This document discusses genetic linkage and crossing over. It explains that genes located close together on the same chromosome are linked and tend to be inherited together, while genes on different chromosomes assort independently. Crossing over occurs when homologous chromosomes exchange segments during meiosis, resulting in new combinations of linked genes and the production of both parental and recombinant gametes. The frequency of crossing over between two genes decreases as they are located closer together on a chromosome.
Linkage and crossing over , discovery of linked genes,types of crossing over,significance and difference between linkage and crossing over, complete presentation with suitable examples and figures
Linkage and Crossing over (Sanjay Chetry).pptxsanjaychetry2
Linkage
1. Linkage ensures to keep the genes in a chromosome to inherit together
2. The strength of linkage between two genes is inversely proportional to the distance between them in the chromosome
3. The strength of linkage between two genes increases with the decrease in distance between them.
4. The strength of linkage decrease with increase in distance between the genes.
5. Linkage ensures the maintenance of parental trait in the offspring.
6. Linkage reduces the chance of creation of variability with sexual reproduction.
Crossing Over
1. Crossing over facilitates the separation of genes present chromosome and segregate into different gametes.
2. The chance of crossing over between two genes is directly proportional to the distance between them in the chromosome
3. The chance of crossing over between two genes decreases with the decrease in the distance between them.
4. The chance of crossing increases with increase in distance between the genes.
5. The crossing over causes alterations in the parental traits in the offspring.
6. Crossing over increases the chance of variability with sexual reproduction.
Linkage and crossing over , discovery of linked genes,types of crossing over,significance and difference between linkage and crossing over, complete presentation with suitable examples and figures
Linkage and Crossing over (Sanjay Chetry).pptxsanjaychetry2
Linkage
1. Linkage ensures to keep the genes in a chromosome to inherit together
2. The strength of linkage between two genes is inversely proportional to the distance between them in the chromosome
3. The strength of linkage between two genes increases with the decrease in distance between them.
4. The strength of linkage decrease with increase in distance between the genes.
5. Linkage ensures the maintenance of parental trait in the offspring.
6. Linkage reduces the chance of creation of variability with sexual reproduction.
Crossing Over
1. Crossing over facilitates the separation of genes present chromosome and segregate into different gametes.
2. The chance of crossing over between two genes is directly proportional to the distance between them in the chromosome
3. The chance of crossing over between two genes decreases with the decrease in the distance between them.
4. The chance of crossing increases with increase in distance between the genes.
5. The crossing over causes alterations in the parental traits in the offspring.
6. Crossing over increases the chance of variability with sexual reproduction.
Linkage
Genes far apart on the same assort independently are not linked
The position of the gene – locus
Occurs in the prophase of meiosis 1 where homologous chromosomes break at identical locations and rejoin with each other
Two genes are said to be under linkage, or linked, when they are located on the same chromosome.
Example: peas T=tall; t=short R=red; r=white
Crossing Over
Crossing over is a recombination of genes due to exchange of genetic material between two homologous chromosomes
It is the mutual exchange of segments of genetic material between non-sister chromatids of two homologous chromosomes, so as to produce re-combinations or new combinations of genes.
It occurs in the pachytene stage, at four strand stage with the help of enzymes (endonuclease, exo-nuclease, R-protein or recombinase;
Stern and Hotta,(1969, 1978).
There is breakage of chromatid segments, exchange of nonsister chromatid segments and later their fusion in new places.
Chromosomal crossover, is the exchange of genetic material during sexual reproduction between two homologous chromosomes' non-sister chromatids that results in recombinant chromosomes.
Introduction, Types-somatic and germinal; Mechanism of meiotic crossing oversynapsis, duplication of chromosomes, breakage and union, terminalization;
Cytological basis of crossing over - Stern’s experiment in Drosophila; Creighton
and McClintock’s experiment in Maize; Crossing over in Drosophila, Construction
of genetic maps in Drosophila - two point and three-point crosses; Interference and
coincidence.
