This document describes modeling and simulating a differential high-speed backplane channel using rational functions in MATLAB. It reads in S-parameter data for a 4-port single-ended backplane channel, converts it to a 2-port differential model, fits a rational function to the differential transfer function, validates the frequency response fit, simulates the channel response to a 2 Gbps random pulse signal, and plots the input, output and eye diagram. The rational function model contains 25 poles.