Event Details
This webinar will introduce the Advanced MethylDetox Profile, discuss the scientific underpinnings of methylation and detoxifications, and explain how this test can benefit your patients. Our speakers have a diverse range of backgrounds from research to clinical practice.
Key Learning Points
-Discover the critical genes in the methylation pathway
-Understand each gene’s role in patient methylation function
-See how the MethylDetox Profile can be used clinically
-Learn how to monitor treatment progress
Understanding Methylation, Gene Regulation and the MethylDetox ProfileCell Science Systems
This exciting educational presentation shines light on the methylation cycle and discusses the role of nutrients as a clinical strategy. This event will be in a round table format including in-studio discussion surrounding the topics presented. In this round-table, Dino Celeda, Ph.D is accompanied by Amy Pieczarka, RD, LDN, CCN, CDE and Andrew Campbell, M.D.
Key Topics covered during this presentation:
• Learn about methylation and methylation potential
• Discover how methylation potential is correlated with neurotransmitter balance
• Learn the significance of the methionine and homocysteine ratio
• See how the MTHFR gene affects homocysteine balance
• Understand patient methylation with the Methyl Detox Profile
This presentation tackles the growing problem of chronic toxicity and its effects on living systems, including the living system that is you. It describes toxin types, detoxification pathways, and a systems medicine model for supporting your body's detox capacity, and for thinking about what's really needed to reduce the pollution we're spewing into the world.
general information regarding single nucleotide polymorphism.
A Single Nucleotide Polymorphisms (SNP), pronounced “snip,” is a genetic variation when a single nucleotide (i.e., A, T, C, or G) is altered and kept through heredity.
Understanding Methylation, Gene Regulation and the MethylDetox ProfileCell Science Systems
This exciting educational presentation shines light on the methylation cycle and discusses the role of nutrients as a clinical strategy. This event will be in a round table format including in-studio discussion surrounding the topics presented. In this round-table, Dino Celeda, Ph.D is accompanied by Amy Pieczarka, RD, LDN, CCN, CDE and Andrew Campbell, M.D.
Key Topics covered during this presentation:
• Learn about methylation and methylation potential
• Discover how methylation potential is correlated with neurotransmitter balance
• Learn the significance of the methionine and homocysteine ratio
• See how the MTHFR gene affects homocysteine balance
• Understand patient methylation with the Methyl Detox Profile
This presentation tackles the growing problem of chronic toxicity and its effects on living systems, including the living system that is you. It describes toxin types, detoxification pathways, and a systems medicine model for supporting your body's detox capacity, and for thinking about what's really needed to reduce the pollution we're spewing into the world.
general information regarding single nucleotide polymorphism.
A Single Nucleotide Polymorphisms (SNP), pronounced “snip,” is a genetic variation when a single nucleotide (i.e., A, T, C, or G) is altered and kept through heredity.
Fundamentals Of Genetic Toxicology In The Pharmaceutical Industry Sept 2010TigerTox
Historical and current perspectives on genetic toxicology, with commentary and slides on assay predictivity and shortcomings, regulatory guidance, and high-throughput screens to enhance preclinical drug safety.
Phytochemicals are considered as natural bio-active compounds with extraordinary bio-activities like free radical scavenging, enhancing mitochondrial integrity. preventing severe inflammation, regulating apoptosis and inhibiting toxic protein aggregations. This presentation deals with how phytochemicals are promoting brain health against various molecular assaults and wide range of diseases and disorders.
This is Part 1 of a presentation on Genetic Toxicology that was given by Dr. David Kirkland to scientific staff at Health Canada in Sept. 2010. Part 2 is availabile in ppt
Cancer Epigenetics: Concepts, Challenges and PromisesMrinmoy Pal
The presentation highlights how recent investigations have shown extensive reprogramming of almost every component of the epigenetic machinery in cancer leading to the emergence of the promising field of epigenetic therapy.
Epigenetic silencing of MGMT (O6-methylguanine DNA methyltransferase) gene in...arman170701
O6–methylgunine-DNA methyltransferace (MGMT) is a DNA binding protein that is involved in repairing mutations.
MGMT gene - a tumor suppressor gene that codes MGMT (O6-methylguanine DNA methyltransferase) protein.
The MGMT protein removes mutagenic methyl groups from guanines through the methyltransferase activity.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Fundamentals Of Genetic Toxicology In The Pharmaceutical Industry Sept 2010TigerTox
Historical and current perspectives on genetic toxicology, with commentary and slides on assay predictivity and shortcomings, regulatory guidance, and high-throughput screens to enhance preclinical drug safety.
Phytochemicals are considered as natural bio-active compounds with extraordinary bio-activities like free radical scavenging, enhancing mitochondrial integrity. preventing severe inflammation, regulating apoptosis and inhibiting toxic protein aggregations. This presentation deals with how phytochemicals are promoting brain health against various molecular assaults and wide range of diseases and disorders.
This is Part 1 of a presentation on Genetic Toxicology that was given by Dr. David Kirkland to scientific staff at Health Canada in Sept. 2010. Part 2 is availabile in ppt
Cancer Epigenetics: Concepts, Challenges and PromisesMrinmoy Pal
The presentation highlights how recent investigations have shown extensive reprogramming of almost every component of the epigenetic machinery in cancer leading to the emergence of the promising field of epigenetic therapy.
Epigenetic silencing of MGMT (O6-methylguanine DNA methyltransferase) gene in...arman170701
O6–methylgunine-DNA methyltransferace (MGMT) is a DNA binding protein that is involved in repairing mutations.
