Design of aseptic area plant layout
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This document provides guidelines for the layout of sterile and non-sterile areas in a plant. For sterile areas, it outlines airflow patterns with air entering at positive pressure above atmospheric pressure. It describes personnel movement through airlocks and changing rooms to maintain cleaner conditions moving from potential contamination to less. Material passes through hatches and airlocks. For non-sterile areas, it presents three layout options: a central storage warehouse with perimeter production, side-by-side storage and production, and a straight-line layout. The layouts aim to optimize space, traffic flow, and separation of functions.
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INTRODUCTION TO HERBAL FORMULATIONS.pptx
Herbal formulation shall mean a dosage form consisting of one or more herbs in specified quantities to provide specific nutritional, cosmetic benefits, or other benefits meant for use to diagnose treat, mitigate diseases of human beings or animals.
Herbal preparations are obtained by subjecting herbal substances to treatments such as extraction, distillation, expression, fractionation, purification, concentration or fermentation.
These include comminuted or powdered herbal substances, tinctures, extracts, essential oils, expressed juices and processed exudates.
Herbal cosmetic is defined as “ the beauty products, which possess desirable physiological activities such as skin healing, smoothening, appearance enhancing properties with the help of herbal ingredients.”
almond oil
olive oil
rosemarry oil
sandalwood oil
PLANT FIBRES USED AS SURGICAL DRESSING.pptx
Fibers are elongated thick walled cells with pointed ends, cell walls of which may consist of cellulose and may or may not contain lignin
Plant fibers
Jute
Flax
Cotton
Banana
Hemp
Animal fiber
Silk
wool
Minerals
Glass
Asbestos
Surgical dressings are the materials used alone or in combination for protection and healing of wound
e.g. cotton, wool, rayon
Official requirements of surgical dressings are as;
They should be sterilized before use
They should be stored in dry-ventilated place at temperature not exceeding 250c
They should not be dyed unless mentioned in the monograph
There should not be any loose threads fibres-ends in dressings
They should be used with permitted prescribed concentrations only.
Sutures
Sutures are threads used for stiching the tissues like skin, muscles by using needle.
Two types of sutures;
Absorbable sutures: these are absorbed in the body
E.g catgut, kangaroo tendon and some synthetic polymers
Non-absorbable sutures: these are not absorbed by skin.
E.g silk, nylon
Requirements of sutures;
They must be sterile and cause no irritation
They should be stored in dry place
They are intended for one use.
DIURETICS.pptx
A diuretic is any substance that increases production of urine.
Sometimes called water pills, help rid your body of salt (sodium) and water.
Gokharu
Synonym: Puncture vine, devil’s thorn, Caltrops fruit.
B.S.: Gokhru is the dried ripe seeds of Tribulus terrestris Linn., Family: Zygophyllaceae.
Morphological characters:
Color: fruits are yellowish in colour
Odor: odorless
Taste: slightly bitter
Shape: globose, 1.2 cm in diameter containing five woody, densely hairy, spiny cocci
Size: 1-1.5cm in diameter and 8.5mm thick
Chemical Constituents
consist of steroidal saponins as the major constituents.which are;
terestrosins A, B, C, D and E,.
F-gitonin and gitonin.
Certain other steroidal such as terestroside F, tribulosin, trillin, gracillin, dioscin
Therapeutic uses
The fruit has cooling, anti inflammatory, antiarthritic, diuretic, tonic, properties.
It is used in building immune system, in painful micturition, calculus affections and impotency.
Improves and prolongs the duration of erection
It exerts a stimulating effect on reproductary organs.
Punarnava
Synonym: rakta punarnava, hog-weed
B.S.: freh dried herb of Boerhhavia diffusa
Family: Nyctagineacea.
Morphological characters:
Color: green on upper surface,
Odor: odorless
Taste: slightly bitter
Shape: ovate
Size: 25-30mm long
Therapeutic uses
In the treatment of urogenital disorders
In the renal diseases
Fever, cough, dysponea and bronchial complaints
Herbs as health food.pptx
The term "Nutraceutical" was coined by combining the terms "Nutrition" and "Pharmaceutical" in 1989 by Dr. Stephen De Felice.
