This document presents an inventory model for deteriorating products with constant demand and time-varying deterioration rate, allowing for permissible delays in payments. The model is developed mathematically in two cases: when the permissible delay period is less than or equal to the replenishment cycle, and when it is greater than the cycle. The objective is to minimize total costs. Numerical examples are provided for each case and sensitivity analysis is conducted by varying holding cost and deterioration rate parameters.
Modeling Of an Inventory System for Non-Instantaneous decaying Items with Par...iosrjce
We will discuss an inventory model is investigates with variable demand rate and time dependent deteriorating items.In this study, we have taken shortages in inventory are allowed and fully backlogged. This model is studied under the condition for decaying items of permissible delay in payments which is most
important and an outcome of interaction between product and financial markets which arises. This model based on time-dependent, holding cost, shortages cost and the combination of model is unique and practical.
Welcome to International Journal of Engineering Research and Development (IJERD)IJERD Editor
call for paper 2012, hard copy of journal, research paper publishing, where to publish research paper,
journal publishing, how to publish research paper, Call For research paper, international journal, publishing a paper, IJERD, journal of science and technology, how to get a research paper published, publishing a paper, publishing of journal, publishing of research paper, reserach and review articles, IJERD Journal, How to publish your research paper, publish research paper, open access engineering journal, Engineering journal, Mathemetics journal, Physics journal, Chemistry journal, Computer Engineering, Computer Science journal, how to submit your paper, peer reviw journal, indexed journal, reserach and review articles, engineering journal, www.ijerd.com, research journals,
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Inventory Management Models with Variable Holding Cost and Salvage valueIOSR Journals
Inventory management models are developed for deteriorating items when the demand rate is
assumed to be linear function of time and the deterioration rate is proportional to time. The model is solved
when shortages are allowed. The salvage value is used for deteriorated items in the system. A numerical
example is taken to discuss the sensitivity of the models.
Modeling Of an Inventory System for Non-Instantaneous decaying Items with Par...iosrjce
We will discuss an inventory model is investigates with variable demand rate and time dependent deteriorating items.In this study, we have taken shortages in inventory are allowed and fully backlogged. This model is studied under the condition for decaying items of permissible delay in payments which is most
important and an outcome of interaction between product and financial markets which arises. This model based on time-dependent, holding cost, shortages cost and the combination of model is unique and practical.
Welcome to International Journal of Engineering Research and Development (IJERD)IJERD Editor
call for paper 2012, hard copy of journal, research paper publishing, where to publish research paper,
journal publishing, how to publish research paper, Call For research paper, international journal, publishing a paper, IJERD, journal of science and technology, how to get a research paper published, publishing a paper, publishing of journal, publishing of research paper, reserach and review articles, IJERD Journal, How to publish your research paper, publish research paper, open access engineering journal, Engineering journal, Mathemetics journal, Physics journal, Chemistry journal, Computer Engineering, Computer Science journal, how to submit your paper, peer reviw journal, indexed journal, reserach and review articles, engineering journal, www.ijerd.com, research journals,
yahoo journals, bing journals, International Journal of Engineering Research and Development, google journals, hard copy of journal
Inventory Management Models with Variable Holding Cost and Salvage valueIOSR Journals
Inventory management models are developed for deteriorating items when the demand rate is
assumed to be linear function of time and the deterioration rate is proportional to time. The model is solved
when shortages are allowed. The salvage value is used for deteriorated items in the system. A numerical
example is taken to discuss the sensitivity of the models.
Inventory Model with Different Deterioration Rates for Imperfect Quality Item...IJLT EMAS
One of the assumptions for an economic order quantity
model is that all items received in an order are of perfect quality
is not always fulfilled. Some of the items are of defective qual ity
in the lot received. Another assumption is that as soon as items
are received, payments are made. In today’s competitive the
supplier allows certain fixed period known as permissible delay
for payment to the retailer for settling the amount of items
received. Keeping this reality, a deterministic inventory model
with imperfect quality is developed when deterioration rate is
different during a cycle. Here it is assumed that demand is a
function of time and price. Numerical example is taken to
support the model. Sensitivity analysis is also carried out for
parameters.
Perishable Inventory Model with Time Dependent Demand and Partial BackloggingIJERA Editor
An Inventory Model For Decaying Items Under Inflation Has Been Developed. Demand Rate Is Taken As Linear Time Dependent. Holding Cost Is Also Taken As Time Dependent. We Have Developed The Two Cases: In The First Case Shortages Are Not Allowed And In The Second Case Partially Backlogged Shortages Are Allowed. Cost Minimization Technique Is Used In This Study.
