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CRYPTORCHIDISM
DR MUHAMMAD AAMIR
PGR UROLOGY TEAM C
DEFINITION
 Retention of testis in the
abdomen or arrest of its
descent at any point along
its natural pathway.
EMBRYOLOGY
 DEVELOPMENT- From genital fold
 Descent – three phases
A-Intra abdominal (1-7 months)
B-Canalicular ( 7-8months)
C-Scrotal (8-9month)
EPIDEMIOLOGY
 Most common congenital malformation of male
neonates.
 Incidence depends on gestational age
full term: 1-4.6%
preterm neonates: 1.1-45%
Bilateral undesend in upto 30% of cases
AETIOLOGY AND PATHOPHYSIOLOGY
 Specific cause is unknown in most cases
 May be heterogenous or due to multiple genetic and envoirnmental risk
factors e.g
abnormal testes or gubernaculm
low level of androgens, HCG, LH, Calcitonin, gene related peptide and
maternal or paternal hormonal exposure,
decreased intraabdominal pressure(prune belly syndrome)
prior inguinal surgery of child
CLASSIFICATION
A. Palpable (80%)
Inguinal
Ectopic : MC position is superficial inguinal
pouch
Retractile : overactive cremasteric reflex,
upto 1/3rd ascends
B. Non-palpable(20%)
Intrabdominal (50-60%) MC found close to
internal inguinal ring
Inguinal
Ectopic
Absent a. agenesis b. vanishing testis
Mechanism of absent testis include testicular
agenesis and atrophy after intrauterine torsion.
DIAGNOSTIC EVALUATION
 HISTORY :
Empty scrotum since birth
Swelling in the groin which is reducible
May present with complication
PHYSICAL EXAMINATION:
IN standing sitting or squatting position
In case of unilateral non palapable teste, contralateral teste need to be
examined. A compensatory hypertrophy suggest testicular absence or atrophy.
In case of b/l UDT and any sign of DSD such as genital ambiguity or scrotal
hyperpigmentation further evaluation including endocrine and genetic
assessment becomes mandatory.
Continue…
 IMAGING STUDIES:
Ultrasound; lacks diagnostic
sentivity
MRI; recommended in selected and
specific clinical scenarios
Diagnostic Laproscopy; procedure
of choice
WHY TO TREAT…???
 COMPLICATNS;
Infertility
Trauma
Torsion
Malignant changes
Psychological
MANAGEMENT
 TX SHOULD BE STARTED AT 6-12MONTHS OR 18 MONTHS ATLEAST
 Medical therapy ; not currently recommended as 20% of descended
testes have risk of re-ascend later on..
 The higher the testes located prior to therapy the lower the success rate
 Hcg or GNRH has success rate of 20%.
 Some studies reported combined HCG and Gnrh therapy to cause successful
descent in upto 38% of non-responders to monotherapy.
CONTINUE….
 SURGICAL MANAGEMENT
 PALAPABLE TESTIS
a- Inguinal orchidopexy
Success rate upto 92%
Mobiloization of testis and
spermatic cord to the level of
internal inguinal ring.
Dissection and division of all
cremasteric fibers.
Mobilzed testicle needs to be
placed in subdartos pouch within
the hemiscrotum without tention.
b- Scrotal orchidopexy
Success rate 88-100%
Done for low position palpable
UDT
Shorter operative time
 B- Non palpable testis
a-Open transabdominal
orchidopexy
Success rate 95%
The internal ring is approached via
muscle splitting incision.
Peritoneum opened and testis
delivered.
A tunnel is created to scrotum and
testis is secured
b- Fowler-Stephens orchidopexy;
testis lying greater than 2cm
above the internal inguinal ring
can be done laproscopically as
well as open
1-one stage technique
Involves proximal cutting and
transection of testicular vessels,
conservation of collateral arterial
blood supply via the deferential
atery and cremesteric vessels.
The testis is then mobililized and
brought down in scrotum.
 2-staged technique
The procedure is same as one stage technique but testis are mobilized six
months later with its new collaterals.
 MODIFIED FOWLER-STEPHEN TECHNIQUE
 COMPLICATIONS…
A- testicular atrophy
B-testicular ascend
C-vas derens injury
D-wound infections dehiscence and heamatoma.
PROGNOSIS
 Sperm count are reduced in atleast 25% of formerly unilateral and
majority of formerly b/l cryptorchoid men but paternity rates in
unilateral groups are similar to those in control men.
 TGCT risk is 2-5 times higher in boys with cryptorchidism especially
after pubertal orchoidopexy.