Definition Of Nutraceuticals...
A nutraceutical is any substance considered as a food, or its part which, in addition to its normal which, in addition to its normal nutritional value provides health benefits including the prevention of disease or promotion of health.
Antioxidants are substance that can prevent or minimize cell damage caused by free radicals.
These are live microbial feed supplement which improves intestinal microbial balance when administered
E.g. lactobacilli such as L. acidophilus, gram +ve cocci such as enterococcus foecium etc.
A non- digestible food ingredient that stimulates the growth or activity of number of bacteria in colon.
TRADITIONAL SYSTEM OF MEDICINE.pptx
what is TSM?
WHO defines traditional medicine as including diverse health practices, approaches, knowledge and beliefs incorporating plant, animal, and/or mineral based medicines, spiritual therapies, manual techniques and exercises which can be used to maintain well-being, as well as to treat, diagnose or prevent illness.
TYPES OF TSM (AYUSH)
A-AYURVEDA
Y-YOGA & NATUROPATHY
U-UNANI
S-SIDDHA
H-HOMEOPATHY
Classification of Ayurvedic dosage form
CLINICAL PHARMACY.pptx
POINTS TO BE INCLUDED
Definition, scope,
Technical definitions, common terminologies used in clinical
settings
Daily activities of clinical pharmacists
Ward round participation
Treatment Chart Review
Adverse drug reaction monitoring
Interprofessional collaboration
DIFFERENT COMMITTEES IN THE HOSPITAL.pptx
This document discusses different committees in hospitals, including the Pharmacy & Therapeutics Committee (PTC) and Infection Control Committee (ICC).
The PTC is an advisory group that makes recommendations on drug evaluation, selection, and therapeutic use. It assists in educating healthcare professionals and sets policies like approving new drugs for the hospital formulary. The PTC also plays roles in drug safety monitoring, adverse drug reaction monitoring, and developing an emergency drug list.
The document further discusses the hospital formulary, its definition and need. It outlines the preparation process and principles for inclusion or removal of drugs from the formulary.
Finally, it states that the ICC is responsible for planning, monitoring, evaluating,
SUPPLY CHAIN & INVENTORY CONTROL.pptx
The list of drugs guides to detect medications that require special precautions to reduce risk of errors
Precautions may include limiting access to certain drugs.
The list of drugs categorised into
High risk drugs
Emergency drugs
Schedule H1 drugs
NDPS drugs
Reserved antibiotics
High risk medications are drugs that have a heightened risk of causing significant patient harm when they are misused.
List of high risk drugs
Adrenaline 1mg/ml inj
Cobra antivenom inj
Dextrose 30% and 50% inj
Digoxin 0.5 mg inj
Dopamine 200mg/ 20ml inj
Heparin 5000unit/ml inj
Actrapid1000 unit/10ml inj
Morphine 10mg/ml inj
Noradrenaline inj
All high medication containers or loose vials/ampoules stored must be labelled as high risk medicines
Use TALL-man lettering to emphasize difference in medication name e.g. DOPamine abd DOButamine
Prescribing: do not use abbreviations when prescribing
Do not use trailing zero when prescribing e.g. 5.0mg can be mistaken as 50mg
Administration: the following particulars shall be checked before administration;
Patient’s name
Strength of medication
Dose
Route and expiry
DRUG DISTRIBUTION.pptx
Drug distribution is defined as, "Physical transfer of drugs from storage area in the hospital to the patient's bedside".
This involves two types of drug distribution. They are:
In-patient distribution
Out-patient distribution
The drug distribution to the in patient department can be carried out from the out patient dispensing area.
The pharmacists involved in dispensing the drugs for out patient can dispense drugs for in patients too.
The pharmacist employed for drug distribution to the in patient wards should be well skilled and qualified staff.