MGMT gene - a tumor suppressor gene that codes MGMT (O6-methylguanine DNA methyltransferase) protein.
The MGMT protein removes mutagenic methyl groups from guanines through the methyltransferase activity.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
3. As Always…
Tonight’s discussion does not take into consideration
your patient’s medical history, drug/supplement
interactions and/or allergies/sensitivities. It is the
responsibility of the practitioner to determine
appropriate supplement and dosing choices for each
patient.
4. About the Speakers
• Friedrich Schiller Universitaet – Heidelberg, Germany
• Institut National de La Recherche Agronomique - France
• Krankenhaus Harlaching -Germany
Dr. Dino Celeda holds a Ph.D in Biology specialized in
Human Genetics from the Ruprecht Karls Universitaet,
Heidelberg, Germany. He completed his training and held
positions at many renowned institutions including:
Dr. Celeda has authored numerous publications in the field of Human Genetics. Included in
his experience are Senior R&D, Scientific Advisor, Director of Genetic Testing and Director of
Science positions.
Dr. rer. nat. Dino Celeda (PhD)
Scientific Officer
5. About the Speakers
Roger Davis Deutsch is one of the
pioneers of food and chemical
sensitivities testing with involvement
in this field since 1986. He has been
responsible for the
commercialization of the Alcat Test
throughout the world. He is the co-
author of Your Hidden Food Allergies
are Making You Fat. Roger serves as
the Founder and CEO of Cell Science
Systems.
6. About the Speakers
Jim Hoover has been with
Cell Science Systems for six
years and currently serves
as the Sales Director for the
company.
7. Objectives
Identify themostimportant genesinvolved inthemethionine/
homocysteine cycle:
• mutations (SNPs), controlling methionine/homocysteine cycle.
• impact on homocysteine levels.
Personalized intervention according tothegenetic testresult:
• Targeted nutrition
• Targeted supplementation
• Monitoring of individual progress by measuring homocysteine
levels in the blood
10. Genetic Polymorphism (SNP)
A SNP can lead to a change in protein sequence and thus influence the 3-D
conformation. In the example here, the SNP disrupts hemoglobin formation and
causes sickle cell anemia.
11. Functional Genetic Test Results
The individual’s functional genetic test results are shown on a level
of functionality and/or expression of the corresponding enzyme.
• homozygous positive, -;-, both alleles from both parents
show mutation. Reduced function/expression.
• heterozygous +;-, one allele from one parent shows
mutation, the other allele shows the normal, wild-type. 50%
of the genes are normal
• homozygous negative +;+, both alleles from both parents
have no mutation and show the normal, wild type. 100% of
the genes are normal.
12. Genomic Insights TM
– TEST
Individual’s current status: testing of relevant SNPs and
corresponding metabolic markers in blood
– TARGET
Targeted intervention: personalized, specific supplementation
according to individual results of relevant of SNPs, and
corresponding metabolic markers in blood
– MONITOR
Individual progress: monitoring and maintaining the progress
of personalized, specific supplementation with measurement
of metabolic markers in blood
Applying Functional Genetics for targeted intervention
by personalized, specific supplementation
13. Genes in the Methionine/Homocysteine
Cycle
• MTHFR (Methylenetetrahydrofolate reductase)
C677T and A1298C mutations in the MTHFR gene are known to cause a diminished methylation
capacity, by a reduction in 5-MTHF synthesis.
• Methionine synthase (MS)
MS is encoded by the 5-methyltetrahydrofolate-homocysteine-methyltransferase gene (MTR). Its task
is to generate methionine from homocysteine by using methylcobalamin (methylated vitamin B12)
obtained when 5-MTHF donates its methyl group to vitamin B12. The mutation at position C3518T in
the gene is described with a reduced activity of the resulting enzyme.
• MTRR(5-Methyltetrahydrofolate-Homocysteine
Methyl-Transferase Reductase)
codes for the enzyme methionine synthase reductase. The methionine synthase reductase
enzyme is responsible to keep Methionine synthase (MS see above) in an active (reduced)
form in order to guarantee the proper conversion of homocysteine to methionine. Both
enzymes function together in a so called “ping-pong reaction. If the process is inefficient
because of a mutation, in both genes, homocysteine builds up and the methylation is impaired..
14. • COMT (Catechol-O-Methyltransferase)
COMT is responsible for the transfer of the methyl group from SAMe to specific substances (e.g.
catecholamines) for removal. COMT is also involved in drug metabolism/clearance, neurotransmitter
regulation, gene expression as well as in the detoxification of a variety of environmental toxins.
The mutations at position G472A (Val108/158Met) and G304A (Ala52/102Thr) are described with a
reduced activity of the resulting enzyme.
• AHCY (S-Adenosylhomocysteine hydrolase)
SAMe is converted to S-Adenosylhomocysteine (AdoHcy) after the donation of its methylgroup by
COMT. High levels of AdoHcy, however impair the methylation by SAMe and reduce the
“methylation potential” of the body. In order to maintain proper methylation potential ADoHcy,
must be converted again to homocysteine by the enzyme AHCY. It is crucial that AdoHcy is converted
immediately by AHCY to homocysteine and adenine because it has a higher affinity to COMT and
thus can even block methylation processes.
Genes in the Methionine/Homocysteine
Cycle
28. Collection Type
Profiles
One blue top vial and gold top
vial are required for the
profile. Gold top vials must be
spun within one hour of draw.
Genetic Only
Buccal swabs allow for easy
and convenient testing.
Buccal swabs can only be
used for genetic testing.
Homocysteine
Serum gold top vials are required
for homocysteine monitoring.
Gold top vials must be spun
within one hour of blood draw.