A Deterministic Inventory Model for Perishable Items with Price Sensitive Qua...IJMERJOURNAL
ABSTRACT: An inventory system is considered with trended demand which is assumed to be a function of price and time dependent quadratic demand. For minimizing the total cost of the inventory system, it is assumed that the deterioration rate is constant and the supplier offers the retailer a credit period to settle the account of the procurement units. To solve the model it is further assumed that shortages are not allowed. Salvage value is also considered and observed its effect on the total cost. A numerical example is given to test the strength of the model. Critical parameters are identified by studying the sensitivity of the system.
An inventory model for variable demand, constant holding cost and without sho...iosrjce
Deterioration is defined as decay, change, damage, spoilage or obsolescence that results in decreasing usefulness from its original purpose. Some kinds of inventory products (e.g., vegetables, fruit, milk, and others) are subject to deterioration
Volume Flexibility in Production Model with Cubic Demand Rate and Weibull Det...IOSR Journals
In the present paper a volume flexible production inventory model is developed for deteriorating items with time dependent demand rate. The demand rate is taken as cubic function of time and production rate is decision variable. Production cost becomes a function of production rate. Unit production cost is depending upon material cost, Labor cost and tool or die cost. The deteriorating of unit in an inventory system is taken to weibull distribution. Shortage with partially backlogged are allowed a very natural phenomenon in inventory model.
Refining Measure of Central Tendency and DispersionIOSR Journals
A unified approach is attempted to bring the descriptive statistics in to a more refined frame work. Different measure of central tendencies such as arithmetic mean, median, mode, geometric mean and harmonic mean are derived from a generalized notion of a measure of central tendency developed through an optimality criteria. This generalized notion is extended to introduce the concept of an interval of central tendency. Retaining the spirit of this notion, measure of central tendency may be called point of central tendency. The same notion is further extended to obtain confidence interval for population mean in a finite population model and confidence interval for probability of success in Bernoulli population.
An Empirical Study on the Satisfaction Level of Women Lawyers towards Their W...IOSR Journals
Legal profession is one of the growing and lucrative professions all over the world. It is one of the most adventurous as well as exciting career. Lawyers are held in high esteem in our society, and there remains the faith that when all else fails, one can still take recourse to the legal system. In such a valued profession women doesn’t occupy a valuable space. Though participation of Women in legal profession has grown in the recent years, women were not given equivalent power and opportunities. Less frequently given the opportunity to move onto the occupational fast track, women face subtle but often self-perpetuating cycles of gender bias that limit their career choices. Although women qualify in equal proportions to men at the entry point of professional courses, there is a progressive decline in the number of women as one move up the hierarchy. Our legal structure should be modified wherein women are encouraged to get into legal profession and gender specific issues are to be eliminated in order to reduce the attrition rate of women lawyers.
Inventory Model with Different Deterioration Rates for Imperfect Quality Item...IJLT EMAS
One of the assumptions for an economic order quantity
model is that all items received in an order are of perfect quality
is not always fulfilled. Some of the items are of defective qual ity
in the lot received. Another assumption is that as soon as items
are received, payments are made. In today’s competitive the
supplier allows certain fixed period known as permissible delay
for payment to the retailer for settling the amount of items
received. Keeping this reality, a deterministic inventory model
with imperfect quality is developed when deterioration rate is
different during a cycle. Here it is assumed that demand is a
function of time and price. Numerical example is taken to
support the model. Sensitivity analysis is also carried out for
parameters.
Perishable Inventory Model with Time Dependent Demand and Partial BackloggingIJERA Editor
An Inventory Model For Decaying Items Under Inflation Has Been Developed. Demand Rate Is Taken As Linear Time Dependent. Holding Cost Is Also Taken As Time Dependent. We Have Developed The Two Cases: In The First Case Shortages Are Not Allowed And In The Second Case Partially Backlogged Shortages Are Allowed. Cost Minimization Technique Is Used In This Study.
A Deterministic Inventory Model for Perishable Items with Price Sensitive Qua...IJMERJOURNAL
ABSTRACT: An inventory system is considered with trended demand which is assumed to be a function of price and time dependent quadratic demand. For minimizing the total cost of the inventory system, it is assumed that the deterioration rate is constant and the supplier offers the retailer a credit period to settle the account of the procurement units. To solve the model it is further assumed that shortages are not allowed. Salvage value is also considered and observed its effect on the total cost. A numerical example is given to test the strength of the model. Critical parameters are identified by studying the sensitivity of the system.