Out patient refers to the patients not occupying beds in hospital or in clinics, health centers and other places where out patients usually go for health care.
No medicaments should be issued without the prescription.
After the issue has been made the quantities supplied must be recorded.
In short form the out patient department was called as OPD.
CLASSIFICATION OF PATIENTS
EMERGENCY
TERTIARY CARE
PRIMARY CARE
AMBULATORY.
HOSPITAL PHARMACY.pptx
A hospital pharmacy is a department within a hospital that prepares, compounds, stocks and dispenses inpatient medications.
What is the role of hospital pharmacist?
Hospital pharmacists work in hospital pharmacy services belong to the MOH as well as the private sector. Pharmacists work in this field are responsible for dispensing of medications, quality testing, formulating and re-formulating dosage forms, monitoring and reporting drug safety, and preparing budges for medications.
INVENTORY MANAGEMENT OF CENTRAL DRUG STORES.pptx
The document discusses various aspects of inventory management and storage of drugs at central drug stores. It provides guidelines on proper storage conditions for drugs including temperature, humidity and light exposure. It describes different inventory control techniques like economic order quantity, reorder quantity level, ABC analysis and VED analysis. The document also outlines standard operating procedures for storage, handling and disposal of expired or damaged drugs. It discusses various disposal methods for different drug types including return, incineration and landfilling while following safety protocols.
VITAMINS ENZYMES.pptx
Vitamins are organic chemical compounds which cannot be synthesized in the body but are essential for normal metabolic functions
ANTI-RHEUMATIC.pptx
This document discusses anti-rheumatic drugs and colchicum, a crude drug used to treat rheumatism. Rheumatism is characterized by increased uric acid in the blood and recurrent joint inflammation due to urate crystal deposition. Rheumatoid arthritis is an autoimmune disorder where the immune system attacks the synovial membrane. Colchicum, also known as meadow saffron, contains the toxic but potent anti-rheumatic alkaloid colchicine in its seeds and corms. It is used to treat gout and rheumatism due to its analgesic, antirheumatic, cathartic and emetic properties, but its toxicity requires caution, especially in pregnant women and those with kidney
RADIOPHARMACEUTICAL.pptx
They are radioactive substances or radioactive medications for diagnostic & therapeutic intervention
Radiopharmaceutical are medicinal formulations containing radioisotopes which are safe for organization in people for analysis or for treatment
Usually radiopharmaceuticals contain at least 2major components;
Radionuclide that provides the desired radiation characteristics &
Chemical compound with structural or chemical properties that determine the physiological behavior of radiopharmaceutical
Pharmaceutical Aids.pptx
"Pharmaceutical aids are the drugs or substances which have no or little pharmacological.but they are essentially used in the preparation of pharmaceutical dosage form
Antimalarials.pptx
This document discusses antimalarial drugs, focusing on Cinchona and Artemisia. It defines antimalarials as drugs used to prevent or treat malaria, which is caused by four Plasmodium species and transmitted via mosquito bites. Cinchona, whose active compound is quinine, is derived from Cinchona trees and has been used traditionally to treat malaria. It also has other medicinal properties. Artemisia annua contains the antimalarial compound artemisinin and has been used to treat malaria as well as conditions like epilepsy and irregular periods.
Anti Tussives.pptx
Antitussives can be defined as the drugs which ae used in treatment of cough.
vasaka
honey
balsam of tolu
Anti-tumour.pptx
nticancer drug, also called antineoplastic drug, any drug that is effective in the treatment of malignant, or cancerous, disease.
Vinca have been used to treat diabetes, high blood pressure and have been used as disinfectants and anti-cancer.
oxytocic.pptx
A drug that stimulates contraction of the myometrium. Oxytocics are used to induce labour, obstetric at term, to prevent or control postpartum or postabortion haemorrhage, and to assess foetal status in high risk pregnancies.
crude drug used is Ergot
ergot life cycle
1. over wintering stage
2. sexual reproduction
3. asexual reproduction
Vitamins.pptx
Vitamins can be soluble in fat or water, that effect allows classifying them on liposoluble or water-soluble.
