The Columbian Exchange began after Christopher Columbus' voyage to the Americas in 1492 and involved the widespread exchange of plants, animals, crops, populations, and diseases between the Eastern and Western hemispheres. Major impacts included the introduction of devastating diseases from Europe that killed around 80% of the indigenous population in the Americas by 1650. Agricultural products like corn, potatoes, and cacao were brought to Europe while crops like wheat, sugarcane, and livestock spread in the Americas, transforming farming. The introduction of horses had significant cultural impacts for some Native American tribes. Overall, the Columbian Exchange dramatically altered societies and ecosystems on both sides of the Atlantic.