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By: Shivani K. Saxena
Biology Faculty
Khare.forensics@gmail.com
1SKH_CBSE11
3/11/2016 SKH 2
3/11/2016 SKH 3
3/11/2016 SKH 4
Structure Of Skeletal Muscle
• Muscle
•Muscle Fascicle
• Muscle Fiber
• Myofibrils
5SKH_CBSE11
Skeletal Muscle
Muscle Fiber
1. Sarcolemma
2. Sarcoplasm Actin
3. Myofibrils – contractile elements
Myosin
a. Actin Filament
 F- actin strands
 Tropomyosin
 Troponin
b. Myosin Filament
6SKH_CBSE11
Structure of Skeletal Muscle:
Microstructure
Sarcolemma
 Muscle cell membrane
Myofibrils
 Threadlike strands
within muscle fibers
 Actin (thin filament)
 Troponin
 Tropomyosin
 Myosin (thick filament)
– A polymer made up of
monomer Meromyosin
Further divisions of
Myofibrils
 Z-line
 A-band
 I-band
Sarcoplasm
 Sarcoplasmic reticulum
 Storage sites for calcium
 Surrounds myofibrils
 Transverse tubules
Sarcomere
8SKH_CBSE11
SKH_CBSE11 9
SKH_CBSE11 10
Mechanism of Muscle contraction
11SKH_CBSE11
 Nerve impulse (Na – K pump action) travels to synaptic
knob.
 Ruptured Ach. Vesicles and release of Ach. into synaptic
cleft by exocytosis.
 Ach. Binds to receptor and stimulates it to generate a
action potential.
 Electrical impulse stimulates Ca++ from sarcoplasmic
reticulum .
 Actin and Myosin interaction (causing contraction).
 Actin and Myosin dissociation (causing relaxation).
SKH_CBSE11 12
Actin and Myosin Interaction
 Calcium bind with troponin and activates myosin
ATPase.
 As myosin ATPase become active. Tropomyosin
slipped off, G-action exposed.
 ATPase react with ATP.
ATP+ATPase ADP+ ~P
(Muscle contraction takes place.)
Ca++
13SKH_CBSE11
Actin and Myosin dissociation
 After muscle contraction occurs when calcium
is pumped back into the sarcoplasmic
reticulum, away from the actin and myosin.
 When Calcium moves in this way, the actin
and myosin cannot interact, and the muscle
relaxes.
14SKH_CBSE11
SLIDING FILAMENT
15SKH_CBSE11
Sarcomere completely contracted
16SKH_CBSE11
CONTRACTION
In Contraction
I- band disappear
H- band disappear
M- band disappear
Length of sarcomere decreases.
17SKH_CBSE11
Sarcomere Relaxed
18SKH_CBSE11
Relaxation
In Relaxation
 I- band reappear
 H- band reappear
 M- band reappear
 Length of sarcomere increases.
SKH_CBSE11 19
Sarcomere Partially contracted
20SKH_CBSE11
Stages Of Muscle Contraction
21SKH_CBSE11
8/3/2017 SKH 22

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