptibilities to
slowed detox function at various
systemic pathway points.
• Higher environmental exposure =
greater risk of detox traffic jams.
27. Review: Basic Necessities for
High-Performance Detoxification
Functional glutathione-dependent pathways
Functional phase 1 and 2 detoxification pathways
Functional phase 3 transporter pathways
A non-inflamed, non-toxic gut.
29. Glutathione
Mammalian biology’s best friend.
Phase 1 Pathways
The ninjas warriors of biotransformation.
Phase 2 Pathways
The US Marshalls of cellular biology.
Phase 3 Pathways
The fast and reliable way to ship.
30. Toxicity creep: it gets worse
• 10 billion pounds of toxic waste produced annually in US alone.
• 47 million pounds of mercury dumped into US environment each year.
• Xenobiotics and POPs a growing problem: bisphenols, PCBs, flame
retardants, pesticides, combustion products, acrylamides, and more.
• Toxins disrupt bodily systems: reproductive, developmental,
circulatory, mental, neurological, hormonal, immune, digestive,
metabolic, and most ironically - detoxification systems.
31. Ruzzin J. BMC Public Health 2012;12:298
The time for
action is now!
“The general population is exposed
to sufficient POPs, in terms of
concentration and diversity, to
induce metabolic disorders. The
situation should attract the greatest What’s the
attention from the public health and
governmental authorities.” hangup?
32. Moral Man and Immoral Society
Reinhold Niebuhr (1892–1971) is credited with coining the first
circulated version of what’s now known as the Serenity Prayer. He
was, and remains, widely admired for his theological, moral, and
political insights, including the idea that humankind would always
struggle to make the world a better place if left to its own authority.
33. Moral Hazard
Niebuhr observed that groups
condone immorality more than
individuals because the moral
responsibility for harms caused
gets diffused within the group,
making it easier to deflect
accountability. Corporations and
bureaucracies provide ample
cover for greed, corruption, and
the temptation to play God.
We depend on social cooperation to achieve things we cannot accomplish on our own.
That corporate needs conflict with social needs defines the moral hazard of our time.
Niebuhr concluded that we cannot trust ourselves to find the path that leads to human
flourishing and that we must defer to a higher source of wisdom if we are to find a
road to health and sustainability.
- excerpted from Seek Wisdom: The Modern Quest for Health and Sustainability
34. And Where is Our Medical Profession
on the Issue of Chronic Toxicity?
The Prayer of Maimonides
(excerpted)
Almighty God, you have created the human body with infinite
wisdom. You have blessed the earth, the rivers and the
mountains with healing substances that enable your creatures
to alleviate their sufferings and heal their illnesses. You have
endowed man with the wisdom to relieve suffering and to
recognize disorders, to extract the healing substances, to
discover their powers, and to apply them to suit every ill.
Inspire me with love for my art, and let me be content with
everything except the great science of my profession. Never let
the thought arise that I have attained sufficient knowledge, for
the art of medicine is great and the mind of man is ever
expanding.
1135 -1204
35. Do we have a medical model to handle
the complexity of chronic toxicity?
•Medical toxicologists address
the more straightforward
problem of acute toxicity.
•The chronic toxicity issue
paralyzes doctors who lack the
time and tools needed to deal
with this level of complexity.
•A systems medicine model can
handle the clinical complexity of
chronic toxicity.
•What is this model and why is
outside the mainstream?
36. The Systems Medicine Model
Environmental Systems: World System:
Merge ecological science Coordinated efforts
with corporate stewardship. to reduce toxicity.
Most moral hazards Cultural Systems:
Encourage health
found here
and sustainability.
Political and
Economic Systems:
Develop policies that The Human Bodymind:
reward progress toward Maintain and restore
healthy and sustainable functional integrity
living systems. through wise self-care
and clinical methods that
reduce chronic toxicity.
Copyright Keith Berndtson, MD
37. Living Systems as Overlapping Networks
A modern systems medicine model
Text
Diagram from: De Keulenaer GW, Brutsaert DL. Circulation 2011;123:1996-2005
38. Living Systems as Overlapping Networks
An ancient systems medicine model
39. Factors underlying our different
responses to toxic exposures:
Species A
• Genetic susceptibilities
• Levels of exposure
• Quality of nutrition
• Organ reserves
Pollution A
• Hormone balance
Species B
• Tissue barrier integrity
• Detoxification strength
• Restorative strength
• Emotional/spiritual balance
Pollution B
How are the As and Bs different? How are they the same?
40. How to Repair and Amplify
Your Body’s Detoxification Systems
• Get professional help. Find a good
source of detoxification expertise.
• Repair the gut. Restrict reactive foods
and restore a healthy gut microbiome.
• Mercury speciation testing. Assess the
need for mercury detox support.
• Test for biotoxin susceptibility. As
warranted based on history.
• Test for stealth infection. As
warranted based on history.
• Get nutrition counseling. For help
with dietary changes, detox support.
• Try acupuncture. And other methods
for balancing energy flow.
• Healthy lifestyle change. Find the
structure and support you need. Warrior One Pose
41. Conclusions
1. Hordes of toxins are infiltrating the living systems of the world.
2. Natural detoxification pathways are overworked and undernourished.
3. Healthy barriers support healthy detoxification (including moral barriers).
4. The prognosis for any chronic disease relates to detoxification capacity.
5. To reduce the costs of chronic disease, reduce chronic toxicity.
6. Chronic toxicity is best addressed using the systems medicine model.
7. Up with the systems medicine model!
42. Your source for
professional detox support.
For advanced detoxification expertise and
a chance at feeling better no matter what
your chronic health condition,
call to schedule:
847-232-9800
or register online:
www.parkridgemultimed.com
15 N. Prospect Avenue, Park Ridge, IL 60068