This document discusses the structure and function of skeletal muscle. It begins with an introduction to skeletal muscle and describes the characteristics of muscle fibers, including that they are multinucleated and striated. It then details the structure of the sarcomere, the basic contractile unit of skeletal muscle, including the thin actin filaments and thick myosin filaments. The document also describes excitation-contraction coupling and the sliding filament model of muscle contraction in which myosin cross-bridges attach to actin and generate force through an ATP-fueled cycling process.
The muscle are biological motors which convert chemical energy into force and mechanical work.
This biological machinery is composed of proteins – which is actomyosin and the fuel is ATP.
With the use of muscles we are able to act on our environment.
This document aims at highlighting the key aspects of muscle contraction from the time the signal is received to when the actin and myosin act against each other to cause shortening of the sarcomere. The document is for academic purposes and may not be exhaustive for those that intend to seek all the necessary molecular and bioenergetic expenditures during the process. However, all the important introduction elements to make it easier for you to build on are included. If you would like to discuss details about the subject, send me an email and we will surely have one.
1. Locomotion
2. Vasoconstriction and vasodilatation- constriction and
dilation of blood vessel Walls are the results of smooth muscle
contraction.
3. Peristalsis – wavelike motion along the digestive tract is
produced by the Smooth muscle.
4. Cardiac motion
5. Posture maintenance- contraction of skeletal muscles
maintains body posture and muscle tone.
6. Heat generation – about 75% of ATP energy used in
muscle contraction is released as heat. 1. Contracts for a longer time than skeletal muscle
because transverse tubules supply extra Ca+2 ions .
2. intercalated disc connects the ends of adjacent
muscles and hold cells together as a unit (syncytium) .
3. Fibers contracts as a unit .
4. Muscle fibers are self – exiting , rhythmic , and
remain refractory until a contraction is completed.
Chemical and molecular basis of muscle contractionChirag Dhankhar
here in this ppt I have told about the different types of muscles their biological cycle of muscle contraction, needs of contraction, neural network working for muscle contraction, atp and cp energy use in muscles , how energy is used and made by muscles in middle of the exercise, anatomy of muscles, working of muscles, different types of bands and proteins needed for muscle contraction
The muscle are biological motors which convert chemical energy into force and mechanical work.
This biological machinery is composed of proteins – which is actomyosin and the fuel is ATP.
With the use of muscles we are able to act on our environment.
This document aims at highlighting the key aspects of muscle contraction from the time the signal is received to when the actin and myosin act against each other to cause shortening of the sarcomere. The document is for academic purposes and may not be exhaustive for those that intend to seek all the necessary molecular and bioenergetic expenditures during the process. However, all the important introduction elements to make it easier for you to build on are included. If you would like to discuss details about the subject, send me an email and we will surely have one.
1. Locomotion
2. Vasoconstriction and vasodilatation- constriction and
dilation of blood vessel Walls are the results of smooth muscle
contraction.
3. Peristalsis – wavelike motion along the digestive tract is
produced by the Smooth muscle.
4. Cardiac motion
5. Posture maintenance- contraction of skeletal muscles
maintains body posture and muscle tone.
6. Heat generation – about 75% of ATP energy used in
muscle contraction is released as heat. 1. Contracts for a longer time than skeletal muscle
because transverse tubules supply extra Ca+2 ions .
2. intercalated disc connects the ends of adjacent
muscles and hold cells together as a unit (syncytium) .
3. Fibers contracts as a unit .
4. Muscle fibers are self – exiting , rhythmic , and
remain refractory until a contraction is completed.
Chemical and molecular basis of muscle contractionChirag Dhankhar
here in this ppt I have told about the different types of muscles their biological cycle of muscle contraction, needs of contraction, neural network working for muscle contraction, atp and cp energy use in muscles , how energy is used and made by muscles in middle of the exercise, anatomy of muscles, working of muscles, different types of bands and proteins needed for muscle contraction
Actin filaments, usually in association with myosin, are responsible for many types of cell movements. Myosin is the prototype of a molecular motor—a protein that converts chemical energy in the form of ATP to mechanical energy, thus generating force and movement. The most striking variety of such movement is muscle contraction, which has provided the model for understanding actin-myosin interactions and the motor activity of myosin molecules. However, interactions of actin and myosin are responsible not only for muscle contraction but also for a variety of movements of nonmuscle cells, including cell division, so these interactions play a central role in cell biology. Moreover, the actin cytoskeleton is responsible for the crawling movements of cells across a surface, which appear to be driven directly by actin polymerization as well as actin-myosin interactions.
