This document discusses congenital/essential infantile esotropia, beginning with definitions and prevalence. It notes hereditary and genetic factors, as well as risk factors like prematurity. Diagnostic criteria for congenital esotropia include onset by 6 months, deviation of at least 30 prism diopters, and asymmetry of optokinetic nystagmus. Management involves early surgery before 18 months for best binocularity outcomes, with options like recession of medial rectus muscles or resection of lateral rectus muscles depending on deviation size. Early alignment improves stereoacuity outcomes by making additional surgery and DVD less likely.
Presenters :
Jenil Shelsiya
Sisira PS
Gopika Jyothirmayan
Special Thanks To Sushma Shrestha
and Mentor Deepak Rai (Optometrist).
If any query,Viewers are requested to refer to book for detailed explanation or can ask me question directly in the comment box. Answers will be given from Presenter's side.
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Presenters :
Jenil Shelsiya
Sisira PS
Gopika Jyothirmayan
Special Thanks To Sushma Shrestha
and Mentor Deepak Rai (Optometrist).
If any query,Viewers are requested to refer to book for detailed explanation or can ask me question directly in the comment box. Answers will be given from Presenter's side.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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2. Esotropia(Convergent Squint)..Cornea deviated nasally
4-5% of squint in gen population.
0.1% of population have CET
50% ocular deviations in paed age group are Esotropias
40% cong ET of all ET
4. Heredity: multifactorial genetic basis for
congenital esotropia.
suggested loci on regions 3p26.3-26.2 and
6q24.2-25.1 and may share alleles that
underlie Duane retraction syndrome
Unaffected parents are more likely to have
slightly deficient stereopsis, but do not have
OKN asymmetry.
5. pathogenesispathogenesis
Worths sensory concept. Inborn and
irreversible defect of fusion.
Chavasse mechanical concept. Neural
components necessary for normal
binocular vision are present in strabismic
individuals at birth, but the development
of fusion is eventually impeded by
abnormalities of optical input (eg,
monocular cataracts) or muscular output
(eg, cranial nerve palsies)
6. Certain risk factors .
prematurity, family history, perinatal or
gestational complications, systemic
disorders, use of supplemental oxygen as
a neonate, use of systemic medications.
Awareness of these risk factors can lead
to early detection and management of
esotropia
7. CETCET
Alignment is achieved by 4mths in the
normal infant and stereopsis can be
measured in the laboratory.
Early misalignment constant or intermittent
beyond 2-4 months is required to be sure of
the diagnosis of congenital ET.
OKN asymmetry present in all infants
becomes symmetrical by 6 months in the
normal. Patients with congenital ET retain
OKN asymmetry
8. What to be seen in a patient with
congenital esotropia? (Diagnostic
criteria)
* Neurologically normal 70% (except for
ET)
* Hyperopia less than +3.50 (A greater
hyperopia does not rule out congenital
ET)
* Esotropia (30-70PD ± nystagmus)
9. A special characteristic of congenital
esotropia - OKN asymmetry
Temporal to Nasal (T/N).Smooth
following, rapid and accurate Refixation
Nasal to Temporal (N/T).Jerky,
inaccurate movement with halting
refixation
10. Congenital ETCongenital ET
ET by 6 mths
> 30 D ET & Stable
Assymetry of OKN
Cross fixation
Abd restriction
No clinical CNS involement
Deviation same for D & N
Consistant features
11. Associated featuresAssociated features
IO overaction 60%,
nystagmus,DVD 50% > 1yr
Amblypoia (35%)
AHP
It can be associated with a systemic
disease such as Down’s syndrome,
albinism, cerebral palsy, or
hydrocephaly.1-4
16. Management goalManagement goal
To make the eyes as close to orthotropia
with normal vision,develop some fusion
to keep alignment
May require multiple surgeries
Alignment with 8-10d results in
monofixation syndrome …comfortable
surgical result
18. Non surgical interventionNon surgical intervention
Botulinum toxin
To postpone surgery
Not as effective as surgery
Spects
Acc ET
Prisms
Temp measure
Small angle
19. SurgerySurgery
40d ET at 4 mths will not resolve
spontaneously
Must be as done early as possible to get
binocular function.
Large deviation…..correction is more
ET + amb…more correction
Fusion potential must be undercorrected
20. timing of surgerytiming of surgery
Early surgery decreases the severity of DVD and
lowers the need for additional operation for DVD
oblique overaction. Yagasaki et al, Zak and
Morin
Early vs. Late Infantile Strabismus Surgery Study
(ELISS), children operated at age 6-24 months had
better gross stereopsis at age 6 years compared
with those operated on later
21. Surgical alignment before 18 mos. better
binocularity
will even better binocularity be achieved with
alignment before 12 mo.
The Pediatric Eye Disease Investigator Group
(PEDIG) in the Congenital Esotropia Observation
Study (CEOS) determined that ET of 40 diopters
or more present at 2 months persists until 7
months - diagnosis of congenital ET can be made
ET of less than 40 prism diopters or intermittent
ET at 2 mos. has a 50% chance of persisting at 7
mos.
22. Surgical options
Recession of both MR
Symmetrical or asymmetrical
No of muscles depends upon
amount of deviation
Weakening of IO
rece.wmv
23. Results to be expected fromResults to be expected from
surgery for CETsurgery for CET
Single muscle..Sparingly MR Recession
Small angle (10-15pd),fusion potential,diplopia
DRS
Possible OVER CORRECTION
24. RESULT TO BE EXPECTED FROM
SURGERY FOR CET
Cong ET 50pd
Adult ET 40pd
Equal vision
ET .>N more AC/A
+Oblique muscle for
AV,&IOOA
BMR Recession
Minimal 2.5mm MR for 15-
20pd
Maxim.7mm for 40pd
BLR Resection
Div insufficiency. 20pd .5mm
Res ET 40pd 9mm
R&R
CET ..poor vision one eye
2.5MR-5LR..20-25pd
5MR+9LR <1yr….50pd
7MR+10LR..>3yrs 50pd+
Two muscle surgery
Measurement from
insertion
27. Why does early alignmentWhy does early alignment
improve stereoacuityimprove stereoacuity
outcomes in CET?outcomes in CET?
patients with stereo less likely to need a 2nd
surgery [p=0.05] and less likely to have DVD (P
<.001).
CONGENITAL ESOTROPIA 27
30. Management of CETManagement of CET
Confirm diagnosis
Fixation
fusion
Amblyopia
Accomadation,Refraction
Associated features
Surgery as early as possible
depending on anesthetist readiness
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