An inventory model for variable demand, constant holding cost and without sho...iosrjce
Deterioration is defined as decay, change, damage, spoilage or obsolescence that results in decreasing usefulness from its original purpose. Some kinds of inventory products (e.g., vegetables, fruit, milk, and others) are subject to deterioration
Volume Flexibility in Production Model with Cubic Demand Rate and Weibull Det...IOSR Journals
In the present paper a volume flexible production inventory model is developed for deteriorating items with time dependent demand rate. The demand rate is taken as cubic function of time and production rate is decision variable. Production cost becomes a function of production rate. Unit production cost is depending upon material cost, Labor cost and tool or die cost. The deteriorating of unit in an inventory system is taken to weibull distribution. Shortage with partially backlogged are allowed a very natural phenomenon in inventory model.
Refining Measure of Central Tendency and DispersionIOSR Journals
A unified approach is attempted to bring the descriptive statistics in to a more refined frame work. Different measure of central tendencies such as arithmetic mean, median, mode, geometric mean and harmonic mean are derived from a generalized notion of a measure of central tendency developed through an optimality criteria. This generalized notion is extended to introduce the concept of an interval of central tendency. Retaining the spirit of this notion, measure of central tendency may be called point of central tendency. The same notion is further extended to obtain confidence interval for population mean in a finite population model and confidence interval for probability of success in Bernoulli population.
An Empirical Study on the Satisfaction Level of Women Lawyers towards Their W...IOSR Journals
Legal profession is one of the growing and lucrative professions all over the world. It is one of the most adventurous as well as exciting career. Lawyers are held in high esteem in our society, and there remains the faith that when all else fails, one can still take recourse to the legal system. In such a valued profession women doesn’t occupy a valuable space. Though participation of Women in legal profession has grown in the recent years, women were not given equivalent power and opportunities. Less frequently given the opportunity to move onto the occupational fast track, women face subtle but often self-perpetuating cycles of gender bias that limit their career choices. Although women qualify in equal proportions to men at the entry point of professional courses, there is a progressive decline in the number of women as one move up the hierarchy. Our legal structure should be modified wherein women are encouraged to get into legal profession and gender specific issues are to be eliminated in order to reduce the attrition rate of women lawyers.
Synthesis of 3-methoxy-6-phenyl-6, 6a-dihydro-[1] benzopyrano-[3, 4-b] [1] be...IOSR Journals
Abstract: The 3-methoxy-6-phenyl-6,6a-dihydro-[1]benzopyrano-[3,4-b][1]benzopyran has been synthesised according to eight-steps synthesis. The target compound was obtained using a synthetic route based on two key cyclisations steps including the platinum chlorides-catalysed of alkynones and intramolecular oxo-Michael addition.
LC-MS/MS method for the quantification of carbinoxamine in human plasmaIOSR Journals
A simple, reverse-phase high performance liquid chromatographic method with mass spectrometric detection (HPLC-MS/MS) was developed for determination of carbinoxamine in human plasma using pargeverine HCl as an internal standard. The procedure involves a simple protein precipitation technique using BDS HYPERSIL C8 (100 x 4.6mm) column. The mobile phase used was acetonitrile: buffer (25mm ammonium formate solution) (80:20). Precipitation was done using acetonitrile and detection was done in MRM mode, using an Electro Spray positive ionization. The ion transition monitored was (m/z) carbinoxamine (Q1 Mass: 291.2; Q3 Mass: 167.1), Internal standard (Q1 Mass: 338.1; Q3 Mass; 167.0). The retention time of carbinoxamine and internal Standard were 1.61 and 1.75 respectively. Method was evaluated in terms of linearity, accuracy, precision, recovery, sensitivity. The simple extraction procedure and short chromatographic runtime make the method suitable for therapeutic drug monitoring studies.