Contraction of muscles takes place with relativity between Actin and Myosin Filaments. Here, Ach. regards to acetylchloine. Interaction between Actin and myosin will bring contraction in muscle.
Muscle movement plays an important role in day to day life where the contraction and relaxation of muscle is significant. The current slide has been developed with the focus on different phases during muscle contraction and the physiological change involved on it.
Actin filaments, usually in association with myosin, are responsible for many types of cell movements. Myosin is the prototype of a molecular motor—a protein that converts chemical energy in the form of ATP to mechanical energy, thus generating force and movement. The most striking variety of such movement is muscle contraction, which has provided the model for understanding actin-myosin interactions and the motor activity of myosin molecules. However, interactions of actin and myosin are responsible not only for muscle contraction but also for a variety of movements of nonmuscle cells, including cell division, so these interactions play a central role in cell biology. Moreover, the actin cytoskeleton is responsible for the crawling movements of cells across a surface, which appear to be driven directly by actin polymerization as well as actin-myosin interactions.
Contraction of muscles takes place with relativity between Actin and Myosin Filaments. Here, Ach. regards to acetylchloine. Interaction between Actin and myosin will bring contraction in muscle.
Muscle movement plays an important role in day to day life where the contraction and relaxation of muscle is significant. The current slide has been developed with the focus on different phases during muscle contraction and the physiological change involved on it.
Muscle is one of the four primary tissue types of the body, and the body contains three types of muscle tissue: skeletal muscle, cardiac muscle, and smooth muscle.
three types: skeletal, cardiac, smooth
Muscle cells are called muscle fibers
Contraction depends on two kinds of Myofilaments
Actin
Myosin
Prefixes to know: myo, mys, or sarco – word relates to muscle
Each muscle is a discrete organ
Muscle Type Overview
Skeletal Muscle tissue
Skeletal
Striated
Voluntary
Cardiac Muscle tissue
Cardiac
Striated
Involuntary
Smooth Muscle tissue
Visceral
Non-striated
Involuntary
Muscle Functions
1. Producing movement
2. Maintaining posture
3. Stabilizing joints
4. Generating heat
Functional Characteristics of Muscles
Excitability (or Irritability) = ability to receive and respond to stimuli
Contractility = ability to shorten forcibly
Extensibility = ability to be stretched or extended beyond resting length
Elasticity = ability to resume resting length after stretchingMuscle (organ)
Fascicle (a portion of the muscle)
Muscle Fiber (a cell)
These levels are supracellular
Connective Tissue Layer
Epimysium
Perimysium
Endomysium
Anatomy of a Muscle
Typical ex. is a skeletal muscle
The following are all subcellular.
Myofibril = or fibril, complex organelle composed of bundles of
myofilaments
Myofilament = macromolecular structure of contractile proteins
Sarcomere = the smallest, single contracting unit of a myofibril, a segment
Gross Anatomy
Deep fascia = binds large groups of muscles into functional groups
Muscle = hundreds of fascicles bound together by epimysium
Fascicle = thousands of muscle fibers bound into discrete units by
perimysium
Muscle fiber = single muscle cell surrounded by endomysium
Generous blood and nerve supply
Microscopic Anatomy of a Muscle Fiber
Muscle Fiber = elongated, cylindrical, multinucleated muscle cell
Sarcolemma = plasma (cell) membrane of a muscle cell
Sarcoplasm = cytoplasm of muscle cell with large amounts of glycogen and
Anatomy of the masticatory machine. It consists of a fixed and a movable member. The movable member is activated by a series of voluntary muscles, and its efficiency is increased by another set of voluntary muscles that feed the machine.
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3. Introduction
Human body contains over 400 skeletal muscles
40-50% of total body weight
Functions of skeletal muscle
Body movement (Locomotion)
Maintenance of posture
Respiration
Diaphragm and intercostal contractions
Communication (Verbal and Facial)
Constriction of organs and vessels
Peristalsis of intestinal tract
Vasoconstriction of b.v. and other structures (pupils)
Production of body heat (Thermogenesis)
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9. Skeletal muscle structure
Composed of muscle cells (fibers),
connective tissue, blood vessels,
nerves
Fibers are long, cylindrical, and
multinucleated
Tend to be smaller diameter in small
muscles and larger in large muscles. 1
mm- 4 cm in length
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10. •Develop from myoblasts;
numbers remain constant
•Striated appearance
•Nuclei are peripherally
located
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12. Muscle fiber anatomy
Sarcolemma - cell membrane
Surrounds the sarcoplasm (cytoplasm of fiber)
Contains many of the same organelles seen in other cells
An abundance of the oxygen-binding protein myoglobin
Punctuated by openings called the transverse tubules (T-tubules)
Narrow tubes that extend into the sarcoplasm at right angles to
the surface
Filled with extracellular fluid
Myofibrils -cylindrical structures within muscle fiber
Are bundles of protein filaments (=myofilaments)
Two types of myofilaments
1. Actin filaments (thin filaments)
2. Myosin filaments (thick filaments)
– At each end of the fiber, myofibrils are anchored to the inner surface
of the sarcolemma
– When myofibril shortens, muscle shortens (contracts)
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17. Actin (Thin)
Myofilaments
Thin Filament: composed of 3 major
proteins
1. F (fibrous) actin
2. Tropomyosin
3. Troponin
Two strands of fibrous (F) actin form
a double helix extending the length
of the myofilament; attached at
either end at sarcomere.
