The document discusses the challenges of oral rehabilitation in cases of combination syndrome, a condition characterized by severe anterior maxillary resorption and associated issues in dental management. Conventional treatments, like full upper and partial lower dentures, often fall short due to ongoing bone resorption, necessitating advanced techniques such as the modified window technique and the use of implant-supported overdentures for better outcomes. Recent studies indicate that mandibular implant-supported fixed prostheses can achieve excellent long-term results when opposing a maxillary complete denture.