A Novel Approach of Area-Efficient FIR Filter Design Using Distributed Arithm...IOSR Journals
Abstract: In this paper, a highly area-efficient multiplier-less FIR filter is presented. Distributed Arithmetic (DA) has been used to implement a bit-serial scheme of a general asymmetric version of an FIR filter, taking optimal advantage of the 3-input LUT-based structure of FPGAs. The implementation of FIR filters on FPGA based on traditional arithmetic method costs considerable hardware resources, which goes against the decrease of circuit scale and the increase of system speed. This paper presents the realization of area efficient architectures using Distributed Arithmetic (DA) for implementation of Finite Impulse Response (FIR) filter. The performance of the bit-serial and bit parallel DA along with pipelining architecture with different quantized versions are analyzed for FIR filter Design. Distributed Arithmetic structure is used to increase the resource usage while pipeline structure is also used to increase the system speed. In addition, the divided LUT method is also used to decrease the required memory units. However, according to Distributed Arithmetic, we can make a Look-Up-Table (LUT) to conserve the MAC values and callout the values according to the input data if necessary. Therefore, LUT can be created to take the place of MAC units so as to save the hardware resources. The simulation results indicate that FIR filters using Distributed Arithmetic can work stable with high speed and can save almost 50 percent hardware resources to decrease the circuit scale, and can be applied to a variety of areas for its great flexibility and high reliability. This method not only reduces the LUT size, but also modifies the structure of the filter to achieve high speed performance. Keywords: DSP, Digital Filters, FIR , FPGA, MAC, Distributed Arithmetic(DA),Divided LUT, pipeline
Calcium Chloride Applications to Improve Fruit Quality on Bruised and Disease...IOSR Journals
The problems faced by producer canned of pineapple are the high of bruised which caused by the mechanical damage such as pressure, vibration during harvest, transport to the fruit processing and pathological damage caused by fruit diseases. The objective of research was to obtain the treatment time of CaCl2 applications and dosage of CaCl2 to improve the fruit quality of pineapple. This research used Split Plot Design and each treatment replicated 3 times. The main plot is time of CaCl2 applications that consists of three levels, thats are : 90 day after forcing (daf) (W90), 120 daf (W120) and twice time of CaCl2 applications on 90 and 120 daf (W90+120). The sub plot is dosage of CaCl2 that consists of three levels, thats are : 50 kg ha-1 (C50), 75 kg ha-1 (C75) and 100 kg ha-1 (C100). The results of research showed that the combined treatment twice time of CaCl2 applications on 90 and 120 day after forcing and dosage of CaCl2 100 kg ha-1 produces the calcium content on fruit is higher than the other combined treatments and produce the fruit texture, percentage of fruit diseases and percentage of bruised are lower than the other combined treatments
An Inventory Management System for Deteriorating Items with Ramp Type and Qua...ijsc
The present paper deals with an inventory management system with ramp type and quadratic demand rates. A constant deterioration rate is considered into the model. In the two types models, the optimum time and total cost are derived when demand is ramp type and quadratic. A structural comparative study is demonstrated here by illustrating the model with sensitivity analysis.
9 different deterioration rates of two warehouse inventory model with time a...BIOLOGICAL FORUM
ABSTRACT: A two warehouse inventory model with different deterioration rates is developed. Demand is considered as function of price and time. Holding cost is considered as linear function of time. Inflation factor is also considered with permissible delay. Shortages are not allowed. Numerical case is given to represent the model. Affectability investigation is likewise done for parameters.
Inventory Model with Different Deterioration Rates under Exponential Demand, ...inventionjournals
An inventory model with different deterioration rates under exponential demand with inflation and permissible delay in payments is developed. Holding cost is taken as linear function of time. Shortages are allowed. Numerical examples are provided to illustrate the model and sensitivity analysis is also carried out for parameters.
International Journal of Mathematics and Statistics Invention (IJMSI)inventionjournals
International Journal of Mathematics and Statistics Invention (IJMSI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJMSI publishes research articles and reviews within the whole field Mathematics and Statistics, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
International Journal of Mathematics and Statistics Invention (IJMSI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJMSI publishes research articles and reviews within the whole field Mathematics and Statistics, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Perishable Inventory Model Having Weibull Lifetime and Time Dependent DemandIOSR Journals
In this paper we develop and analyse an inventory model for deteriorating items with Weibull rate of decay and time dependent demand. Using the differential equations, the instantaneous state of inventory at time‘t’, the amount of deterioration etc. are derived. With suitable cost considerations the total cost function and profit rate function are also obtained by maximizing the profit rate function, the optimal ordering and pricing policies of the model are derived. The sensitivity of the model with respect to the parameters is discussed through numerical illustration. It is observed that the deteriorating parameters have a tremendous influence on the optimal selling price and ordering quantity.