In the first classification are the vitamins A, D, E and K. Due to the ease of their solution in body fat they stored and need not consume daily.
In the water-soluble group are B Complex and Vitamin C that can not be stored since they´re easily removed by body fluids and should be consumed daily preferably, with some exceptions.
useful for D>Pharm as per PCI syllabus
The human body does not synthesize vitamins and should be acquired by the daily intake of food, the lack of any of them can cause various diseases.
More from Archana Chavhan (20)
Recently uploaded
PGx Analysis in VarSeq: A User’s Perspective
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
District Residency Programme (DRP) for PGs in India.pptx
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Helminthiasis or Worm infestation in Children for Nursing students
Brief description worm infestation/Helminthiasis for Basic B.Sc Nursing students
Dr. Tan's Balance Method.pdf (From Academy of Oriental Medicine at Austin)
Home
Organization
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
About AOMA: The Academy of Oriental Medicine at Austin offers a masters-level graduate program in acupuncture and Oriental medicine, preparing its students for careers as skilled, professional practitioners. AOMA is known for its internationally recognized faculty, award-winning student clinical internship program, and herbal medicine program. Since its founding in 1993, AOMA has grown rapidly in size and reputation, drawing students from around the nation and faculty from around the world. AOMA also conducts more than 20,000 patient visits annually in its student and professional clinics. AOMA collaborates with Western healthcare institutions including the Seton Family of Hospitals, and gives back to the community through partnerships with nonprofit organizations and by providing free and reduced price treatments to people who cannot afford them. The Academy of Oriental Medicine at Austin is located at 2700 West Anderson Lane. AOMA also serves patients and retail customers at its south Austin location, 4701 West Gate Blvd. For more information see www.aoma.edu or call 512-492-303434.
TEST BANK For Brunner and Suddarth's Textbook of Medical-Surgical Nursing, 14...
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TEST BANK For Brunner and Suddarth's Textbook of Medical-Surgical Nursing, 14th Edition (Hinkle, 2017) Verified Chapter's 1 - 73 Complete.pdf
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Cervical Disc Arthroplasty ORSI 2024.pptx
Indication and installation of a mobile cervical disc prosthesis. Benefits of the PRODISC C VIVO mobile disc prosthesis (Centinel Spine)
Pollen and Fungal allergy: aeroallergy.pdf
Pollen and Fungal allergy: aeroallergy.pdfChulalongkorn Allergy and Clinical Immunology Research Group
Pollen and Fungal allergy
Presented by Chaloemchai Chumsaengchotsakul, MD.
June 14, 2024Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
Breast cancer: Post menopausal endocrine therapy
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Public Health Lecture 4 Social Sciences and Public Health
Sociology, Anthropology and Psychology as applied to Public Health
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KENT'S REPERTORY by dr niranjan mohanty.pptx
its a presentation on Dr kents Repertory by Dr niranjan Mohanty
Nano-gold for Cancer Therapy chemistry investigatory project
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
Gene Expression System-viral gene delivery Mpharm(Pharamaceutics)
Gene therapy can be broadly defined as the transfer of genetic material to cure a disease or at least to improve the clinical status of a patient.
One of the basic concepts of gene therapy is to transform viruses into genetic shuttles, which will deliver the gene of interest into the target cells.
Safe methods have been devised to do this, using several viral and non-viral vectors.
In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient's cells instead of using drugs or surgery.
The biggest hurdle faced by medical research in gene therapy is the availability of effective gene-carrying vectors that meet all of the following criteria:
Protection of transgene or genetic cargo from degradative action of systemic and endonucleases,
Delivery of genetic material to the target site, i.e., either cell cytoplasm or nucleus,
Low potential of triggering unwanted immune responses or genotoxicity,
Economical and feasible availability for patients .
Viruses are naturally evolved vehicles that efficiently transfer their genes into host cells.
