This document discusses cystic diseases of the liver, classifying them into infectious, congenital, neoplastic, and traumatic hepatic cysts. It focuses on infectious cysts including pyogenic liver abscess, amebic liver abscess, and hydatid cyst of the liver. For each condition, it covers epidemiology, etiology, pathology, clinical presentation, diagnosis, treatment including antibiotics, drainage and surgery, and complications. Surgical drainage is currently reserved for patients that have failed nonoperative therapy or those with multiple macroscopic abscesses.
This is very important topic for Laparoscopic surgeons,as bile injury is not uncommon,how to approach such biliary injuries is prime to know for evolving surgeons.This slide would also helpful for surgery residents.
This is very important topic for Laparoscopic surgeons,as bile injury is not uncommon,how to approach such biliary injuries is prime to know for evolving surgeons.This slide would also helpful for surgery residents.
how can you diagnose splenic abscess and how to manage whether medical or surgical and what are the complications with pictures for diagnosis and treatment
Carcinoma rectum the complete aproach to how to investigate and treat a case ...nikhilameerchetty
this is a complete guide to the understanding of the anatomy clinical features and the latest investigation to the most modern methods of treating the case of carcinoma rectum , all the latest journal published and the ongoing trials hav been searched and incorporated
Component seperation technique for the repair of very large ventral hernias nikhilameerchetty
Includes all the ventral hernia repairs with the loss of domain and the various methods of component separation technique with their success rate for their repair ,few videos showing the methods of repair in addition to the latest techniques of repair .
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
4. PYOGENIC LIVER ABSCESS
EPIDEMIOLOGY
• The first description of hepatic abcess is credited to Hippocrates in the year 4000BC
• In 1938 ochsner’s classic described this disease
• 5–13 patients per 100,000 admissions prior to 1970,
• 15 cases per 100,000 admissions today.
• This rising incidence is attributed to a more aggressive management approach to hepatobiliary
and pancreatic cancers as well as major improvements in diagnostic imaging.
5. PYOGENIC LIVER ABSCESS
Aetiology
1. Bile Ducts Causing Ascending Cholangitis
2. Portal Vein Pylephlebitis From Appendicitis Or Diverticulitis
3. Direct Extension From The Contagious Disease
4. Trauma Due To The Blunt Or Penetrating Injuries
5. Hepatic Artery Due To Septicaemia
6. Cryptogenic
7. PATHOLOGY
• SOURCE NUMBER SIZE LOCATION
PORTAL SINGLE LARGE RIGHT LOBE
TRAUMATIC USUALLY SINGLE LARGE PREFERENTIAL
CRYPTOGENIC SINGLE LARGE PREFERENTIAL
BILIARY MULTIPLE SMALL BILATERAL
ARTERIAL MULTIPLE SMALL BILATERAL
FUNGAL MULTIPLE MILLIARY BILATERAL
12. RADIOLOGY
PLAIN CHEST X RAYS
• Abnormal In 50% Of Patients.
• Elevated Right Hemidiaphragm,
• Right Pleural Effusion,
• Right Lower Lobe Atelectasis)
ABDOMINAL FILMS
• Hepatomegaly
• Air-fluid Levels In The Presence Of Gas-forming Organisms
• Portal Venous Gas If Pylephlebitis Is The Source
13. ULTRASOUND
ADVANTAGES
• Distinguish Solid From Cystic Lesions
• Cost Effective
• Portable.
• 80–95% Sensitive
LIMITATIONS
• Morbidly Obese
• Lesions That Are Located Under The Ribs
• Homogeneous Liver.
COMPUTED TOMOGRAPHY (CT)
• sensitive (95–100%)
• Lesions are detectable to around 0.5 cm
• not limited by shadowing from ribs or air.
cholangiography, often via an indwelling biliary stent, may visualize the abscess
14. TREATMENT
1. ANTIBIOTIC ADMINISTRATION
2. DRAINAGE
3. SURGERY
EXCEPTION
1. Multiple small abcesses
2. Milliary fungal abcesses
• I/V antibiotics
• Antifungals
• No drainage
15. ANTIBIOTICS
• AMINOGLYCOSIDES, CLINDAMYCIN, AMPICILLIN , VANCOMYCIN, FLUOROQUINOLONES AND METRONIDAZOLE
• Single-agent therapy with TICARCILLIN-CLAVULANATE, IMIPENEM-CILASTATIN OR PIPERACILLIN-TAZOBACTAM
• Treatment used to be given for 4–6 weeks
• multiple abscesses <1.5 cm in size and no concurrent surgical disease, patients may be treated with IV antibiotics
alone.
• Candidial infections AMPHOTERICIN B (2-9g)
• FLUCONAZOLE in a dose of 6mg/kg/day is a suitable alternative .
16. ASPIRATION AND PERCUTANEOUS CATHETER
DRAINAGE
• similar mortality rates
• Rate of recurrence
• Patients in whom percutaneous drainage is not appropriate include those patients with
(1) multiple large abscesses
(2) known intra-abdominal source that requires surgery
(3) an abscess of unknown etiology
(4) ascites
(5) abscesses that would require transpleural drainage.