A Retail Category Inventory Management Model Integrating Entropic Order Quant...Waqas Tariq
A retail category inventory management model that considers the interplay of entropic product assortment and trade credit financing is presented. Specifically, the proposed model takes into consideration of key factors like discounted cash flow. Therefore, to incorporate the concept of supplier-retailer integration and order size dependent trade credit, we established a stylized model to determine the optimal strategy for an integrated supplier-retailer inventory system under the condition of trade credit financing and is entropy type demand. This paper demonstrates that the optimal solution is flexible enough to accommodate the supplier retail relationship under a perfect trade credit understanding without significantly deviating from the main goal at increasing sales revenue of supplier and retailer. Finally numerical examples are used to illustrate the theoretical results followed by the insights into a lot of managerial inputs.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
11 two warehouse production inventory model with different deterioration rate...BIOLOGICAL FORUM
ABSTRACT: A two warehouse production inventory model with different deterioration rates under linear demand is developed. Holding cost is considered as linear function of time. Shortages are not allowed. Numerical case is given to represent the model. Affectability investigation is likewise done for parameters.
Keywords: Two warehouse, Production, deterioration, Linear demand, Time varying holding costs.
A Marketing-Oriented Inventory Model with Three-Component Demand Rate and Tim...IJAEMSJORNAL
This paper, an attempt has been made to extend the model of “An EOQ model for perishable items under stock-dependent selling rate and time-dependent partial backlogging” with a view to making the model more flexible, realistic and applicable in practice. Here, objectives are to maximize the profit and minimize the total shortage cost. In this model, fuzzy goals are used by linear membership functions and after fuzzification, it is solved by weighted fuzzy non-linear programming technique. The model is illustrated with a numerical example adopted partially from “An EOQ model for perishable items under stock-dependent selling rate and time-dependent partial backlogging”.
Genetic Algorithm for solving Dynamic Supply Chain Problem AI Publications
The solution of dynamic supply chain problem is studied using both genetic algorithms and multistage dynamic programming. This is possible by employing Euler approximation method to approximate the differential of the variables. The problem is reformulated as unconstrained optimization problem which solved by genetic Algorithm and Multi Stages Dynamic Programming. The solution evaluation results from using dynamic programming and genetic algorithm is performed
Fuzzy Inventory Model of Deteriorating Items under Power Dependent Demand and...orajjournal
The present paper deals with the development of a fuzzy inventory model of deteriorating items
under power demand rate and inventory level dependent holding cost function. The deterioration
rate, demand rate, holding cost and unit cost are considered as trapezoidal fuzzy numbers. Both
the crisp model and fuzzy model are developed in this paper. The graded mean integration
method(GM) and signed distance method(SD) are used to defuzzify the total cost of the present
model. Both the models are illustrated by suitable numerical examples and a sensitivity analysis
for the optimal solution towards changes in the system parameters are discussed. Lastly a
graphical presentation is furnished to compare the total costs under the above two mentioned
methods in the fuzzy model.
In many fuel stations there had always been long
queues to collect the fuel as a result there may be a scarcity of the
product in recent times. This type of situation makes the buyers
to wait for more than hours. Especially the scarcity is higher in
the festive periods. The service station in cities sells products to
the available customers in a random order, which results to long
queue in fuel stations. In this paper a single channel multiple –
server model is considered to reduce the waiting time of the
customers.
Time and size covariate generalization of growth curves and their extension t...bimchk
Growth curve models are developed over a long period of time and it has immense importance in various fields of studies. In this presentation we have developed a new class of generalized model based on some real phenomena.
Similar to An Inventory Model for Constant Demand with Shortages under Permissible Delay in Payments (20)
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
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An Inventory Model for Constant Demand with Shortages under Permissible Delay in Payments
1. IOSR Journal of Mathematics (IOSR-JM)
e-ISSN: 2278-5728,p-ISSN: 2319-765X, Volume 6, Issue 5 (May. - Jun. 2013), PP 28-33
www.iosrjournals.org
www.iosrjournals.org 28 | Page
An Inventory Model for Constant Demand with Shortages under
Permissible Delay in Payments
R.Amutha1
, Dr.E.Chandrasekaran2
1
(Research Scholar, Department of Mathematics, presidency college-05)
2
(Associate Professor, Department of Mathematics, presidency college-05)
Abstract : This paper presents an inventory model for deteriorating products with constant demand and time
varying deteriorating rate, under permissible delay in payments. It discussed in two cases whether the
permissible periods are less than or equal to or greater than replenishment cycle. During the permissible period
both supplier and retailer got some benefits. Shortages are allowed and are completely backlogged. This model
is explained with numerical example and sensitivity analysis.
Keywords - Deteriorating Products, Economic Order Quantity, Holding Cost, Permissible delay in periods.