Choice of viral vector is dependent on gene transfer efficiency, capacity to carry foreign genes, toxicity, stability, immune responses towards viral antigens and potential viral recombination.
There are a wide variety of vectors used to deliver DNA or oligo nucleotides into mammalian cells, either in vitro or in vivo.
The most common vector system based on retroviruses, adenoviruses, herpes simplex viruses, adeno associated viruses.
biomechanics of running. Dr.dhwani.pptx
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
NARCOTICS- POLICY AND PROCEDURES FOR ITS USE
This document outlines policies and procedures for handling narcotic and controlled drugs in NABH accredited hospitals.
Pharmacology of Prostaglandins, Thromboxanes and Leukotrienes
This presentation gives information on the pharmacology of Prostaglandins, Thromboxanes and Leukotrienes i.e. Eicosanoids. Eicosanoids are signaling molecules derived from polyunsaturated fatty acids like arachidonic acid. They are involved in complex control over inflammation, immunity, and the central nervous system. Eicosanoids are synthesized through the enzymatic oxidation of fatty acids by cyclooxygenase and lipoxygenase enzymes. They have short half-lives and act locally through autocrine and paracrine signaling.
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdf
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort. Recently uploaded (20)
District Residency Programme (DRP) for PGs in India.pptx
District Residency Programme (DRP) for PGs in India.pptx
Helminthiasis or Worm infestation in Children for Nursing students
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Dr. Tan's Balance Method.pdf (From Academy of Oriental Medicine at Austin)
Dr. Tan's Balance Method.pdf (From Academy of Oriental Medicine at Austin)
TEST BANK For Brunner and Suddarth's Textbook of Medical-Surgical Nursing, 14...
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Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)
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Public Health Lecture 4 Social Sciences and Public Health
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Call Girls Lucknow 9024918724 Vip Call Girls Lucknow
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Nano-gold for Cancer Therapy chemistry investigatory project
Nano-gold for Cancer Therapy chemistry investigatory project
Gene Expression System-viral gene delivery Mpharm(Pharamaceutics)
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Pharmacology of Prostaglandins, Thromboxanes and Leukotrienes
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Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdf
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Design of aseptic area plant layout
- 1. DESIGN OF PLANT LAYOUT STERILE & NON STERILE By- Quality Assurance Department Guide- Prof. S. Shelke RSCP, Buldana 1
- 2. STERILE AREA LAYOUT a = transfer hatch b = step over barrier C = viewing pannel d = gown racks e =water still f = vertical barrier tube g = wash basin/dryer mm = air press. In mm water A /c =air changes per hr. LF= laminar flow 2
- 3. Air flow: As per figure the air supply enters from the back at a press. Of 5mm water gauge above atm. Press. To the class-1 rooms. Alternatively, air enters through roof of the laminar bench to the workstations at a press. Of 5mm water gauge. Air leaves via vents to the class-2 and to the changing rooms flowing in from the inner door and venting to outside via the entrance door. 3
- 4. 4
- 5. Personnel movement Acess to area is restricted to authorized persons who enter through air locked changing rooms where normal clothing is exchanged for special protective garments The rooms should be flushed with filtered air at a positive pressure lower than that in the clean area or aseptic areas. From the point of entrance of the aseptic area, personnel move against the airflow and the area is enclosed in cleaner conditions (from black to grey white) 5
- 6. Material traffic Hatchways and airlocks are used for the passage of materials and equipments into clean and aseptic area. These should be interlocked so that only one side is opened at any one time 6
- 7. NON STERILE AREA LAYOUT 7
- 8. LAYOUT NO. 1- CENTER STORAGE AND PERIMETER PRODUCTION At the center, the storage or warehouse area is provided for raw materials, packing components and bulk stocks. The mfg. and packaging operations are located at the outet perimeter Advantage of this layout is space conservation and disadvantage is the cross over of traffic pattern of materials. 8
- 9. LAYOUT NO.2- STORAGE AND PRODUCTION SIDE-BY-SIDE 9
- 10. LAYOUT NO.3- STRAIGHT-LINE TYPE 10