CRYPTORCHIDISM.pptx

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CRYPTORCHIDISM.pptx

  • 1.
  • 3.
  • 4. DEFINITION  Retention of testis in the abdomen or arrest of its descent at any point along its natural pathway.
  • 5. EMBRYOLOGY  DEVELOPMENT- From genital fold  Descent – three phases A-Intra abdominal (1-7 months) B-Canalicular ( 7-8months) C-Scrotal (8-9month)
  • 6. EPIDEMIOLOGY  Most common congenital malformation of male neonates.  Incidence depends on gestational age full term: 1-4.6% preterm neonates: 1.1-45% Bilateral undesend in upto 30% of cases
  • 7. AETIOLOGY AND PATHOPHYSIOLOGY  Specific cause is unknown in most cases  May be heterogenous or due to multiple genetic and envoirnmental risk factors e.g abnormal testes or gubernaculm low level of androgens, HCG, LH, Calcitonin, gene related peptide and maternal or paternal hormonal exposure, decreased intraabdominal pressure(prune belly syndrome) prior inguinal surgery of child
  • 8. CLASSIFICATION A. Palpable (80%) Inguinal Ectopic : MC position is superficial inguinal pouch Retractile : overactive cremasteric reflex, upto 1/3rd ascends B. Non-palpable(20%) Intrabdominal (50-60%) MC found close to internal inguinal ring Inguinal Ectopic Absent a. agenesis b. vanishing testis Mechanism of absent testis include testicular agenesis and atrophy after intrauterine torsion.
  • 9. DIAGNOSTIC EVALUATION  HISTORY : Empty scrotum since birth Swelling in the groin which is reducible May present with complication PHYSICAL EXAMINATION: IN standing sitting or squatting position In case of unilateral non palapable teste, contralateral teste need to be examined. A compensatory hypertrophy suggest testicular absence or atrophy. In case of b/l UDT and any sign of DSD such as genital ambiguity or scrotal hyperpigmentation further evaluation including endocrine and genetic assessment becomes mandatory.
  • 10. Continue…  IMAGING STUDIES: Ultrasound; lacks diagnostic sentivity MRI; recommended in selected and specific clinical scenarios Diagnostic Laproscopy; procedure of choice
  • 11. WHY TO TREAT…???  COMPLICATNS; Infertility Trauma Torsion Malignant changes Psychological
  • 12. MANAGEMENT  TX SHOULD BE STARTED AT 6-12MONTHS OR 18 MONTHS ATLEAST  Medical therapy ; not currently recommended as 20% of descended testes have risk of re-ascend later on..  The higher the testes located prior to therapy the lower the success rate  Hcg or GNRH has success rate of 20%.  Some studies reported combined HCG and Gnrh therapy to cause successful descent in upto 38% of non-responders to monotherapy.
  • 13. CONTINUE….  SURGICAL MANAGEMENT  PALAPABLE TESTIS a- Inguinal orchidopexy Success rate upto 92% Mobiloization of testis and spermatic cord to the level of internal inguinal ring. Dissection and division of all cremasteric fibers. Mobilzed testicle needs to be placed in subdartos pouch within the hemiscrotum without tention.
  • 14. b- Scrotal orchidopexy Success rate 88-100% Done for low position palpable UDT Shorter operative time
  • 15.  B- Non palpable testis a-Open transabdominal orchidopexy Success rate 95% The internal ring is approached via muscle splitting incision. Peritoneum opened and testis delivered. A tunnel is created to scrotum and testis is secured
  • 16. b- Fowler-Stephens orchidopexy; testis lying greater than 2cm above the internal inguinal ring can be done laproscopically as well as open 1-one stage technique Involves proximal cutting and transection of testicular vessels, conservation of collateral arterial blood supply via the deferential atery and cremesteric vessels. The testis is then mobililized and brought down in scrotum.
  • 17.  2-staged technique The procedure is same as one stage technique but testis are mobilized six months later with its new collaterals.  MODIFIED FOWLER-STEPHEN TECHNIQUE  COMPLICATIONS… A- testicular atrophy B-testicular ascend C-vas derens injury D-wound infections dehiscence and heamatoma.
  • 18. PROGNOSIS  Sperm count are reduced in atleast 25% of formerly unilateral and majority of formerly b/l cryptorchoid men but paternity rates in unilateral groups are similar to those in control men.  TGCT risk is 2-5 times higher in boys with cryptorchidism especially after pubertal orchoidopexy.