Composed of G actin monomers
each of which has a myosin-
binding site
Actin site can bind myosin during
muscle contraction.
Tropomyosin: an elongated protein
winds along the groove of the F actin
double helix.
Troponin is composed of three
subunits:
Tn-A : binds to actin
Tn-T :binds to tropomyosin,
Tn-C :binds to calcium ions.
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19. Myosin (Thick)
Myofilament
Many elongated myosin molecules
shaped like golf clubs.
Single filament contains roughly 300
myosin molecules
Molecule consists of two heavy myosin
molecules wound together to form a rod
portion lying parallel to the myosin
myofilament and two heads that extend
laterally.
Myosin heads
1. Can bind to active sites on the actin
molecules to form cross-bridges.
(Actin binding site)
2. Attached to the rod portion by a
hinge region that can bend and
straighten during contraction.
3. Have ATPase activity: activity that
breaks down adenosine
triphosphate (ATP), releasing
energy. Part of the energy is used to
bend the hinge region of the myosin
molecule during contraction
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21. Sarcomeres: Z Disk
to Z Disk
Sarcomere - repeating functional units of
a myofibril
About 10,000 sarcomeres per
myofibril, end to end
Each is about 2 µm long
Differences in size, density, and
distribution of thick and thin filaments
gives the muscle fiber a banded or striated
appearance.
A bands: a dark band; full length of thick
(myosin) filament
M line - protein to which myosins attach
H zone - thick but NO thin filaments
I bands: a light band; from Z disks to ends of
thick filaments
Thin but NO thick filaments
Extends from A band of one sarcomere to A
band of the next sarcomere
Z disk: filamentous network of protein.
Serves as attachment for actin myofilaments
Titin filaments: elastic chains of amino
acids; keep thick and thin filaments in
proper alignment
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24. Sarcoplasmic Reticulum (SR)
SR is an elaborate, smooth endoplasmic
reticulum
runs longitudinally and surrounds each myofibril
Form chambers called terminal cisternae on either
side of the T-tubules
A single T-tubule and the 2 terminal cisternae
form a triad
SR stores Ca++ when muscle not contracting
When stimulated, calcium released into sarcoplasm
SR membrane has Ca++ pumps that function to pump
Ca++ out of the sarcoplasm back into the SR after
contraction
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28. Muscular Contraction
The sliding filament model
Muscle shortening occurs due to the movement of the
actin filament over the myosin filament
Formation of cross-bridges between actin and myosin
filaments
Reduction in the distance between Z-lines of the
sarcomere
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29. Sliding Filament Theory
Rest – uncharged ATP cross-bridge complex
Excitation-coupling – charged ATP cross-bridge
complex, “turned on”
Contraction – actomyosin – ATP > ADP & Pi +
energy
Recharging – reload cross-bridge with ATP
Relaxation – cross-bridges “turned off”
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30. Sliding Filament Model of
Contraction
Thin filaments slide past the thick ones so that the
actin and myosin filaments overlap to a greater degree
In the relaxed state, thin and thick filaments overlap
only slightly
Upon stimulation, myosin heads bind to actin and
sliding begins
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36. Excitation-Contraction Coupling
Mechanism where an
action potential causes
muscle fiber
contraction
Involves
Sarcolemma
Transverse or T tubules
Terminal cisternae
Sarcoplasmic reticulum
Ca2+
Troponin
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37. Sources of ATP for Muscle
Contraction
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38. Energy Sources
ATP provides immediate energy for muscle
contractions from 3 sources
Creatine phosphate
During resting conditions stores energy to synthesize ATP
Anaerobic respiration
Occurs in absence of oxygen and results in breakdown of
glucose to yield ATP and lactic acid
Aerobic respiration
Requires oxygen and breaks down glucose to produce
ATP, carbon dioxide and water
More efficient than anaerobic
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