17. SURGICAL DRAINAGE
• Traditional approach :
Extraperitoneally via a 12th-rib resection to avoid contamination of the peritoneal cavity.
• Newer concept
Transperitoneal surgical exploration
• Advantages
(1) treat the inciting pathology in the remainder of the abdomen/pelvis
(2) gain access and exposure of the entire liver for evaluation and treatment
(3) access the biliary tree for cholangiography and bile duct exploration
Surgical drainage is currently reserved for patients that have
• Failed Nonoperative Therapy,
• Those With Multiple Macroscopic Abscesses,
• Those On Steroids,
• Concomitant Ascites.
18. COMPLICATIONS
• Up to 40% of patients develop complications from pyogenic liver abscesses
• Generalized Sepsis (Most Common)
• Pleural Effusions
• Empyema
• Pneumonia
• Perihepatic Abscess
• Hemobilia
• Hepatic Vein Thrombosis.
19. FACTORS ASSOCIATED WITH POOR OUTCOME
Failure To Establish A Diagnosis
Inability To Achieve Adequate Drainage
Diabetes mellitus
Associated malignancy
Multiple abscesses
Septicemia
20. AMEBIC LIVER ABSCESS
• Amebic liver abscess is caused by the parasitic protozoan Entamoeba histolytica.
• First described by Hippocrates and other associates in 5tH century BC
• Second only to malarial disease as a cause of protozoan-mediated death.
21.
22. PATHOLOGY
• 90% of people are asymptomatically colonized,
• Incubation takes 1–4 weeks.
• invasive disease is colitis
• Licqufied hepatic parenchyma with debris and blood – ANCHOVY SAUSE
• 70–80% diarrhea, abdominal pain, weight loss, and stools consisting of blood and
mucus.
• "buttonhole" ulcers with undermined edges.
• The most common extraintestinal site of amebiasis is the liver, occurring in 1–7% of
children and 50% of adults
23. Symptom Percentage
Pain 90
Fever 87
Nausea and vomiting 85
Anorexia 50
Weight loss 45
Malaise 25
Diarrhoea 25
Cough and pleurisy 25
Pruritis <1
CLINICAL PRESENTATION
26. DIAGNOSIS
• The Definitive Diagnosis Of Amebic Liver Abscess Is By E. Histolytica
Trophozoites In The Pus
• Detection Of Serum Antibodies To The Ameba.
27. DISTINGUISHING CLINICAL CHARECTERISTICS
AMEBIC PYOGENIC
Age <50yrs Age >50yrs
M:F 10:1 M:F 1.5:1
PAIN FEVER
DIARROHEA JAUNDICE,PRURITIS
ABDOMINAL TENDERNESS PALPABLE MASS
RECENT H/O TRAVEL TO ENDEMIC AREA NO HISTORY
PULMONARY COMPLICATIONS MALIGNANCY
28. RADIOLOGY
• Chest radiographs
pleural effusion
infiltrates
elevated hemidiaphragm.
• Ultrasound, CT, and magnetic resonance imaging (MRI)
Excellent but are nonspecific.19
In 75–80% of cases, only a single abscess is present and in the right lobe
10% are in the left lobe
The mean resolution time is 7 months, and 70% have findings that persist for more than 6
months.
29. TREATMENT
• Since the introduction of metronidazole in the 1960s, surgical drainage of
amebic liver abscesses has become virtually unnecessary
30. ANTIBIOTICS
• Noninvasive infections can be treated with paromomycin.
• Nitroimidazoles, especially metronidazole, are the mainstays of treatment for invasive amebiasis.
• This antibiotic crosses the placenta and blood-brain barrier and is contraindicated in the first trimester of
pregnancy.
• Positive responses to metronidazole should be seen by the third day of treatment.
• nitroimidazole treatment should be followed with paromomycin or diloxanide furoate to cure luminal
infection
31. THERAPEUTIC ASPIRATION
• Drainage should be considered in patients that have no clinical response to drug therapy within 5–7
days
• those with a high risk of abscess rupture defined as having a cavity >5 cm in diameter
• by the presence of lesions in the left lobe.
• Bacterial coinfection of amebic liver abscess has been observed
32. PERCUTANEOUS DRAINAGE
• Most useful for treating pulmonary, peritoneal, and pericardial
complications.
• The high viscosity of amebic abscess fluid, requires a large
diameter catheter for adequate drainage.
33. SURGICAL
• Failed To Respond To Conservative Therapy (Most Common Indication).
• Laparotomy Is Indicated For Life-threatening Hemorrhage
• When The Amebic Abscess Erodes Into A Neighboring Viscus
• Sepsis Due To A Secondarily Infected Amebic Abscess
34. COMPLICATIONS
• Complications from amebic abscesses occur secondary to rupture of the abscess into the peritoneum,
pleural cavity, or pericardium (Fig 28–7). incidence 2–17% ,mortality rates between 12% and 50%.23
SEQUELAE
• Thoracic amebiasis (empyema, bronchohepatic fistulas, and pleuropulmonary abscess) is the most
common complication,
• Pericardial amebiasis (acute pericarditis with tamponade).