I. Introduction
In Recent periods, researchers are developing inventory models for deteriorating items by introducing
new concepts. For example there are few inventory models in association with salvage Value or disposal cost or
sales revenue etc. Similarly researchers have developed trade credit with new ideas. This trade credit means that
the supplier offers the customer (Case I) a permissible delay in payments to attract new customers to increase
sales (Case II) and cash discount to motivate quick payment and reduce credit expenses. Case (I) has been
derived under two different situations, (a) the permissible delay period less than or equal to replenishment cycle
period for setting the account and (b) the permissible delay period is greater than replenishment cycle period for
settling the account. Ouyang L-Y, C-T Chang and J-T Teng [14] developed an economic order quantity model
under trade Credit .Mukesh Kumar, Anand Chauhan, Rajat Kumar [12] extended Ajantha Roy [1]model with
trade credit for the purpose of maximizing the profit. Chaitanya Kumar Tripathy and Umakanta Mishra [2] and
Shital S.Patel and R.D.Patel [17] gave inventory models with permissible delay in periods which include
purchase cost and selling price with shortages and without shortages respectively. Kun –Shan Wu [8] made an
attempt in his paper to obtain the optimal ordering quantity of deteriorating items for two parameters of Weibull
distribution deterioration with shortages under permissible delay in payments. Manish pal and Sanjay Jain,
Mukesh Kumar and Priya Advani [16], Tripathi R.P [20] discussed permissible delay in payments without
deterioration. It means that they obtain an optimal ordering policy only for demand rate and not for any
deterioration rate. Nita H.Shah, Poonam Pandey [13] prepared inventory model under delay in payment is
permissible. Tripathy P.K, S.Pradhan [22] and Hesam Saiedy, Mohammed Bamani Moghadam [4] discussed
partial backlogging in trade credit. Hardik Soni, Nita H.Shan and Chandra K.Jaggi [3] presented a review about
trade credit. Trailokyanath Singh, Hadibandhu Pattanayak [19] formulated a model for exponentially declining
demand under permissible delay in payments without shortages. Ravi Gor, Nita H Shah [15] developed a selling
price dependent demand rate in which selling price is exponentially increasing with respect to time.
In our proposed model an attempt is made to develop an EOQ model for deteriorating items under
permissible delay in payment with constant demand and time proportional deterioration rate. Shortages are
allowed and are completely backlogged. Mathematical model has been developed in two cases. (I) The Credit
period is less than or equal to the cycle time for settling the account and (ii) the credit period is greater than the
cycle time for settling the account. Our aim is to minimize the total cost. Numerical examples are given and
sensitivity analysis is carried out for changes in.
II. ASSUMPTIONS AND NOTATIONS
The inventory system involves only one item
Lead time is zero
Shortages are not allowed
Replenishment is instantaneous
Delay in payment is allowed.
Time horizon is infinite
During time T1the inventory level becomes Zero due to demand and deterioration. At time T1the shortages
start occurring.
The demand for the item is constant with time.
2. An Inventory Model for Constant Demand with Shortages under Permissible Delay in Payments
www.iosrjournals.org 29 | Page
A = set up cost
Q = the initial order quantity
h = holding cost per unit
θ = θt, time proportional deterioration rate.
C = the unit purchasing cost
Ie = The Interest earned per unit time
Ic= the interest Charged per unit time.
I(t) = Inventory level at any instant of time, 0 ≤ t≤ T
T = Time interval (in Years) between two successive orders.
M = Permissible period of delay in selling the accounts with the supplier.
C3 = The Inventory shortage cost per unit time
III. MATHEMATICAL MODEL
THE DIFFERENTIAL EQUATION THAT GOVERNS THE VARIATION OF INVENTORY WITH RESPECT TO TIME IS
Fig 1
dt
tdI )(
+ )(ttI = -a, 0 1Tt ` (1)
dt
tdI )(
= -a, T Tt 1 (2)
With boundary condition I (T1) = 0 and I (0) = Q.
