Linkage and crossing over , discovery of linked genes,types of crossing over,significance and difference between linkage and crossing over, complete presentation with suitable examples and figures
Cytological proof of crossing over
Stern's Experiment (Drosophila)
Stern's experiment to demonstrate cytological crossing over
Factors affecting Crossing over
Significance of crossing over in plant breeding
coincidence
Coefficient of Coincidence
Interference
Linkage and crossing over , discovery of linked genes,types of crossing over,significance and difference between linkage and crossing over, complete presentation with suitable examples and figures
Cytological proof of crossing over
Stern's Experiment (Drosophila)
Stern's experiment to demonstrate cytological crossing over
Factors affecting Crossing over
Significance of crossing over in plant breeding
coincidence
Coefficient of Coincidence
Interference
Linkage
Genes far apart on the same assort independently are not linked
The position of the gene – locus
Occurs in the prophase of meiosis 1 where homologous chromosomes break at identical locations and rejoin with each other
Two genes are said to be under linkage, or linked, when they are located on the same chromosome.
Example: peas T=tall; t=short R=red; r=white
Crossing Over
Crossing over is a recombination of genes due to exchange of genetic material between two homologous chromosomes
It is the mutual exchange of segments of genetic material between non-sister chromatids of two homologous chromosomes, so as to produce re-combinations or new combinations of genes.
It occurs in the pachytene stage, at four strand stage with the help of enzymes (endonuclease, exo-nuclease, R-protein or recombinase;
Stern and Hotta,(1969, 1978).
There is breakage of chromatid segments, exchange of nonsister chromatid segments and later their fusion in new places.
Introduction, Types-somatic and germinal; Mechanism of meiotic crossing oversynapsis, duplication of chromosomes, breakage and union, terminalization;
Cytological basis of crossing over - Stern’s experiment in Drosophila; Creighton
and McClintock’s experiment in Maize; Crossing over in Drosophila, Construction
of genetic maps in Drosophila - two point and three-point crosses; Interference and
coincidence.
Linkage
Genes far apart on the same assort independently are not linked
The position of the gene – locus
Occurs in the prophase of meiosis 1 where homologous chromosomes break at identical locations and rejoin with each other
Two genes are said to be under linkage, or linked, when they are located on the same chromosome.
Example: peas T=tall; t=short R=red; r=white
Crossing Over
Crossing over is a recombination of genes due to exchange of genetic material between two homologous chromosomes
It is the mutual exchange of segments of genetic material between non-sister chromatids of two homologous chromosomes, so as to produce re-combinations or new combinations of genes.
It occurs in the pachytene stage, at four strand stage with the help of enzymes (endonuclease, exo-nuclease, R-protein or recombinase;
Stern and Hotta,(1969, 1978).
There is breakage of chromatid segments, exchange of nonsister chromatid segments and later their fusion in new places.
Introduction, Types-somatic and germinal; Mechanism of meiotic crossing oversynapsis, duplication of chromosomes, breakage and union, terminalization;
Cytological basis of crossing over - Stern’s experiment in Drosophila; Creighton
and McClintock’s experiment in Maize; Crossing over in Drosophila, Construction
of genetic maps in Drosophila - two point and three-point crosses; Interference and
coincidence.
Principles of inheritance & Variation-IVChethan Kumar
The topic of discussion here is about Mutation & different types of mutation in organism, their effects & Mutational theory of evolution. Further the changes in the Number of chromosomes due to mutation and its effects & Mendelian disorders & their patterns of inheritance including the numerical abberations in chromosomes & the disorders associated with it.
Chromosomal crossover, is the exchange of genetic material during sexual reproduction between two homologous chromosomes' non-sister chromatids that results in recombinant chromosomes.
A chromosome abnormality, disorder, anomaly, aberration, or mutation is a missing, extra, or irregular portion of chromosomal DNA. It can be from an atypical number of chromosomes or a structural abnormality in one or more chromosomes
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5. Crossing Over
• Occurs during Meiosis-I
• Crossing over occur in mitotic division cause Loss of heterozygosity
• Loss of heterozygosity (LOH) is a gross chromosome even that
results in loss of the entire gene and the surrounding chromosomal
region
6. Crossing Over
• Crossing over is essential for normal segregation of chromosomes
during meiosis.
• Crossing over also accounts for genetic variation because due to the
swapping (to exchange something for another) of genetic materials
during crossing over.
7. Percentage of Crossing Over
• The percentage of crossing over is directly proportional to the distance between two genes
• Unit of distance between genes is centimorgan (cM)
9. 1) Percentage of crossing over is more when
a) Genes are located in a different cell
b) Genes are not linked
c) Linked genes are located close to each other
d) Linked genes are located far apart from each other
Answer: d
10. 2) If the percentage of crossing over between two genes is 10, then the distance between two
genes will be
a) 5 centimorgans
b) 10 centimorgans
c) 20 centimorgans
d) 40 map units
Answer: b
11. 3) Alleles of different genes that are on the same chromosome may occasionally be separated
by a phenomenon known as
a) Pleiotropy
b) Epistasis
c) Continuous variation
d) Crossing over
Answer: d
12. 4) Crossing over in diploid organism is responsible for
a) Dominance of gene
b) Linkage between genes
c) Recombination of linked allele
d) Segregation of alleles
Answer: c