• Pleural cavity drainage of the pleural cavity with tube thoracostomy.
• Bronchi, Surgical intervention is not required,
• Cerebral amebiasis - seizures.
36. HYDATID LIVER CYST
• E. granulosus and
• E. multilocularis
• Zoonosis
• Humans are accidental intermediate hosts, whereas animals can be both
intermediate hosts and definitive hosts.
• In humans, 50–75% of the cysts occur in the liver,
• 25% are located in the lungs, and
• 5–10% distribute along the arterial system
37.
38. LIFE CYCLE OF ECHINOCOCCUS GRANULOSUS.• parasite lives in the proximal small bowel
• Eggs are released into the host's intestine
• excreted in the feces
• humans are the intermediate host
• ingest the ovum
• The ovum loses the protective chitinous layer and is digested in the duodenum
• The released hexacanth embryo (oncosphere) passes through the intestinal wall into the portal circulation
and develops into cysts within the liver
39. Pathology
PERICYST,
ECTOCYST
ENDOCYST IS THE GERMINAL MEMBRANE
BROOD CAPSULES
PROTOSCOLECES
A PROTOSCOLEX.
ADULT TAPE WORM DAUGHTER CYST
endogenic vesiculation.
Ectogenic vesiculation
41. signs percentage
Right upper quadrent mass 70
Right upper quadrent tenderness 20
Laboratory data percentage
Eosnophilia 35
Bilirubin > 2mg/dl 20
Wbc count<10,000 10
Elisa 90
Arc 5 91
42. RADIOLOGY
CHEST X RAYS
• Elevated diaphragm
• concentric calcifications in the cyst wall
• ULTRASOUND
• Specificity- approx 90%
• hydatid sand,daughter cyst,unilocular & calcified cyst wall
• Internal structure,number,and location of the cysts and the presence of complication
43. Type I has a pure fluid collection
Type II has a fluid collection with a split wall (floating membrane)
Type III reveals a fluid collection with septa (honeycomb image)
Type IV has heterogenous echographic patterns
Type V has reflecting thick walls(dead calcified wall)
GHARBI’S CLASSIFICATION
44. COMPUTED TOMOGRAPHY
• specific information about the location
• depth of the cyst within the liver
MRI
• structural details of the hydatid cyst
Endoscopic retrograde cholangiopancreatography (ERCP)
• communication between the cysts and bile ducts
45. DIFFERENTIAL IMAGING AND CHARACTER OF
HEPATIC CYSTS
Pyogenic Amoebic Hydatid
Number Single or
multiple
One or few Usually single
Wall character Uniform or
multiloculated
Usually
uniform
Uniform, daughter
cysts; 50%
calcified
Cyst contents Usually pus Red-brown;
like anchovy
paste
Clear or bilious;
gelatinous
46. TREATMENT
PRINCIPLES
(1) Eradication Of The Parasite Within The Cyst
(2) Protection Of The Host Against Spillage Of Scoleces,
(3) Management Of Complications.
48. Medical treatment
Success rate of 30%
-Albendazole (10-15mg/kg/day) is drug of choice
- decreases the size of cyst
- decreases intracystic pressure
- decreases risk of rupture
Mebendazole (50mg /kg)& Praziquantel ( 50mg/kg)
Indications
Small cysts (<4 cm) located deep in the
parenchyma of the liver
TREATMENT
49. PERCUTANEOUS ASPIRATION AND DRAINAGE
• Surgical dictum
• “ PERCUTANEOUS PUNCTURE OF A HYDATID CYST IS A DANGEROUS AND CONTRAINDICATED “
• 1983, Fornagechallenged this axiom
• FREQUENTLY USED PROTOSCOLICIDAL AGENTS
• 15–20% Saline
• 95% Ethanol
• A Combination Of 30% Saline And 95% Ethanol,
• Mebendazole Solution.
The PAIR technique (percutaneous aspiration, injection and re-aspiration) has also been combined with
albendazole therapy with 70% success rate
50. SURGERY
• OBJECTIVES
• (1) Inactivate The Scoleces
• (2) Prevent Spillage Of Cyst Contents
• (3) Eliminate All Viable Elements Of The Cyst
• (4) Manage The Residual Cavity Of The Cyst.
51. • Preparation
• Give 4-6 week of albendazole tablet before surgery (800mg/day in divided doses) in adult
• Pre operative visualization of biliary tract by ERCP.
• Anaesthesist warned of sudden anaphylactic shock in case of spillage.
SURGERY
53. TREATMENT OPTIONS FOR HYDATID CYSTS
Uncomplicated cysts
Percutaneous or laparoscopy
Gharbi type I or II
Anterior cysts
Peripheral cyst
Small cyst
No or minimal calcification
Open surgery
Gharbi type IV or V
Posterior cyst
Central cyst
Large cyst
Heavy calcification
Complicated cysts
Open surgery
Biliary communication
Pleural communication
Peritoneal rupture
54. • Rupture into CBD causing obstructive jaundice
• Anaphylactic shock
• Rupture into peritoneal cavity
• Rupture into lung
COMPLICATIONS OF HYDATID CYST