Linkage
Genes far apart on the same assort independently are not linked
The position of the gene – locus
Occurs in the prophase of meiosis 1 where homologous chromosomes break at identical locations and rejoin with each other
Two genes are said to be under linkage, or linked, when they are located on the same chromosome.
Example: peas T=tall; t=short R=red; r=white
Crossing Over
Crossing over is a recombination of genes due to exchange of genetic material between two homologous chromosomes
It is the mutual exchange of segments of genetic material between non-sister chromatids of two homologous chromosomes, so as to produce re-combinations or new combinations of genes.
It occurs in the pachytene stage, at four strand stage with the help of enzymes (endonuclease, exo-nuclease, R-protein or recombinase;
Stern and Hotta,(1969, 1978).
There is breakage of chromatid segments, exchange of nonsister chromatid segments and later their fusion in new places.
Chromosomal crossover, is the exchange of genetic material during sexual reproduction between two homologous chromosomes' non-sister chromatids that results in recombinant chromosomes.
Introduction, Types-somatic and germinal; Mechanism of meiotic crossing oversynapsis, duplication of chromosomes, breakage and union, terminalization;
Cytological basis of crossing over - Stern’s experiment in Drosophila; Creighton
and McClintock’s experiment in Maize; Crossing over in Drosophila, Construction
of genetic maps in Drosophila - two point and three-point crosses; Interference and
coincidence.
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1. Genetic linkage and Crossing
Over
Prepared by
Samira Fattah
Assis. Lec.
College of health sciences-HMU
Lecture 4
G.BHAGIRATH
Asst.Prof of Botany
GDC Rangasaipet,Warangal
2. Is independent assortment always
the case? No
• Independent assortment states that during gamete
formation, the two alleles for one gene segregate or assort
independently of the alleles for other genes.
• But if two genes are found on the same chromosome, they
will not assort independently, and do not follow Mendelian
inheritance patterns.
• Genes that are inherited together are said to be “linked.”
3. • Genes located on different chromosomes are not linked
This allows independent assortment – in a di-hybrid cross
the traits show the classic 9:3:3:1 inheritance pattern.
• Genes that are located very close together on the same
chromosome may show complete linkage
They may be so close to each other that they cannot be
separated by recombination during meiosis.
4. (c) Genes located far apart on the same chromosome
typically show incomplete (partial) linkage
because they are easily separated by recombination.
5. Genetic linkage is the tendency of alleles that are located close
together on a chromosome to be inherited together
during meiosis.
Genes whose loci are nearer to each other are less likely to be
separated on to different chromatids during chromosomal
crossover, and are therefore said to be genetically linked.
In other words, the nearer two genes are on a chromosome, the
lower is the chance of a swap occurring between them, and the
more likely they are to be inherited together.
6. • William Bateson and Reginald Punnett completed a
study in 1905 that determined the movement of alleles
found on the same chromosome.
• The study used sweet peas, particularly flower colour
and pollen shape, they followed the inheritance pattern.
The discovery of genetic linkage
7. • For flower colour, purple is dominant over red, and
for pollen shape long is dominant over round.
• A cross was performed using a true breeding
purple/long and red/round.
• The F1 generation was 100% purple/long.
8. • Crossing two individuals from the F1 generation
resulted in a F2 generation with four different
phenotypes. (purple/long, purple/round, red/long
and red/round).
• The alleles that created these combinations did not
follow the 9:3:3:1 pattern, but supported the idea
that these alleles did not assort independently and
therefore must be linked.
9.
10. Why Linkage
• Linkage refers to packaging genes onto chromosomes.
• Chromosomes (and therefore linkage) are for
organizing genes for their safe coordinated
transmission from cell to cell( parent to offspring).
11. Types of Linkage
Depending upon the presence or absence of new
combinations or non-parental combinations, linkage can
be of two types:
(i) Complete Linkage:
If two or more characters are inherited together and
consistently appear in two or more generations in their
original or parental combinations, it is called complete
linkage. These genes do not produce non-parental
combinations.
Genes showing complete linkage are closely located in
the same chromosome.