Solving equation (1)
I (t) = a ( )1 tT + a [
6
3
1T
-
6
3
t
-
2
2
1tT
+
2
3
t
] + a
2
[
40
5
1T
-
40
5
t
-
6
25
1 tT
+
6
5
t
+
8
4
1tT
-
8
5
t
] (3)
Solving equation (2)
I (t) = a (T1-t) (4)
Shortage cost
SC =
T
T
dttI
1
)(
= - 3C
T
T
dttTa
1
)( 1
=
2
3aC
[2TT1 – T2
- T1
2
] (5)
Put I (0) = Q in (3)
Q = aT1 +
6
3
1Ta
+
40
51
2
Ta
(6)
Deterioration cost
DC= C (Q -
`1
0
))(
T
dttD
3. An Inventory Model for Constant Demand with Shortages under Permissible Delay in Payments
www.iosrjournals.org 30 | Page
= -C (Q -
1
0
T
adt )
DC = C (
6
3
1Ta
+
40
51
2
Ta
) (7)
Inventory holding cost
HC = h
1
0
)(
T
dttI
= h
1
0
1 )([
T
atTa (
66
33
1 tT
-
2
2
1tT
+
2
3
t
) + a
2
(
4040
55
1 tT
-
60
23
1 tT
+
6
5
t
+
408
54
1 ttT
)] dt
=
T
h
[
720
11
122
6
1
24
1
2
1 TaTaaT
] (8)
The setup cost per cycle :
T
A
(9)
Case I: M ≤ T1 (Payment at or before total depletion of inventory)
Fig. 2
In this case, the credit time expires on or before the inventory depleted completely to zero. The interest payable
per cycle for the inventory not being sold after the due date M is Interest payable in the horizon when M < t ≤ T1
IE1 = CIe
1
0
1 )(
T
dttT
=
2
2
1TaCIe
(10)
IC1 = CIc adt
T
M
1
= CIc (T1- M). (11)
Total average cost of the system per unit time is given by
K1 (T, T1) =
T
1
(setup cost + Deterioration cost + holding cost + shortages cost + IC1 – IE1)
K1 (T, T1 ) =
T
1
[A + C (
6
3
1Ta
+
40
5
1
2
Ta
) + h (
2
2
1aT
+
12
4
1Ta
+
720
11 6
1
2
Ta
) -
2
3ac
(2TT1- T2
- T1
2
) +
2
2
1TaCIe
– CIc a(T1- M)]. (12)
Our objective is to minimize the total cost. The necessary conditions for minimizing the total cost are
4. An Inventory Model for Constant Demand with Shortages under Permissible Delay in Payments
www.iosrjournals.org 31 | Page
1
11 ),(
T
TTK
= 0 and
T
TTK
),( 11
= 0
1
11 ),(
T
TTK
=
T
1
[C (
2
2
1Ta
+
8
4
1
2
Ta
) + h (aT1+
3
3
1Ta
+
120
11 5
1
2
Ta
) –
2
3aC
(2T -2T1) +
2
1TaCIe
–
CIc a] = 0 (13)
T
TTK
),( 11
= 2
1
T
[A+C (
6
3
1Ta
+
40
5
1
2
Ta
) h (
2
2
1aT
+
12
4
1Ta
+
720
11 6
1
2
Ta
)] -
2
3aC
(0-1 + 2
2
1
T
T
) -
( 2
2
1
2T
TaCIe
+ 2
1 )(
T
MTaCIc
} = 0 (14)
Provided they (equations (13) and (14)) satisfy the conditions
( 2
11
2
),(
T
TTK
) > 0, ( 2
1
11
2
),(
T
TTK
) > 0 & ( 2
11
2
),(
T
TTK
) ( 2
1
11
2
),(
T
TTK
) – (
1
11
2
),(
TT
TTK
) > 0
Case II: M > T1 (Payment after depletion)
Fig.3
In this case, the interest payable per cycle is zero, IC2 = 0, when T1 < M ≤ T
IE2 = CIe [
1
0 0
11 ])()())((
T T
dtaTMdtatT
= CIe [aMT1 -
2
2
1aT
] (15)
Total average cost of the system per unit time is given by
K2 (T , 1T ) =
T
1
[set up cost + Deterioration cost + holding cost + Shortage cost – IE2]
K2 (T , 1T ) =
T
1
[A + C (
6
3
1Ta
+
40
5
1
2
Ta
) + h (
2
2
1aT
+
12
4
1Ta
+
720
11 6
1
2
Ta
) -
2
3ac
(2TT1- T2
- T1
2
) – CIe
(aMT1-
2
2
1aT
)] (16)
Our objective is to minimize the total cost. The necessary conditions for minimizing the total cost are
1
12 ),(
T
TTK
= 0 and
T
TTK
),( 12
= 0
1
12 ),(
T
TTK
=
T
1
[C (
2
2
1Ta
+
8
4
1
2
Ta
) + h (aT1+
3
3
1Ta
+
120
11 5
1
2
Ta
) –
2
3aC
(2T -2T1) – CIe (aM – aT1)]
= 0 (17)
5. An Inventory Model for Constant Demand with Shortages under Permissible Delay in Payments
www.iosrjournals.org 32 | Page
T
TTK
),( 12
= 2
1
T
[A+C (
6
3
1Ta
+
40
5
1
2
Ta
) h (
2
2
1aT
+
12
4
1Ta
+
720
11 6
1
2
Ta
)] -
2
3aC
(-1 + 2
2
1
T
T
) +
( 2
1 )(
T
aMTCIe
- 2
2
1
2
)
T
aTCIe
) = 0 (18)
Provided they (equations (17) & (18)) satisfy the conditions
( 2
1
12
2
),(
T
TTK
)> 0, ( 2
12
2
),(
T
TTK
)> 0and ( 2
12
2
),(
T
TTK
) ( 2
1
12
2
),(
T
TTK
)-(
TT
TTK
1
12
2
),(
) > 0.
