Purpose of the work is to create a compact, easy to use specialized hardware-software system based on the measuring module to implement methods of the spectral studies of thin films of biological agents in the mid-IR, suitable for use in clinical practice for the diagnosis of cancer pathologies.

1. №17/15 "Creation of hardware-software complex for spectral studies of thin films of
biological agents in the mid-IR"
tskmp "Molecular and cellular biotechnology for medicine, industry and agriculture"
Project Manager - Head of the State Institution "Department of Biotechnical Research Diagnostic
Institute of Cryobiology and Cryomedicine Ukraine", PhD, medicine M.V. Sidorenko
Purpose of the work is to create a compact, easy to use specialized
hardware-software system based on the measuring module to implement
methods of the spectral studies of thin films of biological agents in the mid-
IR, suitable for use in clinical practice for the diagnosis of cancer
pathologies.
к онтроль 1 3 5 6
0
0,02
0,04
0,06
0,08
0,1
0,12
0,14
ж иві мертві
Конце нтра ц ія на ноча стинок , мк г/мл
Кількістьклітин,млн/мл
контроль 1 3 5 6
ж иві мертвіонцентрація наночасток, мкг/мл
The main task of the stage:
1. Improvement of the interferometer, aimed
at reducing the parasitic interference pattern.
The measuring unit of hardware and
software is based on a Fourier spectrometer.
Accordingly, one of the main components of
its optical system is a Michelson
interferometer:
1 - a telescope with a filter housing;
2 - fixed mirror
3 - beam-splitting plate;
4 - output (focusing) lens;
5 - movable mirror with a micrometer screw.

2. The formation of the interference pattern
№17/15 "Creation of hardware-software complex for spectral studies of thin films of biological agents in
the mid-IR"
tskmp "Molecular and cellular biotechnology for medicine, industry and agriculture"
Project Manager - Head of the State Institution "Department of Biotechnical Research Diagnostic Institute of
Cryobiology and Cryomedicine Ukraine", PhD, medicine M.V. Sidorenko
In fact, at the output of the interferometer are available
just two interference patterns: useful (1), by recording
which is formed interferogram required to obtain a desired
spectrum, and parasitic concentric rings of small
diameter, which is due to unwanted reflection beams from
the edges beamsplitter plate (2).
During improving the model sample measurement module with a MgF2 plate was replaced with a plate of
ZnSe (refractive index of about 2.45), with the appropriate anti-reflective coating. These changes have
greatly improved the quality of the spectra obtained due to reduction of parasitic interference pattern, and
thus, increase the signal-to-noise ratio at the receiver output.

3. №17/15 "Creation of hardware-software complex for spectral studies of thin films of
biological agents in the mid-IR"
tskmp "Molecular and cellular biotechnology for medicine, industry and agriculture"
Project Manager - Head of the State Institution "Department of Biotechnical Research Diagnostic
Institute of Cryobiology and Cryomedicine Ukraine", PhD, medicine M.V. Sidorenko
Development of spectra registration path
In the order of finalizing of spectra registration path spectra a new Infratec LIM-262 IR receiver
was used, which, compared with the previous one, has a much higher sensitivity and better noise
and frequency characteristics.

4. A new circuit of receiver signal amplifier and ADC was developed.
№17/15 "Creation of hardware-software complex for spectral studies of thin films of biological
agents in the mid-IR"
tskmp "Molecular and cellular biotechnology for medicine, industry and agriculture"
Project Manager - Head of the State Institution "Department of Biotechnical Research Diagnostic
Institute of Cryobiology and Cryomedicine Ukraine", PhD, medicine M.V. Sidorenko

5. №17/15 "Creation of hardware-software complex for spectral studies of thin films of
biological agents in the mid-IR"
tskmp "Molecular and cellular biotechnology for medicine, industry and agriculture"
Project Manager - Head of the State Institution "Department of Biotechnical Research Diagnostic
Institute of Cryobiology and Cryomedicine Ukraine", PhD, medicine M.V. Sidorenko
In recent years, a variety of devices, including measuring devices are increasingly equipped with a
web user interface (WUI). Web user interface is a set of tools with which the user interacts with the
website or web application through a browser. Equipment developed hardware-software system will
allow access to the measuring module from any desktop or laptop computer, connected to this local
area network, and in the case of a part of the measuring module Wi-Fi adapter - also from mobile
devices (tablet, smart phone, etc.). This accessibility does not depend either on the hardware
configuration of the client device, or from the OS installed on it, and other software - is obligatory
only availability of the client device, a full-featured web browser.

6. №17/15 «Створення апаратно-програмного комплексу для спектрального
дослідження тонких плівок біологічних речовин у середньому ІЧ-діапазоні»,
цкмп “Молекулярні та клітинні біотехнології для потреб медицини, промисловості та сільського господарства”
керівник проекту – керівник Відділення біотехнічних проблем діагностики
ІПКК НАНУ, к.мед.н. Сидоренко М.В.
Interferogram processing requires
significant computing resources. For this
purpose, measuring module needs
appropriate CPU power. At the same time
the CPU can successfully manage the
module hardware during the measurement
process.
This eliminates the need to install on the
client device, a specialized (and tied to a
particular operating system) software, as
well as avoid the issues related to its
service and maintenance in operational
condition.
During the development of hardware and software of the model sample, such as multi-function controller
used compact computer based on Mini-ITX form factor VIA Technologies Inc motherboard VIA EPIA
ML6000EA with VIA Eden 600 MHz processor.
Important advantages of this board are the small dimensions (170 x 170 mm) and low power consumption
(less than 22 W, of which only 7 W falls on CPU) and passive cooling, which greatly simplifies its
placement in the housing managed by the equipment.

7. №17/15 "Creation of hardware-software complex for spectral studies of thin films of biological agents in
the mid-IR"
tskmp "Molecular and cellular biotechnology for medicine, industry and agriculture"
Project Manager - Head of the State Institution "Department of Biotechnical Research Diagnostic Institute of
Cryobiology and Cryomedicine Ukraine", PhD, medicine M.V. Sidorenko
Why Linux?
- Linux is a reliable and free OS.
- Linux source code can be modified and used on their own.
- Availability of many thousands of free open source applications, including a
variety of software development tools.
- Excellent opportunities for programmers. Integrated compilers console, the
ability to create your own scripts, and more available.
- High degree of protection against tampering and malicious software.
- Built-in support for a wide range of internal and external devices eliminates the
need to search for special drivers.

8. CONCLUSIONS
During the period under review on the subject the following works:
1. Improvement of the interferometer, aimed at reducing the parasitic interference
pattern.
2. Development of elements and nodes registration path spectra: receiver signal
amplifier and ADC.
3. Development of mock-control scheme, identified the necessary hardware and
software development started, which should fully comply with the performance
standards for hardware and software.
№17/15 "Creation of hardware-software complex for spectral studies of thin films of biological agents in
the mid-IR"
tskmp "Molecular and cellular biotechnology for medicine, industry and agriculture"
Project Manager - Head of the State Institution "Department of Biotechnical Research Diagnostic Institute of
Cryobiology and Cryomedicine Ukraine", PhD, medicine M.V. Sidorenko