12. (ii) Incomplete Linkage:
Incomplete linkage is exhibited by those genes
which produce some percentage of non-parental
combinations. Such genes are located distantly
on the chromosome. It is due to accidental or
occasional breakage of chromosomal segments
during crossing over.
14. Significance of Linkage
1. Linkage does not permit the breeders to bring
the desirable characters in one variety. For this
reason plant and animal breeders find it difficult
to combine various characters.
2. Linkage reduces the chance of recombination of
genes and thus helps to hold parental
characteristics together. It thus helps organism to
maintain its parental, racial and other characters.
15. • Linked genes are not inherited together every time
Chromosomes exchange homologous genes during
meiosis.
16. Crossing Over and the Inheritance of
Linked Genes
• Linked genes don’t always stay linked.
• These linkage groups can be separated by
crossing over during prophase I of meiosis.
17.
18. • When crossing over occurs, the genes that were
previously linked become unlinked, creating four
different types of chromosomes (gametes).
• The proportions are not equal because crossing over
does not occur in every cell during meiosis.
19. Crossing Over
• A random exchange
of DNA between
two non-sister
chromatids of
homologous
chromosomes.
• Results in
recombination of
genetic material
20. • Prevalence of recombination is dependent on
the distance between linked genes
21. FACTORS AFFECTING CROSS OVER
1. Sex:
there is a tendency of reduction of crossing over in male
mammals.
2. Mutation:
mutation reduces crossing over
3. Temperature:
high and low temperature variations increase the percentage
of crossing over in certain parts of the chromosome.
4. X-ray Effect:
X-ray irradiations increase crossing over near centromere.
5. Age:
older age increases the rate of crossing over.
22. Significance of Crossing-over
1. Produces new combinations of traits.
2. Through crossing over segments of homologous chromosomes
are interchanged and hence provide origin of new characters
and genetic variations.
3. Crossing over plays a very important role in the field of
breeding to improve the varieties of plants and animals.
23. Theories of Crossing Over
(i) Contact First Theory :
According to this theory the inner two chromatids of the
homologous chromosomes undergoing crossing over, first
touch each other and then cross over. At the point of contact
breakage occurs. The broken segments again unite to form
new combinations.
(ii) The Breakage-First Theory :
According to this theory the chromatids under-going crossing
over, first of all break into two without any crossing over and
after that the broken segments reunite to form the new
combinations.
24.
25. Types of Crossing Over
(i) Single Crossing Over:
In this type of crossing over only one chiasma is formed
(a chiasma is the point where two homologous non-
sister chromatids exchange genetic material
during chromosomal crossover in meiosis ) all along the
length of a chromosome pair. Gametes formed by this
type of crossing over are called single cross over
gametes .
26. Types of Crossing Over
(ii) Double Crossing Over:
In this type two chiasmata are formed along the entire
length of the chromosome leading to breakage and rejoin
of chromatids at two points. The gametes produced are
called double cross over gametes.
(iii) Multiple Crossing Over:
In this type more than two chiasmata are formed and
thus crossing over occurs at more than two points on the
same chromosome pair. It is a rare phenomenon.
27.
28. Difference between linkage and crossing
over
Linkage
1. It is tendency of genes on a chromosome to remain
together and passed as such in next generation.
2. It brings more parental types.
3. Strength of linkage between two genes increases if
they are closely placed on a chromosome.
4. It helps to maintain a newly improved variety.
29. Difference between linkage and crossing
over
Crossing over
1. It is exchange of genes or chromosomal parts to
break established linkage and formation of new
linkage.
2. It produces recombination.
3. Frequency of crossing over between two genes
decreases if they are closely placed .
4. It is the source of variation for producing new
varieties.
30. In genetic recombination by crossing over, what is the
difference between parental gametes and
recombinant gametes?
• Parental gametes are the gametes that maintain the
original linkage of genes (alleles) in the chromosome.
• Recombinant gametes are those in which the
original linkage is undone due to exchange of
chromosomal pieces via crossing over during
meiosis.