IV. NUMERICAL EXAMPLES
Case I: M ≤ T1
Let us take A = 1000, a = 300, h= 5, θ = 0.6, C3=0.8, Ie = 0.09, M = 0.08, Ic = 0.12, C= 20 in the
respective proper units. Then we get T1=0.4801 is greater than M = 0.08. Also T = 2.9532,
TC = 593.5394 and Q = 247.4187
Case II: M > T1
Let us take A = 1000, a = 300, h= 5, θ = 0.6, C3=0.8, Ie = 0.09, M = 0.35, C= 20 in the respective
proper units. Then we get T1=0.3143 is less than M = 0.35. Also T = 2.9899, TC = 642.1459 and Q =
95.2297
V. SENSITIVITY ANALYSIS
Sensitivity analysis has been carried out by keeping one variable changing while all other variables as
constant.
Table 1
h T1 T TC Q
6 0.4456 2.9588 603.1786 136.3818
7 0.4148 2.9627 611.5131 126.6143
8 0.3873 2.9655 618.7733 117.9564
9 0.3627 2.9675 625.1404 110.2584
θ T1 T TC Q
0.7 0.4615 2.9475 596.6431 141.9671
0.8 0.4452 2.9430 599.4622 137.1735
0.9 0.4308 2.9393 602.0433 132.9280
1.0 0.4178 2.9362 604.4248 129.0820
a T1 T TC Q
350 0.4667 2.7278 633.0839 166.9725
400 0.4557 2.5453 668.6476 186.1360
450 0.4464 2.3935 700.9201 204.9548
500 0.4385 2.2645 730.4170 223.5387
C3 T1 T TC Q
0.7 0.4715 3.1414 560.6751 144.6575
0.6 0.4619 3.3757 524.4924 141.5832
0.5 0.4510 3.6785 484.1174 138.1024
0.4 0.4385 4.0903 438.2180 134.1232
Table - 2
h T1 T TC Q
6 0.2886 2.9833 646.7447 87.3065
7 0.2662 2.9772 650.6418 80.4295
8 0.2467 2.9716 653.9757 74.4629
9 0.2295 2.9664 656.8530 69.2144
θ T1 T TC Q
0.7 0.3054 2.9854 643.1991 92.6267
0.8 0.2973 2.9814 644.1701 90.2523
0.9 0.2900 2.9778 645.0703 88.1100
1.0 0.2832 2.9745 645.9087 86.1093
6. An Inventory Model for Constant Demand with Shortages under Permissible Delay in Payments
www.iosrjournals.org 33 | Page
a T1 T TC Q
350 0.2991 2.7680 691.2791 105.6291
400 0.2866 2.5888 736.6964 115.5886
450 0.2761 2.4402 779.0716 125.1986
500 0.2671 2.3143 818.8957 134.5089
C3 T1 T TC Q
0.7 0.3029 3.1824 604.6992 91.7106
0.6 0.2901 3.4220 563.7346 87.7680
0.5 0.2758 3.7314 518.3469 83.3737
0.4 0.2592 4.1521 467.1546 78.2856
VI. Conclusion
This model developed in this paper assumes that demand of the product is constant and deteriorating
rate is time proportional. The benefit of the trade credit for the retailer is illustrated with numerical example and
sensitivity analysis. It can be noted down that increase of holding cost, deterioration rate and demand give
increase in total cost. Similarly decrease in shortage cost decreases the total cost for case (I). For Case (II) also
increase in the parameters increases the total cost and decreases causes decrease in the total cost.
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